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| 1 | Terrestrial input and nutrient change reflected by sediment records of the Changjiang River Estuary in recent 80 years显示文摘A variety of environmental problems have been observed in the Changjiang River Estuary and adjacent coastal area, including eutrophication, harmful algal blooms(HABs), and hypoxia in recent decades. Application of sedimentary biogenic element indicators on the study of paleoenvironment can reconstruct environmental evolution history of waters. Two 210Pb-dated cores were collected from the Changjiang River Estuary(S3) and adjacent coastal area(Z13), and total organic carbon(TOC), total nitrogen(TN), biogenic silicon(BSi), total phosphorus(TP) and phosphorus(P) species were analyzed. Three stages of environmental changes are deduced by the nutrient sedimentary records. First, nutrient concentration increased rapidly since the 1950 s, which attributed to agriculture development and overused chemical fertilizers. Second, nutrient concentration kept high and primary production began to promote during the 1960 s to 1980 s, while diatom abundance and proportion began to decline since the 1970 s, accompanied by reduced 23 Si O- concentration and flux from the river. Third, due to several dams and bridges constructed, river runoff and coastal hydrodynamic conditions reduced to a certain extent since the 1990 s, which aggravated the unbalance in nutrient structure. Multi-nutrient proxies in sediment can reflect the natural environm-ental changes as well as influence of human activities. | LI Junlong ZHENG Binghui HU Xupeng WANG Yiming DING Ye LIU Fang | 2015 | Acta Oceanologica Sinica2015，34，2： | 4 |
| 2 | Classification of estuaries in China based on eutrophication susceptibility to nutrient load显示文摘Recently, environmental pressures along coasts have increased substantially. Classification of estuaries according to their susceptibility to eutrophication nutrient load is a useful method to determine priority management objects and to enforce control measures. Using historical monitoring data from 2007 to 2012, from 65 estuaries, including 101 estuarine monitoring sections and 260 coastal monitoring stations, a nutrient-driven phytoplankton dynamic model was developed based on the relationship among phytoplankton biomass, Total Nitrogen(TN) load and physical features of estuaries. The ecological filter effect of estuaries was quantified by introducing conversion efficiency parameter values into the model. Markov Chain Monte Carlo algorithm of Bayesian inference was then employed to estimate parameters in the model. The developed model fitted well to the observed chlorophyll, primary production, grazing, and sinking rates. The analysis suggests that an estuary with Q/V(the ratio of river flow to estuarine volume) greater than 2.0 per year and ε(conversion efficiency ratio) less than 1.0 g C/g N can be classified as less susceptible to TN load, Q/V between 0.7 to 2.0 per year and ε between 1.0 to 3.0 g C/g N as moderately susceptible, and ε greater than 3.0 g C/g N as very susceptible. The estuaries with Q/V less than 0.7 per year vary greatly in their susceptibility. The estuaries with high and moderate susceptibility accounted for 67% of all the analyzed estuaries. They have relatively high eutrophication risks and should be the focus of environmental supervision and pollution prevention. | LI JunLong ZHENG BingHui LIU Yong WU Zhen LIU Fang SHAO JunBo HU XuPeng | 2015 | Science China Earth Sciences2015，58，6： | 2 |
| 3 | TRIB3-GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target显示文摘Pulmonary fibrosis(PF)is a chronic,progressive,fatal interstitial lung disease with limited available therapeutic strategies.We recently reported that the protein kinase glycogen synthase kinase-3β(GSK-3β)interacts with and inactivates the ubiquitin-editing enzyme A20 to suppress the degradation of the transcription factor CCAAT/enhancer-binding protein beta(C/EBPβ)in alveolar macrophages(AMs),resulting in a profibrotic phenotype of AMs and promoting the development of PF.Here,we showed that chronic lung injury upregulated the stress response protein tribbles homolog 3(TRIB3),which interacted with GSK-3βand stabilized GSK-3βfrom