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| 1 | Dermoscopy in China: current status and future prospective显示文摘Objective: Dermoscopy is a useful technique for improving the diagnostic accuracy of various types of skin disorders. In China, dermoscopy has been widely accepted, and domestic researchers have made tremendous progress in the field of dermoscopy. The main purpose of this review is to summarize the current status of dermoscopy in China and identify its future directions. Data sources: Articles included in this review were obtained by searching the following databases: Wanfang, China National Knowledge Infrastructure, PubMed, and the Web of Science. We focused on research published before 2019 with keywords including dermoscopy, dermoscopic, dermoscope and trichoscopy. Study selection: A total of 50 studies were selected. Of these studies, 20 studies were in Chinese and 30 in English, research samples of all the studies were collected from Chinese populations. Results: Since 2000, more than 380 articles about dermoscopy have been published in domestic or foreign journals. Dermoscopy can improve the diagnostic accuracy of neoplastic diseases, evaluating the therapeutic effect of treatment, and determining the treatment endpoint, and it can also assist in the differential diagnosis of inflammatory diseases and in the assessment of the severity of the disease. In addition, researches about the applications of dermoscopy during surgical treatment have been published. Training courses aiming to improve the diagnostic ability of dermatologists, either face-to-face or online, have been offered. The Chinese Skin Image Database, launched in 2017 as a work platform for dermatologists, has promoted the development of dermoscopy in China. Computer-aided diagnostic systems based on the Chinese population are ready for use. In the future, cooperation, resource sharing, talent development, image management, and computer-aided diagnosis will be important directions for the development of dermoscopy in China. Conclusion: Dermoscopy has been widely used and developed in China, however, it still needs to address more challenges in the future. | Xue Shen Rui-Xing Yu Chang-Bing Shen Cheng-Xu Li Yan Jing Ya-Jie Zheng Zi-Yi Wang Ke Xue Feng Xu Jian-Bin Yu Ru-Song Meng Yong Cui | 2019 | Chinese Medical Journal2019，，17： | 15 |
| 2 | Impact Assessments of Transgenic cry1Ab Rice on the Population Dynamics of Five Non-Target Thrips Species and Their General Predatory Flower Bug in Bt and Non-Bt Rice Fields Using Color Sticky Card Traps显示文摘A 2-yr field study was conducted to assess the effects of transgenic japonica rice(KMD1 and KMD2) with a synthetic cry1 Ab gene from Bacillus thuingiensis Berliner on population dynamics and seasonal average densities of five thrips species including Stenchaetothrips biformis(Bagnall),Frankliniella intonsa(Trybom),F.tenuicornis(Uzel),Haplothrips aculeatus(Fabricius),Haplothrips tritici(Kurd) and their general predatory flower bug,Orius similis Zheng as compared to the parental control rice line using the white,blue and yellow sticky card traps.Population dynamics and seasonal average densities of these five thrips species and their general predatory flower bug were not significantly affected by rice type.Additionally,the white sticky card trap was suggested to be the most suitable for monitoring the population of these five thrips species and their general predator.These results show that our tested Bt rice lines do not interrupt the population of non-target thrips species and their general predatory flower bug in the field,and also cannot result in more occurrence of these thrips species in the rice ecosystem. | Akhtar Zunnu Raen YE Gong-yin LU Zeng-bin CHANG Xue SHEN Xiao-jing PENG Yu-fa HU Cui | 2013 | Journal of Integrative Agriculture2013，12，10： | 9 |
