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| 1 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 2 | Orbital angular momentum mode logical operation using optical diffractive neural network显示文摘Optical logical operations demonstrate the key role of optical digital computing,which can perform general-purpose calculations and possess fast processing speed,low crosstalk,and high throughput.The logic states usually refer to linear momentums that are distinguished by intensity distributions,which blur the discrimination boundary and limit its sustainable applications.Here,we introduce orbital angular momentum(OAM)mode logical operations performed by optical diffractive neural networks(ODNNs).Using the OAM mode as a logic state not only can improve the parallel processing ability but also enhance the logic distinction and robustness of logical gates owing to the mode infinity and orthogonality.ODNN combining scalar diffraction theory and deep learning technology is designed to independently manipulate the mode and spatial position of multiple OAM modes,which allows for complex multilight modulation functions to respond to logic inputs.We show that few-layer ODNNs successfully implement the logical operations of AND,OR,NOT,NAND,and NOR in simulations.The logic units of XNOR and XOR are obtained by cascading the basic logical gates of AND,OR,and NOT,which can further constitute logical half-adder gates.Our demonstrations may provide a new avenue for optical logical operations and are expected to promote the practical application of optical digital computing. | PEIPEI WANG WENJIE XIONG ZEBIN HUANG YANLIANG HE ZHIQIANG XIE JUNMIN LIU HUAPENG YE YING LI DIANYUAN FAN SHUQING CHEN | 2021 | Photonics Research2021，9，10： | 5 |
| 3 | Molecular basis for ligand activation of the human KCNQ2 channel显示文摘The voltage-gated potassium channel KCNQ2 is responsible for M-current in neurons and is an important drug target to treat epilepsy,pain and several other diseases related to neuronal hyper-excitability.A list of synthetic compounds have been developed to directly activate KCNQ2,yet our knowledge of their activation mechanism is limited,due to lack of high-resolution structures.Here,we report cryo-electron microscopy(cryo-EM)structures of the human KCNQ2 determined in apo state and in complex with two activators,ztz240 or retigabine,which activate KCNQ2 through different mechanisms.The activator-bound structures,along with electrophysiology analysis,reveal that ztz240 binds at the voltage-sensing domain and directly stabilizes it at the activated state,whereas retigabine binds at the pore domain and activates the channel by an allosteric modulation.By accurately defining ligand-binding sites,these KCNQ2 structures not only reveal different ligand recognition and activation mechanisms,but also provide a structural basis for drug optimization and design. | Xiaoxiao Li Qiansen Zhangc Peipei Guo Jie Fu Lianghe Mei Dashuai Lv Jiangqin Wang Dongwu Lai Sheng Ye Huaiyu Yang Jiangtao Guo | 2021 | Cell Research2021，31，1： | 3 |
| 4 | Identification of two novel mutations in the GALNT3 gene in a Chinese family with hyperphosphatemic familial tumoral calcinosis显示文摘Hyperphosphatemic familial tumoral calcinosis(HFTC) is a rare, autosomal recessive genetic disease.This disease is characterized by the progressive calcification of soft tissues leading to symptoms of pressure and hyperphosphatemia but normal concentrations of serum calcium with or without an elevation of1,25-dihydroxyvitamin D3 levels.HFTC is caused by loss-of-function mutations in the GALNT3, FGF23 or KL genes. Here, we identified two novel mutations in the GALNT3 gene in a Chinese family with HFTC.Identification of a novel genotype in HFTC provides clues for understanding the phenotype–genotype relationships in HFTC and may assist not only in the clinical diagnosis of HFTC but also in the interpretation of the genetic information used for prenatal diagnosis and genetic counseling. | Lihao Sun Lin Zhao Lianiun Du Peipei Zhang Minjia Zhang Min Li Tingting Liu Lei Ye Bei Tao Hongyan Zhao Jianmin Liu Xiaoyi Ding | 2016 | Bone Research2016，4，4： | 2 |
| 5 | A Lipoxin A4 Analog Ameliorates Blood–Brain Barrier Dysfunction and Reduces MMP-9 Expression in a Rat Model of Focal Cerebral Ischemia–Reperfusion Injury显示文摘 | Yan Wu Yan-Ping Wang Peipei Guo Xi-Hong Ye Jie Wang Shi-Ying Yuan Shang-Long Yao You Shang | 2012 | Journal of Molecular Neuroscience2012，，3： | 1 |
