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| 1 | Ultrafast epitaxial growth of metre-sized single-crystal graphene on industrial Cu foil显示文摘A foundation of the modern technology that uses single-crystal silicon has been the growth of highquality single-crystal Si ingots with diameters up to 12 inches or larger. For many applications of graphene, large-area high-quality(ideally of single-crystal) material will be enabling. Since the first growth on copper foil a decade ago, inch-sized single-crystal graphene has been achieved. We present here the growth, in 20 min, of a graphene film of(5 ×50) cm^2 dimension with >99% ultra-highly oriented grains.This growth was achieved by:(1) synthesis of metre-sized single-crystal Cu(1 1 1) foil as substrate;(2)epitaxial growth of graphene islands on the Cu(1 1 1) surface;(3) seamless merging of such graphene islands into a graphene film with high single crystallinity and(4) the ultrafast growth of graphene film.These achievements were realized by a temperature-gradient-driven annealing technique to produce single-crystal Cu(1 1 1) from industrial polycrystalline Cu foil and the marvellous effects of a continuous oxygen supply from an adjacent oxide. The as-synthesized graphene film, with very few misoriented grains(if any), has a mobility up to ~23,000 cm^2 V^(-1)s^(-1)at 4 K and room temperature sheet resistance of ~230 Ω/□. It is very likely that this approach can be scaled up to achieve exceptionally large and high-quality graphene films with single crystallinity, and thus realize various industrial-level applications at a low cost. | Xiaozhi Xu Zhihong Zhang Jichen Dong Ding Yi Jingjing Niu Muhong Wu Li Lin Rongkang Yin Mingqiang Li Jingyuan Zhou Shaoxin Wang Junliang Sun Xiaojie Duan Peng Gao Ying Jiang Xiaosong Wu Hailin Peng Rodney S. Ruoff Zhongfan Liu Dapeng Yu Enge Wang Feng Ding Kaihui Liu | 2017 | Science Bulletin2017，62，15： | 40 |
| 2 | Grasping institutional complexity in infrastructure megaprojects through the multi-level governance system: A case study of the Hong Kong-Zhuhai-Macao Bridge construction显示文摘This study analyzes the design and operation of multi-level governance system for the smooth delivery of infrastructure mega-projects with high institutional complexity caused by market transition. From an institutional perspective, this study scrutinizes the structure,elements, and dynamics of the governance system of infrastructure mega-projects and then proposes an integrative framework based on the inductive case study of the Hong Kong-Zhuhai-Macao Bridge mega-project. Multiple evidences of archives, field studies, and interviews related to the case project are triangulated to further analyze the institutional effects, specifically those with government logics and market structures, on the design and operation of the three-level governance system. Results reveal that the co-evolution between governments and markets in China has shaped the vertical levels of the mega-project governance system and has further affected their evolution and operation across various stages of project development. This study contributes to the rapidly emerging research on complex system governance by proposing a systematic model of three-level mega-project governance to enhance the timely delivery of infrastructure megaprojects within budget. | Yi HU Yun LE Xinglin GAO Yongkui LI Mingqiang LIU | 2018 | Frontiers of Engineering Management2018，5，1： | 9 |
| 3 | Size-Dependent Oxidation-Induced Phase Engineering for MOFs Derivatives Via Spatial Confinement Strategy Toward Enhanced Microwave Absorption显示文摘Precisely reducing the size of metal-organic frameworks(MOFs)derivatives is an effective strategy to manipulate their phase engineering owing to size-dependent oxidation;however,the underlying relationship between the size of derivatives and phase engineering has not been clarified so far.Herein,a spatial confined growth strategy is proposed to encapsulate small-size MOFs derivatives into hollow carbon nanocages.It realizes that the hollow cavity shows a significant spatial confinement effect on the size of confined MOFs crystals and subsequently affects the dielectric polarization due to the phase hybridization with tunable coherent interfaces and heterojunctions owing to size-dependent oxidation motion,yielding to satisfied microwave attenuation with an optimal reflection loss of-50.6 d B and effective bandwidth of 6.6 GHz.Meanwhile,the effect of phase hybridization on dielectric polarization is deeply visualized,and the simulated calculation and electron holograms demonstrate that dielectric polarization is shown to be dominant dissipation mechanism in determining microwave absorption.This spatial confined growth strategy provides a versatile methodology for manipulating the size of MOFs derivatives and the understanding of size-dependent oxidation-induced phase hybridization offers a precise inspiration in optimizing dielectric polarization and microwave attenuation in theory. | Hanxiao Xu Guozheng Zhang Yi Wang Mingqiang Ning Bo Ouyang Yang Zhao Ying Huang Panbo Liu | 2022 | Nano-Micro Letters2022，14，6： | 7 |
