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| 1 | Defined tumor antigen-specific T cells potentiate personalized TCR-T cell therapy and prediction of immunotherapy response显示文摘Personalized immunotherapy targeting tumor-specific antigens(TSAs)could generate efficient and safe antitumor immune response without damaging normal tissues.Although neoantigen vaccines have shown therapeutic effect in clinic trials,precise prediction of neoantigens from tumor mutations is still challenging.The host antitumor immune response selects and activates T cells recognizing tumor antigens.Hence,T cells engineered with T-cell receptors(TCRs)from these naturally occurring tumor antigen-specific T(Tas)cells in a patient will target personal TSAs in his/her tumor.To establish such a personalized TCR-T cell therapy,we comprehensively characterized T cells in tumor and its adjacent tissues by single-cell mRNA sequencing(scRNA-seq),TCR sequencing(TCR-seq)and in vitro neoantigen stimulation.Compared to bystander T cells circulating among tissues,Tas cells were characterized by tumor enrichment,tumor-specific clonal expansion and neoantigen specificity.We found that CXCL13 is a unique marker for both CD4^(+)and CD8^(+)Tas cells.Importantly,TCR-T cells expressing TCRs from Tas cells showed significant therapeutic effects on autologous patient-derived xenograft(PDX)tumors.Intratumoral Tas cell levels measured by CXCL13 expression precisely predicted the response to immune checkpoint blockade,indicating a critical role of Tas cells in the antitumor immunity.We further identified CD200 and ENTPD1 as surface markers for CD4^(^(+))and CD8^(^(+))Tas cells respectively,which enabled the isolation of Tas cells from tumor by Fluorescence Activating Cell Sorter(FACS)sorting.Overall,our results suggest that TCR-T cells engineered with Tas TCRs are a promising agent for personalized immunotherapy,and intratumoral Tas cell levels determine the response to immunotherapy. | Jingjing He Xinxin Xiong Han Yang Dandan Li Xuefei Liu Shuo Li Shuangye Liao Siyu Chen Xizhi Wen Kuai Yu Lingyi Fu Xingjun Dong Kaiyu Zhu Xiaojun Xia Tiebang Kang Chaochao Bian Xiang Li Haiping Liu Peirong Ding Xiaoshi Zhang Zhenjiang Liu Wende Li Zhixiang Zuo Penghui Zhou | 2022 | Cell Research2022，32，6： | 10 |
| 2 | A Lamb wave quantification model for inclined cracks with experimental validation显示文摘This paper investigates the influence of crack orientation on damage quantification using Lamb wave in plate structures. Finite element simulation is performed to acquire Lamb wave signal responses for different configurations of crack orientations and crack lengths. Two Lamb wave features, namely the normalized amplitude and the phase change, are used as damage sensitive features to develop a crack size quantification model. A hypothesis based on the geometrical influence on signal features is proposed, and the crack size quantification model incorporating the orientation angle is established using the hypothesis. An index of Probability of Reliable Quantification(PRQ) is proposed to evaluate the performance of the model. The index can be used to determine the sizing risk in terms of probabilities. A realistic aluminum plate is used to obtain the experimental data using piezoelectric(PZT) wafer-type sensors around a center through crack. The experimental data are used to validate the overall method. Results indicate that the proposed model can yield reliable results for size quantification of inclined cracks. | Jingjing HE Haode HUO Xuefei GUAN Jinsong YANG | 2021 | Chinese Journal of Aeronautics2021，34，2： | 5 |
| 3 | Electronic-property dependent interactions between tetracycline and graphene nanomaterials in aqueous solution显示文摘Understanding the interactions between graphene nanomaterials(GNMs) and antibiotics in aqueous solution is critical to both the engineering applications of GNMs and the assessment of their potential impact on the fate and transport of antibiotics in the aquatic environment. In this study, adsorption of one common antibiotic, tetracycline, by graphene oxide(GO) and reduced graphene oxide(RGO) was examined with multi-walled carbon nanotubes(MWCNTs) and graphite as comparison. The results showed that the tetracycline adsorption capacity by the four selected carbonaceous materials on the unit mass basis followed an order of GO > RGO > MWCNTs > graphite. Upon normalization by surface area,graphite, RGO