| 3 | Artificial intelligence in dermatology: past, present, and future显示文摘Artificial intelligence (AI) had been first coined at a famous Dartmouth College conference in 1956. AI is gradually interrelated with all disciplines, and also permeates all aspects of the medical field. In the early 1970s, medical researchers discovered the applicability of AI in life sciences.[1] AI can play a role in many aspects, such as medical image recognition and auxiliary diagnosis,[2] biotechnology,[3] drug research and development,[4] etc. Currently, medical image recognition is the most widely used. | Cheng-Xu Li Chang-Bing Shen Ke Xue Xue Shen Yan Jing Zi-Yi Wang Feng Xu Ru-Song Meng Jian-Bin Yu Yong Cui | 2019 | Chinese Medical Journal2019，，17： | 6 |
| 4 | Transplantation of human umbilical cord blood mesenchymal stem cells to treat a rat model of traumatic brain injury显示文摘In the present study, human umbilical cord blood mesenchymal stem cells were injected into a rat model of traumatic brain injury via the tail vein. Results showed that 5-bromodeoxyuridine-labeled cells aggregated around the injury site, surviving up to 4 weeks post-transplantation. In addition, transplantation-related death did not occur, and neurological functions significantly improved. Histological detection revealed attenuated pathological injury in rat brain tissues following human umbilical cord blood mesenchymal stem cell transplantation. In addition, the number of apoptotic cells decreased. Immunohistochemistry and in situ hybridization showed increased expression of brain-derived neurotrophic factor, nerve growth factor, basic fibroblast growth factor, and vascular endothelial growth factor, along with increased microvessel density in surrounding areas of brain injury. Results demonstrated migration of transplanted human umbilical cord blood mesenchymal stem cells into the lesioned boundary zone of rats, as well as increased angiogenesis and expression of related neurotrophic factors in the lesioned boundary zone. | Junjian Zhao Naiyao Chen Na Shen Hui Zhao Dali Wang Jun Shi Yang Wang Xiufeng Cui Zhenyu Yan Hui Xue | 2012 | Neural Regeneration Research2012，7，10： | 5 |
| 5 | Synthesis and antibacterial activity of 4″-O-carbamoyl analogs of clarithromycin显示文摘A series of novel 4'-O-carbamoyl analogs of clarithromycin were synthesized and evaluated for their in vitro antibacterial activity. All of the desired compounds showed excellent activity against erythromycin-susceptible S.pneumoniae.Particularly,4-fluorobenzyl carbamate 7a demonstrated potent activity against erythromycin-resistant S.pneumoniae encoded by the mef gene,and remarkably improved activity against erythromycin-resistant S.pneumoniae encoded by the erm gene,and the erm and mef genes. | Xue Cui Shen Bo Jiao Shu Tao Ma | 2010 | Chinese Chemical Letters2010，21，3： | 3 |
| 6 | New microbiota found in sputum from patients with community-acquired pneumonia显示文摘获得社区的肺病(帽子) 是医院和哪个还全身地没被讨论的细菌的社区里的一颗主要担心。从在尖锐阶段的病人的唾沫是反映它的特征的一种可存取的样品。在我们的学习,我们与帽子从 45 个病人分析了 45 件唾沫样品。从健康的人的十八件唾沫样品被选择为控制。在唾沫包含的所有细菌的 16 年代 rDNA V3 hypervariable 区域的 Pyrosequencing 被用作一个文化无关的方法揭示社区体质。另外,我们为在唾沫的获得医院的肺病(幸运) 的出版数据被用于比较。由 pyrosequencing, > 90,000 DNA 读被检测。在被工具在 Ribosomal 数据库工程分析以后, reads 被分类进五个主要的数并且 > 100 个类。在数水平,读的帽子的分发类似于健康的人并且在类水平的,每个类的出现在三个范畴拥有他们的特征。象链球菌和 Neisseria 那样的类在他们的百分比显示出稳定性,显示如此的类被外长的细菌或抗菌素很少影响。象在帽子的 Moraxella 和 Rothia 那样的另外的类的角色应该被强调。根据我们的分析,当时,帽子的细菌的社区与细微变化与那些相比健康的人,但是有在幸运之间的大差距。同时, Rothia 可能是一个重要内长的引起肺病的因素。 | Chunyan Chen Tian Shen Fei Tian Ping Lin Qingtian Li Zelin Cui Yajuan Zhang Min Xue Jing Ye Xiaokui Guo YuhuaZhou | 2013 | Acta Biochimica et Biophysica Sinica2013，45，12： | 3 |
