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| 1 | Evolution Stages of Oasis Economy and Its Dependence on Natural Resources in Tarim River Basin显示文摘This paper examines spatio-temporal characteristics of an oasis economy and its relationship with water and mineral resources in the Tarim River Basin from 1965 to 2005. A spatial autocorrelation model, the center of gravity model, and index system of the regional central city are used to probe the evolution laws of spatial structure of oasis economy. The study finds that: 1) The economic centre of gravity, whose variation track during this period follows linear rate law, was moving from headstream to middle reaches of the Tarim River. 2) Positive spatial autocorrelation which showed a waving and ascending trend of regional economy was significant and the neighbor effect of regional economic growth was strengthened continuously. 3) The regional economic centre was located in Hotan City before 1980, moved to Aksu City during the 1980s and to Korla City after 1990. We conclude that above all, during the recent four decades the evolution of the oasis economy in this region has gone through three stages: a traditional agriculture stage (before 1980), oasis agriculture and agricultural product processing stage (1980–1990) and oasis energy industry stage (after 1990). Furthermore, the dependence degree of the oasis economy on natural resources in different stages are studied by using dominance index, regression model, and grey relation method, which shows that an oasis econ- omy highly depends on water resources in the oasis agriculture and agricultural product processing stage while it de- pends more on mineral resources such as oil and natural gas during the oasis energy industry stage. | QIAO Xuning YANG Degang ZHANG Xinhuan | 2009 | Chinese Geographical Science2009，19，2： | 8 |
| 2 | Implementation of 1.7 kV Silicon Carbide Metal Oxide Semiconductor Field Effect Transistors in Auxiliary Power Supplies for Industrial Applications显示文摘An auxiliary power supply(Aux-PS)has become an essential component of electronic equipment for many industrial applications,such as in motor drives,photovoltaic(PV)inverters,uninterruptible power supply(UPS)systems and modular multilevel converters.The introduction of 1700 V silicon carbide(SiC)metal oxide semiconductor field effect transistors(MOSFETs)is useful for such applications,providing benefits with respect to a low on-state resistance,smaller package,low switching loss and single-switching implementation.A single end flyback Aux-PS is designed for industrial applications with a wide input voltage range using 1.7 kV SiC MOSFETs.The special design tradeoffs involved in the usage of SiC MOSFETs are discussed in detail,such as those with regard to gate driving voltage selection,isolation transformer design considerations,and clamping circuit design details.A 60 W demonstration hardware is developed and tested under different working conditions.The results verify the higher efficiency and better thermal performance of the proposed hardware relative to those of traditional Si solutions. | Xuning Zhang Gin Sheh | 2020 | Chinese Journal of Electrical Engineering2020，6，3： | 2 |
| 3 | Bilevel model for multi-reservoir operating policy in inter-basin water transfer-sup- ply project显示文摘 | Guo Xuning Hu Tiesong Zhang Tao | 2012 | Journal of Hydrology2012，424，： | 1 |
| 4 | A novel transgenic mouse model of Chinese CharcotMarie-Tooth disease type 2L显示文摘We previously found that the K141N mutation in heat shock protein B8(HSPB8) was responsible for Charcot-Marie-Tooth disease type 2L in a large Chinese family.The objective of the present study was to generate a transgenic mouse model bearing the K141N mutation in the human HSPB8 gene,and to determine whether this K141NHSPB8 transgenic mouse model would manifest the clinical phenotype of Charcot-Marie-Tooth disease type 2L,and consequently be suitable for use in studies of disease pathogenesis.Transgenic mice overexpressing K141NHSPB8 were generated using K141N mutant HSPB8 cDNA cloned into a pCAGGS plasmid driven by a human cytomegalovirus expression system.PCR and western blot analysis confirmed integration of the K141NHSPB8 gene and widespread expression in tissues of the transgenic mice.The K141NHSPB8 transgenic mice exhibited decreased muscle strength in the hind limbs and impaired motor coordination,but no obvious sensory disturbance at 6 months of age by behavioral