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| 1 | The Beishan underground research laboratory for geological disposal of high-level radioactive waste in China:Planning, site selection,site characterization and in situ tests显示文摘With the rapid development of nuclear power in China, the disposal of high-level radioactive waste(HLW) has become an important issue for nuclear safety and environmental protection. Deep geological disposal is internationally accepted as a feasible and safe way to dispose of HLW, and underground research laboratories(URLs) play an important and multi-faceted role in the development of HLW repositories. This paper introduces the overall planning and the latest progress for China's URL. On the basis of the proposed strategy to build an area-specific URL in combination with a comprehensive evaluation of the site selection results obtained during the last 33 years, the Xinchang site in the Beishan area,located in Gansu Province of northwestern China, has been selected as the final site for China's first URL built in granite. In the process of characterizing the Xinchang URL site, a series of investigations,including borehole drilling,geological mapping, geophysical surveying,hydraulic testing and in situ stress measurements, has been conducted. The investigation results indicate that the geological,hydrogeological, engineering geological and geochemical conditions of the Xinchang site are very suitable for URL construction. Meanwhile, to validate and develop construction technologies for the Beishan URL, the Beishan exploration tunnel(BET), which is a 50-m-deep facility in the Jiujing sub-area, has been constructed and several in situ tests, such as drill-and-blast tests, characterization of the excavation damaged zone(EDZ), and long-term deformation monitoring of surrounding rocks, have been performed in the BET. The methodologies and technologies established in the BET will serve for URL construction.According to the achievements of the characterization of the URL site, a preliminary design of the URL with a maximum depth of 560 m is proposed and necessary in situ tests in the URL are planned. | Ju Wang Liang Chen Rui Su Xingguang Zhao | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，3： | 62 |
| 2 | Mycorrhizal symbiosis modulates the rhizosphere microbiota to promote rhizobia–legume symbiosis显示文摘Plants establish symbioses with mutualistic fungi,such as arbuscular mycorrhizal(AM)fungi,and bacteria,such as rhizobia,to exchange key nutrients and thrive.Plants and symbionts have coevolved and represent vital components of terrestrial ecosystems.Plants employ an ancestral AM signaling pathway to establish intracellular symbioses,including the legume–rhizobia symbiosis,in their roots.Nevertheless,the relationship between the AM and rhizobial symbioses in native soil is poorly understood.Here,we examined how these distinct symbioses affect root-associated bacterial communities in Medicago truncatula by performing quantitative microbiota profiling(QMP)of 16S rRNA genes.We found that M.truncatula mutants that cannot establish AM or rhizobia symbiosis have an altered microbial load(quantitative abundance)in the rhizosphere and roots,and in particular that AM symbiosis is required to assemble a normal quantitative root-associated microbiota in native soil.Moreover,quantitative microbial co-abundance network analyses revealed that AM symbiosis affects Rhizobiales hubs among plant microbiota and benefits the plant holobiont.Through QMP of rhizobial rpoB and AM fungal SSU rRNA genes,we revealed a new layer of interaction whereby AM symbiosis promotes rhizobia accumulation in the rhizosphere of M.truncatula.We further showed that AM symbiosis-conditioned microbial communities within the M.truncatula rhizosphere could promote nodulation in different legume plants in native soil.Given that the AM and rhizobial symbioses are critical for crop growth,our findings might inform strategies to improve agricultural management.Moreover,our work sheds light on the co-evolution of these intracellular symbioses during plant adaptation to native soil conditions. | Xiaolin Wang Huan Feng Yayu Wang Mingxing Wang Xingguang Xie Huizhong Chang Like Wang Jicheng Qu Kai Sun Wei He Chunyan Wang Chuanchao Dai Zhaohui Chu Changfu Tian Nan Yu Xuebin Zhang Huan Liu Ertao Wang | 2021 | Molecular Plant2021，14，3： | 6 |
