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| 1 | Current Trends of the Prevalence of Childhood Asthma in Three Chinese Cities: A Multicenter Epidemiological Survey显示文摘Objective To analyze the prevalence of asthma and asthma related symptoms among children aged 0-14 years in three Chinese cities and to obtain a crude estimation of the trend of childhood asthma prevalence in China. Methods A cross-sectional, population-based survey of prevalence of asthma was conducted in children aged from 0 to 14 years in 3 major cities of China (Beijing, Chongqing, and Guangzhou) with different geographic locations. All the subjects were randomly selected by a multi-stage sampling method. Three to five schools and kindergartens in 2 urban districts in each city were randomly selected for the survey, and a validated questionnaire that included the core questions of the International Study of Asthma and Allergies in Childhood, Phase Ⅲ questionnaire and several additional questions were used. All questionnaires were completed by parents or guardians of the selected children. Children whose parents responded affirmatively to the question' Has your child ever been diagnosed as asthma by a doctor' were recognized as victims of asthma. Results The prevalence of asthma in Beijing, Chongqing, and Guangzhou was 3.15%, 7.45%, and 2.09%, respectively. These values were significantly higher than those obtained 10 years ago in the national epidemiological survey in 2000 which used the same method of investigation and the same diagnotic criteria (χ2 =3.938, P=0.047; χ2 =73.506, P≤0.001; χ2 =11.956, P=0.001, in each city). Of the asthmatic children 57.21%, 69.91%, and 60.00% had their first attack before the age of 3 in Beijing, Chongqing, and Guangzhou, respectively. Wheezing was the primary clinical manifestation for all asthmatic children , followed by persistent cough and repeated respiratory infections. Both the prevalence of asthma and asthma-related symptoms were statistically higher in males than in females. Conclusion The prevalence of childhood asthma is statistically higher than that 10 years ago in the three Chinese cities. | JUAN BAI JiNG ZHAO KUN-LING SHEN LI XIANG AI-HUAN CHEN SUI HUANG YING HUANG JIAN-SHENG WANG RONG-WEI YE | 2010 | Biomedical and Environmental Sciences2010，23，6： | 37 |
| 2 | Treating ischaemic stroke with intravenous tPA beyond 4.5 hours under the guidance of a MRI DWI/T2WI mismatch was safe and effective显示文摘Purpose Clinical trials have provided evidence that treating patients with acute ischaemic stroke(AIS)beyond 4.5 hours was feasible.Among them using MRI diffusion-weighted imaging/fluid attenuation inversion response(DWI/FLAIR)mismatch to guide intravenous tissue plasminogen activator(tPA)was successful.Our study explored the outcome and safety of using DWI/T2-weighted imaging(T2WI)mismatch to guide intravenous tPA therapy for patients with AIS between 4.5 hours and 12 hours of onset.Method This was a retrospective study.Records of 1462 AIS patients with the time of onset of<12 hours were reviewed.Those had MRI rapid sequence study and had hyperintense signal on DWI but normal T2WI and received intravenous tPA up to 12 hours of onset were included in the analysis.Their demographics,risk factors,post-tPA complications,National Institutes of Health Stroke Scale(NIHSS)scores and outcome were recorded and analyse.