| 7 | Chemical cocktails enable hepatic reprogramming of human urine-derived cells with a single transcription factor显示文摘Human liver or hepatocyte transplantation is limited by a severe shortage of donor organs. Direct reprogramming of other adult cells into hepatic cells may offer a solution to this problem. In a previous study, we have generated hepatocyte-like cells from mouse fibroblasts using only one transcription factor (TF) plus a chemical cocktail. Here, we show that human urine-derived epithelial-like cells (hUCs) can also be transdifferentiated into human hepatocyte-like cells (hiHeps) using one TF (Foxa3, Hnf1α, or Hnf4α) plus the same chemical cocktail CRVPTD (C, CHIR99021;R, RepSox;V, VPA;P, Parnate;T, TTNPB;and D, Dznep). These hiHeps express multiple hepatocyte-specific genes and display functions characteristic of mature hepatocytes. With the introduction of the large T antigen, these hiHeps can be expanded in vitro and can restore liver function in mice with concanavalin-A-induced acute liver failure. Our study provides a strategy to generate functional hepatocyte-like cells from hUCs by using a single TF plus a chemical cocktail. | Wei Tang Ren Guo Shi-jun Shen Yang Zheng Yu-ting Lu Meng-meng Jiang Xue Cui Ci-zhong Jiang Xin Xie | 2019 | Acta Pharmacologica Sinica2019，40，5： | 3 |
| 8 | Association of the Asp312Asn and Lys751 Gln polymorphisms in the XPD gene with the risk of non-Hodgkin's lymphoma:evidence from a meta-analysis显示文摘Polymorphisms in DNA repair genes may alter DNA repair capacity and,consequently,lead to genetic instability and carcinogenesis.Several studies have investigated the association of the Asp312 Asn and Lys751 Gln polymorphisms in the xeroderma pigmentosum complementation group D {XPD) gene with the risk of non-Hodgkin's lymphoma(NHL),but the conclusions have been inconsistent.Therefore,we performed this meta-analysis to more precisely estimate these relationships.A systematic literature search was performed using the PubMed,Embase,and Chinese Biomedical(CBM) databases.Ultimately,6 studies of Asp312 Asn,comprising 3,095 cases and 3,306 controls,and 7studies of Lys751 Gln,consisting of 3,249 cases and 3,676 controls,were included.Pooled odds ratios(ORs) and 95%confidence intervals(CIs) were calculated to assess the strength of each association.Overall,no association was observed between the Asp312 Asn polymorphism and NHL risk(homozygous:OR = 1.11,95%CI = 0.94-1.32;heterozygous:OR = 1.00,95%CI = 0.89-1.11;recessive:OR = 1.12,95%CI = 0.95-1.31;dominant:OR = 1.02,95%CI = 0.92-1.13;and allele comparison:OR = 1.04,95%CI = 0.96-1.12) or between the Lys751 Gln polymorphism and NHL risk(homozygous:OR = 0.97,95%CI = 0.83-1.15;heterozygous:OR = 0.96,95%CI = 0.86-1.06;recessive:OR = 1.00,95%CI = 0.86-1.16;dominant:OR = 0.96,95%CI = 0.87-1.06;and allele comparison:OR = 0.98,95%CI = 0.91-1.05).Furthermore,subgroup analyses did not reveal any association between these polymorphisms and ethnicity,the source of the controls,or the NHL subtype.These results indicated that neither the Asp312 Asn nor Lys751 Gln XPD polymorphism was related to NHL risk.Large and well-designed prospective studies are required to confirm this finding. | Shen Chen Jin-Hong Zhu Fang Wang Shao-Yi Huang Wen-Qiong Xue Zhuo Cui Jing He Wei-Hua Jia | 2015 | Chinese Journal of Cancer2015，34，3： | 3 |
| 9 | Mouse knockout models reveal largely dispensable but context-dependent functions of IncRNAs during development显示文摘 | Xue Han Sai Luo Guangdun Peng Yuyang Lu Guizhong Cui Lichao Liu Pixi Yan Yafei Yin Wei Liu Ran Wang Jiejie Zhang Shanshan Ai Zai Chang Jie Na Aibin He Naihe Jing Xiaohua Shen | 2018 | Journal of Molecular Cell Biology2018，10，2： | 3 |
| 10 | Accuracy of dermoscopic and reflectance confocal microscopic criteria for diagnosis of psoriasis显示文摘To the Editor:Psoriasis is a chronic inflammatory disease that is usually diagnosed on the basis of typical clinical features.However,ambiguous cases can exist at times and are sometimes mistaken for other erythematosquamous diseases.Although histopathologic diagnosis remains the gold standard in such cases,it is frequently bypassed to avoid damage to the lesion areas and reduce discomfort for patients.Because a biopsy cannot provide real-time monitoring,non-invasive techniques that are cost-effective,such as dermoscopy and reflectance confocal microscopy(RCM),have increasingly been used in clinical practice during the past few years. | Zi-Yi Wang Chang-Bing Shen Wen-Min Fei Xue Shen Cheng-Xu Li Yan Jing Yong Cui | 2020 | Chinese Medical Journal2020，，24： | 2 |
