|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Shuganjieyu capsule increases neurotrophic factor expression in a rat model of depression显示文摘Shuganjieyu capsule has been approved for clinical treatment by the State Food and Drug Administration of China since 2008. In the clinic, Shuganjieyu capsule is often used to treat mild to moderate depression. In the rat model of depression established in this study, Shuganjieyu capsule was administered intragastrically daily before stress. Behavioral results confirmed that depressive symptoms lessened after treatment with high-dose(150 mg/kg) Shuganjieyu capsule. Immunohistochemistry results showed that high-dose Shuganjieyu capsule significantly increased phosphorylation levels of phosphorylation cyclic adenosine monophosphate response element binding protein and brain-derived neurotrophic factor expression in the medial prefrontal cortex and hippocampal CA3 area. Overall, our results suggest that in rats, Shuganjieyu capsule effectively reverses depressive-like behaviors by increasing expression levels of neurotrophic factors in the brain. | Jinhua Fu Yingjin Zhang Renrong Wu Yingjun Zheng Xianghui Zhang Mei Yang Jingping Zhao Yong Liu | 2014 | Neural Regeneration Research2014，9，5： | 10 |
| 2 | Characterization of Carotenoid Accumulation and Carotenogenic Gene Expression During Fruit Development in Yellow and White Loquat Fruit显示文摘Accumulation of carotenoids in peel and pulp of the yellow-fleshe loquat ‘Zaozhong 6'(ZZ6) and the white-fleshe loquat ‘Baiyu'(BY) were tracked during different fruit development stages, and the expression of 15 carotenogenic genes were analyzed. During loquat fruit ripening the fresh weight content of β-carotene in peel and pulp of ZZ6 increased gradually and peaked at the fully ripe stage, reaching 68.53 μg·g^(-1)FW in the peel and 11.92 μg·g^(-1)FW in the pulp. In BY, the content of β-carotene in the peel increased and peaked at the fully ripe stage, reaching38.89 μg·g^(-1)FW, while it decreased in the pulp from the original 0.47 μg·g~(^(-1))FW and reduced to 0.29 μg·g~(^(-1))FW. The content of β-cryptoxanthin in the peel and pulp of ZZ6 and BY both increased steadily, and peaked at the fully ripe stage; however, the content of lutein decreased in the peel of ZZ6 and increased in the pulp, but in BY, it dropped and then rose in the peel. There was no significan change of β-cryptoxanthin in the pulp of BY. After the breaker stage, the m RNA levels of phytoene synthase(PSY) and chromoplast-specifi lycopene β-cyclase(CYCB) were higher in the peel, while CYCB and β-carotene hydroxylase(BCH) m RNAs were higher in the fles of ZZ6, compared with BY. The results showed that the expression level of PSY, CYCB, and BCH appeared to cooperatively regulate the accumulation of carotenoids. | ZHANG Ling ZHANG Zhike ZHENG Tingting WEI Weilin ZHU Yunmei GAO Yongshun YANG Xianghui LIN Shunquan | 2016 | Horticultural Plant Journal2016，2，1： | 6 |
| 3 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 4 | Fabrication of Bionic Superhydrophobic Manganese Oxide/Polystyrene Nanocomposite Coating显示文摘 | Xianghui Xu Zhaozhu Zhang Fang Guo Jin Yang Xiaotao Zhu Xiaoyan Zhou Qunji Xue | 2012 | Journal of Bionic Engineering2012，9，1： | 5 |
| 5 | Control System Development and Experimental Study on Ultrasonic Vibration Feeding显示文摘Ultrasonic vibration feeding(UVF) method which can quantitatively feed and precisely deposit fine powder is a potential technique for micro feeding.The excitation sources transmit vibration to capillary though the third medium for most UVF devices.The vibrator is directly touched with the capillary can transmit mechanical energy on the capillary as much as possible,and the powder feeding can be controlled more precise.However,there are few reports about it.A direct UVF system which integrates the function of micro feeding,process observing,and powder forming was developed in this work.In order to analyze the effect of the system factors on feeding,a group of L9(33) orthogonal experiments are selected to confirm the effect of level change of factors.The three factors are capillary nozzle diameter,amplitude and signal.The