|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes显示文摘细胞毒素的 T 房间(CTL ) 在肝炎 B 的控制起一个关键作用病毒(HBV ) 感染和病毒的清理。然而,大多数识别 CTL epitopes 从遗传型 A 和 D 的 HBV 被导出,并且很少在在亚洲更流行的遗传型 B 和 C 的病毒被定义。因为 HBV 核心蛋白质(HBc ) 是最保守、产生免疫性的部件,在这研究,我们使用了盖住 HBc 屏蔽并且识别特定的 CTL epitopes 的一个重叠 9-mer 肽水池。异乎寻常的 HLA-A2-restricted epitope HBc141149 被结晶化分析发现,在结构上描绘了。immunogenicity 和 anti-HBV 活动进一步在 HBV 和 HLA-A2 被决定转基因的老鼠。最后,我们证明在 HBc141149 epitope 的变化与病毒的参数被联系,在 HBV 的疾病前进感染了病人。我们的数据因此提供卓见进这异乎寻常的 epitope 绑定的结构特征给 MHC-I 分子,以及 epitope 特定的 CTL 活动在 HBV 安排 T 房间反应和有免疫力的避免感染的病人。 | Lu Sun Yu Zhang Bao Zhao Mengmeng Deng Jun Liu Xin Li Junwei Hou Mingming Gui Shuijun Zhang Xiaodong Li George F. Gao Songdong Meng | 2014 | Protein & Cell2014，5，4： | 7 |
| 2 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 3 | Analysis on CO2 Emissions Transferred from Developed Economies to China through Trade显示文摘 | Wencheng Zhang Shuijun Peng | 2016 | China & World Economy2016，24，2： | 3 |
| 4 | Core antigen tests for hepatitis C virus: a meta-analysis显示文摘 | Shuijun Gu Jun Liu Huijun Zhang Baoluo Gu Hanjiang Lai Hongliang Zhou Chaoqi He Yingying Chen | 2012 | Molecular Biology Reports2012，，8： | 2 |
| 5 | Technology spillo- vcrs absorptive capacity and economic growth显示文摘 | LAI Mingyong PENG Shuijun BAO Qun | 2006 | China Eco- nomic Review2006，17，： | 1 |
| 6 | Technology Spillovers, Absorptive Capacity and Economic Growth 显示文摘 | Lai Mingyong Peng Shuijun and Bao Qun | 2006 | China Economic Review2006，17，3： | 1 |
| 7 | Study on remote monitoring and control system for construction vehicle显示文摘 | Song Shenli Huang Shuijun Su Fantun | 2011 | Advanced Materials Research2011，142，1： | 1 |
| 8 | Norcantharidin enhances ABT-737-induced apoptosis in hepatocellular cainoma cells by transcriptional repression of Mcl-1 显示文摘 | SHUIJUN ZHANG GONGQUAN L I XIUXIAN M A | 2012 | Ellular Signalling2012，24，： | 1 |
| 9 | Technology Spillovers,Absorptive Capacity and Economic Growth 显示文摘 | Lai Mingyong Peng Shuijun and Bao Qun | 2006 | China Economic Review2006，，17： | 1 |
| 10 | Technology spillover, absorptive capacity and economic growth 显示文摘 | LAI MINGYONG PENG Shuijun BAO Qun | 2006 | China Economic Review2006，，： | 1 |
| 11 | Role of Leptin Receptor ( LEPR ) Gene Polymorphisms and Haplotypes in Susceptibility to Hepatocellular Carcinoma in Subjects with Chronic Hepatitis B Virus Infection显示文摘 | Zhen Li Weitang Yuan Shijie Ning Jie Li Wenlong Zhai Shuijun Zhang | 2012 | Molecular Diagnosis & Therapy2012，，6： | 1 |
| 12 | Technology spillovers, absorptive capacity and economic growth显示文摘 | Mingyong LAI Shuijun PENG Qun BAO | 2006 | China Economic Review2006，，3： | 1 |
| 13 | Surgical therapy of Budd-Chiari syndrome:Report of 528 cases显示文摘 | Xu peiqin Zhao yongfu Zhang shuijun | 1998 | Journal of Henan Medical University1998，33，5： | 1 |
| 14 | Determination of melamine and cyanuric acid in human urine by a liquid chromatography tandem mass spectrometry显示文摘 | Mengqi Zhang Shuijun Li Chengyin Yu Gangyi Liu Jingying Jia Chuan Lu Jian He Yinghua Ma Jianmin Zhu Chen Yu | 2010 | Journal of Chromatography B2010，，9： | 1 |