| 3 | Excavation of underground research laboratory ramp in granite using tunnel boring machine: Feasibility study显示文摘Underground research laboratory(URL)plays an important role in safe disposal of high-level radioactive waste(HLW).At present,the Xinchang site,located in Gansu Province of China,has been selected as the final site for China’s first URL,named Beishan URL.For this,a preliminary design of the Beishan URL has been proposed,including one spiral ramp,three shafts and two experimental levels.With advantages of fast advancing and limited disturbance to surrounding rock mass,the tunnel boring machine(TBM)method could be one of the excavation methods considered for the URL ramp.This paper introduces the feasibility study on using TBM to excavation of the Beishan URL ramp.The technical challenges for using TBM in Beishan URL are identified on the base of geological condition and specific layout of the spiral ramp.Then,the technical feasibility study on the specific issues,i.e.extremely hard rock mass,high abrasiveness,TBM operation,muck transportation,water drainage and material transportation,is investigated.This study demonstrates that TBM technology is a feasible method for the Beishan URL excavation.The results can also provide a reference for the design and construction of HLW disposal engineering in similar geological conditions.2020 Institute of Rock and Soil Mechanics,Chinese Academy of Sciences.Production and hosting by Elsevier B.V.This is an open access article under the CC BY-NC-ND license(http://gffzzeb6f7f563f66445dh5k6vvcv5u9vw6u09.ffgz.tsg.suse.edu.cn/licenses/by-nc-nd/4.0/). | Hongsu Ma Ju Wang Ke Man Liang Chen Qiuming Gong Xingguang Zhao | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，6： | 6 |
| 4 | The distribution and characteristics of suspended particulate matter in the Chukchi Sea显示文摘Samples taken from the ChukchiSea(CS) during the 4th Chinese National Arctic Research Expedition, 2010, were analyzed to determine the content and composition of suspended particulate matter(SPM) to improve our understanding of the distribution, sources and control factors of the SPM there. The results show that the SPM in the water column is highest in the middle and near the bottom in the south and central–north CS, followed by that off the Alaskan coast and in Barrow Canyon. The SPM content is lowest in the central CS. Scanning electron microscope(SEM) analysis shows that the SPM in the south and central–north CS is composed mainly of diatoms, but the dominant species in those two areas are different. The SPM off the Alaskan coast and in Barrow Canyon is composed mainly of terrigenous material with few bio-skeletal clasts. The distribution of temperature and salinity and the correlation between diatom species in SPM indicate that the diatom dominant SPM in the south CS is from the Pacific Ocean via the Bering Strait in summer. The diatom dominant SPM in the central–north CS is also from Pacific water, which reaches the CS in winter. The SPM in the middle and near the bottom of the water column off the Alaskan coast and in Barrow Canyon is from Alaskan coastal water and terrigenous material transported by rivers in Alaska. | WANG Weiguo FANG Jianyong CHEN Lili WU Risheng YU Xingguang | 2014 | Advances in Polar Science2014，25，3： | 3 |