flow rate was stable for each combined factors,and the optimum combination for the minimum flow rate are choosing small capillary,small amplitude,and triangular wave orderly.The whole process of feeding includes start point,middle stage and stop stage.Starting of feeding was synchronized to vibration when the amplitude of capillary nozzle is larger than critical amplitude.Then,the feeding process enters the middle stage,the feeding state is observed by the CCD,and it is very stable in the middle stage.Overflow of feeding can't be eliminated during the stop stage.The features of the deposited powder lines are analyzed;the overflow can be diminished by choosing small capillary and appropriate ratio of the capillary nozzle diameter to the particle size.Chinese characters lattices were deposited to validate the ability of quantitatively feeding and fixed feeding of UVF.Diameters of all powder dots show normal distribution,and more than 60% dots are concentrated from 550 μm to 650 μm,and the average diameter for all the dots is 597 μm.Most dots positions are well approached to their scheduled positions,and the maximum deviation is 0.27 mm.The new direct UVF system is used to implement experiments,which confirms the precise controllable of feeding.According improve the feeding technique,it suits well for rapid prototyping,chemistry,pharmaceutics and many other fields,which require precise measurement and feed minim powder. | ZENG Xianghui QI Lehua HUANG Hua LI Yang YANG Fang | 2011 | Chinese Journal of Mechanical Engineering2011，24，6： | 5 |
| 6 | Effects of genistein, daidzein and glycitein on the osteogenic and adipogenic differentiation of bone marrow stromal cells and on the adipogenic trans-differentiation of osteoblasts显示文摘The 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT), alkaline phosphatase (ALP) activity and oil red O assays were used to examine the effects of genistein, daidzein and glycitein on the osteogenic and adipogenic differentiation of primary mouse bone marrow stromal cells (MSCs) and the adipogenic trans-differentiation of primary mouse osteoblasts. The results indicated that daidzein, genistein and glycitein at concentrations from 1×10 -8 mol/L to 1×10 -5 mol/L promoted the proliferation of MSCs and osteoblasts; genistein, daidzein and glycitein promoted osteogenic differentiation and inhibited adipogenic differentiation of MSCs, and inhibited adipocytic transdifferentiation of osteoblasts at appropriate concentrations as 17β-estradiol. It suggests that genistein, daidzein and glycitein regulate a dual differentiational process of MSCs into the osteogenic and adipogenic lineages, and trans-differentiational process of primary osteoblasts into the adipocyte lineages, causing a lineage shift toward osteoblast. Protective effects of them on bone may be mediated by a reversal of adipogenesis which may promote the proliferation, differentiation and mineralization of osteoblasts, and make adipocytes secrete less cytokines which may promote osteoclast formation and activation. In addition, the results also indicated that genistein, daidzein and glycitein may be helpful in preventing the development of steroid induced osteonecrosis. | LI Xianghui ZHANG Jinchao SUI Senfang YANG Mengsu | 2005 | Progress in Natural Science:Materials International2005，15，11： | 5 |
| 7 | Diagnosis of CO2 dynamics and fluxes in global coastal oceans显示文摘Global coastal oceans as a whole represent an important carbon sink but,due to high spatial–temporal variability,a mechanistic conceptualization of the coastal carbon cycle is still under development,hindering the modelling and inclusion of coastal carbon in Earth SystemModels.Although temperature is considered an important control of sea surface pCO2,we show that the latitudinal distribution of global coastal surface pCO2 does not match that of temperature,and its inter-seasonal changes are substantially regulated by non-thermal factors such as watermassmixing and net primary production.These processes operate in both ocean-dominated and river-dominated margins,with carbon and nutrients sourced from the open ocean and land,respectively.These can be conceptualized by a semi-analytical framework that assesses the consumption of dissolved inorganic carbon relative to nutrients,to determine how a coastal system is a CO2 source or sink.The framework also finds utility in accounting for additional nutrients in organic forms and testing hypotheses such as using Redfield stoichiometry,and is therefore an essential step toward comprehensively understanding and modelling the role of the coastal ocean in the global carbon cycle. | Zhimian Cao Wei Yang Yangyang Zhao Xianghui Guo Zhiqiang Yin Chuanjun Du Huade Zhao Minhan Dai | 2020 | National Science Review2020，7，4： | 5 |
