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| 1 | Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles显示文摘颠倒使人重新住入肿瘤的房间(TRC ) 的药抵抗或起源的发展中的新奇途径像房间的癌症房间是迫切临床的需要改进癌症病人的结果。这里,我们显示出用肿瘤颠倒 TRC 的药抵抗的一条创新途径包含反肿瘤药的导出房间的 microparticles (T-MPs ) 。由比区分的癌症房间更可变形的优点, TRC 优先地收起 T-MPs 在进入房间以后释放反肿瘤药,它接着导致 TRC 的死亡。内在的机制包括防碍药流出并且支持这些药的原子入口。我们的调查结果在用有希望的临床的应用程序颠倒 TRC 的药抵抗在 T-MPs 的举起和一条新奇途径的有效性表明肿瘤房间柔软的重要性。 | Jingwei Ma Yi Zhang Ke Tang Huafeng Zhang Xiaonan Yin Yong Li Pingwei Xu Yanling Sun Ruihua Ma Tiantian Ji Junwei Chen Shuang Zhang Tianzhen Zhang Shunqun Luo Yang Jin Xiuli Luo Chengyin Li Hongwei Gong Zhixiong Long Jinzhi Lu Zhuowei Hu Xuetao Cao Ning Wang Xiangliang Yang Bo Huang | 2016 | Cell Research2016，26，6： | 17 |
| 2 | Multi-scale thermodynamic analysis method for 2D SiC/SiC composite turbine guide vanes显示文摘Ceramic Matrix Composite(CMC) turbine guide vanes possess multi-scale stress and strain with inhomogeneity at the microscopic scale.Given that the macroscopic distribution cannot reflect the microscopic stress fluctuation, the macroscopic method fails to meet the requirements of stress and strain analysis of CMC turbine guide vanes.Furthermore, the complete thermodynamic properties of 2 D woven SiC/SiC-CMC cannot be obtained through experimentation.Accordingly,a method to calculate the thermodynamic properties of CMC and analyze multi-scale stress and strain of the turbine guide vanes should be established.In this study, the multi-scale thermodynamic analysis is investigated.The thermodynamic properties of Chemical Vapor Infiltration(CVI) processed SiC/SiC-CMC are predicted by a Representative Volume Element(RVE) model with porosity, leading to the result that the relative error between the calculated in-plane tensile modulus and the experimental value is 4.2%.The macroscopic response of a guide vane under given conditions is predicted.The relative error between the predicted strain on the trailing edge and the experimental value is 9.7%.The calculation of the stress distribution of micro-scale RVE shows that the maximum value of microscopic stress, which is located in the interlayer matrix, is more than 1.5 times that of macroscopic stress in the same direction and the microscopic stress distribution of the interlayer matrix is related to the pore distribution of the composite. | Xin LIU Xiuli SHEN Longdong GONG Peng LI | 2018 | Chinese Journal of Aeronautics2018，31，1： | 9 |
| 3 | The Mesenchymal Stem Cells Derived from Transgenic Mice Carrying Human Coagulation Factor Ⅷ Can Correct Phenotype in Hemophilia A Mice显示文摘Hemophilia A(HA)is an inherited X-linked recessive bleeding disorder caused by coagulant factor Ⅷ(FⅧ)deficiency.Previous studies showed that introduction of mesenchymal stem cells(MSCs)modified by FⅧ-expressing retrovirus may result in phenotypic correction of HA animals.This study aimed at the investigation of an alternative gene therapy strategy that may lead to sustained FⅧ transgene expression in HA mice.B-domain-deleted human FⅧ(hFⅧBD)vector was microinjected into single-cell embryos of wild-type mice to generate a transgenic mouse line,from which hFⅧBD-MSCs were isolated,followed by transplantation into HA mice.RT-PCR and real-time PCR analysis demonstrated the expression of hFⅧBD in multi-organs of recipient HA mice.Immunohistochemistry showed the presence of hFⅧBD positive staining in multi-organs of recipient HA mice.ELISA indicated that plasma hFⅧBD level in recipient mice reached its peak(77 ng/mL)at the 3rd week after implantation,and achieved sustained expression during the 5-week observation period.Plasma FⅧ activities of recipient HA mice increased from 0%to 32%after hFⅧBD-MSCs transplantation.APTT(activated partial thromboplastin time)value decreased in hFⅧBD-MSCs transplanted HA mice compared with untreated HA mice(45.5 s vs.91.3 s).Our study demonstrated an effective phenotypic correction in HA mice using genetically modified MSCs from hFⅧBD transgenic mice. | Qing Wang Xiuli Gong Zhijuan Gong Xiaoyie Ren Zhaorui Ren Shuzhen Huang Yitao Zeng | 2013 | Journal of Genetics and Genomics2013，40，12： | 2 |