| 15 | Polymorphisms of DNA repair gene XRCC1 and hepatocellular carcinoma risk among East Asians: a meta-analysis显示文摘 | Jie Li Zhenzhen Li Liushun Feng Wenzhi Guo Shuijun Zhang | 2013 | Tumor Biology2013，，1： | 1 |
| 16 | Human Capital Expansion and Global Value Chain Upgrading:Firm-level Evidence from China显示文摘Firms actively participate in the production of the global value chain(GVC),which is an important driving force for economic development.Using a difference-in-difference method,our research shows that industries that are relatively more human-capital intensive experienced a larger GVC position upgrading after 2003 than they had in prior years.Second,mechanism analysis shows that human capital expansion increases firms’GVC position not only through an imported intermediate input effect but also through an innovation effect.Third,this study shows that increases in the college-educated labor force have a heterogeneous effect on a firm's GVC position across firms’various characteristics.Human capital expansion has the largest positive effect on state-owned firms relative to foreign and domestic private firms.Human capital expansion has also significantly improved the GVC position of firms located in China's eastern and central regions.The findings of this study indicate that it helps upgrading the GVC position of Chinese firms. | Lamei Wu Guifu Chen Shuijun Peng | 2021 | China & World Economy2021，29，5： | 1 |
| 17 | The Effect of FOXP3^(+) Regulatory T Cells on Infectious and Inflammatory Diseases显示文摘CD4^(+)CD25^(+)FOXP3^(+)regulatory T cells(Tregs)contribute to the maintenance of immune homeostasis and tolerance in the body.The expression levels and functional stability of FOXP3 control the function and plasticity of Tregs.Tregs critically impact infectious diseases,especially by regulating the threshold of immune responses to pathogenic microorganisms.The functional regulatory mechanism and cell-specific surface markers of Tregs in different tissues and inflammatory microenvironments have been investigated in depth,which can provide novel ideas and strategies for immunotherapies targeting infectious diseases. | Yakun Bai Fang Gao Dan Li Suyuan Ji Shuijun Zhang Wenzhi Guo Bin Li | 2021 | Infectious Microbes & Diseases2021，3，4： | 1 |
| 18 | Norcantharidin enhances ABT-737-induced apoptosis in hepatocellular carcinoma cells by transcriptional repression of Mcl-1显示文摘 | Shuijun Zhang Gongquan Li Xiuxian Ma Yu Wang Guangzhi Liu Liushun Feng Yongfu Zhao Gong Zhang Yang Wu Xuexiang Ye Baoming Qin Jianfeng Lu | 2012 | Cellular Signalling2012，，9： | 1 |
| 19 | Influence Study of Organic and Inorganic Additive to Coal Combustion Characteristic显示文摘 | Yu Shuijun Xie Fengcheng Jia Boyu | 2012 | Procedia Environmental Sciences2012，12，： | 1 |
| 20 | SAFETY FIRST显示文摘China improves its nuclear emergency response capability Summer is the busy season for the Dayawan nuclear power plant, located on the scenic Daya Bay in the south China city of Shenzhen. Not only is there a peak demand for electricity, but the typhoon season also means the plant must be ready to handle any emergency. On the | Yu Shuijun | 2013 | Beijing Review2013，56，29： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员