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| 1 | Paroxetine engenders analgesic effects through inhibition of p38 phosphorylation in a rat migraine model显示文摘In this study,a model of migraine was established by electrical stimulation of the superior sagittal sinus in rats.These rats were then treated orally with paroxetine at doses of 2.5,5,or 10 mg/kg per day for 14 days.Following treatment,mechanical withdrawal thresholds were significantly higher,extracellular concentrations of 5-hydroxytryptamine in the periaqueductal grey matter and nucleus reticularis gigantocellularis were higher,and the expression of phosphorylated p38 in the trigeminal nucleus caudalis was lower.Our experimental findings suggest that paroxetine has analgesic effects in a rat migraine model,which are mediated by inhibition of p38 phosphorylation. | Chuanming Wang Wei Bi Yanran Liang Xiuna Jing Songhua Xiao Yannan Fang Qiaoyun Shi Enxiang Tao | 2012 | Neural Regeneration Research2012，7，13： | 2 |
| 2 | Delivery of cationic polymer-siRNA nanoparticles for gene therapies in neural regeneration显示文摘 | Yanran Liang Zhonglin Liu Xintao Shuai Weiwei Wang Jun Liu Wei Bi Chuanming Wang Xiuna Jing Yunyun Liu Enxiang Tao | 2012 | Biochemical and Biophysical Research Communications2012，，4： | 1 |
| 3 | Parameter Calibration of SWMM Model Based on Optimization Algorithm显示文摘For the challenge of parameter calibration in the process of SWMM(storm water management model)model application,we use particle Swarm Optimization(PSO)and Sequence Quadratic Programming(SQP)in combination to calibrate the parameters and get the optimal parameter combination in this research.Then,we compare and analyze the simulation result with the other two respectively using initial parameters and parameters obtained by PSO algorithm calibration alone.The result shows that the calibration result of PSO-SQP combined algorithm has the highest accuracy and shows highly consistent with the actual situation,which provides a scientific and effective new idea for parameter calibration of SWMM model,moreover,has practical guidance for flood control and disaster mitigation. | Fengchang Xue Juan Tian Wei Wang Yanran Zhang Gohar Ali | 2020 | Computers, Materials & Continua2020，，12： | 1 |
| 4 | Designing and deploying a mixed-reality aquarium for cognitive training of young children with autism spectrum disorder显示文摘Autism spectrum disorder(ASD),a developmental disorder severely affecting cognition and social behavior,is increasing in prevalence[1].This increasing trend is especially severe in children,making the early intervention crucial to ASD treatment.Children with ASD have been found impairments in several aspects of cognition functions. | Juan LIU Yulong BIAN Yanran YUAN Yuting XI Wenxiu GENG Xinpei JIN Wei GAI Xiangmin FAN Feng TIAN Xiangxu MENG Chenglei YANG | 2021 | Science China(Information Sciences)2021，64，5： | 1 |
| 5 | Effects of the submerged macrophyte Ceratophyllum demersum L. on restoration of a eutrophic waterbody and its optimal coverage显示文摘 | Yanran Dai Chenrong Jia Wei Liang Shenghua Hu Zhenbin Wu | 2011 | Ecological Engineering2011，，： | 1 |
| 6 | Removal of arsenic by pilot-scale vertical flow constructed wetland显示文摘Four pilot-scale Vertical Flow Constructed Wetlands(VFCWs)filled with gravel and planted with Phragmites australis were operated for seven months in the field to study the efficiency of arsenic removal in contaminated wastewater.The average arsenic removal efficiency by the VFCWs was 52.0%±20.2%,52.9%±21.3%,and 40.3%±19.4%at the theoretical concentrations of 50µg/L(CW50),100µg/L(CW100),and 500µg/L(CW500)arsenic in the wastewater,respectively.The results also showed no significant differences in the removal efficiency for conventional contaminants(nitrogen,phosphorus,or chemical oxygen demand)between wastewater treatments that did or did not contain arsenic(P>0.05),except for phosphorus in CW500.The highest average monthly removal rate of arsenic occurred in August(55.9%–74.5%)and the lowest in November(7.8%–15.5%).The arsenic removal efficiency of each VFCW was positively correlated with temperature(P<0.05).Arsenic accumulated in both substrates and plants,with greater accumulation associated with increased arsenic concentrations in the influent.The maximum accumulated arsenic concentrations in the substrates and plants at the end of the experiment were 4.47 mg/kg and 281.9 mg/kg,respectively,both present in CW500.The translocation factor(TF)of arsenic in the reeds was less than 1,with most of the arsenic accumulating in the roots.The arsenic mass balance indicated that substrate accumulation contributed most to arsenic removal(19.9%–30.4%),with lower levels in plants(3.8%–9.5%).In summary,VFCWs are effective for the treatment of arsenic-containing wastewater. | Yaocheng Fan Tiancui Li Deshou Cun Haibing Tang Yanran Dai Feihua Wang Wei Liang | 2021 | Frontiers of Environmental Science & Engineering2021，15，4： | 0 |
