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| 1 | Genetic Mapping of Laminaria japonica and L. Iongissima Using Amplified Fragment Length Polymorphism Markers in a "Two-Way Pseudo- Testcross" Strategy显示文摘 | Yuhui Li Yingxia Yang Jidong Liu Xiuliang Wang Tianxiang Gao Delin Duan | 2007 | Journal of Integrative Plant Biology2007，49，3： | 8 |
| 2 | Using irrigation intervals to optimize water-use efficiency and maize yield in Xinjiang,northwest China显示文摘Worldwide, scarce water resources and substantial food demands require efficient water use and high yield.This study investigated whether irrigation frequency can be used to adjust soil moisture to increase grain yield and water use efficiency(WUE) of high-yield maize under conditions of mulching and drip irrigation.A field experiment was conducted using three irrigation intervals in 2016: 6, 9, and 12 days(labeled D6, D9, and D12) and five irrigation intervals in 2017: 3, 6, 9, 12, and 15 days(D3, D6, D9, D12, and D15).In Xinjiang, an optimal irrigation quota is 540 mm for high-yield maize.The D3, D6, D9, D12, and D15 irrigation intervals gave grain yields of 19.7, 19.1–21.0, 18.8–20.0, 18.2–19.2, and 17.2 Mg ha^-1 and a WUE of 2.48, 2.53–2.80, 2.47–2.63, 2.34–2.45, and 2.08 kg m-3, respectively.Treatment D6 led to the highest soil water storage, but evapotranspiration and soil-water evaporation were lower than other treatments.These results show that irrigation interval D6 can help maintain a favorable soil-moisture environment in the upper-60-cm soil layer, reduce soilwater evaporation and evapotranspiration, and produce the highest yield and WUE.In this arid region and in other regions with similar soil and climate conditions, a similar irrigation interval would thus be beneficial for adjusting soil moisture to increase maize yield and WUE under conditions of mulching and drip irrigation. | Guoqiang Zhang Dongping Shen Bo Ming Ruizhi Xie Xiuliang Jin Chaowei Liu Peng Hou Jun Xue Jianglu Chen Wanxu Zhang Wanmao Liu Keru Wang Shaokun Li | 2019 | The Crop Journal2019，7，3： | 4 |
| 3 | m6A RNA methylation-mediated HNF3γreduction renders hepatocellular carcinoma dedifferentiation and sorafenib resistance显示文摘Hepatocyte nuclear factor 3γ(HNF3γ)is a hepatocyte nuclear factor,but its role and clinical significance in hepatocellular carcinoma(HCC)remain unclear.Herein,we report that HNF3γexpression is downregulated in patient HCC and inversely correlated with HCC malignancy and patient survival.Moreover,our data suggested that the HNF3γreduction in HCC could be mediated by METTL14-dependent m6A methylation of HNF3γmRNA.HNF3γexpression was increased during hepatic differentiation and decreased in dedifferentiated HCC cells.Interestingly,HNF3γdelivery promoted differentiation of not only HCC cells but also liver CSCs,which led to suppression of HCC growth.Mechanistic analysis suggested an HNF3γ-centered regulatory network that includes essential liver differentiation-associated transcription factors and functional molecules,which could synergistically facilitate HCC cell differentiation.More importantly,enforced HNF3γexpression sensitized HCC cells to sorafenib-induced growth inhibition and cell apoptosis through transactivation of OATP1B1 and OATP1B3 expression,which are major membrane transporters for sorafenib uptake.Clinical investigation showed that patient-derived HCC xenografts with high HNF3γexpression exhibited a sorafenib response and patients with high HCC HNF3γlevels benefited from sorafenib therapy.Together,these results suggest that HNF3γplays an essential role in HCC differentiation and may serve as a therapeutic target and predictor of sorafenib benefit in patients. | Tengfei Zhou Shichao Li Daimin Xiang Junyu Liu Wen Sun Xiuliang Cui Beifang Ning Xiao Li Zhuo Cheng Weiqi Jiang Cheng Zhang Xijun Liang Liang Li Xin Cheng Liu Hui Hongyang Wang Jin Ding | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 4 |
| 4 | Conversion of hepatoma cells to hepatocyte-like cells by defined hepatocyte nuclear factors显示文摘Normal cells become cancer cells after a malignant transformation,but whether cancer cells can be reversed to normal status remains elusive.Here,we report that the combination of hepatocyte nuclear factor IA (HNFIA),HNF4A and forkhead box protein A3 (FOXA3)synergistically reprograms hepatocellular carcinoma (HCC)cells to hepatocyte-like cells (reprogrammed hepatocytes, rHeps).Our results show that rHeps lose the malignant phenotypes of cancer cells and retrieve hepatocyte-specific characteristics including hepatocyte-like morphology;global expression pattern of genes and specific biomarkers of hepatocytes;and the unique hepatic functions