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| 1 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 2 | Impact of acetochlor on ammonia-oxidizing bacteria in microcosm soils显示文摘Acetochlor is an increasingly used herbicide on corn in North China. Currently, the effect of acetochlor on soil ammonia-oxidizing bacteria (AOB) communities is not well documented. Here, we studied the diversity and community composition of AOB in soil amended with three concentrations of acetochlor (50, 150, 250 mg/kg) and the control (0 mg acetochlor/kg soil) in a microcosm experiment by PCR-DGGE (polymerase chain reaction-denaturing gradient gel electrophoresis) and the phylogenetic analysis of excised DGGE bands. DGGE profiles showed that acetochlor had a stimulating effect on AOB at the early stage after acetochlor amended, and the order of intensity and duration is medium-acetochlor amended samples (AM) > low-acetochlor amended samples (AL) > high-acetochlor amended samples (AH). At the end of 60 d microcosm, acetochlor had a negative effect on the diversity of AOB. Cluster analysis of DGGE profiles showed that acetochlor had a greater effect on the community structure of AOB on day 60 than on day 1. The phylogenetic analysis revealed that all the sequences of excised DGGE bands were closely related to members of the genus Nitrosospira and formed two separate subclusters designated as subcluster 1 and subcluster 2 affiliated respectively with clusters 3 and 4 in Nitrosospira as defined by Stephen. Some dominant AOB had a change from subcluster 2 to subcluster 1 with the incubation. The results showed that acetochlor had an effect on the AOB on a long-term basis and the chronic effect of acetochlor should be paid more attention in future. | Xinyu LI Chenggang ZHANG | 2008 | Journal of Environmental Sciences2008，20，9： | 7 |
| 3 | Soil fungistasis and its relations to soil microbial composition and diversity:A case study of a series of soils with different fungistasis显示文摘Fungistasis is one of the important approaches to control soil-borne plant pathogens.Some hypotheses about the mechanisms for soil fungistasis had been established,which mainly focused on the soil bacterial community composition,structure,diversity as well as function.In this study,the bacterial community composition and diversity of a series of soils treated by autoclaving,which coming from the same original soil sample and showing gradient fungistasis to the target soil-borne pathogen fungi Fusarium gr... | Wu Minna Zhang Huiwen Ll Xinyu Zhang Yan Su Zhencheng Zhang Chenggang | 2008 | Journal of Environmental Sciences2008，20，7： | 7 |
| 4 | Characteristics and significance of the penecontemporaneous karst in lacustrine carbonate, Da'anzhai Member, Lower Jurassic, Beibei area, eastern Sichuan Basin显示文摘There are few reports about the penecontemporaneous karst of the lacustrine carbonate of Da'anzhai Member which developed on the top of Lower Jurassic Ziliujing Formation,eastern Sichuan Basin.Based on the analysis of the macroscopic and microscopic characteristics of Heping Reservoir section in Beibei area,It is discovered that the penecontemporaneous karst in the lacustrine carbonate,Da'anzhai Member,and its characters as follows:(1)The dissolved fractures and karrens are common,which have been filled with vadose silts,bioclasts,terrigenous quartzes,crystal and intergrown calcites;(2)The penecontemporaneous karstification mainly occurs in the micrites and shell limestones of the middle and upper part of the shallowing-upward sequence,and the desiccation cracks occur in some shallowing-upward sequences;(3)Three meteoric-water diagenetic lenses are identified in this section.By further study we also find the factures,stylolite and burial dissolution pores occur along the karst system(tubes,conduits and caves of the karst).And the asphalt not only fills the stylolites and fractures,but also is mixed with the vadose silt in the karst system,although the pore space formed by penecontemporaneous karstification is filled with vadose material and cements.Therefore it is concluded that the development and modification of the tight lacustrine carbonate reservoir of Da'anzhai Member,to some extent,are relevant with the penecontemporaneous karstification,and the penecontemporaneous karst reservoir may develop in the buried Da'anzhai carbonate of the basin. | Chengpeng Su Xiucheng Tan Kailan Shi Juan Zou Feifan Lu Sicong Luo Hao Tang Xinyu Zhang | 2017 | Petroleum2017，3，3： | 5 |