| 8 | Biomass Inspired Nitrogen Doped Porous Carbon Anode with High Performance for Lithium Ion Batteries显示文摘白果树叶子,一个自然地丰富的资源,成功地作为原料被采用了准备氮做的多孔的碳(NDPC ) 材料。多孔的碳的准备不包含任何激活或模板技术的帮助。同样获得的 NDPC 为电气化学的精力存储显示出有利特征,它不能仅仅为李离子的存储和插入提供多重地点,而且便于电子和李离子的快速的集体运输。作为结果, NDPC 当是评估了时,为锂离子电池的阳极材料交付高可逆的能力(在 0.1 C 的 505 mAh·g −1) ,优秀的率能力(在 10 C 的 190 mAh·g −1) 。这些有利性质建议 NDPC 能是为锂离子电池(解放) 的有希望的阳极材料。 | Junke Ou Lin Yang Xianghui Xi | 2016 | Chinese Journal of Chemistry2016，34，7： | 3 |
| 9 | Crustal P-wave velocity structure in the northeastern margin of the Qinghai-Tibetan Plateau and insights into crustal deformation显示文摘The transitional area between the northeastern margin of the Qinghai-Tibetan Plateau, Ordos Block and Alxa Block,also being the northern segment of the North-South Seismic Belt, is characterized by considerably high seismicity level and high risk of strong earthquakes. In view of the special tectonic environment and deep tectonic setting in this area, this study used two seismic wide-angle reflection/refraction cross profiles for double constraining, so as to more reliably obtain the fine-scale velocity structure characteristics in both the shallow and deep crust of individual blocks and their boundaries in the study area,and further discuss the seismogenic environment in seismic zones with strong historical earthquakes. In this paper, the P-wave data from the two profiles are processed and interpreted, and two-dimensional crustal velocity structure models along the two profiles are constructed by travel time forward modeling. The results show that there are great differences in velocity structure,shape of intra-crustal interfaces and crustal thickness among different blocks sampled by the two seismic profiles. The crustal thickness along the Lanzhou-Huianbu-Yulin seismic sounding profile(L1) increases from ~43 km in the western margin of Ordos Block to ~56 km in the Qilian Block to the west. In the Ordos Block, the velocity contours vary gently, and the average velocity of the crust is about 6.30 km s-1; On the other hand, the velocity structures in the crust of the Qilian Block and the arclike tectonic zone vary dramatically, and the average crustal velocities in these areas are about 0.10 km s-1 lower than that of the Ordos Block. In addition, discontinuous low-velocity bodies(LVZ1 and LVZ2) are identified in the crust of the Qilian Block and the arc-like tectonic zone, the velocity of which is 0.10–0.20 km s-1 lower than that of the surroundings. The average crustal thickness of the Ordos Block is consistently estimated to be around 43 km along both Profile L2(Tongchuan-Huianbu-Alashan left banner seismic sounding profile) and Profile L1. In contrast to the gently varying intra-crustal interfaces and velocity contours in the Ordos Block along Profile L1, which is a typical structure characteristic of stable cratons, the crustal structure in the Ordos Block along Profile L2 exhibits rather complex variations. This indicates the presence of significant structural differences in the crust within the Ordos Block. The crustal structure of the Helan Mountain Qilian Block and the Yinchuan Basin is featured by 'uplift and depression' undulations, showing the characteristics of localized compressional deformation.Moreover, there are low-velocity zones with alternative high and low velocities in the middle and lower crust beneath the Helan Mountain, where the velocity is about 0.15–0.25 km s-1 lower than that of the surrounding areas. The crustal thickness of the Alxa Block is about 49 km, and