| 5 | KDM2B promotes IL-6 production and inflammatory responses through Brg1-mediated chromatin remodeling显示文摘IL-6 plays important and pleiotropic roles in infection and inflammatory diseases,and its production needs to be tightly regulated.However,the epigenetic mechanism underlying Il6 gene transcription remains to be fully elucidated.Here,we report that lysine-specific demethylase 2b(KDM2B),which demethylates H3K4me3 and H3K36me2,is required in macrophages and dendritic cells for the induction of IL-6 but not TNF-α,IL-1,and IFN-β.Compared to wild-type mice,KDM2B-deficient mice were more resistant to endotoxin shock and colitis,with a less severe inflammatory pathogenesis phenotype and decreased IL-6 production in sera.KDM2B selectively bound the Il6 promoter but did not alter histone demethylation;instead,KDM2B interacted with Brahma-related gene 1(Brg1),the core ATPase subunit of SWI/SNF chromatin remodeling complexes,to facilitate chromatin accessibility of the Il6 promoter.Furthermore,KDM2B directly recruited RNA Polymerase II to further initiate and promote Il6 transcription.Thus,our finding identifies a novel nonclassical function of KDM2B in gene-specific transcription initiation and enhancement of Il6 independent of its demethylase activity and adds new insight into the specific epigenetic modification mechanism of inflammatory immune responses. | Qingqing Zhou Yunkai Zhang Bo Wang Wenhui Zhou Yong Bi Wanwan Huai Xi Chen Yihan Chen Zhongmin Liu Xingguang Liu Zhenzhen Zhan | 2020 | Cellular & Molecular Immunology2020，17，8： | 2 |
| 6 | Quantification of SARS-CoV-2 antigen levels in the blood of patients with COVID-19显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused the global outbreak of coronavirus disease 2019(COVID-19).By far,more than 35 million people had been infected by SARS-CoV-2,resulting in more than 1 million deaths globally.It is well recognized that SARSCoV-2 preferentially attacks pulmonary epithelial cells,leading to acute respiratory distress syndrome(ARDS). | Bin Su Jiming Yin Xingguang Lin Tiantian Zhang Xiao Yao Ying Xu Yao Lu Wenzhi Wang Kun Liu Jie Zhang Liangzhi Xie Ronghua Jin Yingmei Feng | 2021 | Science China(Life Sciences)2021，64，7： | 2 |
| 7 | Glycolipid iGb3 feedback amplifies innate immune responses via CD1d reverse signaling显示文摘The cross-talk between cellular lipid metabolism and the innate immune responses remains obscure. In addition to presenting lipid antigens to Natural Killer T-cells (NKT cells), the Cluster of Differentiation 1D Glycoprotein (CD1d) might mediate reverse signaling in antigen-presenting cells (APCs). Here we found CD1d deficiency attenuated Toll-like receptor (TLR)-triggered inflammatory innate responses in macrophages and dendritic cells, protecting mice from endotoxin shock. TLR activation in macrophages induced metabolic changes of glycosphingolipids (GSLs), among which glycolipid isoglobotrihexosylceramide (iGb3) was rapidly produced. The endogenously generated iGb3 bound CD1d in endosomal compartments and then synergized with the initially activated TLR signal to induce Tyr332 phosphorylation of CD1d intracellular domain. This led to the recruitment and activation of proline-rich tyrosine kinase 2 (Pyk2). Pyk2 interacted with IκB kinase β (IKKβ) and TANK-binding kinase 1 (TBK1), and enhanced tyrosine phosphorylation of Tyr188/199 of IKKβ and Tyr179 of TBK1 and thus, their activation to promote full activation of TLR signaling. Thus, intracellular CD1d reverse signaling, triggered by endogenous iGb3, amplifies inflammatory innate responses in APCs. Our findings identify a non-canonical function of CD1d reverse signaling activated by lipid metabolite in the innate immune response. | Xingguang Liu Peng Zhang Yunkai Zhang Zheng Wang Sheng Xu Yingke Li Wanwan Huai Qingqing Zhou Xiang Chen Xi Chen Nan Li Peng Wang Yunsen Li Xuetao Cao | 2019 | Cell Research2019，29，1： | 1 |
| 8 | Study on the coagulation process of polyacrylonitrile nascent fibers during wet-spinning 显示文摘 | Dong Xingguang Wang Chengguo Chen Juan | 2007 | Polymer Bulletin2007，58，56： | 1 |
| 9 | TOPIC SPLITTING: A HIERARCHICAL TOPIC MODEL BASED ON NON-NEGATIVE MATRIX FACTORIZATION显示文摘 | Rui Liu Xingguang Wang Deqing Wang Yuan Zuo He Zhang Xianzhu Zheng | 2018 | Journal of Systems Science and Systems Engineering2018，27，4： | 1 |