| 5 | Inhibition of CDK9 by voruciclib synergistically enhances cell death induced by the Bcl-2 selective inhibitor venetoclax in preclinical models of acute myeloid leukemia显示文摘Venetoclax,an FDA-approved Bcl-2 selective inhibitor for the treatment of chronic lymphocytic leukemia and acute myeloid leukemia(AML),is tolerated well in elderly patients with AML and has good overall response rates;however,resistance remains a concern.In this study,we show that targeting CDK9 with voruciclib in combination with venetoclax results in synergistic antileukemic activity against AML cell lines and primary patient samples.CDK9 inhibition enhances venetoclax activity through downregulation of Mcl-1 and c-Myc.However,downregulation of Mcl-1 is transient,which necessitates an intermittent treatment schedule to allow for repeated downregulation of Mcl-1.Accordingly,an every other day schedule of the CDK9 inhibitor is effective in vitro and in vivo in enhancing the efficacy of venetoclax.Our preclinical data provide a rationale for an intermittent drug administration schedule for the clinical evaluation of the combination treatment for AML. | Daniel A.Luedtke Yongwei Su Jun Ma Xinyu Li Steven ABuck Holly Edwards Lisa Polin Juiwanna Kushner Sijana HDzinic Kathryn White Hai Lin Jeffrey WTaub Yubin Ge | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 3 |
| 6 | Design,preparation and measurement of protein/CNTs hybrids:A concise review显示文摘With the development of nanobiotechnology,the carbon nanotubes(CNTs)and protein hybrids system has attracted an increasing attention for great potential application in nanotechnology,medicine,smart materials,light industry,and biology.In this review,the main preparation processes,impact factors,measurement of interactions and potential applications of CNTs/protein are presented from the aspect of experiments.Meanwhile,the proper forces detection methods are illustrated comprehensively to complete the quantitative measurement.Atomic force microscope(AFM)and surface force apparatus(SFA)experiments are described in detail to confirm the powerful function in measuring the interaction forces.In addition,the impact of different protein structures(amino acid residues,αHelix,polypeptide chain,and assembled subunits)on interactions between CNTs and protein is presented and different amino acid residues may intervene largely on interactions.Owing to the relatively little knowledge about the structure,function,and spatial orientation of proteins interaction with CNTs surface,we assume that the key problem is how to prepare CNTs and protein specimen with unique structure(such as the variation of secondary and tridimensional structure of protein or the single CNTs)to investigate the interaction forces instead of the designed,preparation,and detection methods. | Xing Zhou Jian Su Chenxi Wang Changqing Fang Xinyu He Wanqing Lei Chaoqun Zhang Zhigang Huang | 2020 | Journal of Materials Science & Technology2020，42，11： | 3 |
| 7 | Multi-omic characterization of genome-wide abnormal DNA methylation reveals diagnostic and prognostic markers for esophageal squamous-cell carcinoma显示文摘This study investigates aberrant DNA methylations as potential diagnosis and prognosis markers for esophageal squamous-cell carcinoma(ESCC),which if diagnosed at advanced stages has<30%five-year survival rate.Comparing genome-wide methylation sites of 91 ESCC and matched adjacent normal tissues,we identified 35,577 differentially methylated CpG sites(DMCs)and characterized their distribution patterns. | Yiyi Xi Yuan Lin Wenjia Guo Xinyu Wang Hengqiang Zhao Chuanwang Miao Weiling Liu Yachen Liu Tianyuan Liu Yingying Luo Wenyi Fan Ai Lin Yamei Chen Yanxia Sun Yulin Ma Xiangjie Niu Ce Zhong Wen Tan Meng Zhou Jianzhong Su Chen Wu Dongxin Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 2 |