the velocity contours in the upper and middle-lower crust of the block vary significantly. The complex crustal velocity structure images along the two seismic sounding profiles L1 and L2 reveal considerable structural differences among different tectonic blocks, their coupling relationships and velocity structural features in the seismic zones where strong historical earthquakes occurred. The imaging result of this study provides fine-scale crustal structure information for further understanding the seismogenic environment and mechanism in the study area. | Shuaijun WANG Baojin LIU Xiaofeng TIAN Baofeng LIU Xianghui SONG Xiaoguo DENG Yinan SUN Cejun MA Yudong YANG | 2018 | Science China Earth Sciences2018，61，9： | 3 |
| 10 | EjBZR1 represses fruit enlargement by binding to the EjCYP90 promoter in loquat显示文摘Loquat(Eriobotrya japonica)is a subtropical tree that bears fruit that ripens during late spring.Fruit size is one of the dominant factors inhibiting the large-scale production of this fruit crop.To date,little is known about fruit size regulation.In this study,we first discovered that cell size is more important to fruit size than cell number in loquat and that the expression of the EjBZR1 gene is negatively correlated with cell and fruit size.Virus-induced gene silencing(VIGS)of EjBZR1 led to larger cells and fruits in loquat,while its overexpression reduced cell and plant size in Arabidopsis.Moreover,both the suppression and overexpression of EjBZR1 inhibited the expression of brassinosteroid(BR)biosynthesis genes,especially that of EjCYP90A.Further experiments indicated that EjCYP90A,a cytochrome P450 gene,is a fruit growth activator,while EjBZR1 binds to the BRRE(CGTGTG)motif of the EjCYP90A promoter to repress its expression and fruit cell enlargement.Overall,our results demonstrate a possible pathway by which EjBZR1 directly targets EjCYP90A and thereby affects BR biosynthesis,which influences cell expansion and,consequently,fruit size.These findings help to elucidate the molecular functions of BZR1 in fruit growth and thus highlight a useful genetic improvement that can lead to increased crop yields by repressing gene expression. | Wenbing Su Zikun Shao Man Wang Xiaoqing Gan Xianghui Yang Shunquan Lin | 2021 | Horticulture Research2021，8，1： | 2 |
| 11 | Method for removing interference in chaotic signals based on the Lyapunov exponent显示文摘A new method based on the phenomenon of synchronization and the properties of chaos is proposed to reduce interference in the transferred chaotic signals of synchronized systems. The interference is considered as a series of small deviations from the original clean trajectory in the phase space. By means of our special design, these small deviations can be estimated using positive Lyapunov exponents, and removed from interfered chaotic signals. Application is illustrated for the Lorenz attractor, and numerical computing demonstrates that the method is effective in removing typical external interference. | YANG Nan LONG ZhangCai ZHAO XiangHui | 2012 | Chinese Science Bulletin2012，57，5： | 1 |
| 12 | In situ and ex situ conservation of Eriobotrya in China显示文摘 | Hu Youli Lin Shunquan Yang Xianghui | 2007 | Acta Hort2007，760，： | 1 |
| 13 | A Construction of dz-disjunct Matrices by Orthogonal Space and Discussion on Their Design Parameters显示文摘 | ZHANG Gengsheng YANG Yuqin ZHAO Xianghui | 2009 | Discrete Mathematics2009，309，： | 1 |
| 14 | The synthesis and bioactivities of 2-hydroxyethyl benzoisothiazole- 3 (2H) -one marine antifouling paints 显示文摘 | YANG Jianxin YOU Chenghang WANG Xianghui | 2013 | Advanced Materials Research2013，646，： | 1 |
| 15 | Transferring conjugated poly (γ-glutamic acid-maleimide-co-L-lactide)-1,2-dipalmitoylsn-glycero-3-phosphoethanolamine copolymer nanoparticles for targeting drug delivery显示文摘 | Caiyan Zhao Xiaoguang Liu Junxing Liu Zhiwei Yang Xianghui Rong Mingjun Li Xingjie Liang Yan Wu | 2014 | Colloids and Surfaces B: Biointerfaces2014，，： | 1 |
| 16 | Bt cotton planting does not affect the community characteristics of rhizospherc soil nematodes 显示文摘 | Bing Yang Hui Chen Xianghui Liu | 2014 | Applied Soil Ecology2014，73，1： | 1 |