and MWCNTs had almost the same high tetracycline adsorption affinity while GO exhibited the lowest. We proposed π-electron-property dependent interaction mechanisms to explain the observed different adsorption behaviors. Density functional theory(DFT) calculations suggested that the oxygen-containing functional groups on GO surface reduced its π-electron-donating ability, and thus decreased the π-based interactions between tetracycline and GO surface. Comparison of adsorption efficiency at different p H indicated that electrostatic interaction also played an important role in tetracycline-GO interactions. Site energy analysis confirmed a highly heterogeneous distribution of the binding sites and strong tetracycline binding affinity of GO surface. | Lin He Fei-fei Liu Mengyao Zhao Zhen Qi Xuefei Sun Muhammad Zaheer Afzal Xiaomin Sun Yanhui Li Jingcheng Hao Shuguang Wang | 2018 | Journal of Environmental Sciences2018，30，4： | 4 |
| 4 | Prized edible Asian mushrooms: ecology, conservation and sustainability显示文摘Mushrooms can be found in forests worldwide and have long been exploited as resources in developed economies because of their important agro-industrial,medicinal and commercial uses.For less developed countries,such as those within the Greater Mekong Subregion,wild harvesting and mushroom cultivation provides a much-needed alternative source of income for rural households.However,this has led to over-harvesting and ultimately environmental degradation in certain areas,thus management guidelines allowing for a more sustained approach to the use of wild mushrooms is required.This article addresses a selection of the most popular and highly sought after edible mushrooms from Greater Mekong Subregion:Astraeus hygrometricus,Boletus edulis,Morchella conica,Ophiocordyceps sinensis,Phlebopus portentosus,Pleurotus giganteus,Termitomyces eurhizus,Thelephora ganbajun,Tricholoma matsuake,and Tuber indicum in terms of value,ecology and conservation.The greatest threat to these and many other mushroom species is that of habitat loss and over-harvesting of wild stocks,thus,by creating awareness of these issues we wish to enable a more sustainable use of these natural products.Thus our paper provides baseline data for these fungi so that future monitoring can establish the effects of continued harvesting on mushroom populations and the related host species. | Peter E.Mortimer Samantha C.Karunarathna Qiaohong Li Heng Gui Xueqing Yang Xuefei Yang Jun He Lei Ye Jiayu Guo Huili Li Phongeun Sysouphanthong Dequn Zhou Jianchu Xu Kevin D.Hyde | 2012 | Fungal Diversity2012，，5： | 3 |
| 5 | Corrosion Behavior of Anodic Oxidized TiO_2 Film in Seawater显示文摘TiO2 films were formed on metallic titanium substrates by the anodic oxidation method in H2SO4 solution under the 80V D.C..Phase component and microstructure were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM).Water contact angles on titanium oxide film surface were measured under both dark and sunlight illumination conditions.Corrosion tests were carried out in seawater under different illumination conditions by electrochemistry impedance spectrum (EIS) and polarization curves.The result showed that the TiO2 film prepared by the anodic oxidation method was anatase with a uniform structure and without obvious pores or cracks on its surface.The average water contact angle of the film was 116.4? in dark, in contrast to an angle of 42.7? under the UV illumination for 2 hours, which demonstrates good hydrophobic property.The anti-corrosion behavior of the TiO2 film was declining with the extended immersion time.Under dark conditions, however, the hydrophobic TiO2 film retarded the water infiltrating into the substrate.The impedance changed slowly and the corrosion current density was 2 orders of magnitude lower than that with the film illuminated by sunlight.All of those mentioned above indicate that the TiO2 film possesses much better performance under dark condition, and it can be applied as an engineering material under dark seawater environment. | WANG Min WANG Wei HE Benlin SUN Mingliang YIN Yansheng LIU Lan ZOU Wuyuan XU Xuefei | 2010 | Journal of Ocean University of China2010，9，4： | 2 |
