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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair显示文摘There are intense interests in discovering pro regenerative medicine leads that can promote cardiac differentiation and regeneration,as well as repair damaged heart tissues.We have combined zebrafish embryo-based screens with cardiomyogenesis assays to discover selective small molecules that modulate heart development and regeneration with minimal adverse effects.Two related compounds with novel structures,named as Cardiomogen 1 and 2(CDMG1 and CDMG2),were identified for their capacity to promote myocardial hyperplasia through expansion of the cardiac progenitor cell population.We find that Cardiomogen acts as a Wnt inhibitor by targeting p-catenin and reducing Tcf/Lef-mediated transcription in cultured cells.CDMG treatment of amputated zebrafish hearts reduces nuclear p-catenin in injured heart tissue,increases cardiomyocyte(CM)proliferation,and expedites wound healing,thus accelerating cardiac muscle regeneration.Importantly,Cardiomogen can alleviate the functional deterioration of mammalian hearts after myocardial infarction.Injured hearts exposed to CDMG1 display increased newly formed CMs and reduced fibrotic scar tissue,which are in part attributable to the^-catenin reduction.Our findings indicate Cardiomogen as a Wnt inhibitor in enhancing injury-induced CM proliferation and heart regeneration,highlighting the values of embryo-based small molecule screens in discovery of effective and safe medicine leads. | Shuying Xie Wenbin Fu Guangju Yu Xueli Hu Kaa Seng Lai Xiangwen Peng Yating Zhou Xuejiao Zhu Ptamen Christov Leah Sawyer Terri T.Ni Gary A.Sulikowski Zhongzhou Yang Ethan Lee Chunyu Zeng Wei E.Wang Tao P.Zhong | 2020 | Journal of Molecular Cell Biology2020，12，1： | 4 |
| 3 | Preparation of a novel carbon based solid acid catalyst for biodiesel production via a sustainable route显示文摘 | Song Xueli Fu Xiaobo Zhang Weiya | 2012 | Catalysis Letters2012，142，7： | 1 |
| 4 | An optimal design of the broadcast ephemeris for LEO navigation augmentation systems显示文摘As the deployment of large Low Earth Orbiters(LEO)communication constellations,navigation from the LEO satellites becomes an emerging opportunity to enhance the existing satellite navigation systems.The LEO navigation augmentation(LEO-NA)systems require a centimeter to decimeter accuracy broadcast ephemeris to support high accuracy positioning applications.Thus,how to design the broadcast ephemeris becomes the key issue for the LEO-NA systems.In this paper,the temporal variation characteristics of the LEO orbit elements were analyzed via a spectrum analysis.A non-singular element set for orbit fitting was introduced to overcome the potential singularity problem of the LEO orbits.Based on the orbit characteristics,a few new parameters were introduced into the classical 16 parameter ephemeris set to improve the LEO orbit fitting accuracy.In order to identify the optimal parameter set,different parameter sets were tested and compared and the 21 parameters data set was recommended to make an optimal balance between the orbit accuracy and the bandwidth requirements.Considering the real-time broadcast ephemeris generation procedure,the performance of the LEO ephemeris based on the predicted orbit is also investigated.The performance of the proposed ephemeris set was evaluated with four in-orbit LEO satellites and the results indicate the proposed 21 parameter schemes improve the fitting accuracy by 87.4%subject to the 16 parameters scheme.The accuracy for the predicted LEO ephemeris is strongly dependent on the orbit altitude.For these LEO satellites operating higher than 500 km,10 cm signal-in-space ranging error(SISRE)is achievable for over 20 min prediction. | Xueli Guo Lei Wang Wenju Fu Yingbo Suo Ruizhi Chen Hongxing Sun | 2022 | Geo-Spatial Information Science2022，25，1： | 1 |
| 5 | Error Compensation of Magnetic Measurement System Based on GMR Sensor显示文摘 | Zheng Xueli Fu Jingqi | 2013 | Control andDecivsion Conference2013，，5： | 1 |
| 6 | ZmMS1/ZmLBD30-orchestrated transcriptional regulatory networks precisely control pollen exine development显示文摘Because of its significance for plant male fertility and,hence,direct impact on crop yield,pollen exine development has inspired decades of scientific inquiry.However,the molecularmechanismunderlying exine formation and thickness remains elusive.In this study,we identified that a previously unrecognized repressor,ZmMS1/ZmLBD30,controls proper pollen exine development in maize.Using an ms1 mutant with aberrantly thickened exine,we cloned a male-sterility gene,ZmMs1,which encodes a tapetum-specific lateral organ boundary domain transcription factor,ZmLBD30.Weshowed thatZmMs1/ZmLBD30 is initially turned on by a transcriptional activation cascade of ZmbHLH51-ZmMYB84-ZmMS7,and then it serves as a repressor to shut down this cascade via feedback repression to ensure timely tapetal degeneration and proper level of exine.This activation-feedback repression loop regulating male fertility is conserved in maize and sorghum,and similar regulatory mechanism may also exist in other flowering plants such as rice and Arabidopsis.Collectively,these findings reveal a novel regulatory mechanism of pollen exine development by which a long-sought master repressor of upstream activators prevents excessive exine formation. | Quancan Hou Xueli An Biao Ma Suowei Wu Xun Wei Tingwei Yan Yan Zhou Taotao Zhu Ke Xie Danfeng Zhang Ziwen Li Lina Zhao Canfang Niu Yan Long Chang Liu WeiZhao FeiNi Jinping Li Daolin Fu Zhong-NanYang Xiangyuan Wan | 2023 | Molecular Plant2023，16，8： | 0 |