of albumin (ALB)secretion,glycogen synthesis,low-density lipoprotein (LDL)uptake,urea production, cytochrome P450 enzymes induction and drug metabolism.Intratumoral injection of these three factors efficiently shrank patientderived tumor xenografts and reprogrammed HCC cells in vivo.Most importantly,transplantation of rHeps in the liver of fumarylacetoacetate hydrolase-deficient (Fah^-/-)mice led to the reconstruction of hepatic lobules and the restoration of hepatic function.Mechanistically,exogenous expression of HNF1A,HNF4A and FOXA3 in HCC cells initiated the endogenous expression of numerous hepatocyte nuclear factors,which promoted the conversion of HCC cells to hepatocyte-like cells.Collectively,our results indicate the successful conversion of hepatoma cells to hepatocyte-like cells,not only extending our current knowledge of cell reprogramming but also providing a route towards a novel therapeutic strategy for cancer. | Zhuo Cheng Zhiying He Yongchao Cai Cheng Zhang Gongbo Fu Hengyu Li Wen Sun Changcheng Liu Xiuliang Cui Beifang Ning Daimin Xiang Tengfei Zhou Xiaofeng Li Weifen Xie Hongyang Wang Jin Ding | 2019 | Cell Research2019，29，2： | 3 |
| 5 | Genetic analysis of selected Sargassum fusiforme (Harvey) Setchell (Sargassaceae, Phaeophyta) strains with RAPD and ISSR markers显示文摘Since the 1980s,Sargassum fusiforme has been cultivated in Zhejiang,South China,and nowadays it becomes one of the important commercial seaweeds in China.With traditions of eating habits in the East Asian countries,this brown alga is used as food,because it contained functional oligo/polysaccharides and chemical components,and was regarded playing roles in antioxidant activities and regulating immunology.Through over 15 years’selection,breeding and cultivation,we obtained three strains with good traits and testified their characters during the production,which included the cultivars with high yield and other two good characters,either all the selected strains were applied in the Sargassum production.To avoid confusion during the selection and nursery,it was preferred to establish one fingerprint for distinguishing the Sargassum cultivars from different strains.Random amplified polymorphic DNA(RAPD)and inter-simple sequence repeat(ISSR)methods were adopted to analyze the genetic diversities of the selected S.fusiforme strains.With that,one fingerprint with RAPD markers was constructed,and one sequence characterized amplifi ed region(SCAR)marker to S.fusiforme was obtained.It is indicated that the applied fingerprint could be valid in S.fusiforme genetic and germplasm justification,and will be positive to molecular marker assistance in its selection and cultivation. | YAO Jianting SHUAI Li LI Shengyao XU Caolu WANG Xiuliang | 2019 | Journal of Oceanology and Limnology2019，37，3： | 3 |
| 6 | Faceted Kurdjumov-Sachs interface-induced slip continuity in the eutectic high-entropy alloy,AlCoCrFeNi_(2.1)显示文摘Recently,the eutectic high-entropy alloy(EHEA),AlCoCrFeNi_(2.1),can reach a good balance of strength and ductility.The dual-phase alloy exhibits a eutectic lamellar microstructure with large numbers of interfaces.However,the role of the interfaces in plastic deformation have not been revealed deeply.In the present work,the orientation relationship(OR)of the interfaces has been clarified as the Kurdjumov-Sachs(KS)interfaces presenting〈111〉_(B2) 〈110〉_(FCC)and {110} _(B2){111}_(FCC) independent of their morphologies.There exist three kinds of interfaces in the EHEA,namely,The dominating interface and the secondary interface are both non-slip planes and atomistic-scale faceted,facilitating the nucleation and slip transmission of the dislocations.The formation mechanism of the preferred interfaces is revealed using the atomistic geometrical analysis according to the criteria of the low interfacial energy based on the coincidence-site lattice(CSL)theory.In particular,the ductility of the dual-phase alloy originates from the KS interface-induced slip continuity across interfaces,which provides a high slip-transfer geometric factor.Moreover,the strengthening effect can be attributed to the interface resistance for the dislocation transmission due to the mismatches of the moduli and lattice parameters at the interfaces. | Ting Xiong Wenfan Yang Shijian Zheng Zhaorui Liu Yiping Lu Ruifeng Zhang Yangtao Zhou Xiaohong Shao Bo Zhang Jun Wang Fuxing Yin Peter K.Liaw Xiuliang Ma | 2021 | Journal of Materials Science & Technology2021，，6： | 2 |