| 6 | Dysregulated adaptive immune response contributes to severe COVID-19显示文摘Dear Editor,The outbreak of the new coronavirus 5ARS-CoV-2 has resulted in a global pandemic.Due to the lack of a specific drug against this virus,the current clinical management of this disease mainly depends on supportive care to reduce inflammatory responses and to keep the lung functioning1. | Kuai Yu Jingjing He Yongjian Wu Baosong Xie Xuefei Liu Bo Wei Haibo Zhou Bingliang Lin Zhixiang Zuo Wen Wen Wenxiong Xu Bin Zou Lai Wei Xi Huang Penghui Zhou | 2020 | Cell Research2020，30，9： | 1 |
| 7 | A truncated mutation of MucA in Pseudomonas aeruginosa from a bronchiectasis patient affects T3SS expression and inflammasome activation显示文摘Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic airway infection in bronchiectasis patients and is closely associated with poor prognosis.Strains isolated from chronically infected patients typically have a mucoid phenotype due to the overproduction of alginate.In this study,we isolate a P.aeruginosa strain from the sputum of a patient with bronchiectasis and find that a truncated mutation occurred in mucA,which is named mucA117.mucA117 causes the strain to transform into a mucoid phenotype,downregulates the expression of T3SS and inflammasome ligands such as fliC and allows it to avoid inflammasome activation.The truncated mutation of the MucA protein may help P.aeruginosa escape clearance by the immune system,enabling long-term colonization. | Yanan Liu Lin Du Yongzhang Zhu Xuefei Liu Ning Zhou Congcong Li Qingtian Li Ping He | 2022 | Acta Biochimica et Biophysica Sinica2022，54，11： | 1 |
| 8 | Experimental investigation of shell modes in two-dimensional phononic crystal consisting of hollow cylinders显示文摘 | MEI Xuefei LIU Gangqiang HE Zhaojian | 2010 | Journal of Applied Physics2010，107，06： | 1 |
| 9 | Corrigendum to“First demonstration of improving laser propagation inside the spherical hohlraums by using the cylindrical laser entrance hole”[Matter Radiation Extremes 1(1)(2016)2-7]显示文摘Corrigendum Text:On page 2 of this letter,there is a misprint in the unit.The unit of the geometrical dimension of the spherical hohlraums on this page should always be“mm”rather than“mm”,i.e.in the second paragraph,“…with 800 J per beam at 0.35 mm…”should be“…with 800 J per beam at 0.35 mm…”,“The slit of 400 mm width is parallel…”should be“The slit of 400 mm width is parallel…”,“The laser focal diameter is about 500 mm…”should be“The laser focal diameter is about 500 mm…”;in the third paragraph,“…we take 850 mm as the radius…”should be“…we take 850 mm as the radius…”,“The LEH radius R_(L) is 400 mm…”should be“The LEH radius R_(L) is 400 mm…”,“…the radius of the cylindrical LEH outer ring is taken as 1.5 R_(L)=600 mm”should be“…the radius of the cylindrical LEH outer ring is taken as 1.5 R_(L)=600 mm”.This mistake does not affect any of the main results of the original letter. | Wenyi Huo Zhichao Li Dong Yang Ke Lan Jie Liu Guoli Ren Sanwei Li Zhiwen Yang Liang Guo Lifei Hou Xuefei Xie Yukun Li Keli Deng Zheng Yuan Xiayu Zhan Guanghui Yuan Haijun Zhang Baibin Jiang Lizhen Huang Kai Du Runchang Zhao Ping Li Wei Wang Jingqin Su Yongkun Ding Xiantu He Weiyan Zhang | 2016 | Matter and Radiation at Extremes2016，1，2： | 1 |
| 10 | Med19 Promotes Osteosarcoma Growth and Metastasis and Associates with Prognosis显示文摘 | Wenxi Yu Zhang Zhichang Min Daliu Yang Qingcheng Du Xuefei Tang Lina Lin Feng Sun Yuanjue Zhao Hui Zheng Shuier He Aina Li Hongtao Yao Yang Zan Shen | 2014 | European Journal of Cancer2014，，： | 1 |
| 11 | Experimental study on start-up of a two SBR denit rifying and phosphorus removing system 显示文摘 | LIU Xuefei HE Xinhui YE Xiangle | 2007 | J Xi''an Univ of Arch & Tcch2007，39，3： | 1 |
| 12 | Probabilistic inference of fatigue damage propagation with limited and partial information显示文摘A general method of probabilistic fatigue damage prognostics using limited and partial information is developed.Limited and partial information refers to measurable data that are not enough or cannot directly be used to statistically identify model parameter using traditional regression analysis.In the proposed method, the prior probability distribution of model parameters is derived based on the principle of maximum entropy(Max Ent) using the limited and partial information as constraints.The posterior distribution is formulated using the principle of maximum relative entropy(MRE) to perform probability updating when new information is available and reduces uncertainty in prognosis results.It is shown that the posterior distribution is equivalent to a Bayesian posterior when the new information used for updating is point measurements.A numerical quadrature interpolating method is used to calculate the asymptotic approximation for the prior distribution.Once the prior is obtained, subsequent measurement data are used to perform updating using Markov chain Monte Carlo(MCMC) simulations.Fatigue crack prognosis problems with experimental data are presented for demonstration and validation. | Huang Min He Jingjing Guan Xuefei | 2015 | Chinese Journal of Aeronautics2015，28，4： | 1 |
