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| 1 | A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy显示文摘anti-CTLA-4 抗体由阻止 B7-CTLA-4 相互作用接近否定发信号引起肿瘤拒绝,这被假定。在比临床上有效的 dosing 完成的血浆层次更加高的集中,令人惊讶地, anti-CTLA-4 抗体 Ipilimumab 不由 CTLA-4 也不 CTLA-4 绑定堵住任何一 B7 trans-endocytosis 到使不能调动或联系房间的 B7。因而, Ipilimumab 不从人性化的任何一个 CTLA4 基因在树枝状的房间(DC ) 上增加 B7 (Ctla4 h/h ) 或人的 CD34 + 茎重新组成房间的 NSG 老鼠。在 Ctla4 高效地表示人和老鼠 CTLA4 基因,绑在人的 anti-CTLA-4 抗体然而并非老鼠 CTLA-4 的 h/m 老鼠导致 Treg 弄空和 Fc 受体依赖者肿瘤拒绝。堵住的抗体 L3D10 比得上在引起肿瘤拒绝的非阻塞的 Ipilimumab。显著地,输在人类化期间堵住活动的 L3D10 子孙在导致 Treg 弄空和肿瘤拒绝仍然保持充分能干。有效地在淋巴的器官堵住 CD4 T 细胞激活和 de novo CD8 T 细胞 priming 的 Anti-B7 抗体否定地不影响 Ipilimumab 的 immunotherapeutic 效果。因此,临床上有效的 anti-CTLA-4 mAb 由独立于检查点封锁的机制引起肿瘤拒绝但是依赖于主人 Fc 受体。我们为 CTLA-4 检查点的一个重评价的数据电话封锁假设并且为安全、有效的 anti-CTLA-4 mAbs 的下一代提供新卓见。 | Xuexiang Du Fei Tang Mingyue Liu Juanjuan Su Yan Zhang Wei Wu Martin Devenport Christopher A Lazarski Peng Zhang Xu Wang Peiying Ye Changyu Wang Eugene Hwang Tinghui Zhu Ting Xu Pan Zheng Yang Liu | 2018 | Cell Research2018，28，4： | 25 |
| 2 | Quantitative assessment of acute kidney injury by noninvasive arterial spin labeling perfusion MRI:a pilot study显示文摘The kidneys are essential for maintaining homeostasis,are responsible for the reabsorption of water,glucose and amino acids,and filter the blood by removing waste.Acute kidney injury(AKI) is a syndrome characterized by the rapid loss of renal excretory function and the accumulation of end metabolic products of urea and creatinine.AKI is associated with the later development of chronic kidney disease and end-stage kidney disease,and may eventually be fatal.Early diagnosis of AKI and assessments of the effects of treatment,however,are challenging.The pathophysiological mechanism of AKI is thought to be the imbalance between oxygen supply and demand in the kidneys.We have assessed the ability of arterial spin labeling(ASL) perfusion magnetic resonance imaging(MRI),without the administration of contrast media,to quantify renal blood flow(RBF) non-invasively.We found that RBF was significantly lower in AKI patients than in healthy volunteers.These results suggest that ASL perfusion MRI,a noninvasive measurement of RBF,may be useful in the early diagnosis of AKI. | DONG Jian YANG Li SU Tao YANG XueDong CHEN Bin ZHANG Jue WANG XiaoYing JIANG XueXiang | 2013 | Science China(Life Sciences)2013，56，8： | 8 |
| 3 | The Effect of Tide on the Global Climate Change显示文摘The differential rotation between the solid and fluid spheres caused by tidal force could explain the 1500 to 1800-year cycle of the world's temperature. Strong tide increases the vertical and horizontal mixing of water in the oceans, drawing the cold Pacific water from the depths to the surface and the warm water from the west to the east, where it cools or warms the atmosphere above, absorbs or releases CO2 to decrease or increase greenhouse effect and to make La Nina or El Nino occur in the global. The moon's declination and obliquity of the ecliptic affect the tidal intensity. The exchange of tidal energy and tide-generating force caused by the sun, moon and major planets makes the earth's layers rotate in different speeds. The differenti-al rotation between solid and fluid of the earth is the basic reason for El Nino and global climate change. | YANG Xuexiang, CHEN Zhen and CHEN Dianyou( College of Ceo - exploration Science and Technology, Jilin University, Changchun 130026, P. R. China)Qiao Qiyuan(National Astronomical Observatory, Chinese Academy of Science, Beijing 100012, P. R. China) | 2002 | Global Geology2002，7，1： | 7 |