assessment.Electrophysiological analysis showed that the compound motor action potential amplitude in the sciatic nerve was significantly decreased,but motor nerve conduction velocity remained normal at 6 months of age.Pathological analysis of the sciatic nerve showed reduced myelinated fiber density,notable axonal edema and vacuolar degeneration in K141NHSPB8 transgenic mice,suggesting axonal involvement in the peripheral nerve damage in these animals.These findings indicate that the K141NHSPB8 transgenic mouse successfully models Charcot-Marie-Tooth disease type 2L and can be used to study the pathogenesis of the disease. | Ruxu Zhang Fufeng Zhang Xiaobo Li Shunxiang Huang Xiaohong Zi Ting Liu Sanmei Liu Xuning Li Kun Xia Qian Pan Beisha Tang | 2014 | Neural Regeneration Research2014，9，4： | 1 |
| 5 | Thermal runaway features of large format prismatic lithium ion battery using extended volume accelerating rate calorimetry显示文摘 | Xuning Feng Mou Fang Xiangming He Minggao Ouyang Languang Lu Hao Wang Mingxuan Zhang | 2014 | Journal of Power Sources2014，，： | 1 |
| 6 | Insight into the Inhibition of the Poisonous Sulfide Production from Sulfate-Reducing Microbiota in Mariculture Habitat显示文摘The production of toxic sulfides is a common environmental problem in mariculture.Therefore,the effective inhibition of sulfidogens is the key to prevent sulfides production.In this study,the possibility and mechanism of nitrate(NO_(3)^(−))inhibiting the activity of the sulfate-reducing microbiota(SRM)from mariculture sediments was investigated.The results showed that 1,3,and 5 mmol L^(−1)NO_(3)^(−)continuously inhibited sulfide production for 1-3 d.As NO_(3)^(−) dosage increased to 7 mmol L^(−1),the duration of inhibition increased to 6 days.Denitrifying product NO_(2)^(−)heavily inhibited the activity of dissimilar sulfate reductase gene(dsrB)by 3 orders,which was the main reason that the sulfate-reducing activity was inhibited.The SRM structure changed significantly with the dosage of NO_(3)^(−),while the abundance of sulfidogens Desulfovibrio species increased due to their capability of detoxifying nitrite through nitrite reductase.Hence,sulfidogens Desulfovibrio species are more adaptable to a high nitrate/nitrite environment,and the traditional control strategies by dosing nitrate/nitrite should be paid more attention to.The findings will serve as helpful guidelines for sulfate-reducing microbiota in the habitat of mariculture to reduce their generation of poisonous sulfide. | ZHAO Xuning ZHANG Zhiming ZHAO Yangguo MUPINDU Progress | 2024 | Journal of Ocean University of China2024，23，2： | 0 |
| 7 | Electrolyte induced synergistic construction of cathode electrolyte interphase and capture of reactive free radicals for safer high energy density lithium-ion battery显示文摘As the energy density of battery increases rapidly,lithium-ion batteries(LIBs)are facing serious safety issue with thermal runaway,which largely limits the large-scale applications of high-energy-density LIBs.It is generally agreed that the chemical crosstalk between the cathode and anode leads to thermal runaway of LIBs.Herein,a multifunctional high safety electrolyte is designed with synergistic construction of cathode electrolyte interphase and capture of reactive free radicals to limit the intrinsic pathway of thermal runaway.The cathode electrolyte interphase not only resists the gas attack from the anode but suppresses the parasitic side reactions induced by electrolyte.And the function of free radical capture has the ability of reducing heat release from thermal runaway of battery.The dual strategy improves the intrinsic safety of battery prominently that the triggering temperature of thermal runaway is increased by 24.4℃and the maximum temperature is reduced by 177.7℃.Simultaneously,the thermal runaway propagation in module can be self-quenched.Moreover,the electrolyte design balances the trade-off of electrochemical and safety performance of high-energy batteries.The capacity retention of LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)|graphite pouch cell has been significantly increased from 53.85%to 97.05%with higher coulombic efficiency of 99.94%at operating voltage extended up to 4.5 V for 200 cycles.Therefore,this work suggests a feasible strategy to mitigate the safety risk of high-energy-density LIBs without sacrificing electrochemical performances. | Mengfei Ding Xuning Feng Yong Peng Jing Jing Tong Bowen Hou Yalan Xing Weifeng Zhang Li