| 13 | Blockchain-based vehicular edge computing networks:the communication perspective显示文摘Vehicular edge computing(VEC)networks can satisfy the increasing demands of data processing by offloading the computation tasks to multiple distributed edge computing nodes assisted by servers.These edge servers generally combine with roadside units(RSUs).However,RSUs with edge servers cannot be fully trusted,possibly leading to serious security and privacy problems.Combining blockchain with VEC networks may establish a trusted and decentralized vehicular environment,but the coexistence of multiple communication modes comprising vehicle-to-vehicle(V2V),vehicle-to-RSU(V2R),and RSU-to-RSU(R2R)makes the block propagation patterns have different effects on the block consensus process.In this paper,we study the block propagation patterns between vehicles and RSUs with edge servers under three communication modes.We first give the closed-form expressions for the single-block and multiblock propagation times in two specific conditions to explore how the priority of a block generated from a specific node affects the block propagation process,in which multiblock propagation embodies competitive propagation due to blockchain forking.Then,an innovative consensus mechanism that fully invokes the communication capability of the nodes is proposed,and the block propagation time and frequency can be substantially reduced under this mechanism.In addition,an important finding is that under the conventional and proposed consensus mechanisms,an RSU or a vehicle that creates a new block plays a decisive role in the block propagation pattern. | Lin HE Fuchang LI Haikun XU Wenbo XIA Xuefei ZHANG Xiaofeng TAO | 2023 | Science China(Information Sciences)2023，66，7： | 1 |
| 14 | Matsutake Trade in Yunnan Province, China: An Overview显示文摘 | Xuefei Yang Jun He Chun Li Jianzhong Ma Yongping Yang Jianchu Xu | 2008 | Economic Botany2008，，3： | 1 |
| 15 | Carbon fluxes and soil carbon dynamics along a gradient of biogeomorphic succession in alpine wetlands of Tibetan Plateau显示文摘Hydrological changes under climate warming drive the biogeomorphic succession of wetlands and may trigger substantial carbon loss from the carbon-rich ecosystems.Although many studies have explored the responses of wetland carbon emissions to short-term hydrological change,it remains poorly understood how the carbon cycle evolves with hydrology-driven wetland succession.Here,we used a space-for-time approach across hydrological gradients on the Tibetan Plateau to examine the dynamics of ecosystem carbon fluxes(carbon dioxide(CO_(2))and methane(CH4))and soil organic carbon pools during alpine wetland succession.We found that the succession from mesic meadow to fen changed the seasonality of both CO_(2) and CH4 fluxes,which was related to the shift in plant community composition,enhanced regulation of soil hydrology and increasing contribution of spring-thaw emission.The paludification caused a switch from net uptake of gaseous carbon to net release on an annual timescale but produced a large accumulation of soil organic carbon.We attempted to attribute the paradox between evidence from the carbon fluxes and pools to the lateral carbon input and the systematic changes of historical climate,given that the wetlands are spatially low-lying with strong temporal climate-carbon cycle interactions.These findings demonstrate a systematic change in the carbon cycle with succession and suggest that biogeomorphic succession and lateral carbon flows are both important for understanding the long-term dynamics of wetland carbon footprints. | Hao Wang Lingfei Yu Litong Chen Zhenhua Zhang Xuefei Li Naishen Liang Changhui Peng Jin-Sheng He | 2023 | Fundamental Research2023，3，2： | 1 |
| 16 | βII‐Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin显示文摘 | Xiuling Zhi Ling Lin Shaoxian Yang Krithika Bhuvaneshwar Hongkun Wang Yuriy Gusev Mi‐Hye Lee Bhaskar Kallakury Narayan Shivapurkar Katherine Cahn Xuefei Tian John L. Marshall Stephen W. Byers Aiwu R. He | 2015 | Hepatology2015，，2： | 1 |