ubiquitination and degradation.Elevated GSK-3βexpression phosphorylated A20 to inhibit its ubiquitin-editing activity,causing the accumulation of C/EBPβand the production of several profibrotic factors in AMs and promoting PF development.Activated C/EBPβ,in turn,increased the transcription of TRIB3 and GSK-3β,thereby establishing a positive feedback loop in AMs.The knockdown of TRIB3 expression or the pharmacologic disruption of the TRIB3-GSK-3βinteraction was an effective PF treatment.Our study reveals an intact profibrotic axis of TRIB3-GSK-3β-A20-C/EBPβin AMs,which represents a target that may provide a promising treatment strategy for PF. | Shanshan Liu Xiaoxi Lv Xupeng Wei Chang Liu Qiao Li Jiali Min Fang Hua Xiaowei Zhang Ke Li Pingping Li Yang Xiao Zhuowei Hu Bing Cui | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 2 |
| 4 | Surface hydrophobic modification enhanced catalytic performance of electrochemical nitrogen reduction reaction显示文摘Electrocatalytic nitrogen reduction reaction(NRR)is a sustainable approach for NH_(3)production with low energy consumption.However,competing hydrogen reduction reaction(HER)in aqueous solution results in low NH_(3)production and Faraday efficiency(FE).Here,MoS_(2)nanostructures with a hydrophobic surface are synthesized by alkyl thiols modification.Aerophilic and hydrophobic surface facilitates an efficient three-phase contact of N_(2),H_(2)O,and catalyst.Thus,localized concentrated N_(2)molecules can overcome the mass transfer limitation of N2 and depress the HER due to lowering the proton contacts.Although the active-sites decrease with the increase of the alkyl chain since the thiol may cover the active site,the optimized electrocatalyst achieves NH_(3)yield of 12.86×10^(-11)mol·cm^(-2)·s^(-1)at-0.25 V and 22.23%FE,which are 4.3 and 24 times higher than those of MoS2-CP electrocatalyst,respectively.The increased catalytic performance is attributed to the high N_(2)adsorption and depressed HER. | Lijuan Niu Ziwen Liu Guohua Liu Mengxuan Li Xupeng Zong Dandan Wang Li An Dan Qu Xiaoming Sun Xiayan Wang Zaicheng Sun | 2022 | Nano Research2022，15，5： | 2 |
| 5 | Green synthesis of enantiomerically pure l -lactide and d -lactide using biogenic creatinine catalyst显示文摘 | Wei Huang Yunbiao Qi Na Cheng Xupeng Zong Tianrong Zhang Wei Jiang Hong Li Quanxing Zhang | 2014 | Polymer Degradation and Stability2014，，： | 1 |
| 6 | 同基因混合G-CSF动员的异基因骨髓移植物诱导的抗白血病效应(英文)显示文摘Objective: To study clinical characteristics of non-Hodgkin's lymphoma (NHL) in order to diagnose and treat early and improve prognosis. Methods: 112 cases with NHL were pathologically diagnosed and treated in 1992-2005. Results: Among all cases, 30 were not treated previously, 79 were involved in peripheral lymph nodes, 55 deep lymph nodes, 18 Waldeyer's ring, 25 respiratory system, 26 digestive system, 26 spleen, 13 bone, 13 skin and subcutaneous, 4 urinogenital system, 13 other sites. Among 30 previously untreated patients, there were 4 staged I, 3 IE, 5 II, 1 IIE, 9 III, 1 IIIS and 7 IV. Among 82 patients with prior treatment, 29 were involved in lymph nodes only, 53 involved in different organs and tissues. In our series, there were 38 cases and 74 cases belonged to subtype A and subtype B respectively. Conclusion: The enlargement of peripheral lymph nodes is main clinical characteristic in NHL, but lesions also involve different organs and tissues. The diagnosis of NHL depends upon pathological examination. | Yihong Huang Bing Du Kailin Xu Depeng Li Xupeng He Qunxian Lu Xiuying Pan | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，9： | 1 |
| 7 | MicroRNA-223 functions as an oncogene in human colorectal cancer cells显示文摘 | Jufeng Zhang Xia Luo Huiming Li Xupeng Yue Lin Deng Yuanyuan Cui Yanxin Lu | 2014 | Oncology Reports2014，，1： | 1 |