Wang Yu Wu Jiabin Lv Chunyan Luo Dejun Xiong Shichao Zhang Minggao Ouyang | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 8 | Urban Expansion in Major Grain Producing Area from 1978 to 2017:A Case Study of Zhengzhou Metropolitan Area,China显示文摘The spatial form of urbanization in China has developed from single-core city expansion to a multi-center metropolitan area.However,little attention has been paid to the growth process of the emerging metropolitan area situated in major grain producing locations in the central China.Taking the Zhengzhou metropolitan area(ZZMA)as a case study,we developed an inverse S-shape model to characterize the spatial distribution of urban land density,and constructed an urban expansion core index,urban expansion intensity index,and urban compactness index to quantify the spatial structure change that has taken place from 1978 to 2017 during the process of urban expansion.Moreover,cropland contribution rate(CR)was constructed to evaluate the impacts of urban expansion on croplands.We uncovered four key findings.First,over the past 40 yr,the ZZMA has experienced dramatic expansion,and the central city of Zhengzhou expanded faster than other cities.The gravity centers of urban expansion of surrounding cities were moving toward to Zhengzhou City.Second,the urban land density decreased with the distance from the city center to the outskirts.As the only large city,Zhengzhou has experienced the fastest and most compact centralized urban expansion,especially after 2000,while other medium-and small-sized cities have experienced low-intensity decentralized expansion.Third,the urban core has been gradually expanding outward.From 1978 to 2017,the hot-zone of urban growth has moved progressively with the acceleration of urbanization.All cities except Jiaozuo had a single peak in different periods.Forth,the cities in national core grain-producing areas has higher cropland contribution rates and lower urban expansion areas,which was closely related to cropland protection.Further analysis showed that large city was relatively better positioned than smaller cities in the efficiency of their urban infrastructure and the effectiveness of wealth creation efficiency in the urbanized area could be tested in all cities,and the policy factor seemed to play an important role in the urban expansion process. | YANG Yongju ZHANG Hebing QIAO Xuning LIU Liang ZHENG Jinchan | 2023 | Chinese Geographical Science2023，33，1： | 0 |
| 9 | All-temperature area battery application mechanism,performance,and显示文摘Further applications of electric vehicles(EVs)and energy storage stations are limited because of the thermal sensitivity,volatility,and poor durability of lithium-ion batteries(LIBs),especially given the urgent requirements for all-climate utilization and fast charging.This study comprehensively reviews the thermal characteristics and management of LIBs in an all-temperature area based on the performance,mechanism,and thermal management strategy levels. | Siqi Chen Xuezhe Wei Guangxu Zhang Xueyuan Wang Jiangong Zhu Xuning Feng Haifeng Dai Minggao Ouyang | 2023 | The Innovation2023，4，4： | 0 |
| 10 | Mitigating thermal runaway hazard of high-energy lithium-ion batteries by poison agent显示文摘Lithium-ion batteries with high-energy density are extensively commercialized in long-range electric vehicles. However, they are poor in thermal stability and pose fire or explosion, which has attracted the global attention. This study describes a new route to mitigate the battery thermal runaway(TR) hazard by poison agents. First, the self-destructive cell is built using the embedded poison layer. Then, the poisoning mechanism and paths are experimentally investigated at the material, electrode, and cell levels. Finally, the proposed route is verified by TR tests. The results show the TR hazard can be significantly reduced in the self-destructive cell based on a new reaction sequence regulation. Specifically, the maximum temperature of the self-destructive cell is more than 300℃ lower than that of the normal cell during TR. The drop in maximum temperature can reduce total heat release and the probability of TR propagation in the battery system, significantly improving battery safety. | Xin Lai Zheng Meng Fangnan Zhang Yong Peng Weifeng Zhang Lei Sun Li Wang Fei Gao Jie Sheng Shufa Su Yuejiu Zheng Xuning Feng | 2023 | Journal of Energy Chemistry2023，，8： | 0 |