χ2 was used to compare the intergroup variables.SAS was used to perform statistical calculation.A p<0.05 was considered statistically significant.results Of 1462 identified,601(41%)patients were entered into the final analysis.Among them,327(54%)had intravenous tPA within 4.5 hours of onset and 274(46%)were treated between 4.5-12 hours.After intravenous tPA,426 cases(71%)had>4 pints of improvement on NIHSS score within 24 hours.Postintravenous tPA,32(5.32%)cases had haemorrhagic transformation.26(4.33%)were asymptomatic ICH and 4(0.67%)died.At 90 days,523(87%)achieved a modified Rankin scale of 0-2.Conclusion Using MRI DWI/T2WI mismatch to identify patients with AIS for intravenous tPA between 4.5 hours and 12 hours was safe and effective.The outcome was similar to those used DWI/PWI or DWI/FLAIR mismatch as the screening tool.However,obtaining DWI/T2WI was faster and avoided the need of contrast material. | Qing-ke Bai Zhen-guo Zhao Lian-jun Lu Jian Shen Jian-ying Zhang Hai-jing Sui Xiu-hai Xie Juan Chen Juan Yang Cui-rong Chen | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 3 | Primary research on neoplasm needle track implantation metastasis after radioactive seeds implantation and preventive measures显示文摘Objective:To observe the possibility of neoplasm needle track implantation after radioactive seeds implantation and seek preventive measures to avoid it.Methods:Superficial tissue of 250 seeding needle cores and 250 stylophores employed in neoplasm radioactive seeds implantation was smeared on slides to search for tumor cells.All patients received chemotherapy or endocrine therapy after operations.Ultrasound B-mode or computer tomography(CT)was performed at 10th day,30th day,60th day,and 180th day post operation to detect neoplasm implantation metastasis through needle tracks. Results:Positive cells were found on 13 of 250(5.20%)cores,and 7 of 250(2.80%)stylophores.The difference was not sta- tistically significant(P>0.05).The positive cells frequency of needles those traversed distance less than 3 cm in normal tissue was 6.19%(13/210),while the frequency of the others those traversed longer distance in normal tissue was 2.41%(7/290). The positive cells frequency of needles traversing different distances in normal tissues is significantly different(P<0.05).No neoplasm was detected through needle tracks by ultrasound B-mode or CT in 180 days after operation.Conclusion:Tumor cells could ablate into the needle track during radioactive seed implantation.Some preventive measures,such as optimization of pre-operation and intra-operation treatment plan,chemotherapy or endocrine therapy after operation,may be beneficial to avoid the implantation metastasis of neoplasm in seeding needle tracks. | Juan Wang Weihong Gong Huige Fan Aixia Sui Na Zhao Yongqing Shen | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，4： | 5 |
| 4 | A widely adaptable approach to generate integration-free iPSCs from non-invasively acquired human somatic cells显示文摘 | Zhichao Ding Lina Sui Ruotong Ren Yanjun Liu Xiuling Xu Lina Fu Ruijun Bai Tingting Yuan Ying Hao Weiqi Zhang Huize Pan Wensu Liu Han Yu Concepcion Rodriguez Esteban Xiaobing Yu Ze Yang Jian Li Xiaomin Wang Juan Carlos Izpisua Belmonte Guang-Hui Liu Fei Yi Jing Qu | 2015 | Protein & Cell2015，6，5： | 5 |
| 5 | Heterosis and heritability estimates for the survival of the Pacific white shrimp(Litopenaeus vannamei) under the commercial scale ponds显示文摘The aim of the present study is to detect the potential of the base population from diallel crosses of eight introduced strains of the Pacific white shrimp(Litopenaeus vannamei) for improving the yield. Heterosis and heritability were estimated for pond survival at commercial farm conditions for the base population that included 207 full-sib families from a nested mating design by artificial insemination. Among all the hybrids,the heterosis ranged from –11.37%(UA1×UA2) to 20.53%(UA3×SIN) with an average of 0.953%. The results showed that more than half of the hybrids(51.85%) have negative heterosis for survival rate, but most of the hybrids with positive heterosis have high estimates. The high proportion of negative heterosis for survival rate reminders us that the survival trait also should be considered in the crossbreeding program to avoid yield decrease. However, high positive heterosis manifested in most of the hybrids for survival indicates the usefulness of these hybrids for improving the survival to obtain higher yield by crossbreeding in this breeding program. The heritability estimate for pond survival was 0.092±0.043 when genetic groups were included in the pedigree, and it was significantly different from zero(P<0.05). The results from this study also indicated that significant improvement for survival is possible through selection in L. vannamei. | LU Xia LUAN Sheng CAO Baoxiang SUI Juan DAI Ping MENG Xianhong LUO Kun KONG Jie | 2017 | Acta Oceanologica Sinica2017，36，2： | 4 |