| 8 | Parametrization of woods-saxon potential for heavy-ion systems显示文摘Several elastic scattering angular distributions of ^(12)C from target nuclei of A ≥39 are analyzed to extract the Woods-Saxon potential parameters with the fixed imaginary potential and Coulomb radius parameters.Using the best fitted diffuseness parameters,the correlations of the real part parameters with A_1^(1/3)+ A_2^(1/3) and incident energy are revealed, and the systematic Woods-Saxon potential parameters are presented for nucleus-nucleus interaction.The proposed potential parameters can reproduce not only the elastic scattering angular distributions induced by ^(12)C,but also many elastic scattering angular distributions induced by the projectiles other than ^(12)C,thus providing important inputs for the study of nuclear reactions of heavy-ion systems. | Lin Gan ZhiHong Li HuiBin Sun DanYang Pang Bing Guo YunJu Li Jun Su ShengQuan Yan ErTao Li YouBao Wang Gang Lian ZhiYu Han XinYue Li DongHui Li TianLi Ma ChangJin Pei YangPing Shen Yi Su Sheng Zeng Yong Zhou WeiPing Liu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，8： | 2 |
| 9 | ALYREF mediates RNA m^(5)C modification to promote hepatocellular carcinoma progression显示文摘Dear Editor,The incidence of hepatocellular carcinoma(HCC)is increasing in many countries due to hepatic virus infection and unhealthy diet habits,and the unsatisfactory overall survival rate calls for novel treatments with higher efficacy.1 Recent studies have shown that RNA modifications are likely to participate in the progression of HCC,2 suggesting new methods for tumor growth control.Specifically,5-methylcytosine(m5C)is one of the most interesting RNA modification types,as accumulating evidence suggests its role in the promotion of HCC tumorigenesis.3 The RNA methyltransferase Aly/REF export factor(ALYREF)is considered one type of“reader”protein located in the nucleus that recognizes and binds directly with m5C sites in RNA and facilitates the export of RNA from the nucleus to the cytoplasm.4 Notably,ALYREF is considered a promising target for diagnosis and prognosis prediction.5 However,until now,the low number of related studies has limited the understanding of the mechanism of the HCC-promoting effects of ALYREF. | Chen Xue Xinyu Gu Qiuxian Zheng Qingmiao Shi Xin Yuan Yuanshuai Su Junjun Jia Jianwen Jiang Juan Lu Lanjuan Li | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 10 | Immobilization of heparin on decellularized kidney scaffold to construct microenvironment for antithrombosis and inducing reendothelialization显示文摘In recent years, rapid development of tissue engineering technology provides possibilities for the construction of artificial tissues or organs. In construction of engineered kidneys, researchers used native decellularized extracellular matrix(ECM) as the scaffolds to recellularization. However, thrombosis has been a great issue that hinders the progress of transplantation in vivo. In this study, heparin was immobilized to the collagen part of decellularized scaffold with collagen-binding peptide(CBP). Through the anticoagulant and endothelial cell reperfusion experiments, it can be demonstrated that the heparinized scaffolds absorbed less platelets and red blood cells which can effectively reduce the formation of thrombosis. Moreover, it is conducive to longterm adhesion of endothelial cells which is important for the formation of subsequent vascularization. Taken together, our results reveal that the whole kidney can be modified by CBP-heparin composite to reduce the thrombosis and provide the better conditions for neovascularization. | Miao Wang Lili Bao Xinyu Qiu Xiaoshan Yang Siying Liu Yuting Su Lulu Wang Bo Liu Qing He Shiyu Liu Yan Jin | 2018 | Science China(Life Sciences)2018，61，10： | 1 |
| 11 | 显示文摘 | Su Junfeng Wang Xinyu Dong Hua | 2012 | Materials Letters2012，84，： | 1 |
| 12 | Influence of temperature on the deformation behaviors of melamine-formal- dehyde microcapsules containing phase change material 显示文摘 | SU Jurdeng WANG Xinyu DONG Hua | 2012 | Materials Letters2012，84，： | 1 |
| 13 | Extended Overlapping Community Detection Algorithm by Label Propagation for Internet Application Identification显示文摘The increased capacity and availability of the Internet has led to a wide variety of applications.Internet traffic characterization and application identification is important for network management.In this paper,based on detailed flow data collected from the public networks of Internet Service Providers,we construct a flow graph to model the interactions among users.Considering traffic from different applications,we analyze the community structure of the flow graph in terms of community size,degree distribution of the community,community overlap,and overlap modularity.The near linear time community detection algorithm in complex networks,the Label Propagation Algorithm(LPA),is extended to the flow graph for application identification.We propose a new initialization and label propagation and update scheme.Experimental results show that the proposed algorithm has high accuracy and efficiency. | Yu Ke Zhang Xinyu Di Jiaxi Wu Xiaofei Su Sixi | 2012 | China Communications2012，9，12： | 1 |