| 7 | Comprehensive analysis of miRNA-gene regulatory network with clinical significance in human cancers显示文摘microRNAs(miRNAs),particularly the exosomal miRNAs have been widely used as biomarkers and promising therapeutic targets in cancer.However,a comprehensive analysis of miRNA-gene regulatory network with clinical significance remains scarce.The emergence of high-throughput multi-omics data over large,well-characterized patient cohorts provides an unprecedented opportunity to address this problem.Herein,we performed a clinic-centered analysis to identify cancer-associated miRNAs,miRNA-target axis.We first calculated the correlation among miRNA,mRNA and 75 unique clinico-pathological characteristics(CPCs)in 26 cancer types,and established an online resource(4CR).Interestingly,we found that the high expression of several DNA methylation-related enzymes was associated with adverse outcomes of cancer patients,and these genes were regulated by a cluster of miRNAs.Furthermore,by integrating exosomal miRNA and m RNA databases,we identified exosomal miRNA biomarkers for non-invasive cancer surveillance and therapy monitoring.Finally,we explored the role of CPC-related miRNAs for therapeutic effect prediction of drugs based on their shared targets.Our analysis pipeline illustrated the significance of clinic-centered analysis in miRNA-gene pair identification and provided helpful clues for future cancer studies. | Xiuliang Cui Yang Liu Wen Sun Jin Ding Xiaochen Bo Hongyang Wang | 2020 | Science China(Life Sciences)2020，63，8： | 2 |
| 8 | Phosphate limitation increases coenzyme Q10 production in industrial Rhodobacter sphaeroides HY01显示文摘Coenzyme Q10(CoQ10)is an important component of the respiratory chain in humans and some bacteria.As a high-value-added nutraceutical antioxidant,CoQ10 has excellent capacity to prevent cardiovascular disease.The content of CoQ10 in the industrial Rhodobacter sphaeroides HY01 is hundreds of folds higher than normal physiological levels.In this study,we found that overexpression or optimization of the synthetic pathway failed CoQ10 overproduction in the HY01 strain.Moreover,under phosphate-limited conditions(decreased phosphate or in the absence of inorganic phosphate addition),CoQ10 production increased significantly by 12%to220 mg/L,biomass decreased by 12%,and the CoQ10 productivity of unit cells increased by 27%.In subsequent fed-batch fermentation,CoQ10 production reached 272 mg/L in the shake-flask fermentation and 1.95 g/L in a 100-L bioreactor under phosphate limitation.Furthermore,to understand the mechanism associated with CoQ10 overproduction under phosphate-limited conditions,the comparatve transcriptome analysis was performed.These results indicated that phosphate limitation combined with glucose fed-batch fermentation represented an effective strategy for CoQ10 production in the HY01.Phosphate limitation induced a pleiotropic effect on cell metabolism,and that improved CoQ10 biosynthesis efficiency was possibly related to the disturbance of energy metabolism and redox potential. | Lu Zhang Leshi Liu Ke-Feng Wang Lan Xu Liming Zhou Weishan Wang Chuan Li Zheng Xu Tong Shi Haihong Chen Yuanhang Li Hui Xu XiuLiang Yang Zhichun Zhu Biqin Chen Dan Li Guanghuang Zhan Si-Liang Zhang Li-Xin Zhang Gao-Yi Tan | 2019 | Synthetic and Systems Biotechnology2019，4，4： | 2 |
| 9 | Status of genetic studies and breeding of Saccharina japonica in China显示文摘Saccharina japonica is one of the most important economic brown seaweeds.It is intensively cultivated on large scales in a number of Asian countries.The current annual,global production is about 8 million tons valued as about 4 million US dollars.Considerable efforts have been made to S.japonica in China since the 1950s on its cultivation.To further advance the cultivation of this species,detailed research of genetics and breeding studies are required.Recently,with the advancement of sequencing techniques,the genomics and comparative transcriptomics data were yielded,and quantitative trait locus(QTL)mapping has been conducted,along with genetic linkage maps constructed to this species.New strains have been bred and selected,with better characteristics,e.g.higher seawater temperature resistances and higher yields.In this review,we present the current status of genetic and breeding studies that have been performed to S.japonica in China,and provide guidelines for future developments in the areas of genetic selection and breeding for this species. | WANG Xiuliang YAO Jianting ZHANG Jie DUAN Delin | 2020 | Journal of Oceanology and Limnology2020，38，4： | 1 |
| 10 | Genetic analysis of the gametophytes of Undaria pinnatifida (Phaeophyceae) with ISSR method显示文摘 | Xiuliang Wang Di Wang Dapeng Li Delin Duan | 2006 | Aquaculture2006，，1： | 1 |
| 11 | Improved RNA isolation from Laminaria japonica Aresch (Laminariaceae, Phaeophyta) 显示文摘 | Jianting Yao Wandong Fu Xiuliang Wang | 2009 | Appl Phycol2009，21，： | 1 |