| 4 | Uncoupling therapeutic from effects for safer and effective CTLA4 humanized mice immunotherapy-related adverse anti-CTLA-4 antibodies in显示文摘 | Xuexiang Du Mingyue Liu Juanjuan Su Peng Zhang Fei Tang Peiying Ye Martin Devenport Xu Wang Yan Zhang Yang Liu Pan Zheng | 2018 | Cell Research2018，28，4： | 6 |
| 5 | Hijacking antibody-induced CTLA-4 lysosomal degradation for safer and more effective cancer immunotherapy显示文摘It remains unclear why the clinically used anti-CTLA-4 antibodies, popularly called checkpoint inhibitors, have severe immunotherapy-related adverse effects (irAEs) and yet suboptimal cancer immunotherapeutic effects (CITE). Here we report that while irAE-prone Ipilimumab and TremeIgG1 rapidly direct cell surface CTLA-4 for lysosomal degradation, the non-irAE-prone antibodies we generated, HL12 or HL32, dissociate from CTLA-4 after endocytosis and allow CTLA-4 recycling to cell surface by the LRBA-dependent mechanism. Disrupting CTLA-4 recycling results in robust CTLA-4 downregulation by all anti-CTLA-4 antibodies and confers toxicity to a non-irAE-prone anti-CTLA-4 mAb. Conversely, increasing the pH sensitivity of TremeIgG1 by introducing designed tyrosine-to-histidine mutations prevents antibody-triggered lysosomal CTLA-4 downregulation and dramatically attenuates irAE. Surprisingly, by avoiding CTLA-4 downregulation and due to their increased bioavailability, pH-sensitive anti-CTLA-4 antibodies are more effective in intratumor regulatory T-cell depletion and rejection of large established tumors. Our data establish a new paradigm for cancer research that allows for abrogating irAE while increasing CITE of anti-CTLA-4 antibodies. | Yan Zhang Xuexiang Du Mingyue Liu Fei Tang Peng Zhang Chunxia Ai James K. Fields Eric J. Sundberg Olga S. Latinovic Martin Devenport Pan Zheng Yang Liu | 2019 | Cell Research2019，29，8： | 6 |
| 6 | Initial movement of the Karakorum Fault in western Tibet:constraints from SHRIMP U-Pb dating of zircons显示文摘The Karakorum Fault zone(KFZ)plays an important role in understanding the formation,evolvement and deformation of the Tibetan Plateau.The high-T dextral shearing metamorphic rocks,e.g.,mylonites or mylonitized gneisses-granites,locally crop out along the southeastern part of the KFZ in the Ayila Ri’gyüRange area.The SHRIMP U-Pb dating of the syn-kinematic crystallized zircons indicates that the initial age of the KFZ is^27 Ma,~10 Ma older than previous results.The extensive high-T dextral shearing along the KFZ started at least at 27-20 Ma,accompanied by the syn-kinematic emplacement of leuco-granites.Deformation and concomitant fluid circulation during shearing most likely occurred as early as at 25-13 Ma.The KFZ probably grew from southeast to northwest along the fault as a result of continuous convergence between the India plate and Eurasia plate. | LI HaiBing Franck VALLI LIU DunYi XU ZhiQin YANG JingSui Nicolas ARNAUD Paul TAPPONNIER Robin LACASSIN CHEN SongYong QI xuexiang | 2007 | Chinese Science Bulletin2007，52，8： | 6 |
| 7 | Isolation,Purification and Immunomodifying Activity of Polysaccharides from Phellinus igniarius显示文摘Phellinus igniarius polysaccharides were obtained by hot water extraction of mushroom fruit bodies followed by ethanol precipitation,and further purified by anion exchange and gel filtration chromatography.Immuno-enhancing activity was evaluated by determining the effect of different polysaccharide fractions on mouse spleen lymphocyte proliferation in vitro.Three crude polysaccharide preparations,designated PIP30,PIP60 and PIP80 according to the percentage concentration of ethanol required for precipitation from hot aqueous extracts,promoted lymphocyte proliferation to varying degrees.Purification of polysaccharide present in PIP30 and PIP60 was carried out using anion exchange chromatography.Proliferation rates