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| 1 | Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis显示文摘 | Xu Xiaojie Fan Zhongyi Kang Lei Han Juqiang Jiang Chengying Zheng Xiaofei Zhu Ziman Jiao Huabo Lin Jing Jiang Kai Ding Lihua Zhang Hao Cheng Long Fu Hanjiang Song Yi Jiang Ying Liu Jiahong Wang Rongfu Du Nan Ye Qinong | 2013 | Journal of Clinical Investigation2013，，2： | 7 |
| 2 | Safety and Efficacy of Combined Trabeculectomy for Primary Angle Closure Glaucoma with Persistent Ocular Hypertension显示文摘Purpose:To investigate the safety and efficacy of combined trabeculectomy for primary acute angle closure glaucoma with persistent ocular hypertension.Methods:A total of 36 patients.(40 eyes).with primary acute angle closure glaucoma,who were treated with combined trabeculectomy in the Ophthalmology Unit of our hospital,were selected.Before the procedure,patients were assigned to ocular hypertension group(≥ 40 mm Hg) or control group(< 40 mm Hg) based on intraocular pressure.These two groups were followed up for one year,and compared for post-operative visual acuity,intraocular pressure,filtering bleb,anterior chamber depth,and the occurrence of complications.Results:At 1 week,6 months,and 12 months after the procedure,intraocular pressure was controlled in both the ocular hypertension group and the control group,without significant differences between the two groups(P>0.05).At 1 week,6 months,and 12 months after the procedure,all of the patients,in both groups,had improved in terms of visual acuity,with a significant difference before and after the procedure for the ocular hypertension group(P<0.05).After follow-up at 12 months,the two groups presented no statistically significant differences in anterior chamber depth,filtering bleb survival,or the incidence of post-operative complications(P>0.05 for all).Conclusion:It is feasible,safe,and effective to perform combined trabeculectomy on patients with primary acute angle closure glaucoma complicated by persistent ocular hypertension. | Xiaojie He Runcai Ye Fei Xu Yizong Yuan | 2011 | Eye Science2011，26，3： | 5 |
| 3 | Role of TRIM33 in Wnt signaling during mesendoderm differentiation显示文摘Tripartite motif 33(TRIM33), a member of the transcription intermediate factor 1(TIF1) family of transcription cofactors,mediates transforming growth factor-beta(TGF-β) signaling through its PHD-Bromo cassette in mesendoderm differentiation during early mouse embryonic development. However, the role of the TRIM33 RING domain in embryonic differentiation is less clear. Here, we report that TRIM33 mediates Wnt signaling by directly regulating the expression of a specific subset of Wnt target genes, and this action is independent of its RING domain. We show that TRIM33 interacts with β-catenin, a central player in Wnt signaling in mouse embryonic stem cells(mESCs). In contrast to previous reports in cancer cell lines, the RING domain does not appear to function as the E3 ligase for β-catenin, since neither knockout nor overexpression of TRIM33 had an effect on β-catenin protein levels in mESCs. Furthermore, we show that although TRIM33 seems to be dispensable for Wnt signaling through a reporter assay, loss of TRIM33 significantly impairs the expression of a subset of Wnt target genes, including Mixl1,in a Wnt signaling-dependent manner. Together, our results indicate that TRIM33 regulates Wnt signaling independent of the E3 ligase activity of its RING domain for β-catenin in mESCs. | Xiaojie Xia Feifei Zuo Maoguo Luo Ye Sun Jianbo Bai Qiaoran Xi | 2017 | Science China(Life Sciences)2017，60，10： | 4 |