| 10 | Progress on rock mechanics research of Beishan granite for geological disposal of high-level radioactive waste in China显示文摘The mechanical behavior of host rock for a deep geological repository of high-level radioactive waste plays a key role in ensuring the isolation function of host rock as a natural barrier under the multi-field coupling environment.For a better understanding of granite in China's Beishan pre-selected area for geological disposal of high-level radioactive waste,a series of investigations were carried out on in-situ stress field of rock mass at depth,strength and deformation characteristics of rocks under different stress and temperature conditions,and rock boreability and adaptability to Tunnel Boring Machine(TBM)technology.The results indicate that Beishan granite shows typical characteristics as a hard and brittle rock with a quite low permeability,and it is favorable to geological disposal.Meanwhile,a new rock mass suitability evaluation system was proposed,and the rock mass mainly composed of Beishan granite was proven to be suitable for geological disposal.Besides,the constructability of Beishan granite at engineering scale was tested and verified through field tests in the Beishan Exploration Tunnel(BET).Here,we summarize the main outcomes of rock mechanics research on Beishan granite in the past years and introduced the current progress of Beishan underground research laboratory(URL)for geological disposal. | Liang Chen Xingguang Zhao Jian Liu Hongsu Ma Chunping Wang Haiyang Zhang Ju Wang | 2023 | Rock Mechanics Bulletin2023，2，3： | 1 |
| 11 | Type I IFN Inhibits Innate IL-10 Production in Macrophages through Histone Deacetylase 11 by Downregulating MicroRNA-145显示文摘 | Li Lin Jin Hou Feng Ma Pin Wang Xingguang Liu Nan Li Jianli Wang Qingqing Wang Xuetao Cao | 2013 | The Journal of Immunology2013，，7： | 1 |
| 12 | Zinc Finger Protein 64 Promotes Toll-like Receptor-triggered Proinflammatory and Type I Interferon Production in Macrophages by Enhancing p65 Subunit Activation显示文摘 | Chunmei Wang Xingguang Liu Yin Liu Qian Zhang Zhenyu Yao Bo Huang Peng Zhang Nan Li Xuetao Cao | 2013 | Journal of Biological Chemistry2013，，34： | 1 |
| 13 | Aqueous synthesis of Cu-doped ZnSe quantum dots显示文摘 | Gao Xue Wang Chao Niu Lu Su Xingguang | 2011 | Journal of Luminescence2011，，7： | 1 |
| 14 | Amplitude of low-frequency fluctuations on Alzheimer’s disease with depression: evidence from resting-state fMRI显示文摘Background The prevalence of Alzheimer's disease(AD)comorbid with depression is common.However,the mechanisms of AD with depression remain unclear.Aims To investigate the regional alterations of brain activity of AD with depression in resting-state functional magnetic resonance imaging(rs-fMRI).Methods 154 patients with AD who met the inclusion criteria were recruited from the Zhejiang Provincial People’s Hospital from October 2014 to October 2016.According to whether the core symptoms of depression were present,patients were divided into two groups,22 patients with AD with depression(AD-D)and 52 patients with AD without depression(AD-nD).The amplitude of low frequency fluctuations(ALFF)was compared between two groups by performing independent-samples f-test.Results Compared with the AD-D group,increased ALFF values in the bilateral superior frontal gyrus,left middle frontal gyrus and left inferior frontal gyrus were observed in the AD-nD group.The brain activity in the AD-nD group in the bilateral superior frontal gyrus,left middle frontal gyrus and the left inferior frontal gyrus was higher than the AD-D group.Conclusions Resting-state brain functional alterations may be closely bound up with the pathophysiologic features of patients with AD with depressive symptoms. | Yuzhu Mu Yumei Li Qi Zhang Zhongxiang Ding Mei Wang Xingguang Luo Xiaoyun Guo Maosheng Xu | 2020 | General Psychiatry2020，33，4： | 1 |
| 15 | 酒精依赖的基于基因和基于通路的全基因组关联研究(英文)显示文摘背景:信号通路中风险基因的构成可能可以解释酒精依赖风险基因协同的神经生物学作用。目的:识别酒精依赖的风险基因和风险基因通路。方法:我们采用基因富集(gene-set-rich)分析方法对酒精依赖进行了基于通路的全基因组关联分析(GWAS)。在包括1409名欧裔美国人(European-American,EA)酒精依赖者和1518名EA健康对照者的探索性样本人群中检测了近一百万个基因标志物。此外,将681名非裔美国人(African-American,AA)病例和508名AA健康受试者作为重测样本。结果:我们发现了几个与酒精依赖显著相关的可重复的全基因组风险基因和风险通路。在多重比较Bonferroni校正后,'细胞-细胞外基质相互作用'通路(EA样本中p<2.0E-4)和该通路中PXN基因(编码桩蛋白paxillin)(EA样本中p=3.9E-7)是最有可能的酒精依赖的危险因素。在EA样本(0.015≤p≤0.035)和AA样本(0.025≤p≤0.050)中还有两条富含酒精依赖相关基因的可重复的通路:'Na+/Cl-依赖性神经递质转运体'通路和'其他聚糖降解'通路。结论:一些基因和生物信号传导过程可能与酒精依赖的风险相关,本研究的发现为此提供了新的证据。 | Lingjun ZUO Clarence K.ZHANG Frederick G.SAYWARD Kei-Hoi CHEUNG Kesheng WANG John H.KRYSTAL Hongyu ZHAO Xingguang LUO | 2015 | 上海精神医学2015，27，2： | 1 |