in samples treated with 200 μg/mL of fractions P30U,P30W and P30S1(obtained following anion exchange chromatography of PIP30) were approximately 5-,4-,and 3.5-fold higher,respectively compared with negative controls.Similarly,marked increases(3.4-and 2.8-fold) in cell proliferation rates compared with negative controls were observed with 200 μg/mL concentrations of P60W and P60S2(obtained following anion exchange chromatography of PIP60),respectively.Two purified polysaccharide preparations,P60W1-1 and P60S1-1,were obtained following gel filtation chromatography of fractions P60W1 and P0S1,respectively.Fraction P60W1-1(10-100 g/mL) enhanced splenocyte proliferation 0.5-1.4-fold compared with negative controls,whereas no effects were observed with P60S1-1. | SHEN Xuexiang YANG Yan ZHANG Jinsong TANG Qingjiu JIA Wei | 2008 | 食用菌学报2008，15，2： | 2 |
| 8 | A novel synthetic small molecule YF-452 inhibits tumor growth through antiangiogenesis by suppressing VEGF receptor 2 signaling显示文摘Tumor angiogenesis is characterized by abnormal vessel morphology, endowing tumor with highly hypoxia and unresponsive toward treatment. To date, mounting angiogenic factors have been discovered as therapeutic targets in antiangiogenic drug development. Among them, vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors exerts potent antiangiogenic activity in tumor therapy. Therefore, it may provide a valid strategy for cancer treatment through targeting the tumor angiogenesis via VEGFR2 pathway. In this study, we established a high-profile compounds library and certificated a novel compound named N-(N-pyrrolidylacetyl)-9-(4-bromobenzyl)-1,3,4,9-tetrahydro-β-carboline (YF-452), which remarkably inhibited the migration, invasion and tube-like structure formation of human umbilical vein endothelial cells (HUVECs) with little toxicity invitro. Rat thoracic aorta ring assay indicated that YF-452 significantly blocked the formation of microvascular exvivo. In addition, YF-452 inhibited angiogenesis in chick chorioallantoic membrane (CAM) and mouse corneal micropocket assays. Moreover, YF-452 remarkably suppressed tumor growth in xenografts mice model. Furthermore, investigation of molecular mechanism revealed that YF-452 inhibited VEGF-induced phosphorylation of VEGFR2 kinase and the downstream protein kinases including extracellular signal regulated kinase (ERK), focal adhesion kinase (FAK) and Src. These results indicate that YF-452 inhibits angiogenesis and may be a potential antiangiogenic drug candidate for cancer therapy. | Yongrui Liu Yuan He Feifei Yang Xiaonan Cong Jinhua Wang Shihong Peng Dan Gao Weifang Wang Liping Lan Xuexiang Ying Mingyao Liu Yihua Chen Zhengfang Yi | 2017 | Science China(Life Sciences)2017，60，2： | 2 |
| 9 | Degradation of selected pharmaceuticals in aqueous solution with UV and UV/H 2 O 2显示文摘 | Fang Yuan Chun Hu Xuexiang Hu Jiuhui Qu Min Yang | 2009 | Water Research2009，，6： | 1 |
| 10 | Further study on augmented Lagrangian duality theory 显示文摘 | HUANG Xuexiang YANG Xiaoqi | 2005 | Journal of Global Optimiza- tion2005，31，： | 1 |
| 11 | Effects of disinfectant and biofilm on the corrosion of cast iron pipes in a reclaimed water distribution system显示文摘 | Haibo Wang Chun Hu Xuexiang Hu Min Yang Jiuhui Qu | 2011 | Water Research2011，，4： | 1 |
| 12 | Degradation of selected pharmaceuticals in aqueous solution with UV and UV/H 2 O 2显示文摘 | Fang Yuan Chun Hu Xuexiang Hu Jiuhui Qu Min Yang | 2009 | Water Research2009，，6： | 1 |