| 8 | Discussion on Spatial Optimization Modeling of Water Resource Conservation Forests and Management Practice of Forest Functions显示文摘According to the unification principle of system structure and system function of the Water Resource Conservation Forests,seven factors were selected from stand spatial structure,trees structure and healthy of woods,the multifunction management optimization model target was confirmed by using nonlinearity multi-objective programming approach, and the target function-stand spatial structure homogeneity index was defined to establish spatial optimization models with restraining conditions set up in diversity of stand structure and spatial structure.The spatial structure of available typical stand in the wet land area in southern Donting Lake was optimized by means of selective cutting and reinforcement planting.The results showed that the spatial structure was improved obviously and trees diversity and stand health were not weakened.It’s suggested that the established optimization model can effectively guide multifunction management,stand structure optimization and the steadiness of ecological ecosystem and it is convenient and operable in practice,and it’s very important to protect and recover ecosystem of Water Resource Conservation Forests. | Li Jianjun Zhang Huiru Wang Chuanli Zang Hao Cao Xupeng | 2012 | Chinese Forestry Science and Technology2012，11，3： | 1 |
| 9 | Alkali desilicated coal fly ash as substitute of bauxite in lime - soda sintering process for aluminum production 显示文摘 | BaiGuanghui Teng Wei Wang Xianggang Qin Jinguo XuPeng Li Pengcheng | 2010 | Transactions of Nonferrous Metals Society of China2010，20，： | 1 |
| 10 | Research on side-insulation of tool electrode for micro electrochemical machining 显示文摘 | Liu Gaihong Li Yong Chen Xupeng | 2009 | Advanced Materials Research2009，6061，： | 1 |
| 11 | Alkaidesilicated coal fly ash as substitute of bauxite in lime - sode sintering process for aluminum production 显示文摘 | Bai Guanghui Teng Wei Wang Xianggang Qin Jinguo XuPeng Li Pengcheng | 2010 | Transactions of Nonferrous Metals Society of China2010，20，： | 1 |
| 12 | Research on side-insulation of tool electrode for Micro Electrochemical Machining 显示文摘 | Liu Gaihong Li Yong Chen Xupeng | 2009 | Advanced Materials Research2009，6061，： | 1 |
| 13 | Research on Side- Insulation oir Tool Eleetrocle for Micro Electrochemical Machining 显示文摘 | Liu Gaihong Li Yong Chen Xupeng | 2009 | Advanced Materials Research2009，6061，： | 1 |
| 14 | Design and Optimization of Multiple Interconnected Utility Systems in An Integrated Refining and Petrochemical Complex显示文摘In an integrated refining and petrochemical complex,a centralized utility system(CUS)is introduced to integrate the steam demands of production plants.Besides,two sub-utility systems(SUSs)located inside the alkene and refinery plants,respectively,can satisfy the shaft demands.It is difficult to determine the steam production of the CUS because the steam demands of the alkene and refinery plants also depend on the design and operation of the SUSs.To explore the complicated interaction between the CUS and SUSs,we proposed a mixed-integer nonlinear programming(MINLP)model for the design and optimization of multiple interconnected utility systems to minimize the total annualized cost(TAC).An extended superstructure was suggested to contain multiple inter-plant connected steam pipe alternatives between the CUS and SUSs.A more accurate model of the complex steam turbine was proposed.Then the proposed MINLP framework is applied to a new integrated refining and petrochemical complex.Two scenarios are investigated in the case study to explore the effect of steam main temperatures on system configurations and operating parameters.By optimizing the main temperatures,a TAC of$2.7 million can be saved.Judging from the results of the two scenarios,the feasibility and effectiveness of the proposed framework for the design and optimization of multiple interconnected utility systems have been demonstrated. | Bai Haobo Li Shiyu Wang Xupeng Liu Chang | 2020 | China Petroleum Processing & Petrochemical Technology2020，22，4： | 1 |
