|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | In situ scanning electron microscopy observation of deformation and fracture behavior of Ti-3Zr-2Sn-3Mo-25Nb alloy显示文摘The plastic deformation and fracture processes of Ti-3Zr-2Sn-3Mo-25Nb alloy for surgical implants were directly observed by in situ scanning electron microscopy(SEM).The effect of phase transformations on deformation-induced martensitic transformation accompanying the cyclic tensile fracture processes was investigated.The results reveal that the metastable alpha martensites(α″) promotes deformation-induced martensitic transformation to ductile fracture,whereas the omega(ω) and alpha(α) phases drastically prevent slip dislocation and deformation-induced martensitic transformation to brittle fracture. | Ma, Xiqun Yu, Zhentao Han, Yong Song, Xiping Sun, Qiaoyan | 2012 | Rare Metals2012，31，4： | 9 |
| 3 | Entrapping multifunctional dendritic nanoparticles into a hydrogel for local therapeutic delivery and synergetic immunochemotherapy显示文摘Developing multifunctional nanoparticles to support new therapy models is apromising and challenging task to address the current dilemma on antitumortreatment. Herein, we incorporated multifunctional dendritic nanoparticles intoa poly(D,L-lactide-co-glycolide)-poly(ethylene glycol)-poly(D,Lqactide-co-glycolide)(PLGA-PEG-PLGA) triblock copolymers thermosensitive injectable hydrogelmatrix to construct a localized drug delivery system for combining chemotherapyand immunotherapy. The multifunctional dendritic nanoparticles were designedwith following expectations: i, Dendritic scaffolds provide a hydrophobic interiorto load the anticancer drug, doxorubicin (DOX), for chemotherapy; and ii,dendritic scaffolds are used to build arginine-rich molecules to provide theinducible nitric oxide synthase (iNOS) substrate, L-Arg, to M1 macrophages,which can produce the cytotoxic substance nitric oxide (NO) and subsequentlyinduce tumor cell destruction through immunotherapy. It is noteworthy that thedendritic nanoparticles-in-hydrogel delivery system is able to gel at physiologicaltemperature and serves as a warehouse for the sustained release of the drug.Ultimately, this system showed great efficacy in treating 4T1 cells-xenograftedBALB/C mice (86.62% tumor growth inhibition). Therefore, this localized drugdelivery system combining chemotherapy and immunotherapy provides a novelapproach for cancer therapy. | Lei Jiang Yang Ding Xialin Xue Sensen Zhou Cheng Li Xiaoke Zhang Xiqun Jiang | 2018 | Nano Research2018，11，11： | 3 |
| 4 | Biomedical polymers: synthesis, properties, and applications显示文摘Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation. | Wei-Hai Chen Qi-Wen Chen Qian Chen Chunyan Cui Shun Duan Yongyuan Kang Yang Liu Yun Liu Wali Muhammad Shiqun Shao Chengqiang Tang Jinqiang Wang Lei Wang Meng-Hua Xiong Lichen Yin Kuo Zhang Zhanzhan Zhang Xu Zhen Jun Feng Changyou Gao Zhen Gu Chaoliang He Jian Ji Xiqun Jiang Wenguang Liu Zhuang Liu Huisheng Peng Youqing Shen Linqi Shi Xuemei Sun Hao Wang Jun Wang Haihua Xiao Fu-Jian Xu Zhiyuan Zhong Xian-Zheng Zhang Xuesi Chen | 2022 | Science China Chemistry2022，65，6： | 2 |
| 5 | The associations between Parkinson’s disease and cancer: the plot thickens显示文摘Epidemiological studies support a general inverse association between the risk of cancer development and Parkinson’s disease(PD).In recent years however,increasing amount of eclectic evidence points to a positive association between PD and cancers through different temporal analyses and ethnic groups.This positive association has been supported by several common genetic mutations in SNCA,PARK2,PARK8,ATM,p53,PTEN,and MC1R resulting in cellular changes such as mitochondrial dysfunction,aberrant protein aggregation,and cell cycle dysregulation.Here,we review the epidemiological and biological advances of the past decade in the association between PD and cancers to offer insight on the recent and sometimes contradictory findings. | Danielle D.Feng Waijiao Cai Xiqun Chen | 2015 | Translational Neurodegeneration2015，4，1： | 2 |
| 6 | Shape Effects of Cylindrical versus Spherical Unimolecular Polymer Nanomaterials on in Vitro and in Vivo Behaviors显示文摘To date,how the shape of nanomaterials infuences their biological properties is poorly understood,due to the insufcient controllability of current preparative methods,especially in the shape and size of nanomaterials.In this paper,we achieved the precise syntheses of nanoscale unimolecular cylindrical polymer brushes(CPBs)and spherical polymer nanoparticles(SPNPs)with the same volume and surface chemistry,which ensured that shape was essentially the only variable when their biological performance was compared.Accurate shape efects were obtained.Impressively,the CPBs had remarkable advantage in tissue penetration over the SPNPs.Te CPBs also exhibited higher cellular uptake and rapider body clearance than the SPNPs,whereas the SPNPs had longer blood circulation time,rapider tumor vascular extravasation,and higher tumor accumulation than the CPBs.Additionally,this work also provided a controllable synthesis strategy for nanoscale unimolecular SPNPs by integrating 21 CPBs to a�-cyclodextrin core,whose diameter in dry state could be up to 45 nm. | Zhengkui Zhang Changren Liu Cheng Li Wei Wu Xiqun Jiang | 2019 | Research2019，，1： | 2 |