| 6 | Iron sites on defective BiOBr nanosheets:Tailoring the molecular oxygen activation for enhanced photocatalytic organic synthesis显示文摘Sunlight-driven activation of molecular oxygen(O_(2))for organic oxidation reactions offers an appealing strategy to cut down the reliance on fossil fuels in chemical industry,yet it remains a great challenge to simultaneously tailor the charge kinetics and promote reactant chemisorption on semiconductor catalysts for enhanced photocatalytic performance.Herein,we report iron sites immobilized on defective BiOBr nanosheets as an efficient and selective photocatalyst for activation of O_(2) to singlet oxygen(^(1)O_(2)).These Fe^(3+) species anchored by oxygen vacancies can not only facilitate the separation and migration of photogenerated charge carrier,but also serve as active sites for effective adsorption of 02.Moreover,low-temperature phosphorescence spectra combined with X-ray photoelectron spectroscopy(XPS)and electronic paramagnetic resonance(EPR)spectra under illumination reveal that the Fe species can boost the quantum yield of excited triplet state and accelerate the energy transfer from excited triplet state to adsorbed O2 via a chemical loop of Fe^(3+)/Fe^(2+),thereby achieving highly efficient and selective generation of ^(1)O_(2).As a result,the versatile iron sites on defective BiOBr nanosheets contributes to near-unity conversion rate and selectivity in both aerobic oxidative coupling of amines to imines and sulfoxidation of organic sulfides.This work highlights the significant role of metal sites anchored on semiconductors in regulating the charge/energy transfer during the heterogeneous photocatalytic process,and provides a new angle for designing high-performance photocatalysts. | Xinhui Ye Yu Li Peipei Luo Bingcai He Xinxing Cao Tongbu Lu | 2022 | Nano Research2022，15，2： | 1 |
| 7 | Variations in Dissolved Methane in the Yellow Sea During the Spring Algal Blooms of 2009显示文摘Methane (CH4) is an important greenhouse gas and oceans are net sources of atmospheric CH4. The effects of environ- mental factors on the CH4 variation during different phases of the spring algal blooms were examined during two cruises conducted in the Yellow Sea (YS) from February to April of 2009. During the pre-bloom period from February to March, low CH4 saturation (< 134%) was observed in the surface water, except at two nearshore stations where the CH4 levels were above 140% in March due to mixing with the coastal water. During the bloom period, CH4 increased obviously at two bloom-tracking stations, especially at the surface with mean saturations of 140% and 170%. The increase in CH4 concentration/saturation is thought to be the result of in situ CH4 production. The particulate organic carbon (POC) and chlorophyll a contents were believed to be important factors that influ- enced the CH4 production. In addition, the presence of different dominant phytoplankton species and the grazing pressure may have stimulated the CH4 production by supplying potential methanogenic substrates (such as dimethylsulphoniopropionate (DMSP)). Both the incubation data and the in situ estimations further evidenced the significant influence of the spring blooms on the CH4 production. The calculated sea-to-air CH4 fluxes during the bloom period were not significantly higher than those during the pre-bloom period despite the bloom-increased CH4 saturation. This is due to the variation in physical forcing (such as wind speed), which is the main driver for determining the CH4 flux. Finally, we estimated the annual CH4 flux in the YS as 9.0 μmol m 2 d 1;the findings suggest that the YS is a natural source of atmospheric CH4. | YE Wangwang ZHANG Guiling LI Peipei ZHOU Feng LIU Chenggang | 2019 | Journal of Ocean University of China2019，18，4： | 1 |
| 8 | High-performance supercapacitors based on free-standing SiC@PEDOT nanowires with robust cycling stability显示文摘Conductive polymers as one of the candidate materials with pseudocapacitor behavior have inspired wide attentions,because of their high conductivity,fexibility,low cost and excellent processability.However,the intrinsically poor cycling stability induced by the volume change over the doping/dedoping redox process limits their practical applications.Herein,we report the exploration of electrodes with robust cycling capacity for supercapacitors(SCs),which are rationally designed by coating conductive poly(3,4-ethylenedioxythiophene)(PEDOT)around free-standing SiC nanowires using an all-dry oxidative chemical vaper deposition(oCVD)method.The as-constructed SiC@PEDOT nanowire architecture enables a specific capacitance of 26.53 m F/cm^(2)at 0.2 m A/cm^(2),which is~370%to that of SiC nanowire counterpart(7.04 m F/cm^(2)).Moreover,their aqueous-based SCs exhibit robust cycling stability with104%capacity retention after 10000 cycles,which is among the highest values achieved for PEDOTbased SCs. | Wenna Liu Xiaoxiao Li Weijun Li Yumin Ye Hong Wang Peipei Su Weiyou Yang Ya Yang | 2022 | Journal of Energy Chemistry2022，31，3： | 1 |