| 15 | A metal-free carbon dots for wastewater treatment by visible light active photo-Fenton-like reaction in the broad pH range显示文摘Carbon dots(Cdots)has been proved to possess the catalytic decomposition of H_(2)O_(2) in the photocatalytic system.It is a potential photo-Fenton catalyst.Since multiple emissive Cdots have different light response range.There is rarely investigation on the performance of Cdots based photo-Fenton on the light wavelength.Herein,blue,green and red emissive carbon dots were synthesized from the different ratio of o-phenylenediamine and catechol by the solvothermal method.They exhibit different light adsorption range from UV to visible light.Furthermore,the photo-Fenton reactivity of Cdots was studied for catalyzing the decomposition of H_(2)O_(2) to generate free hydroxyl radicals and consequently applying for the removal of methyl blue.The results exhibit that Cdots with the broader light adsorption rang possess the stro nger catalytic activity for the photo-Fenton reaction.The H_(2)O_(2) decomposition rate of red emissive Cdots is 0.074 min^(-1),which is 2.64 and 1.46 times than the blue and green emissive Cdots,respectively.And the radical detection results confirm that the photo-Fenton happens in the reaction.In addition,the Cdots photo-Fenton can be carried out in the broad pH range from acidic to basic solution,which has a great potential to treat wastewater in the neutral system. | Dongxue Yang Dan Qu Li An Xupeng Zong Zaicheng Sun | 2021 | Chinese Chemical Letters2021，32，7： | 1 |
| 16 | Research on side-insulation of tool electrode for micro electrochemical machining显示文摘 | Liu Gaihong Li Yong Chen Xupeng | 2009 | Advanced Materials Research2009，60，： | 1 |
| 17 | Influence of White Spot Syndrome Virus Infection on Hepatopancreas Gene Expression of ‘Huanghai No.2' Shrimp(Fenneropenaeus chinensis)显示文摘To elucidate the molecular response of shrimp hepatopancreas to white spot syndrome virus(WSSV) infection, microarray was applied to investigate the differentially expressed genes in the hepatopancreas of ‘Huanghai No. 2'(Fenneropenaeus chinensis). A total of 59137 unigenes were designed onto a custom-made 60 K Agilent chip. After infection, the gene expression profiles in the hepatopancreas of the shrimp with a lower viral load at early(48–96 h), peak(168–192 h) and late(264–288 h) infection phases were analyzed. Of 18704 differentially expressed genes, 6412 were annotated. In total, 5453 differentially expressed genes(1916 annotated) expressed at all three phases, and most of the annotated were either up-or down-regulated continuously. These genes function diversely in, for example, immune response, cytoskeletal system, signal transduction, stress resistance, protein synthesis and processing, metabolism among others. Some of the immune-related genes, including antilipopolysaccharide factor, Kazal-type proteinase inhibitor, C-type lectin and serine protease encoding genes, were up-regulated after WSSV infection. These genes have been reported to be involved in the anti-WSSV responses. The expression of genes related to the cytoskeletal system, including β-actin and myosin but without tubulin genes, were down-regulated after WSSV infection. Astakine was found for the first time in the WSSV-infected F. chinensis. To further confirm the expression of differentially expressed genes, quantitative real-time PCR was performed to test the expression of eight randomly selected genes and verified the reliability and accuracy of the microarray expression analysis. The data will provide valuable information to understanding the immune mechanism of shrimp's response to WSSV. | MENG Xianhong SHI Xiaoli KONG Jie LUAN Sheng LUO Kun CAO Baoxiang LIU Ning LU Xia LI Xupeng DENG Kangyu CAO Jiawang ZHANG Yingxue ZHANG Hengheng | 2017 | Journal of Ocean University of China2017，16，5： | 1 |
| 18 | Type I photosensitizer based on AIE chromophore tricyano-methylene-pyridine for photodynamic therapy显示文摘Image guided photodynamic therapy(PDT)combines fluorescence tracing and phototherapy,which can achieve a more accurate and effective treatment effect.However,traditional photosensitizers are limited by the aggregation-caused fluorescence quenching(ACQ)effect and low reactive oxygen species(ROS)generation in a hypoxic environment,resulting in poor imaging and treatment effect.Herein,we report a tricyano-methylene-pyridine(TCM)-based Type I aggregation-induced emission(AIE)photosensitizer(TCM-MBP),the strong elec-tron acceptance(D-A)effect extends the wavelength to near-infrared(NIR)region to reduce the autofluorescence interference,and oxygen atoms provide lone pair electrons to enhance the inter system crossing(ISC)rate,thereby promoting the generation of more triplet states to produce ROS.The AIE photosensitizer TCM-MBP exhibited low oxygen dependence,NIR emission,and higher ROS production compared to commercially avail-able Ce_(6) and RB.After encapsulation with DSPE-PEG 2000,TCM-MBP nanoparticles(TCM-MBP NPs)could penetrate to visualize cells and efficiently kill cancer cells upon light irradiation.This study provides an oxygen-independent AIE photosensitizer,which has great potential to replace the commercial ACQ photosensitizers. | Chao Pan Weijun Zhao Xiaolei Zhao Zhenxing Liu Xiangyu Li Yanting Lyu Xupeng Wu Zhirong Zhu Wei-Hong Zhu Qi Wang | 2023 | Green Chemical Engineering2023，4，3： | 0 |