| 17 | Photocatalytic reduction of Cr ( VI ) by sulfate modified titanium-bearing blast furnace slag 显示文摘 | Xue Xiangxin Lei Xuefei Yang He | 2009 | Dangbei Daxue Xuebao/Joumal of Northeastern University2009，30，2： | 1 |
| 18 | High-voltage,low-temperature supercapacitors enabled by localized“water-in-pyrrolidinium chloride”electrolyte显示文摘Aqueous electrolytes offer superior prospects for advanced energy storage.“Water-in-salt”(WIS)electrolytes exhibit a wide electrochemical stability window(ESW),but their low conductivity,high viscosity,and precipitation at low temperatures restrict their application.Herein,we report a novel localized“water-in-pyrrolidinium chloride”electrolyte(LWIP;1 mol/L,N-propyl-N-methylpyrrolidinium chloride/(water and N,Ndimethylformamide,1:4 by molality))enabling high-voltage,low-temperature supercapacitors(SCs).The greatly improved ESW(3.451 V)is mainly attributed to the strong solvation between Cl-and water molecules,which broadens the negative stability.This water-binding mechanism is very different from that of a WIS electrolyte based on alkali metal salt.SCs using LWIP electrolytes not only yield a high operating voltage of 2.4 V and excellent capacity retention(82.8%after 15,000 cycles at 5 A g^(-1))but also operate stably at-20℃.This work provides new approaches for the design and preparation of novel electrolytes. | Peng Zhang Weili Zhang Zhengjie Wang Xuefei Wang Qingjuan Ren Shuai Zhang Yujia Wang Liang He Pan Liu Qingyin Zhang Zhiqiang Shi | 2023 | eScience2023，3，6： | 0 |
| 19 | First demonstration of improving laser propagation inside the spherical hohlraums by using the cylindrical laser entrance hole显示文摘The octahedral spherical hohlraums have natural superiority in maintaining high radiation symmetry during the entire capsule implosion process in indirect drive inertial confinement fusion.While,in contrast to the cylindrical hohlraums,the narrow space between the laser beams and the spherical hohlraum wall is usually commented.In this Letter,we address this crucial issue and report our experimental work conducted on the SGIII-prototype laser facility which unambiguously demonstrates that a simple design of cylindrical laser entrance hole(LEH)can dramatically improve the laser propagation inside the spherical hohlraums.In addition,the laser beam deflection in the hohlraum is observed for the first time in the experiments.Our 2-dimensional simulation results also verify qualitatively the advantages of the spherical hohlraums with cylindrical LEHs.Our results imply the prospect of adopting the cylindrical LEHs in future spherical ignition hohlraum design. | Wenyi Huo Zhichao Li Dong Yang Ke Lan Jie Liu Guoli Ren Sanwei Li Zhiwen Yang Liang Guo Lifei Hou Xuefei Xie Yukun Li Keli Deng Zheng Yuan Xiayu Zhan Guanghui Yuan Haijun Zhang Baibin Jiang Lizhen Huang Kai Du Runchang Zhao Ping Li Wei Wang Jingqin Su Yongkun Ding Xiantu He Weiyan Zhang | 2016 | Matter and Radiation at Extremes2016，1，1： | 0 |
| 20 | Structures of the endogenous peptide-and selective non-peptide agonist-bound SSTR2 signaling complexes显示文摘Dear Editor,Somatostatin,also known as growth hormone-inhibiting hormone,is an important peptide hormone that mediates predominanty neuroendocrine inhibitory effects in the exocrine and endocrine systems,12 Besides,t can also exert potent regulatory effects on cell proliferation and angiogenesis.3 In human,somatostatin exerts its physiological functions through activating five somatostatin receptors(SSTRs),which are class A Gvo protein-coupled receptors,Pharmacologicaly,somatostatin receptors,especially SSTR2,are the primary drug targets for the treatment of pituitary adenomas and neuroendocrine tumors.-s To date,three somatostatin analogs have been approved for clinical use and two of them(lanreotide and octreotide)are sSTR2-selective drugs.3 In addition to peptidic agonists,extensive efforts have also been made to design selective small-molecule agonists,t which will failitate the development of orly active chemotherapeutic agents. | Li-Nan Chen Wei-Wei Wang Ying-Jun Dong Dan-Dan Shen Jia Guo Xuefei Yu Jiao Qin Su-Yu Ji Huibing Zhang Qingya Shen Qiaojun He Bo Yang Yan Zhang Qinglin Li Chunyou Mao | 2022 | Cell Research2022，32，8： | 0 |
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