| 4 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 5 | Cloning, identification, and expression analysis at the stage of gonadal sex differentiation of chicken miR-363 and 363显示文摘miRNAs (microRNAs ) 是小的,功能的、非编码的 RNA 并且被证明了在从房间区别到有机体开发的多样的生物过程的规定含有。以达到在鸡胚胎上探索 miRNAs 的角色性决心和 gonadal 区别,我们克隆并且识别茎环先锋结构( GenBank 同意没有 GU597370 )鸡肉, miR-363 和363*由在 E3.56.5 d 的阶段在鸡胚胎学习他们的时间、空间的表示模式列在后面(胚胎的天 3.56.5 )由半量的 RT-PCR 和愿望(在 situ 杂交整个山)在这研究。结果显示出那 miR-363 * 根据 miRNAs 的结构的特征在 miR-363 和 363* 的鸡染色体,和 flanking 顺序在未知片断的克隆的顺序定位了先锋。显著地微分的表示(P < 0.05 ) 在雌、雄的鸡肉之间的 gga-miR-363,胚胎的性腺被发现在 E4.5 和 6.5 d,而是 gga-miR-363 的微分表示 * 从 E3.5,到 6.5,在两性之间的 d 达不到重要水平。那个表达式 gga-miR-363 表明的显示的愿望的结果主要在 E6.5 出现在手足芽,脊索,外胚层,在 E4.5 d 鸡胚胎的大脑,和尿生殖的系统(UGS ) d,和 E6.5 d 的表达式水平在男性比那在女性是更高的。gga-miR-363 将在 gonadal 发展和 gga-miR-363 包含,这能被推测 * 可能在鸡胚胎开发的早阶段期间有短暂规章的功能。 | Pan Huang Yanzhang Gong Xiuli Peng ShijunLi Yu Yang Yanping Feng | 2010 | Acta Biochimica et Biophysica Sinica2010，42，8： | 2 |
| 6 | Dendron-polymer hybrid mediated anticancer drug delivery for suppression of mammary cancer显示文摘Dendron-polymer-based nanoscale and stimuli-responsive drug delivery systems have shown great promise in tumor-targeting accumulation without significant toxicity.Here we report a dendronized polymer-doxorubicin(DOX)hybrid(DPDH)with an improved in vivo drug delivery efficiency for cancer therapy compared with a linear polymer-DOX conjugate(LPDC).The in vitro drug release profile of DOX indicates that DPDH displays pH-responsive drug release due to cleavage of hydrazone bonds since a greater amount of DOX is released at pH 5.2 at a faster rate than at pH 7.4.DPDH efficiently enters 4 T1 cells and releases DOX to induce cytotoxicity and apoptosis.Owing to the dendronzied structure,DPDH has a significantly longer blood circulation time than LPDC.DPDH substantially enhances the therapeutic efficacy to suppress tumor growth in a 4 T1 mammary cancer model than LPDC as well as free drug,evidenced from tumor growth inhibition,TUNEL assessment and histological analysis.Biosafety of DPDH is also confirmed from hemolysis,body weight shifts during treatment and pathological analysis.This study demonstrates the use of dendronized polymer-DOX hybrids for specific drug molecules is a promising approach for drug delivery. | Dayi Pan Xiuli Zheng Miao Chen Qianfeng Zhang Zhiqian Li Zhenyu Duan Qiyong Gong Zhongwei Gu Hu Zhang Kui Luo | 2021 | Journal of Materials Science & Technology2021，，4： | 2 |
| 7 | Isolation and characterization of sexual dimorphism genes expressed in chicken embryonic gonads显示文摘在鸡肉,胚胎的性腺区分进一双睾丸或一个卵巢的 bipotential,而是位于 gonadal 性区别下面被识别了的很少基因和性决心基因仍然是未知的。为了识别更多的基因,在鸡性区别包含了,我们采用了孤立差别的减少性的杂交表示了的抑制在从鸡性腺的性之间的基因在 E3.5E6 的一个时期期间。相应于 88 基因的 152 cDNA 克隆的一个总数(41 从 F-M 图书馆并且 47 从 M-F 图书馆) 用点污点分析被屏蔽。这些基因在性染色体与五主要位于宏染色体(15 )( 在 W 的并且四在 Z ) ,编码四统治属于酶, DNA 协会, RNA 协会,和结构的蛋白质的分子的范畴。在鸡 EST 数据库把获得的 cDNA 序列与那些作比较,它从 F-M 图书馆显示出 32 基因的那 cDNAs 并且 16 从 M-F 图书馆,在二的相当或相同的事物报导了胚胎的性腺 cDNA 图书馆。涉及 epigenetic 和抄写规定的八基因的量的即时 PCR 分析证明在 CDK2AP1, SMARCE1, SAP18, SUDS3,和 PQBP1 的性之间的显著地不同的表示在性腺开发(E4 ) 出现在早阶段。把表示基因基于性差别的功能的比较,包括 ATP5A1W 的一些通常认为地重要的基因的角色, CDK2AP1, mitochondrial 抄本,等等被分析了。在结论,孤立的基因的描述将提供珍贵线索识别涉及鸡性区别和性腺开发的基因机制的潜在的候选人。 | Yanping Feng Xiuli Peng Shijun Li Yanzhang Gong | 2009 | Acta Biochimica et Biophysica Sinica2009，41，4： | 2 |
| 8 | Development of raturinary HPLC - UV profiling for metabonomic study on Liuwei Dihuang Pills显示文摘 | Baogang Xiea Tao Gong Rang Gao Jie Liu Jiao Zuo Xiuli Wang Zhirong Zhang | 2009 | Journal of Ptlannaceu- tical and Biomedical Analysis2009，49，： | 1 |
| 9 | Randomized trial of autologous bone marrow mesenchymal stem cells transplantation for hepatitis B virus cirrhosis: Regulation of T reg/ T h17 cells显示文摘 | Lanman Xu Yuewen Gong Benfu Wang Keqing Shi Yijun Hou Liping Wang Zuo Lin Yixiang Han Lu Lu Dazhi Chen Xiuli Lin Qiqiang Zeng Wenke Feng Yongping Chen | 2014 | J Gastroenterol Hepatol2014，，8： | 1 |