| 6 | Superfluorinated copper sulfide nanoprobes for simultaneous 19F magnetic resonance imaging and photothermal ablation显示文摘铜硫化物(Cu 7 与涂的 S 4) nanoparticles 一超离频收费载重(~ 5.0 慮潮牰扯獥 ????????? 桰瑯瑯敨浲污?? | Gaofei Hu Juan Tang Xilin Bai Suying Xu Leyu Wang | 2016 | Nano Research2016，9，6： | 4 |
| 7 | Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells显示文摘 | Haisong Liu Huan Yang Dicong Zhu Xin Sui Juan Li Zhen Liang Lei Xu Zeyu Chen Anzhi Yao Long Zhang Xi Zhang Xing Yi Meng Liu Shiqing Xu Wenjian Zhang Hua Lin Lan Xie Jinning LOU Yong Zhang Jianzhong Xi Hongkui Deng | 2014 | Cell Research2014，24，10： | 3 |
| 8 | Genetic parameters for cold tolerance and body weight of Chinese fleshy prawn,Fenneropenaeus chinensis显示文摘The inability of Fenneropenaeus chinensis to tolerate low temperatures is of major economic concern in temperate climates,as it reduces their growing season and leads to over-winter mortality.In this study,the heritability of body weight under low grow-out temperature and cold tolerance in F.chinensis were first investigated and estimated using 88 ful-sib families,which might provide crucial information in Chinese fleshy prawn breeding programs.The heritability for body weight under suitable and low temperature of F.chinensis were both moderate(0.158 0±0.307 5 and 0.132 0±0.026 9 respectively);the large coefficient of variation(approximately 21%) and moderate estimate of heritability for body weight indicated substantial potential for selective breeding.The heritability estimate for cold tolerance was low(0.019 2±0.023 5),and showed no significant differences from zero(P>0.05).A weak genetic correlation between cold tolerance and body weight was also estimated in the present study,also showing no significant differences from zero(P>0.05).Thus,more research needs to be conducted on the more accurate heritability estimate of cold tolerance and genetic correlations between traits in F.chinensis to further improve the achievement of breeding goals. | LI Wenjia LUAN Sheng LUO Kun SUI Juan LU Xia WANG Qingyin KONG Jie | 2016 | Acta Oceanologica Sinica2016，35，6： | 3 |
| 9 | Characteristics of Long-term Nonprogressors and Viremia Controllers Infected with HIV-1 via Contaminated Blood Donations or Transfusions Conducted 20 Years Earlier显示文摘To characterize long‐term nonprogressors(LTNPs)and viremia controllers(VCs),infected with HIV‐1 through contaminated blood donation or transfusion between 1992 and 1996 in Henan,China.LTNPs and VCs were defined by CD4+T lymphocyte(CD4)count and viral load(VL).Of29,294 patients infected with HIV‐1 via contaminated blood donation or transfusion that had conducted for more than 20 years,92 were LTNPs/VCs.There were 70 LTNPs(0.24%),43 | LIU Jia FAN Pan Ying XUE Xiu Juan YAN Jiang Zhou SUN Guo Qing LIU Chun Hua TIAN Sui An LI Ning SUN Ding Yong ZHU Qian WANG Zhe | 2017 | Biomedical and Environmental Sciences2017，30，12： | 3 |
| 10 | Activation of Uterine Smad3 Pathway Is Crucial for Embryo Implantation显示文摘Embryo implantation is a complicated physiological process tightly regulated by multiple biological molecules including growth factors.Transforming growth factor-betas(TGF-βs)and their most specific signal transduction factors,Smads,are expressed in the endometrium during the window of implantation.Recent researches indicated that Smad dependent TGF-β signaling may play an important role in the process of embryo implantation.In this study,we measured the expression of TGF-β1,TGF-β receptor type I(TpRI),Smad3 and p-Smad3 in the