| 14 | Skeleton extraction for tree models显示文摘 | Zhixun Su Yuandi Zhao Chunjiang Zhao Xinyu Guo Zhiyang Li | 2010 | Mathematical and Computer Modelling2010，，3： | 1 |
| 15 | Empirical formula for β^--decay half-lives of r-process nuclei显示文摘Experimental data ofβ--decay half-lives of nuclei with atomic number between 20 and 190 are investigated.A systematic formula has been proposed to calculateβ^--decay half-lives of neutron-rich nuclei,with a particular consideration on shell and pair effects,the decay energy Q as well as the nucleon numbers(Z,N).Although the formula has relatively few parameters,it reproduces the experimentalβ^--decay half-lives of neutron-rich nuclei very well.The predicted half-lives for the r-process relevant nuclei obtained with the current formula serve as reliable input in the r-process model calculations. | Yong Zhou ZhiHong Li YouBao Wang YongShou Chen Bing Guo Jun Su YunJu Li ShengQuan Yan XinYue Li ZhiYu Han YangPing Shen Lin Gan Sheng Zeng Gang Lian WeiPing Liu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，8： | 1 |
| 16 | Fabrication and properties of microencapsulated-paraffin/gypsum-matrix building materials for thermal energy storage显示文摘 | JunFeng Su XinYu Wang ShengBao Wang | 2012 | Energy Conversion and Management2012，55，： | 1 |
| 17 | Efficacy of Ciji Hua'ai Baosheng formula on the expressions of vascular endothelial growth factor,kinase insert domain-containing receptor and basic fibroblast growth factor in mouse models of H22 hepatocellular carcinoma显示文摘OBJECTIVE: To investigate the efficacy of Ciji Hua'ai Baosheng formula(CHBF) on microvessel density(MVD) and vascular endothelial growth factor(VEGF), kinase insert domain-containing receptor(KDR) and basic fibroblast growth factor(b FGF) expression in serum and tumor tissue of mice receiving chemotherapy for the treatment of H22 hepatocellular carcinoma.METHODS: Sixty Kunming mice were injected subcutaneously with H22 hepatoma carcinoma cell suspensions into the right anterior armpit. Seven days later, all transplanted tumor were formed and the mice were intraperitoneally injected 200 mg/kg cytoxan(CTX) to establish the models of tumor-bearing mouse chemotherapy, then they were randomly divided into model group, continuing CTX chemotherapy group(CTX group), and three CHBF(117, 58.5 and 29.25 g/kg) groups. After ten days of treatments, histology was observed, contents of VEGF, KDR and b FGF in serum and tumor tissue were measured by enzyme-linked immunosorbent assay(ELISA), VEGF and b FGF protein expression and MVD tagged by CD34 were detected by immunohistochemisty.RESULTS: MVD in CHBF(117, 58.5 g/kg) and CTX groups was significantly lower than that in model group(P < 0.01); expressions of VEGF, KDR and b FGF in serum and tumor tissue in CHBF(117 g/kg)group were less than those in model group(P <0.05; P < 0.01); the expressions of MVD, VEGF and b FGF in tumor tissue of CHBF(117 g/kg) groupwere also less than those in CTX group(P < 0.05;P < 0.01).CONCLUSION: CHBF can effectively reduce the expression of VEGF, KDR and b FGF in serum and tumor tissue, and decrease MVD and delay tumor progression. | Zhao Xinyue Xi Shengyan Wang Yanhui Xu Yangxinzi Pollock Galia Su Yu Cheng Yao Loy Guanjie Liu Pei | 2017 | Journal of Traditional Chinese Medicine2017，37，1： | 1 |
| 18 | Effect of endoxylanases on dough properties and making performance of Chinese steamed bread显示文摘 | Dongmin Su Changhe Ding Lite Li Donghai Su Xinyu Zheng | 2005 | European Food Research and Technology (-)2005，，5： | 1 |
| 19 | Incidental prostate cancer in Asian men: High prevalence of incidental prostatic adenocarcinoma in Chinese patients undergoing radical cystoprostatectomy for treatment of bladder cancer and selection of candidates for prostate‐sparing cystectomy显示文摘 | Xinyu Yang M. Francesca Monn Libo Liu Yuli Liu Jinwei Su Tianjing Lyu Yanqing Gong Lisha Wang Darrell D. Davidson Liang Cheng | 2015 | Prostate2015，，： | 1 |
| 20 | InP/InGaAs Heterojunction Bipolar Transistor with Base μ Bridge and Emitter Air Bridge显示文摘 | Yu Jinyong Liu Xinyu Su Shubing | 2007 | Chinese Journal of Semiconductors2007，，2： | 1 |
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