| 12 | Thermally stable microstructures and mechanical properties of B4C-Al composite with in-situ formed Mg(Al)B2显示文摘B4C particulate-reinforced 6061A1 composite was fabricated by powder metallurgy method. The as-rolled composite possesses high tensile strength which is comparable to that of the peak-aged 6061A1 alloy. More importantly, the microstructures and mechanical properties are thermally stable during long-term holding at elevated temperature (400℃). The microstructual contributions to the strength of the composite were discussed. Transmission electron microscopy (TEM) analysis indicates that the in-situ formed reinforcement Mg(Al)B2, as products of the interfacial reactions between B4C and the aluminum matrix, show not only good resistance to thermal coarsening but also strong pinning effect to the grain boundaries in the alloy matrix. | Yangtao Zhou Yuning Zan Shijian Zheng Xiaohong Shao Qianqian Jin Bo Zhang Quanzhao Wang Bolv Xiao Xiuliang Ma Zongyi Ma | 2019 | Journal of Materials Science & Technology2019，35，9： | 1 |
| 13 | Optimization of microbial cell factories for astaxanthin production: Biosynthesis and regulations, engineering strategies and fermentation optimization strategies显示文摘The global market demand for natural astaxanthin is rapidly increasing owing to its safety,the potential health benefits,and the diverse applications in food and pharmaceutical industries.The major native producers of natural astaxanthin on industrial scale are the alga Haematococcus pluvialis and the yeast Xanthopyllomyces dendrorhous.However,the natural production via these native producers is facing challenges of limited yield and high cost of cultivation and extraction.Alternatively,astaxanthin production via metabolically engineered non-native microbial cell factories such as Escherichia coli,Saccharomyces cerevisiae and Yarrowia lipolytica is another promising strategy to overcome these limitations.In this review we summarize the recent scientific and biotechnological progresses on astaxanthin biosynthetic pathways,transcriptional regulations,the interrelation with lipid metabolism,engineering strategies as well as fermentation process control in major native and non-native astaxanthin producers.These progresses illuminate the prospects of producing astaxanthin by microbial cell factories on industrial scale. | Mostafa Basiony Liming Ouyang Danni Wang Jiaming Yu Liming Zhou Mohan Zhu Xuyuan Wang Jie Feng Jing Dai Yijie Shen Chengguo Zhang Qiang Hua Xiuliang Yang Lixin Zhang | 2022 | Synthetic and Systems Biotechnology2022，7，2： | 1 |
| 14 | Genetic analysis of the gametophytes of Undaria pinnatifida (Phaeophyceae) with ISSR method 显示文摘 | Wang Xiuliang Wang Di Li Dapeng | 2006 | Aquaculture2006，258，： | 1 |
| 15 | Data Secure Transmission Model Based on Compressed Sensing and Digital Watermarking Technology显示文摘Since the Internet of Things(IoT) secret information is easy to leak in data transfer,a data secure transmission model based on compressed sensing(CS) and digital watermarking technology is proposed here. Firstly, for node coding end, the digital watermarking technology is used to embed secret information in the conventional data carrier. Secondly, these data are reused to build the target transfer data by the CS algorithm which are called observed signals. Thirdly, these signals are transmitted to the base station through the wireless channel. After obtaining these observed signals, the decoder reconstructs the data carrier containing privacy information. Finally, the privacy information is obtained by digital watermark extraction algorithm to achieve the secret transmission of signals. By adopting the watermarking and compression sensing to hide secret information in the end of node code, the algorithm complexity and energy consumption are reduced. Meanwhile, the security of secret information is increased.The simulation results show that the method is able to accurately reconstruct the original signal and the energy consumption of the sensor node is also reduced significantly in consideration of the packet loss. | WANG Chundong BAI Yi MO Xiuliang | 2014 | Wuhan University Journal of Natural Sciences2014，19，6： | 0 |