| 9 | Fengycin produced by Bacillus subtilis NCD-2 plays a major role in biocontrol of cotton seedling damping-off disease显示文摘 | Qinggang Guo Weixin Dong Shezeng Li Xiuyun Lu Peipei Wang Xiaoyun Zhang Ye Wang Ping Ma | 2013 | Microbiological Research2013，，： | 1 |
| 10 | Mitochondrial Regulation of Macrophages in Innate Immunity and Diverse Roles of Macrophages During Cochlear Inflammation显示文摘Macrophages are essential components of the innate immune system and constitute a non-specific first line of host defense against pathogens and inflammation.Mitochondria regulate macrophage activation and innate immune responses in various inflammatory diseases,including cochlear inflammation.The distribution,number,and morphological characteristics of cochlear macrophages change significantly across different inner ear regions under various pathological conditions,including noise exposure,ototoxicity,and age-related degeneration.However,the exact mechanism underlying the role of mitochondria in macrophages in auditory function remains unclear.Here,we summarize the major factors and mitochondrial signaling pathways(e.g.,metabolism,mitochondrial reactive oxygen species,mitochondrial DNA,and the inflammasome)that influence macrophage activation in the innate immune response.In particular,we focus on the properties of cochlear macrophages,activated signaling pathways,and the secretion of inflammatory cytokines after acoustic injury.We hope this review will provide new perspectives and a basis for future research on cochlear inflammation. | Yuan Zhang Fanglei Ye Xiaolong Fu Shen Li Le Wang Yutian Chen Hongmin Li Shaojuan Hao Kun Zhao Qi Feng Peipei Li | 2024 | Neuroscience Bulletin2024，40，2： | 0 |
| 11 | Methanesulphonic acid in aerosols along a cruise path from China to the Arctic Ocean: Spatial and temporal distributions and link with iodine显示文摘Methanesulphonic acid(MSA) may play an important role in the climate change occurring in response to the warming of the Arctic Ocean. However, the spatial and temporal distributions of MSA in this region are poorly understood. We report on the MSA content of aerosols over oceans measured during the 3rd Chinese National Arctic Research Expedition(CHINARE2008) from July to September, 2008. Results show that the aerosol MSA content can be influenced by multiple processes in different areas. In coastal regions, airborne pollutants, especially nitric oxide, may strongly influence the oxidation of dimethyl sulfide(DMS) and increase the concentration of aerosol MSA. In remote areas of the Pacific and Arctic oceans, changes in plankton will indirectly influence the airborne MSA concentration. Moreover, we found fairly similar trends in the variation of the concentrations of total iodine(TI) and MSA in the Arctic during CHINARE2008, suggesting that iodine and MSA may come from similar sources in the Arctic. Compared with the findings from other two cruises, CHINARE1999 and CHINARE2012, we found that sea ice is an extremely important factor that influences the aerosol MSA content in the Arctic. In addition, MSA concentrations may increase in the Arctic in the future caused by sea ice melting due to global warming. | LIU Haoran XIE Zhouqing YE Peipei KANG Hui XU Siqi | 2015 | Advances in Polar Science2015，26，3： | 0 |
| 12 | The heterochronic gene Oryza sativa LIKE HETEROCHROMATIN PROTEIN 1 modulates miR156b/c/i/e levels显示文摘The juvenile-to-adult transition in plants involves changes in vegetative growth and plant architecture;the timing of this transition has important implications for agriculture.The microRNA miR156 regulates this transition and shoot maturation in plants.In Arabidopsis thaliana,deposition of histone H3 trimethylation on lysine 27(H3K27me3,a repressive mark)at the MIR156A/C loci is regulated by Polycomb Repressive Complex 1(PRC1)or PRC2,depending on the developmental stage.The levels of miR156 progressively decline during shoot maturation.The amount of H3K27me3 at MIR156A/C loci affects miR156 levels;however,whether this epigenetic regulation is conserved remains unclear.Here,we found that in rice(Oryza sativa),the putative PRC1 subunit LIKE HETEROCHROMATIN PROTEIN 1(OsLHP1),with the miR156–SQUAMOSA PROMOTER BINDING PROTEIN-LIKE(SPL)module,affects developmental phase transitions.Loss of OsLHP1 function results in ectopic expression of MIR156B/C/I/E,phenocopy of miR156 overexpression,and reduced H3k27me3 levels at MIR156B/C/I/E.This indicates that OsLHP1 has functionally diverged from Arabidopsis LHP1.Genetic and transcriptome analyses of wild-type,miR156b/c-overexpression,and Oslhp1-2 mutant plants suggest that OsLHP1 acts upstream of miR156 and SPL during the juvenile-to-adult transition.Therefore,modifying the OsLHP1–miR156–SPL pathway may enable alteration of the vegetative period and plant architecture. | Yongtao Cui Jingfei Cheng Shuang Ruan Peipei Qi Wei Liu Hongwu Bian Luhuan Ye Yuping Zhang Jiang Hu Guojun Dong Longbiao Guo Yijing Zhang Qian Qian d Xingming Hu | 2020 | Journal of Integrative Plant Biology2020，62，12： | 0 |