| 11 | Skin diseases in the Da Qing Diabetes Study:a cross-sectional study显示文摘Background:The prevalence of skin diseases and diabetes mellitus(DM)are prominent around the world.The current scope of knowledge regarding the prevalence of skin diseases and comorbidities with type 2 DM(T2DM)is limited,leading to limited recognition of the correlations between skin diseases and T2DM.Methods:We collected 383 subjects from the Da Qing Diabetes Study during the period from July 9th to September 1st,2016.The subjects were categorized into three groups:Normal glucose tolerance(NGT),impaired glucose tolerance(IGT),and T2DM.The prevalence and clinical characteristics of skin diseases were recorded and investigated.Results:In this cross-sectional study,383 individuals with ages ranging from 53 to 89-year-old were recruited.The overall prevalence of skin diseases was 93.5%,and 75.7%of individuals had two or more kinds of skin diseases.Additionally,there were 47 kinds of comorbid skin diseases in patients with T2DM,of which eight kinds of skin diseases had a prevalence>10%.The prevalence of skin diseases in NGT,IGT,and T2DM groups were 93.3%,91.5%,and 96.6%,respectively;stratified analysis by categories showed a statistically significant difference in'disturbances of pigmentation'and'neurological and psychogenic dermatoses'.The duration of T2DM also significantly associated with the prevalence of'disturbances of pigmentation'and'neurological and psychogenic dermatoses'.Subsequently,the prevalence of'disturbances of pigmentation'was higher in males than females in NGT(P<0.01)and T2DM(P<0.01)groups.In addition,the difference in the prevalence of'disturbances of pigmentation'was also significant in NGT and T2DM groups(P<0.01).Conclusions:There was a high prevalence of skin diseases in the Da Qing Diabetes Study.To address the skin diseases in the Da Qing Diabetes Study,increased awareness and intervention measures should be implemented. | Chang-Bing Shen Xin Qian Rui-Xing Yu Xue-Lei Ji Yin-Juan Shi Jing Gao Cheng-Xu Li Ke-Ke Li Wen-Min Fei Xue Shen Zi-Yi Wang Yang Han Xiao-Li Ning Randy Ko Yi-Hsiang Hsu Xian-Yong Yin Guang-Wei Li Yong Cui | 2021 | Chinese Medical Journal2021，，10： | 2 |
| 12 | Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants is still a pandemic raging across the world(Supplementary information,Fig.S1a,b).A new variant,Omicron,was first detected in South Africa and got dominant in many regions.1 Omicron has been classified as a variant of concern by the World Health Organization(WHO),whose spike carried more than 30 mutations(Supplementary information,Fig.S1c).1,2 To make a comprehensive evaluation of the susceptibility of Omicron,we summarized plasma samples from 19 convalescent individuals infected with the wild-type(WT)virus,and measured their neutralizing activities against the WT,Beta,Delta,Mu,C.1.2,and Omicron(Supplementary information,Figs.S1d and S2).The Omicron showed more serious resistance to neutralizing antibodies(nAbs)than other variants including Beta and Mu(45.6-fold,9.6-fold,and 15.4-fold,respectively,compared with that against the WT)。 | Bin Ju Qingbing Zheng Huimin Guo Qing Fan Tingting Li Shuo Song Hui Sun Senlin Shen Xinrong Zhou Wenhui Xue Lingyan Cui Bing Zhou Shaowei Li Ningshao Xia Zheng Zhang | 2022 | Cell Research2022，32，5： | 1 |
| 13 | Draft genome of the wheata-genome progenitor Triticum urartu显示文摘 | Ling HQ Zhao S Liu D Wang J Sun H Zhang C Fan H Li D Dong L Tao Y Gao C Wu H Li Y Cui Y Guo X Zheng S Wang B Yu K Liang Q Yang W Lou X Chen J Feng M Jian J Zhang X Luo G Jiang Y Liu J Wang Z Sha Y Zhang B WuH Tang D Shen Q Xue P Zou S Wang X Liu X Wang F Yang Y An X Dong Z Zhang K Zhang X Luo MC Dvorak J Tong Y Wang J Yang H Li Z Wang D Zhang A Wang J | 2013 | Nature2013，469，7443： | 1 |