| 16 | Surgical instruments hyalinization:Occlusion removal in minimally invasive endoscopic surgery显示文摘Minimal invasion is an important trend in surgery.However,the endoscope,as one of the key devices for monitoring the process of minimally invasive surgery,is limited by its size and working space it operates in,which result in a considerably narrow field of view.In particular,when a surgical instrument enters through the tool channel,the instrument occupies most of the area in an endoscopic image.This hampers the surgeon’s field of view and has a negative impact on the surgery.This study proposes a novel method for removing the occlusion caused by surgical instruments in endoscopic images by making foreground occlusions on endoscopic images transparent using image restoration and interframe information filling.Compared with unprocessed images,this method can provide a clearer field of view that is necessary for minimally invasive endoscopic surgeries and improve the quality of surgeries.Clinical endoscopic images are used to verify the feasibility of the proposed method,and the results show that the proposed method improves the visual effect of endoscopic images by removing surgical-instrument occlusions.This demonstrates the considerable potential of the proposed method for use in clinical applications. | Dongsheng Xie Wenxin Chen Jin Zhao Xinya Song Kaifeng Wang Weiwei Xia Haiying Liu Fangle Chang Changsheng Li Xingguang Duan | 2023 | Biomimetic Intelligence & Robotics2023，3，3： | 1 |
| 17 | The rapidly expanding CRF01_AE epidemic in China is driven by multiple lineages of HIV-1 viruses introduced in the 1990s显示文摘 | Yi Feng Xiang He Jenny H. Hsi Fan Li Xingguang Li Quan Wang Yuhua Ruan Hui Xing Tommy Tsan-Yuk Lam Oliver G. Pybus Yutaka Takebe Yiming Shao | 2013 | AIDS2013，，： | 1 |
| 18 | Photovoltaic Properties of Titanium Dioxide Nanowires with Different Crystal Structures显示文摘 | WANG Xinyan WANG Huan YANG Xiaotian SU Xingguang | 2016 | Chemical Research in Chinese Universities2016，32，4： | 1 |
| 19 | Study on the coagulation mechanism of wet-spinning PAN fibers显示文摘 | Chen Juan Wang Chengguo Dong Xingguang | 2006 | Journal of Polymer Researeh2006，13，6： | 1 |
| 20 | Triamcinolone Intravitreal Injection and Intraocular Pressure in Macular Edema Associated with Retinal Vein Occlusion显示文摘Purpose:To study the risk factors of increased intraocular pressure (IOP) response to triamcinolone acetonide intravitreal (IVTA) injection in eyes with macular edema associated with retinal vein occlusion. Methods:Eighty-nine eyes with macular edema associated with retinal vein occlusion first received periocular injection of 40 mg triamcinolone acetonide (TA) and were followed for one month. According to the diversity of IOP after periocular TA (PTA) injection, they were divided into the elevation IOP group (group A, 26 eyes) and the normal IOP group (group B,63 eyes).They then received 4 mg TA intravitreal injection.IOP measurements were recorded after PTA and IVTA injections, and were followed for six months. Results: Both PTA and IVTA injections caused a rise in IOP, but it was higher in the IVTA injection (40.45%) than in the PTA injection (29.21%). The mean rise in IOP was more significant in eyes with IVTA injection (28.08 ± 8.24 mmHg) than in eyes with PTA injection (20.87 ± 4.07 mmHg). Patients with an elevation IOP above 6 mmHg after PTA injection had a 73.08% chance of developing a pressure of 24 mmHg or higher,whereas only 12.70% of those with an elevation IOP below 6 mmHg after PTA injection experienced pressure elevation. Conclusion:IOP response to PTA injection is a good way to judge IOP response to IVTA. If the patient is highly sensitive to corticosteroid, treatments other than IVTA injection are used to avoid the increased risks associated with intravitreal corticosteroid injection. | Yong Wei Huaizhou Wang Fenghua Chen Runsheng Wang Xingguang Yang | 2012 | Eye Science2012，27，4： | 0 |
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