| 13 | 3D ball-type self-assemble CeO_(2) nanostructure produced by facile hydrothermal strategy for catalytic wet air oxidation of N,N-dimethylformamide显示文摘CeO_(2)plays an important role in heterogeneous catalysis,and its performance is highly dependent on the oxygen vacancies and surface defects,which can be easily tuned by manipulating the particle dimensions and morphology.In this article,we report a facile strategy to synthesize a new type of CeO_(2)with modified surface property which can improve its ability to active oxygen.The obtained ball-type 3D selfassemble CeO_(2)(M-CeO_(2)) is composed of large amounts of small 1D crystals which are stro ngly connected with each other.Detailed characterizations confirm its morphology,particle size and improved reducibility with abundant fraction of Ce^(3+)and more surface active oxygen when compared with CeO_(2)-nanorods and CeO_(2)-nanocubes.In the catalytic wet air oxidation(CWAO)of N,N-dimethylfo rmamide,the total organic carbon(TOC)and total nitrogen(TN)conversion of M-CeO_(2)at 180℃in 3 h are 68%and 46%,respectively,which are higher than that of CeO_(2)-nanorods and CeO_(2)-nanocubes.Besides,M-CeO_(2) presents the lowest activation energy,which is related to its modified surface property.The good stability with consecutive four reactions of M-CeO_(2)in catalytic reactions suggests its potential application in CWAO processes for industrial wastewater treatment. | Sajid Ali Yue Jiang Zhirong Lai Peipei Zhang Songshou Ye Jiexiang Wang Jile Fu Nuowei Zhang Jinbao Zheng Binghui Chen | 2023 | Journal of Rare Earths2023，41，8： | 0 |
| 14 | 不同温度下质子引起特征尺寸为40 nmFPGA器件单粒子翻转研究显示文摘Field-programmable gate arrays(FPGAs)have now become prevalent in aerospace applications because of their high performance,reduced development cost,high logic density,and re-programmability.SRAM-based FPGAs,in particular,are become more attractive for space applications because its ability to reprogram many times as necessary in a very short period[1].In this paper,the single-event upset(SEU)response versus temperature for the 40 nm SRAM-based FPGA was characterized using different energy proton beams from 16 to 200 MeV. | Ye Bing Liu Jie Liu Tianqi Luo Jie Yin Yanan Ji Qinggang Zhao Peixiong Hou Mingdong Sun Youmei Hu Peipei | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 15 | New energy vehicle:an opportunity for rare earth magnets显示文摘Extracted from Securities Guide 1.Popularity of new energy vehicles—an irresistible market trend1.1 Progress of new energy vehicles Chinese Premier Li Keqiang said recently on a visit to Xi'an BYD Autos that new energy vehicles,especially new energy bus,can lessen environment and noise pollution.He encouraged the use of | Ye Peipei | 2014 | China Rare Earth Information2014，20，7： | 0 |
| 16 | Boosting Fischer-Tropsch Synthesis via Tuning of N Dopants in TiO_(2)@CN-Supported Ru Catalysts显示文摘Nitrogen(N)-doped carbon materials as metal catalyst supports have attracted signifi cant attention,but the eff ect of N dopants on catalytic performance remains unclear,especially for complex reaction processes such as Fischer-Tropsch synthesis(FTS).Herein,we engineered ruthenium(Ru)FTS catalysts supported on N-doped carbon overlayers on TiO_(2)nanoparticles.By regulating the carbonization temperatures,we successfully controlled the types and contents of N dopants to identify their impacts on metal-support interactions(MSI).Our fi ndings revealed that N dopants establish a favorable surface environment for electron transfer from the support to the Ru species.Moreover,pyridinic N demonstrates the highest electron-donating ability,followed by pyrrolic N and graphitic N.In addition to realizing excellent catalytic stability,strengthening the interaction between Ru sites and N dopants increases the Ru^(0)/Ru^(δ+)ratios to enlarge the active site numbers and surface electron density of Ru species to enhance the strength of adsorbed CO.Consequently,it improves the catalyst’s overall performance,encompassing intrinsic and apparent activities,as well as its ability for carbon chain growth.Accordingly,the as-synthesized Ru/TiO_(2)@CN-700 catalyst with abundant pyridine N dopants exhibits a superhigh C_(5+)time yield of 219.4 mol CO/(mol Ru·h)and C_(5+)selectivity of 85.5%. | Xincheng Li Yunhao Liu Dejian Zhao Shuaishuai Lyu Jingwei Ye Xiaoshen Li Peipei Wu Ye Tian Yingtian Zhang Tong Ding Song Song Qingpeng Cheng Xingang Li | 2024 | Transactions of Tianjin University2024，30，1： | 0 |