| 11 | Mechanism of internal thermal runaway propagation in blade batteries显示文摘Blade batteries are extensively used in electric vehicles,but unavoidable thermal runaway is an inherent threat to their safe use.This study experimentally investigated the mechanism underlying thermal runaway propagation within a blade battery by using a nail to trigger thermal runaway and thermocouples to track its propagation inside a cell.The results showed that the internal thermal runaway could propagate for up to 272 s,which is comparable to that of a traditional battery module.The velocity of the thermal runaway propagation fluctuated between 1 and 8 mm s^(-1),depending on both the electrolyte content and high-temperature gas diffusion.In the early stages of thermal runaway,the electrolyte participated in the reaction,which intensified the thermal runaway and accelerated its propagation.As the battery temperature increased,the electrolyte evaporated,which attenuated the acceleration effect.Gas diffusion affected thermal runaway propagation through both heat transfer and mass transfer.The experimental results indicated that gas diffusion accelerated the velocity of thermal runaway propagation by 36.84%.We used a 1D mathematical model and confirmed that convective heat transfer induced by gas diffusion increased the velocity of thermal runaway propagation by 5.46%-17.06%.Finally,the temperature rate curve was analyzed,and a three-stage mechanism for internal thermal runaway propagation was proposed.In Stage I,convective heat transfer from electrolyte evaporation locally increased the temperature to 100℃.In Stage II,solid heat transfer locally increases the temperature to trigger thermal runaway.In StageⅢ,thermal runaway sharply increases the local temperature.The proposed mechanism sheds light on the internal thermal runaway propagation of blade batteries and offers valuable insights into safety considerations for future design. | Xuning Feng Fangshu Zhang Wensheng Huang Yong Peng Chengshan Xu Minggao Ouyang | 2024 | Journal of Energy Chemistry2024，89，2： | 0 |
| 12 | Organic Passivation of Deep Defects in Cu(In,Ga)Se_(2) Film for Geometry-Simplified Compound Solar Cells显示文摘Diverse defects in copper indium gallium diselenide solar cells cause nonradiative recombination losses and impair device performance.Here,an organic passivation scheme for surface and grain boundary defects is reported,which employs an organic passivation agent to infiltrate the copper indium gallium diselenide thin films.A transparent conductive passivating(TCP)film is then developed by incorporating metal nanowires into the organic polymer and used in solar cells.The TCP films have a transmittance of more than 90%in the visible and nearinfrared spectra and a sheet resistance of~10.5Ω/sq.This leads to improvements in the open-circuit voltage and the efficiency of the organic passivated solar cells compared with control cells and paves the way for novel approaches to copper indium gallium diselenide defect passivation and possibly other compound solar cells. | Jingwei Chen Xuan Chang Jianxin Guo Qing Gao Xuning Zhang Chenxu Liu Xueliang Yang Xin Zhou Bingbing Chen Feng Li Jianming Wang Xiaobing Yan Dengyuan Song Han Li Benjamin S.Flavel Shufang Wang Jianhui Chen | 2023 | Research2023，，4： | 0 |
| 13 | Smartphone-based rapid and visual pathological diagnosis of glioma using perovskite probes显示文摘Histopathology plays a great role in diagnosing various diseases,which is considered as a golden standard for tumor identification.The tissue constituents must be stained by visible labels for microscopic analysis by medical experts.However,this process is time-consuming,labor-intensive,and expensive,which requires rapid pathological approaches for diagnosis in the operating room.Here,we present an easy-to-process and high-performance perovskite biological probes for rapid and visual pathological diagnosis of glioma.Perovskite quantum dots can be encapsulated by the copolymer into nanocrystals(PNCs)with a diameter of 100 nm,which is modified with chlorotoxin to achieve the specific recognition of glioma.Benefiting from the super photoluminescence quantum yield(above 93%)of EVA@PNCs aqueous solution,the glioma can be clearly imaged and captured via a smartphone under the excitation of a handheld UV lamp.To demonstrate the visualization and efficiency of PNC probes,different malignant grades of brain tumor sections can be distinguished in no more than 5 min.This strategy provides a general auxiliary diagnosis platform for achieving the histopathology analysis near the operating bed,which is currently not feasible with standard histochemical staining methods. | Dongdong Wu Jimei Chi Junzhen Fan Lijun Cheng Xuning Wang Xu Yang Meng Zhang Zewei Lian Zengqi Huang Huadong Wang Hongfei Xie Sisi Chen Qi Pan Zeying Zhang Bingda Chen Guochen Sun Bainan Xu Meng Su Yanlin Song | 2023 | InfoMat2023，5，11： | 0 |