| 19 | Rice OsUBR7 modulates plant height by regulating histone H2B monoubiquitination and cell proliferation显示文摘Plant height is an important agronomic trait for lodging resistance and yield.Here,we report a new plantheight-related gene,OsUBR7 in rice(Oryza sativa L.);knockout of OsUBR7 caused fewer cells in internodes,resulting in a semi-dwarf phenotype.OsUBR7 encodes a putative E3 ligase containing a plant homeodomain finger and a ubiquitin protein ligase E3 component N-recognin 7(UBR7)domain.OsUBR7 interacts with histones and monoubiquitinates H2B(H2Bub1)at lysine148 in coordination with the E2 conjugase OsUBC18.OsUBR7 mediates H2Bub1 at a number of chromatin loci for the normal expression of target genes,including cell-cycle-related and pleiotropic genes,consistent with the observation that cell-cycle progression was suppressed in the osubr7 mutant owing to reductions in H2Bub1 and expression levels at these loci.The genetic divergence of OsUBR7 alleles among japonica and indica cultivars affects their transcriptional activity,and these alleles may have undergone selection during rice domestication.Overall,our results reveal a novel mechanism that mediates H2Bub1 in plants,and UBR7 orthologs could be utilized as an untapped epigenetic resource for crop improvement. | Yangyi Zheng Sensen Zhang Yanqiu Luo Fuquan Li Jiantao Tan Bin Wang Zhe Zhao Huifang Lin Tingting Zhang Jianhong Liu Xupeng Liu Jingxin Guo Xianrong Xie Letian Chen Yao-Guang Liu Zhizhan Chu | 2022 | Plant Communications2022，3，6： | 0 |
| 20 | Reducing the Common Environmental Effect on Litopenaeus vannamei Body Weight by Rearing Communally at Early Developmental Stages and Using a Reconstructed Pedigree显示文摘Heritability estimates may be severely biased when a large common environmental effect on a family arises from a longlasting separate rearing at early stages(SRES)in traditional selective breeding programs,especially when bred populations have weak genetic ties.Communal rearing at early stages(CRES)may reduce common environmental effect since all families are reared in the same environment immediately after hatching.Here,we compared the effects of CRES and SRES strategies on genetic parameter estimation for harvest body weight in a selective breeding population of Litopenaeus vannamei with a small number of half-sib families.Genetic parameters of each strategy were estimated by using animal models excluding and including the common environmental effect(Model 1 and Model 2,respectively).Heritability estimates for body weight were 0.21±0.06(P<0.05)and 0.69±0.09(P<0.05)for CRES and SRES,respectively,in Model 1,and 0.21±0.06(P<0.05)and 0.52±0.27(P>0.05)in Model 2.The ratio of common environmental variance to phenotypic variance was 0.002±0.000 and 0.071±0.112 for CRES and SRES,respectively.Neither strategy precisely partitioned the common environmental variance according to likelihood ratio test.Lower heritability for body weight in CRES than in SRES implied that a large common environmental variance was confounded with additive genetic variance and was not effectively partitioned in SRES.Moreover,genetic correlation of body weight between the two strategies was 0.75±0.15,indicating that family rankings truly changed.The CRES should be followed in the selective breeding program of shrimp,especially in a population with a shallow pedigree and weak genetic ties between families. | KONG Zhangwei KONG Jie HAO Dongchun LU Xia JIAN Tan MENG Xianhong LUO Kun CAO Baoxiang SUI Juan LI Xupeng LUAN Sheng | 2020 | Journal of Ocean University of China2020，19，4： | 0 |
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