| 14 | Safety of butylphthalide and edaravone in patients with ischemic stroke:a multicenter real-world study显示文摘BACKGROUND Butylphthalide(NBP)and edaravone(EDV)injection are common acute ischemic stroke medications in China,but there is a lack of large real-world safety studies on them.This study aimed to determine the incidence of adverse events,detect relevant safety signals,and assess the risk factors associated with these medications in real-world populations.METHODS In this study,data of acute ischemic stroke patients were extracted from the electronic medical record database of six tertiary hospitals between January 2019 and August 2021.Baseline confounders were eliminated using propensity score matching.The drugs’safety was estimated by comparing the results of 24 laboratory tests standards on liver function,kidney function,lipid level,and coagulation function.The drugs’relative risk was estimated by logistic regression.A third group with patients who did not receive NBP or EDV was constructed as a reference.Prescription sequence symmetry analysis was used to evaluate the associations between adverse events and NBP and EDV,respectively.RESULTS 81,292 patients were included in this study.After propensity score matching,the NBP,EDV,and third groups with 727patients in each group.Among the 15 test items,the incidence of adverse events was lower in the NBP group than in the EDV group,and the differences were statistically significant.The multivariate logistic regression equation revealed that NBP injection was not a promoting factor for abnormal laboratory test results,whereas EDV had statistically significant effects on aspartate transaminase,low-density lipoprotein cholesterol and total cholesterol.Prescription sequence symmetry analysis showed that NBP had a weak correlation with abnormal platelet count.EDV had a positive signal associated with abnormal results in gamma-glutamyl transferase,alanine aminotransferase,aspartate aminotransferase,prothrombin time,and platelet count.CONCLUSIONS In a large real-world population,NBP has a lower incidence of adverse events and a better safety profile than EDV or other usual medications. | Shu-Xian LYU Dong-Fang QIAN Yu-Fei FENG Cheng-Wu SHEN Lu-Bo GUO Jian-Tao LYU Peng-Fei JIN Ting LI Si-Yuan TAN Zi-Xuan ZHANG Lin HUANG Xue ZHONG Le-Qun SU Xin HU Xin HUANG Xue-Yan CUI | 2023 | Journal of Geriatric Cardiology2023，20，4： | 1 |
| 15 | Tff3,as a novel Peptide,regulates hepatic glucose metabolism显示文摘 | Xue Y Shen L Cui Y | | 0，，： | 1 |
| 16 | Reflectance confocal microscopy characteristics for melanocytic nevi显示文摘To the Editor: Melanocytic nevi are a common benign tumor disease in dermatology and can occur in all ages and parts of the skin surface. There are different clinical manifestations in pigmented nevus skin lesions. It is difficult to distinguish other diseases which have similar clinical manifestations of pigmented nevus if medical diagnosis is based solely on the color, shape, or clinical experience of the lesion. Nevi are mainly divided into three categories: junctional (melanocytes confined to the epidermis only), intra-dermal (confined to the dermis only), and compound (both an epidermal and a dermal component). The relationships between these three different types of nevi and what factors contribute to the formation of one type vs. another are still unclear.[1] | Yan Jing Chang-Bing Shen Ke Xue Cheng-Xu Li Xue Shen Zi-Yi Wang Feng Xu Ru-Song Meng Jian-Bin Yu Yong Cui | 2019 | Chinese Medical Journal2019，，20： | 1 |