| 10 | Solid lipid nanoparticles for pulmonary delivery of insulin显示文摘 | Jie Liu Tao Gong Hualin Fu Changguang Wang Xiuli Wang Qian Chen Qin Zhang Qin He Zhirong Zhang | 2008 | International Journal of Pharmaceutics2008，，1： | 1 |
| 11 | Non- linear unified strength criterion for concrete under 3-D stress state 显示文摘 | DU Xiuli LU Dechun GONG Qiuming | 2010 | Journal of Engineering Mechanics ASCE2010，136，1： | 1 |
| 12 | Altered brain activity in juvenile myoclonic epilepsy with a monotherapy:a resting-state fMRI study显示文摘Background:Juvenile myoclonic epilepsy(JME)is the most common syndrome of idiopathic generalized epilepsy.Although resting-state functional magnetic resonance imaging(rs-fMRI)studies have found thalamocortical circuit dysfunction in patients with JME,the pathophysiological mechanism of JME remains unclear.In this study,we used three complementary parameters of rs-fMRI to investigate aberrant brain activity in JME patients in comparison to that of healthy controls.Methods:Rs-fMRI and clinical data were acquired from 49 patients with JME undergoing monotherapy and 44 ageand sex-matched healthy controls.After fMRI data preprocessing,the fractional amplitude of low-frequency fluctuation(fALFF),regional homogeneity(ReHo),and degree centrality(DC)were calculated and compared between the two groups.Correlation analysis was conducted to explore the relationship between local brain abnormalities and clinical features in JME patients.Results:Compared with the controls,the JME patients exhibited significantly decreased fALFF,ReHo and DC in the cerebellum,inferior parietal lobe,and visual cortex(including the fusiform and the lingual and middle occipital gyri),and increased DC in the right orbitofrontal cortex.In the JME patients,there were no regions with reduced ReHo compared to the controls.No significant correlation was observed between regional abnormalities of fALFF,ReHo or DC,and clinical features.Conclusions:We demonstrated a wide range of abnormal functional activity in the brains of patients with JME,including the prefrontal cortex,visual cortex,default mode network,and cerebellum.The results suggest dysfunctions of the cerebello-cerebral circuits,which provide a clue on the potential pathogenesis of JME. | Linyuan Qin Yingying Zhang Jiechuan Ren Du Lei Xiuli Li Tianhua Yang Qiyong Gong Dong Zhou | 2022 | Acta Epileptologica2022，5，3： | 0 |
| 13 | Fibronectin-targeted dual-acting micelles for combination therapy of metastatic breast cancer显示文摘Stage IV breast cancer,which has a high risk of invasion,often develops into metastases in distant organs,especially in the lung,and this could threaten the lives of women.Thus,the development of more advanced therapeutics that can efficiently target metastatic foci is crucial.In this study,we built an dual-acting therapeutic strategy using micelles with high stability functionalized with fibronectin-targeting CREKA peptides encapsulating two slightly soluble chemotherapy agents in water,doxorubicin(D)and vinorelbine(V),which we termed C-DVM.We found that small C-DVM micelles could efficiently codeliver drugs into 4T1 cells and disrupt microtubule structures.C-DVM also exhibited a powerful ability to eradicate and inhibit invasion of 4T1 cells.Moreover,an in vivo pharmacokinetics study showed that C-DVM increased the drug circulation half-life and led to increased enrichment of drugs in lung metastatic foci after 24 h.Moreover,dual-acting C-DVM treatment led to 90%inhibition of metastatic foci development and reduced invasion of metastases.C-DVM could potentially be used as a targeted treatment for metastasis and represents a new approach with higher therapeutic efficacy than conventional chemotherapy for stage IV breast cancer that could be used in the future. | Zhuoran Gong Min Chen Qiushi Ren Xiuli Yue Zhifei Dai | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
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