| 4 | Hybrid Method Based on Information Gain and Support Vector Machine for Gene Selection in Cancer Classi?cation显示文摘It remains a great challenge to achieve suf?cient cancer classi?cation accuracy with the entire set of genes, due to the high dimensions, small sample size, and big noise of gene expression data. We thus proposed a hybrid gene selection method, Information Gain-Support Vector Machine(IG-SVM) in this study. IG was initially employed to ?lter irrelevant and redundant genes. Then,further removal of redundant genes was performed using SVM to eliminate the noise in the datasets more effectively. Finally, the informative genes selected by IG-SVM served as the input for the LIBSVM classi?er. Compared to other related algorithms, IG-SVM showed the highest classi?cation accuracy and superior performance as evaluated using ?ve cancer gene expression datasets based on a few selected genes. As an example, IG-SVM achieved a classi?cation accuracy of 90.32% for colon cancer, which is dif?cult to be accurately classi?ed, only based on three genes including CSRP1, MYL9, and GUCA2B. | Lingyun Gao Mingquan Ye Xiaojie Lu Daobin Huang | 2017 | Genomics, Proteomics & Bioinformatics2017，15，6： | 3 |
| 5 | Balancing method without trial weights for rotor systems based on similitude scale model显示文摘 | Ruiduo YE Liping WANG Xiaojie HOU Zhong LUO Qingkai HAN | 2018 | Frontiers of Mechanical Engineering2018，13，4： | 3 |
| 6 | Metabolism and immunity in breast cancer显示文摘Breast cancer is one of the most common malignancies that seriously threaten women’s health.In the process of the malignant transformation of breast cancer,metabolic reprogramming and immune evasion represent the two main fascinating characteristics of cancer and facilitate cancer cell proliferation.Breast cancer cells generate energy through increased glucose metabolism.Lipid metabolism contributes to biological signal pathways and forms cell membranes except energy generation.Amino acids act as basic protein units and metabolic regulators in supporting cell growth.For tumor-associated immunity,poor immunogenicity and heightened immunosuppression cause breast cancer cells to evade the host’s immune system.For the past few years,the complex mechanisms of metabolic reprogramming and immune evasion are deeply investigated,and the genes involved in these processes are used as clinical therapeutic targets for breast cancer.Here,we review the recent findings related to abnormal metabolism and immune characteristics,regulatory mechanisms,their links,and relevant therapeutic strategies. | Deyu Zhang Xiaojie Xu Qinong Ye | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 7 | Hierarchical multialgorithm parallel circuit simulation显示文摘 | YE Xiaoji DONG Wei LI Peng | 2011 | IEEE Transactions on Computer-aided Design of Integrated Circuits and Systems2011，30，1： | 1 |
| 8 | 查看详情显示文摘 | Liang Xiaojie Ye Zhengmao Chang Jun | | 0，，02： | 1 |
| 9 | Ionic liquid-based ultrasonic-assisted extraction of piperine from white pepper显示文摘 | Xiaoji Cao Xuemin Ye Yanbin Lu Yi Yu Weimin Mo | 2009 | Analytica Chimica Acta2009，，1： | 1 |
| 10 | The molecular mechanism and potential role of heat shock-induced p53 protein accumulation显示文摘 | Juqiang Han Xiaojie Xu Hongzhen Qin Anheng Liu Zhongyi Fan Lei Kang Jing Fu Jiahong Liu Qinong Ye | 2013 | Molecular and Cellular Biochemistry2013，，1： | 1 |
| 11 | MiR-495 functions as an adjuvant to radiation therapy by reducing the radiation-induced bystander effect显示文摘 | Jie Fu Mengmeng Jiang Meng Zhang Jing Zhang Yu Wang Shensi Xiang Xiaojie Xu Qinong Ye Haifeng Song | 2016 | Acta Biochimica et Biophysica Sinica2016，48，11： | 1 |
| 12 | A closed-loop detection and open-loop control strategy for booms of truck-mounted concrete pump显示文摘 | Xiaojie Sun Hua Ye Shumin Fei | 2012 | Automation in Construction2012，，： | 1 |
| 13 | A closed-loop de tection and open-loop control strategy for booms of truck-mounted concrete pump显示文摘 | Sun Xiaojie Ye Hua Fei Shumin | 2013 | Automation in Con- struction2013，31，5： | 1 |
| 14 | Novel chela?ting resin with cyanoguanidine group: Useful recyclable ma?terials for Hg ( II) removal in aqueous environment 显示文摘 | Ma Xiaojie Li Yanfeng Ye Zhengfang | 2011 | J Hazard Mater2011，185，： | 1 |
| 15 | A closed- loop detection and open - loop control strategy for booms of truck - mounted concrete pump显示文摘 | Sun Xiaojie Ye Hua Fei Shumin | 2013 | Automation in Construction2013，31，： | 1 |