| 7 | Controllable coating NiAl-layered double hydroxides on carbon nanofibers as anticorrosive microwave absorbers显示文摘For harsh real-world service settings,it is essential to build corrosion-resistant,diverse,and effective microwave absorbers.Herein,we successfully prepared a 3D NiAl-layered double hydroxide/carbon nanofibers(NiAl-LDH/CNFs)composite material as an anticorrosive microwave absorber assisted by an atomic layer deposition(ALD)method.The size,coating thickness,and content of NiAl-LDH can be readily adjusted by changing the ALD cycling numbers.The optimized NiAl-LDH/CNFs demonstrates prominent microwave absorbing properties including the strongest reflection loss of–55.65 dB and the widest effective absorption bandwidth of 4.80 GHz with only 15 wt%loading.The reasons for performance improvement are the cooperative effect of interfacial polarization loss,conduction loss,and three-dimensional porous structure.Moreover,due to the synergistic effects between the excellent impermeability of CNFs and the trapping ability of NiAl-LDH for chloride ions,NiAl-LDH/CNFs exhibits strong corrosion resistances under acidic,neutral,and alkaline conditions.NiAl-LDH/CNFs should be a potential candidate to simultaneously use for microwave absorption and corrosion resistance,and this work provides a certain guiding significance for designing microwave absorbers that satisfy the corrosion resistance. | Ying Zhang Liang Li Changlong Du Gengping Wan Qiyi Wei Xueqing Zhou Yanran Su Yang Xu Guizhen Wang | 2023 | Journal of Materials Science & Technology2023，，20： | 0 |
| 8 | Efficient estimation of smoothing spline with exact shape constraints显示文摘Smoothing spline is a popular method in non-parametric function estimation.For the analysis of data from real applications,specific shapes on the estimated function are often required to ensure the estimated function undeviating from the domain knowledge.In this work,we focus on constructing the exact shape constrained smoothing spline with efficient estimation.The‘exact’here is referred as to impose the shape constraint on an infinite set such as an interval in one-dimensional case.Thus the estimation becomes a so-called semi-infinite optimisation problem with an infinite number of constraints.The proposed method is able to establish a sufficient and necessary condition for transforming the exact shape constraints to a finite number of constraints,leading to efficient estimation of the shape constrained functions.The performance of the proposed methods is evaluated by both simulation and real case studies. | Vincent Chan Kam-Wah Tsui Yanran Wei Zhiyang Zhang Xinwei Deng | 2021 | Statistical Theory and Related Fields2021，5，1： | 0 |
| 9 | TCR–pMHC bond conformation controls TCR ligand discrimination显示文摘A major unanswered question is how a TCR discriminates between foreign and self-peptides presented on the APC surface.Here,we used in situ fluorescence resonance energy transfer(FRET)to measure the distances of single TCR–pMHC bonds and the conformations of individual TCR–CD3ζreceptors at the membranes of live primary T cells.We found that a TCR discriminates between closely related peptides by forming single TCR–pMHC bonds with different conformations,and the most potent pMHC forms the shortest bond.The bond conformation is an intrinsic property that is independent of the binding affinity and kinetics,TCR microcluster formation,and CD4 binding.The bond conformation dictates the degree of CD3ζdissociation from the inner leaflet of the plasma membrane via a positive calcium signaling feedback loop to precisely control the accessibility of CD3ζITAMs for phosphorylation.Our data revealed the mechanism by which a TCR deciphers the structural differences among peptides via the TCR–pMHC bond conformation. | Dibyendu KSasmal Wei Feng Sobhan Roy Peter Leung Yanran He Chufan Cai Guoshuai Cao Huada Lian Jian Qin Enfu Hui Hans Schreiber Erin JAdams Jun Huang | 2020 | Cellular & Molecular Immunology2020，17，3： | 0 |