| 14 | Molecular dispersion enhances photovoltaic efficiency and thermal stability in quasi-bilayer organic solar cells显示文摘In comparison to widely adopted bulk heterojunction(BHJ)structures for organic solar cells(OSC),exploiting the sequential deposition to form planar heterojunction(PHJ)structures enables to realize the favorable vertical phase separation to facilitate charge extraction and reduce charge recombination in OSCs.However,effective tunings on the power conversion efficiency(PCE)in PHJ-OSCs are still restrained by the currently available methods.Based on a polymeric donor PBDBT-2 F(PBDBT=Poly[[4,8-bis[5-(2-ethylhexyl)-4-fluoro-2-thienyl]benzo[1,2-b:4,5-b′]dithiophene-2,6-diyl]-2,5-thiophenediyl[5,7-bis(2-ethylhexyl)-4,8-dioxo-4 H,8 H-benzo[1,2-c:4,5-c′]dithiophene-1,3-diyl]-2,5-thiophenediyl])and a non-fullerene(NF)acceptor Y6,we proposed a strategy to improve the properties of photovoltaic performances in PHJ-based OSCs through dilute dispersions of the PBDBT-2 F donor into the acceptor-dominant phase with the sequential film deposition.With the control of donor dispersions,the charge transport balance in the PHJ-OSCs is improved,leading to the expedited photocarrier sweep-out with reduced bimolecular charge recombination.As a result,a PCE of 15.4%is achieved in the PHJ-OSCs.Importantly,the PHJ solar cells with donor dispersions exhibit better thermal stability than corresponding BHJ devices,which is related to the better film morphology robustness and less affected charge sweep-out during the thermal aging. | Xuning Zhang Yanxun Li Dongyang Zhang Guangbao Wu Hong Zhang Jiyu Zhou Xing Li Saud-uz-Zafar Jianqi Zhang Zhixiang Wei Huiqiong Zhou Yuan Zhang | 2021 | Science China Chemistry2021，64，1： | 0 |
| 15 | Bio-inspired manufacturing of superwetting surfaces for fog collection and anti-icing applications显示文摘As a century-old concept,superwettability has aroused the interest of researchers in the past decades,attributed to the discoveries of the mechanisms of special wetting phenomena in nature.Bio-inspired manufacturing of superwetting surfaces for fog collection and anti-icing applications has become mainstream research,potentially alleviating the problem of water shortage and ice accidents.Superwetting surfaces for fog collection and anti-icing applications involve a reverse process,in which the former gathers water spontaneously,while the latter repels water.Contrastive analysis of the two is essential for the comprehensive understanding of superhydrophilic/superhydrophobic surfaces and boosting their applications.Herein,wetting theories and basic mechanisms for fog collection and anti-icing are briefly introduced.Then,manufacturing methods of bionic structures and surfaces are systematically reviewed after discussing the typical organisms with superwettability.Finally,conclusions are drawn and prospects for future development are proposed. | ZHANG XuNing GAN Lang SUN Bo LIU ZhiYong LIAO GuangLan SHI TieLin | 2022 | Science China(Technological Sciences)2022，65，9： | 0 |
| 16 | Indium-doped perovskite-related cesium copper halide scintillator films for high-performance X-ray imaging显示文摘Scintillators are widely utilized in high-energy radiation detection in view of their high light yield and short fluorescence decay time.However,constrained by their current shortcomings,such as complex fabrication procedures,high temperature,and difficulty in the large scale,it is difficult to meet the increasing demand for costeffective,flexible,and environment-friendly X-ray detection using traditional scintillators.Perovskite-related cesium copper halide scintillators have recently received multitudinous research due to their tunable emission wavelength,high photoluminescence quantum yield(PLQY),and excellent optical properties.Herein,we demonstrated a facile solution-synthesis route for indium-doped all-inorganic cesium copper iodide(Cs_(3)Cu_(2)I_(5))powders and a high scintillation yield flexible film utilizing indium-doped Cs_(3)Cu_(2)I_(5)powders.The large area flexible films achieved a PLQY as high as 90.2%by appropriately