| 7 | HBXIP blocks myosin-ⅡA assembly by phosphorylating and interacting with NMHC-ⅡA in breast cancer metastasis显示文摘Tumor metastasis depends on the dynamic balance of the actomyosin cytoskeleton.As a key component of actomyosin filaments,non-muscle myosin-ⅡA disassembly contributes to tumor cell spreading and migration.However,its regulatory mechanism in tumor migration and invasion is poorly understood.Here,we found that oncoprotein hepatitis B X-interacting protein(HBXIP) blocked the myosin-ⅡA assemble state promoting breast cancer cell migration.Mechanistically,mass spectrometry analysis,co-immunoprecipitation assay and GST-pull down assay proved that HBXIP directly interacted with the assembly-competent domain(ACD) of non-muscle heavy chain myosin-ⅡA(NMHC-ⅡA).The interaction was enhanced by NMHC-ⅡA S1916 phosphorylation via HBXIP-recruited protein kinase PKCβⅡ.Moreover,HBXIP induced the transcription of PRKCB,encoding PKCβⅡ,by coactivating Sp1,and triggered PKCβⅡ kinase activity.Interestingly,RNA sequencing and mouse metastasis model indicated that the anti-hyperlipidemic drug bezafibrate(BZF) suppressed breast cancer metastasis via inhibiting PKCβⅡ-mediated NMHC-ⅡA phosphorylation in vitro and in vivo.We reveal a novel mechanism by which HBXIP promotes myosin-ⅡA disassembly via interacting and phosphorylating NMHC-ⅡA,and BZF can serve as an effective anti-metastatic drug in breast cancer. | Lu Zhang Xiaolei Zhou Bowen Liu Xuhe Shi Xianmeng Li Feifei Xu Xueli Fu Xue Wang Kai Ye Tianzhi Jin Huimin Sun Qianqian Li Weiying Zhang Lihong Ye | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 0 |
| 8 | High current CO_(2)reduction realized by edge/defect-rich bismuth nanosheets显示文摘CO_(2)electroreduction has been regarded as an appealing strategy for renewable energy storage.Recently,bismuth(Bi)electrocatalysts have attracted much attention due to their excellent formate selectivity.However,many reported Bi electrocatalysts suffer from low current densities,which are insufficient for industrial applications.To reach the goal of high current CO_(2)reduction to formate,we fabricate Bi nanosheets(NS)with high activity through edge/terrace control and defect engineering strategy.Bi NS with preferential exposure sites are obtained by topotactic transformation,and the processes are clearly monitored by in-situ Raman and ex-situ X-ray diffraction(XRD).Bi NS-1 with a high fraction of edge sites and defect sites exhibits excellent performance,and the current density is up to ca.870 mA·cm^(−2)in the flow cell,far above the industrially applicable level(100 mA·cm^(−2)),with a formate Faradaic efficiency greater than 90%.In-situ Fourier transform infrared(FT-IR)spectra detect*OCHO,and theoretical calculations reveal that the formation energy of*OCHO on edges is lower than that on terraces,while the defects on edges further reduce the free energy changes(ΔG).The differential charge density spatial distributions reveal that the presence of defects on edges causes charge enrichment around the C–H bond,benefiting the stabilization of the*OCHO intermediate,thus remarkably lowering theΔG. | Jiaqi Xu Siheng Yang Li Ji Jiawei Mao Wei Zhang Xueli Zheng Haiyan Fu Maolin Yuan Chengkai Yang Hua Chen Ruixiang Li | 2023 | Nano Research2023，16，1： | 0 |
| 9 | Guidelines for the diagnosis and treatment of pancreatic cancer in China (2021)显示文摘The incidence of pancreatic cancer has been rising worldwide,and its clinical diagnosis and treatment remain a great challenge.To present the update and improvements in the clinical diagnosis and treatment of pancreatic cancer in recent years,Chinese Pancreatic Association,the Chinese Society of Surgery,Chinese Medical Association revised the Guidelines for the Diagnosis and Treatment of Pancreatic Cancer in China(2014)after reviewing evidence-based and problem-oriented literature published during 2015-2021,mainly focusing on highlight issues regarding diagnosis and surgical treatment of pancreatic cancer,conversion strategies for locally advanced pancreatic cancer,treatment of pancreatic cancer with oligo metastasis,adjuvant and neoadjuvant therapy,standardized processing of surgical specimens and evaluation of surgical margin status,systemic treatment for unresectable pancreatic cancer,genetic testing,as well as postoperative follow up of patients with pancreatic cancer.Forty recommendation items were finally proposed based on the above issues,and the quality of evidence and strength of recommendations were graded using the Grades of Recommendation,Assessment,Development,and Evaluation system.This guideline aims to standardize the clinical diagnosis and therapy,especially surgical treatment of pancreatic cancer in China,and further improve the prognosis of patients with pancreatic cancer. | Yinmo Yang Xueli Bai Dapeng Bian Shouwang Cai Rufu Chen Feng Cao Menghua Dai Chihua Fang Deliang Fu Chunlin Ge Xiaochao Guo Chunyi Hao Jihui Hao Heguang Huang Zhixiang Jian Gang Jin Fei Li Haimin Li Shengping Li Weiqin Li Yixiong Li Hongzhen Li Tingbo Liang Xubao Liu Wenhui Lou Yi Miao Yiping Mou Chenghong Peng Renyi Qin Chenghao Shao Bei Sun Guang Tan Xiaodong Tian Huaizhi Wang Lei Wang Wei Wang Weilin Wang Junmin Wei Heshui Wu Wenming Wu Zheng Wu Jingyong Xu Changqing Yan Xiaoyu Yin Xianjun Yu Chunhui Yuan Taiping Zhang Jixin Zhang Jun Zhou Yupei Zhao on behalf of the Chinese Pancreatic Surgery Association | 2021 | Journal of Pancreatology2021，4，2： | 0 |
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