| 13 | Geopulsation,Volcanism and Astronomical Periods显示文摘Volcanism is mainly controlled by the intermittent release of energy in the earth. As far as the differential rotation of the earth’s inner core is concerned, the Galactic Year may change the gravitational constant G, the solar radiative quantity and the moving speed of the solar system and affect the exchange of angular momentum between core and mantle as well as the energy exchange between crust and mantle. As a result, this leads to eruptions of superplumes and magma, and controls the energy flow from core-mantle boundary (CMB) to crust. When the earth’s speed decreases, it will release a huge amount of energy. They are the reason of the correspondence of the volcanic cycles one by one with the astronomical periods one by one. According to the astronomical periods, volcanic eruptions may possibly be predicted in the future. | Yang Xuexiang Chen Dianyou Yang Xiaoying Yang Shuchen | 2000 | Global Geology2000，5，1： | 1 |
| 14 | Norcantharidin enhances ABT-737-induced apoptosis in hepatocellular carcinoma cells by transcriptional repression of Mcl-1显示文摘 | Shuijun Zhang Gongquan Li Xiuxian Ma Yu Wang Guangzhi Liu Liushun Feng Yongfu Zhao Gong Zhang Yang Wu Xuexiang Ye Baoming Qin Jianfeng Lu | 2012 | Cellular Signalling2012，，9： | 1 |
| 15 | The Relation between Tectonic Movement and Climatic Change显示文摘Climate and tectonics are two interactive factors in the earth’s system. They are controlled by astronomical cy-cles. It has been unheeded for a long time that large-scale material motion caused by global climatic change is one of the powers for tectonic movement. Tectonic movement makes the distributional pattern of continent and ocean change and makes global climate type change strongly in large scale. It is a good example that the change of the sea-ice around Antarctic Continent and in the Drake Passage has the switch process for global climatic changes. Tide makes the oceanic crust of the East Pacific Ocean and the West Pacific Ocean rise or fall 60 cm oppositely. Before and after El Nino events, the oceanic level of the East Pacific Ocean and the West Pacific Ocean may rise or fall 40 cm oppositely. Because of isostasy, oceanic crust may fall or rise 13 or 20 cm. They are the reasons why El Nino events are interrelated with the earthquakes and volcanoes. This is so called seesaw phenomenon of oceanic crust. | Xuexiang Yang Qiyuan Qiao Dianyou Chen | 2003 | Global Geology2003，8，1： | 0 |
| 16 | Strong Tides in 1964 and 1982显示文摘The differential rotation between solid and fluid caused by tidal force can explain a 1 500 to 1 800-year cycle of the climate change. Strong tide increases the vertical and horizontal mixing of water in ocean by drawing the cold Pacific water from the depths to the surface (or by making the warm water flow from the West Pacific to the East as well as from the North to the South). It cools or warms the atmosphere above and makes La Nina or El Nino occur in the whole world. Astronomical data have shown that strong tide is often associated with El Nino events. Volcanic activities at sub-marine are also controlled by strong tide. Volcanic activities can also draw warm water from the depths to the surface in the Pacific and volcanic ash can keep out sunlight, which is the most important external forcing factor for El Nino. If vol-canic ash reaches into the stratosphere, finer aerosols will spread throughout the globe during a few months and will float in it for one to three years to weaken the sun’s direct radiation to the areas. It is one of the factors to postpone EI Nino just like the process of solar eclipse. | Dianyou Chen Xuexiang Yang Qiyuan Qiao | 2003 | Global Geology2003，8，1： | 0 |