| 16 | Research on the Generation Mechanism and Suppression Method of Aerodynamic Noise in Expansion Cavity Based on Hybrid Method显示文摘The expansion chamber serves as the primary silencing structure within the exhaust pipeline.However,it can also act as a sound-emitting structure when subjected to airflow.This article presents a hybrid method for numerically simulating and analyzing the unsteady flow and aerodynamic noise in an expansion chamber under the influence of airflow.A fluid simulation model is established,utilizing the Large Eddy Simulation(LES)method to calculate the unsteady flow within the expansion chamber.The simulation results effectively capture the development and changes of the unsteady flow and vorticity inside the cavity,exhibiting a high level of consistency with experimental observations.To calculate the aerodynamic noise sources within the cavity,the flow field results are integrated using the method of integral interpolation and inserted into the acoustic grid.The acoustic analogy method is then employed to determine the aerodynamic noise sources.An acoustic simulation model is established,and the flow noise source is imported into the sound field grid to calculate the sound pressure at the far-field response point.The calculated sound pressure levels and resonance frequencies show good agreement with the experimental results.To address the issue of airflow regeneration noise within the cavity,perforated tubes are selected as a means of noise suppression.An experimental platformfor airflow regeneration noise is constructed,and experimental samples are processed to analyze and verify the noise suppression effect of perforated tube expansion cavities under different airflow velocities.The research findings indicate that the perforated tube expansion cavity can effectively suppress low-frequency aerodynamic noise within the cavity by impeding the formation of strong shear layers.Moreover,the semi-perforated tube expansion cavity demonstrates the most effective suppression of aerodynamic noise. | Haitao Liu Jiaming Wang Xiuliang Zhang Yanji Jiang Qian Xiao | 2024 | Computer Modeling in Engineering & Sciences2024，139，6： | 0 |
| 17 | Structural and Electronic Properties of BaO/MgO(001)-type Interface Studied via Aberration-corrected Transmission Electron Microscopy and First-principles Calculations显示文摘The properties of BaO/MgO-type interface in the BaZrO3/MgO(001) heterostructure are studied by aberrationcorrected high-resolution transmission electron microscopy combined with first-principles calculations.Experimental evidence demonstrates that cation displacement and vacancies occur at the interface. Our firstprinciple calculations show that cation displacement results from the electrostatic potential effect at the interface,and cation vacancies could lower the interfacial work of separation and enhance the interfacial stability of BaO/MgO-type interface. The results highlight that the effect of interfacial defects should be taken into account in understanding the film growth kinetics and properties in oxide heteroepitaxy. | Lei Deng Shaobo Mi Dong Chen Yuanming Wang Xiuliang Ma | 2015 | Journal of Materials Science & Technology2015，31，2： | 0 |
| 18 | Time series canopy phenotyping enables the identification of genetic variants controlling dynamic phenotypes in soybean显示文摘Advances in plant phenotyping technologies are dramatically reducing the marginal costs of collecting multiple phenotypic measurements across several time points.Yet,most current approaches and best statistical practices implemented to link genetic and phenotypic variation in plants have been developed in an era of single-time-point data.Here,we used time-series phenotypic data collected with an unmanned aircraft system for a large panel of soybean(Glycine max(L.)Merr.)varieties to identify previously uncharacterized loci.Specifically,we focused on the dissection of canopy coverage(CC)variation from this rich data set.We also inferred the speed of canopy closure,an additional dimension of CC,from the time-series data,as it may represent an important trait for weed control.Genome-wide association studies(GWASs)identified 35 loci exhibiting dynamic associations with CC across developmental stages.The time-series data enabled the identification of 10 known flowering time and plant height quantitative trait loci(QTLs)detected in previous studies of adult plants and the identification of novel QTLs influencing CC.These novel QTLs were disproportionately likely to act earlier in development,which may explain why they were missed in previous single-time-point studies.Moreover,this time-series data set contributed to the high accuracy of the GWASs,which we evaluated by permutation tests,as evidenced by the repeated identification of loci across multiple time points.Two novel loci showed evidence of adaptive selection during domestication,with different genotypes/haplotypes favored in different geographic regions.In summary,the time-series data,with soybean CC as an example,improved the accuracy and statistical power to dissect the genetic basis of traits and offered a promising opportunity for crop breeding with quantitative growth curves. | Delin Li Dong Bai Yu Tian Ying-Hui Li Chaosen Zhao Qi Wang Shiyu Guo Yongzhe Gu Xiaoyan Luan Ruizhen Wang Jinliang Yang Malcolm J.Hawkesford James C.Schnable Xiuliang Jin Li-Juan Qiu | 2023 | Journal of Integrative Plant Biology2023，65，1： | 0 |