adjusting the indium doping concentration,much higher than the undoped one(73.9%).Moreover,benefiting from low self-absorption and high PLQY,the Cs_(3)Cu_(2)I_(5):In films exhibited ultralow detection limit of 56.2 n Gy/s,high spatial resolution up to 11.3 lp/mm,and marvelous relative light output with strong stability,facilitating that Cs_(3)Cu_(2)I_(5):In films are excellent candidates for X-ray medical radiography.Our work provides an effective strategy for developing environment-friendly,low-cost,and efficient scintillator films,showing great potential in the application of highperformance X-ray imaging. | RUI LIU ZHIYONG LIU CHENGXU LIN GUANGDA NIU XUNING ZHANG BO SUN TIELIN SHI GUANGLAN LIAO | 2024 | Photonics Research2024，12，2： | 0 |
| 17 | Review on flexible perovskite photodetector:processing and显示文摘Next-generation optoelectronics should possess lightweight and flexible characteristics,thus conforming to various types of surfaces or human skins for portable and wearable applications.Flexible photodetectors as fundamental devices have been receiving increasing attention owing to their potential applications in artificial intelligence,aerospace industry,and wise information technology of 120,among which perovskite is a promising candidate as the light-harvesting material for its outstanding optical and electrical properties,remarkable mechanical flexibility,low-cost and low-temperature processing methods.To date,most of the reports have demonstrated the fabrication methods of the perovskite materials,materials engineering,applications in solar cells,light-emitting diodes,lasers,and photodetectors,strategies for device performance enhancement,few can be seen with a focus on the processing strategies of perovskite-based flexible photodetectors,which we will give a comprehensive summary,herein.To begin with,a brief introduction to the fabrication methods of perovskite(solution and vapor-based methods),device configurations(photovoltaic,photoconductor,and phototransistor),and performance parameters of the perovskite-based photodetectors are first arranged.Emphatically,processing strategies for photodetectors are presented following,including flexible substrates(i.e.,polymer,carbon cloth,fiber,paper,etc.),soft electrodes(i.e.,metal-based conductive networks,carbon-based conductive materials,and two-dimensional(2D)conductive materials,etc.),conformal encapsulation(single-layer and multilayer stacked encapsulation),low-dimensional perovskites(0D,1D,and 2D nanostructures),and elaborate device structures.Typical applications of perovskite-based flexible photodetectors such as optical communication,image sensing,and health monitoring are further exhibited to learn the flexible photodetectors on a deeper level.Challenges and future research directions of perovskite-based flexible photodetectors are proposed in the end.The purpose of this review is not only to shed light on the basic design principle of flexible photodetectors,but also to serve as the roadmap for further developments of flexible photodetectors and exploring their applications in the fields of industrial manufacturing,human life,and health care. | Xuning ZHANG Xingyue LIU Yifan HUANG Bo SUN Zhiyong LIU Guanglan LIAO Tielin SHI | 2023 | Frontiers of Mechanical Engineering2023，18，2： | 0 |
| 18 | Numerical simulations of supercritical carbon dioxide fracturing:A review显示文摘As an emerging waterless fracturing technology,supercritical carbon dioxide(SC-CO_(2))fracturing can reduce reservoir damage and dependence on water resources,and can also promote the reservoir stimulation and geological storage of carbon dioxide(CO_(2)).It is vital to figure out the laws in SC-CO_(2)fracturing for the large-scale field implementation of this technology.This paper reviews the numerical simulations of wellbore flow and heat transfer,fracture initiation and propagation,and proppant transport in SC-CO_(2)fracturing,including the numerical approaches and the obtained findings.It shows that the variations of wellbore temperature and pressure are complex and strongly transient.The wellhead pressure can be reduced by tubing and annulus co-injection or adding drag reducers into the fracturing fluid.Increasing the temperature of CO_(2)with wellhead heating can promote CO_(2)to reach the well bottom in the supercritical state.Compared with hydraulic fracturing,SC-CO_(2)fracturing has a lower fracture initiation pressure and can form a more complex fracture network,but