| 17 | Global influenza in cold phase of Pacific Decade Oscillation显示文摘Based on the study of the cold phase of the Pacific Decade Oscillation, pandemic influenza is related to climate. The relation of low temperature, Pacific Decade Oscillation, strongest earthquake, Influenza, hurricane and El Nino is researched in this study. In the cold period of Pacific Decade Oscillation, the strongest earthquake, hurricane with La Nina, Pandemic Influenza with El Nino will occur stronger and stronger. From 1950 to 1976, the strongest dust-storm is connected with Pandemic Influenza one by one. So, dust-storm is one of factors to spread pandemic influenza viruses. | YANG Donghong YANG Debin YANG Xuexiang | 2010 | Global Geology2010，13，2： | 0 |
| 18 | CD24Fc ameliorates immune-related adverse events while preserving anti-tumor therapeutic effect显示文摘Dear Editor,In combination,anti-CTLA-4 and anti-PD-1 mAb provide the most effective immunotherapy,although severe immune-related adverse events(irAEs)also occur at high frequency.1 It is urgent to develop strategies to reduce irAEs for wide-spread adoption of immune checkpoint inhibitors(ICIs). | Mingyue Liu Xu Wang Xuexiang Du Yan Zhang Chunxia Ai Siwen Hu-Lieskovan Tianhong Li Martin Devenport Yang Liu Pan Zheng | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 19 | The Pythium periplocum elicitin PpEli2 confers broad-spectrum disease resistance by triggering a novel receptor-dependent immune pathway in plants显示文摘Elicitins are microbe-associated molecular patterns produced by oomycetes to elicit plant defense.It is still unclear whether elicitins derived from non-pathogenic oomycetes can be used as bioactive molecules for disease control.Here,for the first time we identify and characterize an elicitin named PpEli2 from the soil-borne oomycete Pythium periplocum,which is a non-pathogenic mycoparasite colonizing the root ecosystem of diverse plant species.Perceived by a novel cell surface receptor-like protein,REli,that is conserved in various plants(e.g.tomato,pepper,soybean),PpEli2 can induce hypersensitive response cell death and an immunity response in Nicotiana benthamiana.Meanwhile,PpEli2 enhances the interaction between REli and its co-receptor BAK1.The receptor-dependent immune response triggered by PpEli2 is able to protect various plant species against Phytophthora and fungal infections.Collectively,our work reveals the potential agricultural application of non-pathogenic elicitins and their receptors in conferring broad-spectrum resistance for plant protection. | Kun Yang Yi Wang Jialu Li Yaxin Du Ying Zhai Dong Liang Danyu Shen Rui Ji Xuexiang Ren Hao Peng Maofeng Jing Daolong Dou | 2023 | Horticulture Research2023，10，2： | 0 |
| 20 | Tectonic Movement and Global Climate Change显示文摘Glaciation between northern hemisphere and southern hemisphere were synchronous, the ice age occurred not in high but in low value of the eccentricity of the earth’s orbit. Such facts went against the precession principle of the astronomical theory of ice age. The inhomogeneous distribution of climate consisted with the inhomogeneous distribution of ocean and continent. The north/south antisymmetry may be attributed to southward deviation of the thermal center and northward deviation of the mass center within the mantle demonstrated by seismic tomography. The core - mantle angular momentum makes rotational energy into thermal energy and mantle plumes erupt in the ocean bottom. The earth’s deformation by tidal force makes the eruption of mantle plumes strong. They are the reason that glaciation between the Northern Hemisphere and Southern Hemisphere are synchronotis and the ice age occurred in low value of the eccentricity of the earth’s orbit. The tectonic movement is playing a most important part in global climate change. | Yang Xuexiang Chen Dianyou | 2000 | Global Geology2000，5，2： | 0 |
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