| 16 | Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis显示文摘 | Xu Xiaojie Fan Zhongyi Kang Lei Han Juqiang Jiang Chengying Zheng Xiaofei Zhu Ziman Jiao Huabo Lin Jing Jiang Kai Ding Lihua Zhang Hao Cheng Long Fu Hanjiang Song Yi Jiang Ying Liu Jiahong Wang Rongfu Du Nan Ye Qinong | 2013 | Journal of Clinical Investigation2013，，2： | 1 |
| 17 | An infeasible interior-point algorithm for solving primal and dual geometric programs显示文摘 | Kortanek K O XU Xiaojie YE Yinyu | 1997 | Mathematical Programming1997，76，： | 1 |
| 18 | An infeasible interior-point algorithm for solving primal and dual geometric pro-grams显示文摘 | KORTANEK K 0 XU Xiaojie YE Yinyu | 1997 | Math Programming1997，76，： | 1 |
| 19 | Experimental investigation and feasibility analysis of a thermophotovoltaic cogeneration system in high-temperature production processes显示文摘在 thermophotovoltaic (TPV ) 的一个 Si 房间模块的试验性的 IV 特征系统被调查原文如此使用或 Yb2O3 散热器。当与 fill 因素一起,当散热器温度从 1273 ~ 1573 K 增加时,开电路的电压与房间温度减少时,结果证明电线走火电流增加,导致系统的产量功率的压制的增加。当时,房间模块的最大的产量力量密度是 0.05 W/cm2 温度原文如此散热器是 1573 K,当系统的电的效率仅仅是 0.22% 时。然而,效率与在一样的温度的一个 Yb2O3 散热器是 1.3% 最大的产量力量密度落下到 0.03 W/cm2。开电路的电压和从理论模型获得的最大的输出力量的值遵循试验性的。但是因为接触电阻的存在,理论电线走火电流是更高的。另外, TPV cogeneration 系统与的表演和费用原文如此或用工业高温度的浪费热的 Yb2O3 散热器被分析。系统电的效率能在 1573 K 与一个 Yb2O3 散热器到达 3.1% 。系统费用和投资恢复时期分别地是 6732 EUR/kWel 和 14 年。 | Jianxiang WANG Hong YE Xi WU Hujun WANG Xiaojie XU | 2013 | Frontiers in Energy2013，7，2： | 0 |
| 20 | Genetic Architecture of Childhood Kidney and Urological Diseases in China显示文摘Kidney disease is manifested in a wide variety of phenotypes,many of which have an important hereditary component.To delineate the genotypic and phenotypic spectrum of pediatric nephropathy,a multicenter registration system is being imple-mented based on the Chinese Children Genetic Kidney Disease Database(CCGKDD).In this study,all the patients with kidney and urological diseases were recruited from 2014 to 2020.Genetic analysis was conducted using exome sequencing for families with multiple affected individuals with nephropathy or clinical suspicion of a genetic kidney disease owing to early-onset or extrarenal features.The genetic diagnosis was confirmed in 883 of 2256(39.1%)patients from 23 provinces in China.Phenotypic profiles showed that the primary diagnosis included steroid-resistant nephrotic syndrome(SRNS,23.5%),glomerulonephritis(GN,32.2%),congenital anomalies of the kidney and urinary tract(CAKUT,21.2%),cystic renal disease(3.9%),renal calcinosis/stone(3.6%),tubulopathy(9.7%),and chronic kidney disease of unknown etiology(CKDu,5.8%).The pathogenic variants of 105 monogenetic disorders were identified.Ten distinct genomic disorders were identified as pathogenic copy number variants(CNVs)in 11 patients.The diagnostic yield differed by subgroups,and was highest in those with cystic renal disease(66.3%),followed by tubulopathy(58.4%),GN(57.7%),CKDu(43.5%),SRNS(29.2%),renal calcinosis/stone(29.3%)and CAKUT(8.6%).Reverse phenotyping permitted correct identification in 40 cases with clinical reassessment and unexpected genetic conditions.We present the results of the largest cohort of children with kidney disease in China where diagnostic exome sequencing was performed.Our data demonstrate the utility of family-based exome sequencing,and indicate that the combined analysis of genotype and phenotype based on the national patient registry is pivotal to the genetic diagnosis of kidney disease. | Ye Fang Hua Shi Tianchao Xiang Jiaojiao Liu Jialu Liu Xiaoshan Tang Xiaoyan Fang Jing Chen Yihui Zhai Qian Shen Guomin Li Li Sun Yunli Bi Xiang Wang Yanyan Qian Bingbing Wu Huijun Wang Wenhao Zhou Duan Ma Jianhua Mao Xiaoyun Jiang Shuzhen Sun Ying Shen Xiaorong Liu Aihua Zhang Xiaowen Wang Wenyan Huang Qiu Li Mo Wang Xiaojie Gao Yubin Wu Fang Deng Ruifeng Zhang Cuihua Liu Li Yu Jieqiu Zhuang Qing Sun Xiqiang Dang Haitao Bai Ying Zhu Siguang Lu Bili Zhang Xiaoshan Shao Xuemei Liu Mei Han Lijun Zhao Yuling Liu Jian Gao Ying Bao Dongfeng Zhang Qingshan Ma Liping Zhao Zhengkun Xia Biao Lu Yulong Wang Mengzhun Zhao Jianjiang Zhang Shan Jian Guohua He Huifeng Zhang Bo Zhao Xiaohua LI Feiyan Wang Yufeng Li Hongtao Zhu Xinhui Luo Jinghai Li Jia Rao Hong Xu | 2021 | Phenomics2021，1，3： | 0 |
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