| 17 | Neural network-based surrogate model for inverse design of metasurfaces显示文摘Metasurfaces composed of spatially arranged ultrathin subwavelength elements are promising photonic devices for manipulating optical wavefronts,with potential applications in holography,metalens,and multiplexing communications.Finding microstructures that meet light modulation requirements is always a challenge in designing metasurfaces,where parameter sweep,gradient-based inverse design,and topology optimization are the most commonly used design methods in which the massive electromagnetic iterations require the design computational cost and are sometimes prohibitive.Herein,we propose a fast inverse design method that combines a physicsbased neural network surrogate model(NNSM)with an optimization algorithm.The NNSM,which can generate an accurate electromagnetic response from the geometric topologies of the meta-atoms,is constructed for electromagnetic iterations,and the optimization algorithm is used to search for the on-demand meta-atoms from the phase library established by the NNSM to realize an inverse design.This method addresses two important problems in metasurface design:fast and accurate electromagnetic wave phase prediction and inverse design through a single phase-shift value.As a proof-of-concept,we designed an orbital angular momentum(de)multiplexer based on a phase-type metasurface,and 200 Gbit/s quadrature-phase shift-keying signals were successfully transmitted with a bit error rate approaching 1.67×10^(-6).Because the design is mainly based on an optimization algorithm,it can address the“one-to-many”inverse problem in other micro/nano devices such as integrated photonic circuits,waveguides,and nano-antennas. | GUOQING JING PEIPEI WANG HAISHENG WU JIANJUN REN ZHIQIANG XIE JUNMIN LIU HUAPENG YE YING LI DIANYUAN FAN SHUQING CHEN | 2022 | Photonics Research2022，10，6： | 0 |
| 18 | Facile synthesis of silicapolymer hybrids via simultaneous RAFT process and hydroxyl-alkoxysilane coupling reaction显示文摘This study aimed at the synthesis of silica particles grafted with better-defined homopolymers and block copolymers by tandem approach.Z-functionalized Sbenzyl S’-(3-trimethoxysilyl)propyltrithiocarbonate(BTPT)was used as a couplable RAFT agent to synthesize the target inorganic-organic hybrids.Simultaneous coupling reaction and RAFT process using silica particles and BTPT as raw materials efficiently afforded homopolymers grafted silica,and RAFTsynthesized macro chain transfer agents withω-terminal trimethoxysilane moiety were utilized to mediate graft reaction to prepare silica particles grafted with di-,tri-and tetrablock copolymers comprised of polymer segments such as polystyrene,polyacrylamides and polyacrylates.When the grafted chains had molecular weights ranging between 3920 and 24800 g/mol,the molar grafting ratios,which were dependent on reaction conditions and types and compositions of grafted chains,were estimated to be in the range of 15.2–101μmol/g,and grafted polymers usually had polydispersity indices lower than 1.3,revealing that the grafting process was almost controllable.To the best of our knowledge,this versatile tandem approach is one of the most facile techniques to prepare silica particles grafted with polymeric chains with controlled molecular weight,low polydispersity and precise composition due to its minimal reaction steps,mild conditions,straightforward synthesis and satisfactory controllability. | Chunnuan YE Weina QI Xinhua YU Peipei ZHANG Tengteng HOU Youliang ZHAO | 2011 | Frontiers of Chemistry in China2011，6，3： | 0 |
| 19 | High-efficiency 3D cell spheroid formation via the inertial focusing effect in rotating droplets显示文摘The three-dimensional(3D)spheroid culture has been widely used as an important tool in biological research.Although several techniques have been established to prepare cell spheroids,fast and controllable production remains one of the major challenges.In this study,a simple but efficient method utilizing the inertial focusing effect in rotating hanging droplets is demonstrated for the rapid and controllable production of cell spheroids. | Tan Tang Peipei Zhang Yanran Wei Hongxing Jia Lin Feng Ye Xu | 2023 | Bio-Design and Manufacturing2023，6，1： | 0 |
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