endometrium of mice and observed their elevation on day 4,5 and 6 of pseudopregnancy.Then we administrated a specific Smad3 inhibitor(Sis3)into the uterine cavity of mice on day 3 of pregnancy.The results showed a reduction in insulin-like growth factor-1(IGFBP-1)expression and the decreased number of implanted embryo after the administration.In addition,Sis3 was found to reduce the IGFBP-1 secretion in decidualized endometrial stromal cells.Taken all together,our findings demonstrated that TGF-β/Smad3 signaling is involved in the process of embryo implantation. | Juan LI Xi-yuan DONG Pei-wen YANG Shu-lin YANG Dan HU Han-wang ZHANG Cong SUI | 2019 | Current Medical Science2019，39，6： | 3 |
| 11 | Treatment of Unresectable Advanced Gastric Cancer Using lodine-125 Brachytherapy显示文摘OBJECTIVE The purpose of the study was to examine the efficacy of treating patients with advanced gastric cancer using iodine -125 (125I) brachytherapy. METHODS Ten patients with unresectable advanced gastric cancer were selected based on their pattern of CT scans. We utilized a brachytherapy planning system to determine the distribution of the 125I seeds, their activity and quantity. The matched peripheral dose (MPD) was 110-135 Gy. 125I seeds were implanted in a single plane or biplane by an intraoperative small incision or percutaneous puncture. The post- operative hemogram, CT, KPS, pain-relieving period and survival period were recorded. RESULTS One patient developed a complete response (CR), 4 patients a partial response (PR), 3 patients showed no change (NC) and 2 pa- tients developed progressive disease (PD). The overall response rate (CR+PR) was 50% (5/10). The pain-relieving rate was 89% (8/9). The pa- tients’ appetite and KPS were improved. The longest survival period was 10 months and median life span was 4 months. There were 8 patients whose seeds fell off resulting in an expulsion rate of 3.8% (26/692). The patients showed 0-1 degree acute radio-therapeutic side-effects without other symptoms such as abdominal pain, vomitus cruentes or intestinal obstruction etc. CONCLUSION Applying 125I implantation to treat advanced gastric can- cer with a reasonable seed distribution can significantly improve clinical symptoms and their quality of life. The radioactive damage is mild. This method can be used as an important supplementary treatment for unre- sectable advanced gastric cancer. | Juan Wang Aixia Sui Yitao Jia Binjian Xu Liang Wei Junqing Chen Wenjiang Shen | 2006 | Chinese Journal of Clinical Oncology2006，3，3： | 2 |
| 12 | Combination of proanthocyanidins extracted from lotus seedpod and L-cysteine ameliorates memory impairment induced by alcohol and scopolamine in mice显示文摘 | XIAO Juan SUI Yong LI Shuyi | 2013 | Eurooean Food Research Technology2013，236，： | 1 |
| 13 | Optical temperature sensor based on ZnO thin film's temperature- dependent optical properties 显示文摘 | SUI Cheng-hua XIA Juan WANG He-lin | 2011 | Review of Scientific Instruments2011，82，8： | 1 |
| 14 | Transfer of classical eyeblink conditioning with electrical stimulation of mPFC or tone as conditioned stimulus in guinea pigs显示文摘 | Juan Yao Guang-yan Wu Guo-long Liu Shu-lei Liu Yi Yang Bing Wu Xuan Li Hua Feng Jian-feng Sui | 2014 | Behavioural Brain Research2014，，： | 1 |
| 15 | Absorption and urinary excretion of A-type procyanidin oligomers from Litchi chinensis pericarp in rats by selected ion monitoring liquid chromatography–mass spectrometry显示文摘 | Shuyi Li Yong Sui Juan Xiao Qian Wu Bei Hu Bijun Xie Zhida Sun | 2013 | 2013 (2-3)2013，，2： | 1 |
| 16 | GPER in CAFs regulates hypoxia-driven breast cancer invasion in a CTGF-dependentmanner显示文摘 | Juan Ren Hui Guo Huili Wu Tao Tian Danfeng Dong Yuelang Zhang Yanxia Sui Yong Zhang Dongli Zhao Shufeng Wang Zongfang Li Xiaozhi Zhang Rui Liu Jianshneg Qian Hongxia Wei Wenjun Jiang Ya Liu Yi Li | 2015 | Oncology Reports2015，，： | 1 |