| 17 | Alcohols Extraction Process and Content of Active Ingredients in Chinese Northeastern Auricularia auricula显示文摘[Objectives] The aim was to study the type and content of alcohol-soluble active ingredients in Auricularia auricula. [Methods]With total yield of alcohol extract as an indicator,the optimal concentrations of ethanol,isopropanol and n-butanol for alcohol extraction of A. auricula powder were determined. The contents of total flavonoids,polyphenols and triterpenoids in three different alcohol extracts of A. auricula,as well as in the alcohol extracts of polysaccharides and melanin extraction residue of A. auricula were determined. [Results] When90% ethanol was used,the yield of alcohol extract of A. auricula was 10. 7%. In the alcohol extract,the contents of total flavonoids,polyphenols and triterpenoids were 5. 68 mg/100 g,0. 43% and 0. 55%,respectively. When 100% isopropanol was used,the yield of alcohol extract was 10. 1%. In the alcohol extract,the contents of total flavonoids,polyphenols and triterpenoids were 4. 84 mg/100 g,0. 66% and 0. 37%,respectively. When 70% n-butanol was used,the yield of alcohol extract was 5. 4%. In the alcohol extract,the contents of total flavonoids,polyphenols and triterpenoids were 4. 07 mg/100 g,1. 68% and 0. 30%,respectively. The yields of ethanol,isopropanol and n-butanol extracts of polysaccharide and melanin extraction residue of A. auricula were 13. 8%,14. 3% and 8. 9%,respectively. In the three kinds of alcohol extracts,the contents of total flavonoids were 8. 28,11. 99,and 12. 38 mg/100 g,respectively; the contents of polyphenols were 0.14%,0. 38% and 0. 75%,respectively; and the contents of triterpenoids were 0. 25%,0. 60% and 0. 58%,respectively. [Conclusions]This study will provide certain reference for the in-depth study and development and utilization of active ingredients in A. auricula. | Xianghui KONG Guoli YANG Xijun CHEN Hui WANG Dan CHEN | 2018 | Medicinal Plant2018，9，4： | 1 |
| 18 | Superhydrophilic-superoleophobic coatings显示文摘 | Yang Jin Zhang Zhaozhu Xu Xianghui | | 0，，： | 1 |
| 19 | Charge-shifting cationic polymers that promote self-assembly and self-disassembly with DNA显示文摘 | Liu Xianghui Yang Jennifer W Miller Adam D | 2005 | Macromolecules2005，38，19： | 1 |
| 20 | Contextual influence on the tilt after-effect in foveal and parafoveal vision显示文摘A sensory stimulus can only be properly interpreted in light of the stimuli that surround it in space and time. The tilt illusion(TI) and tilt after-effect(TAE) provide good evidence that the perception of a target depends strongly on both its spatial and temporal context. In previous studies, the TI and TAE have typically been investigated separately, so little is known about their co-effects on visual perception and information processing mechanisms. Here, we considered the influence of the spatial context and the temporal effect together and asked how centersurround context affects the TAE in foveal and parafoveal vision. Our results showed that different center-surround spatial patterns signifi cantly affected the TAE for both foveal and para-foveal vision. In the fovea, the TAE was mainly produced by central adaptive gratings. Cross-oriented surroundings significantly inhibited the TAE, and iso-oriented surroundings slightly facilitated it; surround inhibition was much stronger than surround facilitation. In the para-fovea, the TAE was mainly decided by the surrounding patches. Likewise, a cross-oriented central patch inhibited the TAE, and an iso-oriented one facilitated it, but there was no significant difference between inhibition and facilitation. Our findings demonstrated, at the perceptual level, that our visual system adopts different mechanisms to process consistent or inconsistent central-surround orientation information and that the unequal magnitude of surround inhibition and facilitation is vitally important for the visual system to improve the detectability or discriminability of novel or incongruent stimuli. | Cheng Chen Xianghui Chen Min Gao Qiong Yang Hongmei Yan | 2015 | Neuroscience Bulletin2015，31，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员