the fracture width is narrower.The technology of SC-CO_(2)fracturing followed by thickened SC-CO_(2)fracturing,which combines with high injection rates and ultra-light proppants,can improve the placement effect of proppants while improving the complexity and width of fractures.The follow-up research is required to get a deeper insight into the SC-CO_(2)fracturing mechanisms and develop cost-effective drag reducers,thickeners,and ultra-light proppants.This paper can guide further research and promote the field application of SC-CO_(2)fracturing technology. | Lin Wu Zhengmeng Hou Zhifeng Luo Ying Xiong Nanlin Zhang Jiashun Luo Yanli Fang Qianjun Chen Xuning Wu | 2023 | Journal of Rock Mechanics and Geotechnical Engineering2023，15，7： | 0 |
| 19 | Altered expression in liver cancer with various hepatic blood flow occlusions: A pilot RNA sequencing study显示文摘Background and aims:Hepatocellular carcinoma is one of the most common cancers worldwide.Previous studies have reported he influence of various hepatic blood flow occlusions on tumor behavior,which is mainly mediated by liver ischemia-reperfusion.Although some genes and pathways have been determined,the whole transcriptome after various hepatic blood flow occlusions is lacking.Methods:We systematically explored transcriptome changes after various hepatic blood flow occlusions,including sham operation(SO;n=10),occlusion of the portal triad(OPT;n=10),and occlusion of the portal vein(OPV;n=10),by RNA-sequencing.Results:HE sections and TUNEL assays showed different liver injury among groups.We identified the top altered genes and pathways.Compared with the SO group,96 genes were altered in OPV,with 81 upregulated and 15 downregulated genes.The top 5 upregulated genes were Pdk4,Serpina12,Depp1,Igfbp1,and Mup22.The top 5 downregulated genes were Sprr1a,Serpinb2,Tnc,Cdkn3,and Cenpu.Compared with the SO group,there were 20 differentially expressed genes in OPT,with 18 upregulated and 2 downregulated genes.The top 5 upregulated genes wereC7,Zbtb16,Gabrp,Pdk4,and Mmrn1.The top 2 downregulated genes were Krt20 and Sis.Compared with the OPV group,72 differentially expressed genes were in OPT,with 39 upregulated and 33 downregulated genes.The top 5 upregulated genes wereHspa1b,Hbb-bs,Phf19,Ddias,and Rad54b.The top 5 downregulated genes were Cish,Socs2,Slc25a30,Rgs3,and Hsd3b5.Conclusion:Various surgical methods have an obvious influence on the transcriptome of tumors. | Xuning Wang Lili Zhang Maolin Xu Bin Shi | 2023 | iLIVER2023，2，2： | 0 |
| 20 | Rapid genetic screening of Charcot-Marie-Tooth disease type 1A and hereditary neuropathy with liability to pressure palsies patients显示文摘We used the allele-specific PCR-double digestion method on peripheral myelin protein 22 (PMP22) to determine duplication and deletion mutations in the proband and family members of one family with Charcot-Marie-Tooth disease type 1 and one family with hereditary neuropathy with liability to pressure palsies. The proband and one subclinical family member from the Charcot-Marie-Tooth disease type 1 family had a PMP22 gene duplication; one patient from the hereditary neuropathy with liability to pressure palsies family had a PMP22 gene deletion. Electron microscopic analysis of ultrathin sections of the superficial peroneal nerve from the two probands demonstrated demyelination and myelin sheath hyperplasia, as well as an 'onion-like' structure in the Charcot-Marie-Tooth disease type 1A patient. We observed an irregular thickened myelin sheath and 'mouse-nibbled'-like changes in the patient with hereditary neuropathy with liability to pressure palsies. In the Charcot-Marie-Tooth disease type 1A patient, nerve electrophysiological examination revealed moderate-to-severe reductions in the motor and sensory conduction velocities of the bilateral median nerve, ulnar nerve, tibial nerve, and sural nerve. Moreover, the compound muscle action potential amplitude was decreased. In the patient with hereditary neuropathy with liability to pressure palsies, the nerve conduction velocity of the bilateral tibial nerve and sural nerve was moderately reduced, and the nerve conduction velocity of the median nerve and ulnar nerve of both upper extremities was slightly reduced. | Xiaobo Li Xiaohong Zi Lin Li Yajing Zhan Shunxiang Huang Jin Li Xuning Li Xigui Li Zhengmao Hu Kun Xia Beisha Tang Ruxu Zhang | 2012 | Neural Regeneration Research2012，7，32： | 0 |
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