| 17 | Awareness is essential for differential delay eyeblink conditioning with soft-tone but not loud-tone conditioned stimuli显示文摘The role of awareness in differential delay eyeblink conditioning(DEC) remains controversial. Here, we investigated the involvement of awareness in differential DEC with a soft or a loud tone as the conditioned stimulus(CS). In the experiment, 36 participants were trained in differential DEC with a soft tone(60 dB) or a loud tone(85 dB) as the CS, paired with a corneal air-puff as the unconditioned stimulus(US). After conditioning, awareness of the relationship between the CS and the US was assessed with a 17-item true/false questionnaire. Interestingly, during differential DEC with a soft-tone CS, a higher proportion of differential conditioned responses(CRs) was evident in participants who were aware than those who were unaware. In contrast, when a loud tone was used as the CS, the proportion of differential CRs of the aware participants did not differ significantly from those who were unaware over any of the blocks of 20 trials. In unaware participants, the percentage of differential CRs with a loud-tone CS was significantly higher than that with a soft-tone CS; however in participants classified as aware, the percentage of differential CRs with a loud-tone CS did not differ significantly from that with a soft-tone CS. The present findings suggest that awareness is critical for differential DEC when the delay task is rendered more difficult. | He Huang Bing Wu Qiong Li Juan Yao Xuan Li Yi Yang Guang-Yan Wu Jian-Feng Sui | 2014 | Neuroscience Bulletin2014，30，3： | 1 |
| 18 | Design of a novel chimeric peptide via dual blockade of CD47/SIRPαand PD-1/PD-L1 for cancer immunotherapy显示文摘Although immune checkpoint inhibition has been shown to effectively activate antitumor immunity in various tumor types,only a small subset of patients can benefit from PD-1/PD-L1 blockade.CD47 expressed on tumor cells protects them from phagocytosis through interaction with SIRPαon macrophages,while PD-L1 dampens T cell-mediated tumor killing.Therefore,dual targeting PD-L1 and CD47 may improve the efficacy of cancer immunotherapy.A chimeric peptide Pal-DMPOP was designed by conjugating the double mutation of CD47/SIRPαblocking peptide(DMP)with the truncation of PD-1/PD-L1 blocking peptide OPBP-1(8-12)and was modified by a palmitic acid tail.Pal-DMPOP can significantly enhance macrophage-mediated phagocytosis of tumor cells and activate primary T cells to secret IFN-γin vitro.Due to its superior hydrolysis-resistant activity as well as tumor tissue and lymph node targeting properties,Pal-DMPOP elicited stronger anti-tumor potency than Pal-DMP or OPBP-1(8-12)in immune-competent MC38 tumor-bearing mice.The in vivo anti-tumor activity was further validated in the colorectal CT26 tumor model.Furthermore,Pal-DMPOP mobilized macrophage and T-cell anti-tumor responses with minimal toxicity.Overall,the first bispecific CD47/SIRPαand PD-1/PD-L1 dual-blockade chimeric peptide was designed and exhibited synergistic anti-tumor efficacy via CD8^(+)T cell activation and macrophage-mediated immune response.The strategy could pave the way for designing effective therapeutic agents for cancer immunotherapy. | Zheng Hu Wanqiong Li Shaomeng Chen Danhong Chen Ran Xu Danlu Zheng Xin Yang Shuzhen Li Xiuman Zhou Xiaoshuang Niu Youmei Xiao Zhuoying He Huihao Li Juan Liu Xinghua Sui Yanfeng Gao | 2023 | Science China(Life Sciences)2023，66，10： | 1 |
| 19 | Synthesis and photoelectric characterization of delafossite conducting oxi- des CuA102 laminar crystal thin films via sol-gel method显示文摘 | Ding Juan Sui Yongming Fu Wuyou | 2010 | Appl Surf Sci2010，256，21： | 1 |
| 20 | Absorption and urinaryexcretion of A-type procyanidin oligomers from litchi chinensispericarp in rats by selected ion monitoring liquid chromatography-mass spectrometry 显示文摘 | LI Shuyi SUI Yong XIAO Juan | 2012 | Food Chemistry2012，138，： | 1 |
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