| 7 | Responsive boron biomaterials and their biomedical applications显示文摘Due to the formation of dynamic boronate ester bonds between phenylboronic acid(PBA) and 1,2-and 1,3-diols, PBAcontaining biomaterials show increasing applications in biomedical areas, including responsive nanobiomaterials for targeting delivery of chemical drugs, protein drugs, gene drugs and imaging agents in vitro and in vivo for detection of various bioactive molecules such as sialic acid, saccharides, adenosine triphosphate(ATP) and dopamine. With the specific reaction between PBA and sialic acid, which is overexpressed in many kinds of cancer cells, PBA has been used as a targeting moiety for tumortargeting drug delivery. Additionally, PBA as an electron acceptor affords nanomaterials Lewis acid-base coordination with electron donor atoms such as nitrogen and oxygen, which can be exploited for developing drug delivery systems with high drug loading. Furthermore, PBA-containing materials can stoichiometric consume reactive oxygen species(ROS) and show a nucleus targeting ability. This current review outlined PBA-containing biomaterials with various responsive abilities including sialic acid-targeting, sugars-binding, ROS-response, ATP-response, dopamine-binding, and nuclear targeting. On this basis, their biomedical applications were summarized. | Weizhi Chen Xu Zhen Wei Wu Xiqun Jiang | 2020 | Science China Chemistry2020，63，5： | 1 |
| 8 | Synthesis and biological evaluation of bis and monocarbonate prodrugs of 10 hydroxycamptothecins显示文摘 | He Xungui Lu Wei Jiang Xiqun | 2004 | Bioorg Med Chem2004，12，15： | 1 |
| 9 | Synthesis and characterization of chitosan-poly (acrylic acid) nanoparticles 显示文摘 | Hu Yong Jiang Xiqun Ding Yin | 2002 | Biomaterials2002，23，： | 1 |
| 10 | Urate: a novel biomarker of Parkinson’s disease risk, diagnosis and prognosis显示文摘 | Sara Cipriani Xiqun Chen Michael A Schwarzschild | 2010 | Biomarkers Med2010，，： | 1 |
| 11 | Thermalanalysis on piston of marine diesel engine显示文摘 | Xiqun Lu Quan Li Wenping Zhang | 2013 | AppliedThermal Engineering2013，50，1： | 1 |
| 12 | Thermalanalysis on piston of marine diesel engine显示文摘 | Xiqun Lu Quan Li Wenping Zhang | 2013 | Applied Thermal Engineering2013，50，1： | 1 |
| 13 | Chronic nicotine treatment leads to induction of tyrosine hydroxylase in locus ceruleus neurons : the role of transcriptional activation 显示文摘 | Baoyong S Xiqun C Lu X | 2004 | Molecular Pharmacology2004，66，： | 1 |
| 14 | Influence of alloxan-induced diabetes and selenite treatment on blood glucose and glutathione levels in mice显示文摘 | SHENG Xiqun HUANG Kaixun Xu Huibi | 2005 | J Trace Elem Med Biol2005，18，3： | 1 |
| 15 | Production of hydrolysate with antioxidative activity by enzymatic hydrolysis of extruded corn gluten显示文摘 | ZHENG Xiqun LI Lite LIU Xiaolan | 2006 | Appl Microbiol Bioteclmol2006，73，4： | 1 |
| 16 | Synthesis of cobalt disulfide nanopartlcles in polymer matrix 显示文摘 | BI Hong JIANG Xiqun YANG Changzheng | 2003 | Materials Letters2003，57，： | 1 |
| 17 | Synthesis of β-Cyclodextrin-[60]fullerene Conjugate and Its DNA Cleavage Performance显示文摘水可溶的 -cyclodextrin (-CD) functionalized [60 ] fullerene (C60CD ) 被综合。反应的氧种类(ROS ) 的 C60-CD-induced 产生,和 DNA 劈开能力和 C60CD 的 cytotoxicity 在可见轻照耀之上被学习,证明混合物在光力学的治疗的应用是很有希望的。组织学的分析证明 C60CD 没有尖锐或稍尖的毒性到生活身体。 | Jingjing Wang Zhaoheng Zhang Wei Wu Xiqun Jiang | 2014 | Chinese Journal of Chemistry2014，32，1： | 1 |
| 18 | Polymer-monomer pairs as a reaction system for the synthesis of magnetic Fe3O4-polymer hybrid hollow nanospheres显示文摘 | Ding Yin Hu Yong Jiang Xiqun | 2004 | Angew Chem Int Ed2004，43，： | 1 |
| 19 | Biocompatibility and osteoconduction of active porous calcium–phosphate films on a novel Ti–3Zr–2Sn–3Mo–25Nb biomedical alloy显示文摘 | Sen Yu Zhentao Yu Gui Wang Jianye Han Xiqun Ma Matthew S. Dargusch | 2011 | Colloids and Surfaces B: Biointerfaces2011，，2： | 1 |
| 20 | Asymmetric stochastic tau theory in car-following显示文摘 | LI Li CHEN Xiqun LI Zhiheng | 2013 | Transportation Research Part F(Traffic Psychology and Behavior)2013，18，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员