| 17 | Zwitterionic monolayer grafted ceramic membrane with an antifouling performance for the efficient oil-water separation显示文摘Enormous demands on the separation of oil/water(O/W)emulsions in various industries,such as petrochemical,food and pharmaceutical industries,are looking for high performance and energy-efficient separation methods.Ceramic membranes have been used to deal with O/W emulsions,for its outstanding characteristics of easy-operation,high-flux,and long-term stability.However,membrane fouling is still a challenge in the industrial application of ceramic membranes.Herein,antifouling ceramic membranes were fabricated by grafting zwitterions on the membrane surface via an environment-friendly two-step grafting method,which improves the antifouling property and permeability.Successful grafting of such zwitterion on the ceramic surface was assessed by the combination of FTIR and XPS characterization.More importantly,the hydration can be formed by electrostatic interactions layer on the modified membrane,which was confirmed by TGA characterization.The antifouling performance of prepared zwitterionic ceramic membranes in the separation of O/W emulsions was systematically tested.The results suggested that zwitterion can significantly improve the flux of ceramic ultrafiltration membrane,and can also improve antifouling property dramatically by reducing the irreversible fouling in the separation of O/W emulsions.Therefore,zwitterionic ceramic membranes hold promising potentials as an antifouling,highly efficient and green method in the practical purification of the O/W emulsions. | Tianyu Zhang Qian Wang Wei Luan Xue Li Xianfu Chen Dong Ding Zhichao Shen Minghui Qiu Zhaoliang Cui Yiqun Fan | 2022 | Chinese Journal of Chemical Engineering2022，35，2： | 1 |
| 18 | RNA-seq analysis of molecular heterogeneity peripheral blood mononuclear cells in systemic lupus erythematosus显示文摘Systemic lupus erythematosus(SLE)is an autoimmune disease characterized by a broad spectrum of clinical manifestations.Although great progress has been made in understanding the contribution of genetic and environmental factors in SLE pathogenesis,as there are over 20,000 published studies evaluating related cellular dysfunction,111 the exact mechanisms that underline this process are still unknown.Over the past 10 years,novel insights have mainly originated from genome-wide association(GWAS)and gene expression studies. | Ke Xue Ya-Jie Zheng Rui-Xing Yu Xue Shen Yong Cui | 2019 | Chinese Medical Journal2019，，7： | 1 |
| 19 | Assessment of imaging diagnosis ability of skin tumors in Chinese dermatologists显示文摘Skin tumors begin from normal skin cells, and some parts of them may transform with the potential to reproduce in an out-of-control manner.[1] Skin tumors are exceedingly common and the incidence is increasing at an alarming rate across the globe. | Chang-Bing Shen Xue Shen Cheng-Xu Li Ru-Song Meng Yong Cui | 2019 | Chinese Medical Journal2019，，17： | 1 |
| 20 | Diagnosis,treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children:experts'consensus statement updatedforthe Omicron variant显示文摘It has been more than 3 years since the novel coronavirus(SARS-CoV-2)pandemic raged globally.The coronavirus disease 2019(COVID-19)has greatly influenced human society.According to data from the World Health Organization(WHO),there were over 656 million confirmed cases of COVID-19 in the world as of January 1,2023,including over 6.6 million deaths[1]. | Rong-Meng Jiang Zheng-De Xie Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Yun-Xiao Shang Bao-Ping Xu Zhi-Sheng Liu Gen Lu Ji-Kui Deng Guang-Hua Liu Xiao-Chuan Wang Jian-She Wang Lu-Zhao Feng Wei Liu Yi Zheng Sai-Nan Shu Min Lu Wan-Jun Luo Miao Liu Yu-Xia Cui Le-Ping Ye A-Dong Shen Gang Liu Li-Wei Gao Li-Juan Xiong Yan Bai Li-Kai Lin Zhuang Wei Feng-Xia Xue Tian-You Wang Dong-Chi Zhao Jian-Bo Shao Daniel Kwok-keung Ng Gary Wing-kin Wong Zheng-Yan Zhao Xing-Wang Li Yong-Hong Yang Kun-Ling Shen | 2024 | World Journal of Pediatrics2024，20，3： | 0 |
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