| 10 | Dibutyl phthalate adsorption characteristics using three common substrates in aqueous solutions显示文摘In recent years,the presence and adverse impacts of phthalic acid esters m aquatic environments have gained increasing attention.This work investigated the adsorption behavior of a typical phthalic acid ester,dibutyl phthalate(DBP),onto steel slag,gravel,and shell sand(substrates commonly used in constructed wetlands).The influence of dissolved organic matter(DOM)on DBP adsorption was investigated using humic acid as a proxy for DOM.The results demonstrated that the adsorption of DBP to three substrates reached equilibrium within 96 h,and the adsorption kinetics were well fitted by a pseudo-second-order model.The DBP adsorption isotherms were best fitted by the Langmuir adsorption model.The DBP adsorption capacity decreased in the order of steel slag>gravel>sheII sand,with values of 656 mg/kg,598 mg/kg,and 6.62 mg/kg at 25°C,respectively.DBP adsorbed to the surface of all substrates in a monolayer via an endothermic process.The DBP adsorption capacities of steel slag and gravel decreased as the DOM content increased.The DBP adsorption mechanisms to steel slag and gravel mainly involved the surface coordination of DBP with-OH or-COOH groups and electrostatic interactions.The results of this work suggest that steel slag and gravel may be ideal substrates for use in constructed wetlands to treat wastewater polluted with DBP. | Tiancui Li Yaocheng Fan Deshou Cun Yanran Dai Wei Liang | 2020 | Frontiers of Environmental Science & Engineering2020，14，2： | 0 |
| 11 | LaNiO3 as a Novel Anode for Lithium-Ion Batteries显示文摘Lithium-ion batteries(LIBs) have been developed for over 30 years;however, existing electrode materials cannot satisfy the increasing requirements of high-energy density, stable cycling, and low cost. Here, we present a perovskite-type LaNiO3 oxide(LNO) as a new negative electrode material. LNO was successfully synthesized by a sol-gel method. The microstructure and electrochemical performance of LNO calcined at various temperatures have been systematically investigated. The LNO electrode shows a high rate capability and long cycling stability. In a C-rate test, a specific capacity of 77 mAh/g was exhibited at 6 C. LNO can also deliver a specific capacity of 92 mAh/g after 200 cycles at 1 C. This paper presents a type of binary metal oxide as a new anode material for high-performance LIBs. | Chang Zhang Cong Wu Zhiwei Zhang Yanran Shen Wei Liu | 2020 | Transactions of Tianjin University2020，26，2： | 0 |
| 12 | Alantolactone inhibits proliferation,metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways显示文摘Although there are many therapeutic strategies such as surgery and chemotherapy,the prognosis of osteosarcoma(OS)is still far from being satisfactory.It is urgent to develop more effective,tolerable and safe drugs for the treatment of OS.In the present study,we investigated the anti-OS activity of Alantolactone(ALT),a natural eucalyptone sesquiterpene lactone mainly exists in Inula helenium,and probed the possible mechanism involved.We demonstrated that ALT significantly inhibited cell proliferation of various human OS cell lines while had relative lower cytotoxicity against normal cells.Then,we validated that ALT reduced migration,decreased invasion possibly through reversing epithelial mesenchymal transition(EMT)process and suppressing Matrix metalloproteinases(MMPs).Moreover,we confirmed that ALT promoted apoptosis and arrested cell cycle at G2/M phase of human OS cells in vitro.In addition,we confirmed that ALT restrained tumor growth and metastasis of OS 143 cells in a xenograft model in vivo.Mechanistically,ALT inhibited the activity of Wnt/β-catenin and p38,ERK1/2 and JNK Mitogen Activated Protein Kinases(MAPKs)signal pathway.Notably,the combination of ALT and Wnt/β-catenin inhibitor,as well as the combination of ALT and MAPKs inhibitors resulted in a synergistically effect on inhibiting the proliferation,migration and invasion of OS cells.Collectively,our results validate the ALT may inhibit proliferation,metastasis and promotes apoptosis of human OS cells possibly through suppressing Wnt/β-Catenin and MAPKs signaling pathways. | Chunmei Yang Lulu Zhang Huakun Huang Xiaohui Yuan Ping Zhang Caihong Ye Mengqi Wei Yanran Huang Xiaoji Luo Jinyong Luo | 2022 | Genes & Diseases2022，9，2： | 0 |
| 13 | Corrigendum to ‘Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways’ [Genes & Diseases 9 (2022) 466–478]显示文摘 | Chunmei Yang Lulu Zhang Huakun Huang Xiaohui Yuan Ping Zhang Caihong Ye Mengqi Wei Yanran Huang Xiaoji Luo Jinyong Luo | 2023 | Genes & Diseases2023，10，2： | 0 |
| 14 | High-efficiency 3D cell spheroid formation via the inertial focusing effect in rotating droplets显示文摘The three-dimensional(3D)spheroid culture has been widely used as an important tool in biological research.Although several techniques have been established to prepare cell spheroids,fast and controllable production remains one of the major challenges.In this study,a simple but efficient method utilizing the inertial focusing effect in rotating hanging droplets is demonstrated for the rapid and controllable production of cell spheroids. | Tan Tang Peipei Zhang Yanran Wei Hongxing Jia Lin Feng Ye Xu | 2023 | Bio-Design and Manufacturing2023，6，1： | 0 |
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