| 19 | m6A RNA methylation-mediated HNF3γ reduction rendershepatocellular carcinoma dedifferentiation and sorafenibresistance显示文摘Hepatocyte nuclear factor 3γ(HNF3γ)is a hepatocyte nuclear factor,but its role and clinical significance in hepatocellular carcinoma(HCC)remain unclear.Herein,we report that HNF3γexpression is downregulated in patient HCC and inversely correlated with HCC malignancy and patient survival.Moreover,our data suggested that the HNF3γreduction in HCC could be mediated by METTL14-dependent m6A methylation of HNF3γmRNA.HNF3γexpression was increased during hepatic differentiation and decreased in dedifferentiated HCC cells.Interestingly,HNF3γdelivery promoted differentiation of not only HCC cells but also liver CSCs,which led to suppression of HCC growth.Mechanistic analysis suggested an HNF3γ-centered regulatory network that includes essential liver differentiation-associated transcription factors and functional molecules,which could synergistically facilitate HCC cell differentiation.More importantly,enforced HNF3γexpression sensitized HCC cells to sorafenib-induced growth inhibition and cell apoptosis through transactivation of OATP1B1 and OATP1B3 expression,which are major membrane transporters for sorafenib uptake.Clinical investigation showed that patient-derived HCC xenografts with high HNF3γexpression exhibited a sorafenib response and patients with high HCC HNF3γlevels benefited from sorafenib therapy.Together,these results suggest that HNF3γplays an essential role in HCC differentiation and may serve as a therapeutic target and predictor of sorafenib benefit in patients. | Tengfei Zhou Shichao Li Daimin Xiang Junyu Liu Wen Sun Xiuliang Cui Beifang Ning Xiao Li Zhuo Cheng Weiqi Jiang Cheng Zhang Xijun Liang Liang Li Xin Cheng Liu Hui Hongyang Wang Jin Ding | 2021 | Signal Transduction and Targeted Therapy2021，6，1： | 0 |
| 20 | Correlation analysis between the Aral Sea shrinkage and the Amu Darya River显示文摘The shrinkage of the Aral Sea,which is closely related to the Amu Darya River,strongly affects the sustainability of the local natural ecosystem,agricultural production,and human well-being.In this study,we used the Bayesian Estimator of Abrupt change,Seasonal change,and Trend(BEAST)model to detect the historical change points in the variation of the Aral Sea and the Amu Darya River and analyse the causes of the Aral Sea shrinkage during the 1950–2016 period.Further,we applied multifractal detrend cross-correlation analysis(MF-DCCA)and quantitative analysis to investigate the responses of the Aral Sea to the runoff in the Amu Darya River,which is the main source of recharge to the Aral Sea.Our results showed that two significant trend change points in the water volume change of the Aral Sea occurred,in 1961 and 1974.Before 1961,the water volume in the Aral Sea was stable,after which it began to shrink,with a shrinkage rate fluctuating around 15.21 km3/a.After 1974,the water volume of the Aral Sea decreased substantially at a rate of up to 48.97 km3/a,which was the highest value recorded in this study.In addition,although the response of the Aral Sea's water volume to its recharge runoff demonstrated a complex non-linear relationship,the replenishment of the Aral Sea by the runoff in the lower reaches of the Amu Darya River was identified as the dominant factor affecting the Aral Sea shrinkage.Based on the scenario analyses,we concluded that it is possible to slow down the retreat of the Aral Sea and restore its ecosystem by increasing the efficiency of agricultural water use,decreasing agricultural water use in the middle and lower reaches,reducing ineffective evaporation from reservoirs and wetlands,and increasing the water coming from the lower reaches of the Amu Darya River to the 1961–1973 level.These measures would maintain and stabilise the water area and water volume of the Aral Sea in a state of ecological restoration.Therefore,this study focuses on how human consumption of recharge runoff affects the Aral Sea and provides scientific perspective on its ecological conservation and sustainable development. | WANG Min CHEN Xi CAO Liangzhong KURBAN Alishir SHI Haiyang WU Nannan EZIZ Anwar YUAN Xiuliang Philippe DE MAEYER | 2023 | Journal of Arid Land2023，15，7： | 0 |
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