| 4 | Tumor microenvironment-responsive hyaluronate-calcium carbonate hybrid nanoparticle enables effective chemo-therapy for primary and advanced osteosarcomas显示文摘Osteosarcoma 是在骨头的最普通的恶意。当前的化疗提议与重要副作用限制了功效,为特别先进并且 relapsed osteosarcomas。提出 Nanoparticle 的化学疗法的药可以被用来解决这些问题,但是这些明确的表达的几个方面仍然保持不能令人满意例如怎么在血液改进他们的稳定性,阻止不受欢迎的药漏,并且在肿瘤提高指向的药累积。在这研究,一个肿瘤微型环境应答的钙碳酸盐(CaCO 3)-crosslinked hyaluronate (哈) nanoparticle 经由一个绿过程被准备有效地为 osteosarcoma 的各种各样的阶段的处理交付 doxorubicin (纪录影片) 。装载纪录影片的 hyaluronate 钙碳酸盐混血儿 nanoparticle (HA-DOX/CaCO 3) 在 vitro 并且在 vivo 表明了优异稳定性,并且当由酸的肿瘤微型环境被触发时,很快在肿瘤地点释放了纪录影片。与免费纪录影片和交叉连接得非的 nanoparticle (哈纪录影片) 相比, HA-DOX/CaCO 3 向鼠科的 osteosarcoma 的主要、先进的模型展出了大多数有势力抑制功效,导致有效肿瘤抑制,改进了幸存时间,并且减少了不利效果。在先进 osteosarcoma 模型,最重要地, HA-DOX/CaCO 3 potently 压制了为特别地的在 84.6% 的生长,为 osteosarcoma 处理显示这个平台的潜力,推进了的肿瘤和 relapsed 盒子。建议多糖 nanoparticle 将是一个有希望的药交货平台预付 osteosarcoma nanomedicine。 | Yi Zhang Lulu Cai Di Li Yeh-Hsing Lao Dingzhuo Liu Mingqiang Li Jianxun Ding Xuesi Chen | 2018 | Nano Research2018，11，9： | 4 |
| 5 | Applications of Nanobiomaterials in the Therapy and Imaging of Acute Liver Failure显示文摘Acute liver failure(ALF),a fatal clinical disease featured with overwhelming hepatocyte necrosis,is a grand challenge in global health.However,a satisfactory therapeutic option for curing ALF is still absent,other than liver transplantation.Nanobiomaterials are currently being developed for the diagnosis and treatment of ALF.The liver can sequester most of nanoparticles from blood circulation,which becomes an intrinsic superiority for nanobiomaterials targeting hepatic diseases.Nanobiomaterials can enhance the bioavailability of free drugs,thereby significantly improving the therapeutic effects in ALF.Nanobiomaterials can also increase the liver accumulation of therapeutic agents and enable more effective targeting of the liver or specific liver cells.In addition,stimuli-responsive,optical,or magnetic nanomaterials exhibit great potential in the therapeutical,diagnostic,and imaging applications in ALF.Therefore,therapeutic agents in combination with nanobiomaterials increase the specificity of ALF therapy,diminish adverse systemic effects,and offer a multifunctional theranostic platform.Nanobiomaterial holds excellent significance and prospects in ALF theranostics.In this review,we summarize the therapeutic mechanisms and targeting strategies of various nanobiomaterials in ALF.We highlight recent developments of diverse nanomedicines for ALF therapy,diagnosis,and imaging.Furthermore,the challenges and future perspectives in the theranostics of ALF are also discussed. | Yuanyuan Jin Haixia Wang Ke Yi Shixian Lv Hanze Hu Mingqiang Li Yu Tao | 2021 | Nano-Micro Letters2021，13，2： | 3 |
| 6 | Generation expansion planning considering efficient linear EENS formulation显示文摘Power system equipment outages are one of the most important factors affecting the reliability and economy of power systems.It is crucial to consider the reliability of the planning problems.In this paper,a generation expansion planning(GEP)model is proposed,in which the candidate generating units and energy storage systems(ESSs)are simultaneously planned by minimizing the cost incurred on investment,operation,reserve,and reliability.The reliability cost is computed by multiplying the value of lost load(VOLL)with the expected energy not supplied(EENS),and this model makes a compromise between economy and reliability.Because the computation of EENS makes the major computation impediment of the entire model,a new efficient linear EENS formulation is proposed and applied in a multi-step GEP model.By doing so,the computation efficiency is significantly improved,and the solution accuracy is still desirable.The proposed GEP model is illustrated using the IEEE-RTS system to validate the effectiveness and superiority of the new model. | Donglei Sun Zhijie Zheng Shuai Liu Mingqiang Wang Yi Sun Dong Liu | 2021 | Global Energy Interconnection2021，4，3： | 1 |
| 7 | Anticarin-β shows a promising antiosteosarcoma effect by specifically inhibiting CCT4 to impair proteostasis显示文摘Unlike healthy, non-transformed cells, the proteostasis network of cancer cells is taxed to produce proteins involved in tumor development. Cancer cells have a higher dependency on molecular chaperones to maintain proteostasis. The chaperonin T-complex protein ring complex(TRiC) contains eight paralogous subunits(CCT1-8), and assists the folding of as many as 10% of cytosolic proteome.TRiC is essential for the progression of some cancers, but the roles of TRiC subunits in osteosarcoma remain to be explored. Here, we show that CCT4/TRiC is significantly correlated in human osteosarcoma,and plays a critical role in osteosarcoma cell survival. We identify a compound anticarin-β that can specifically bind to and inhibit CCT4. Anticarin-β shows higher selectivity in cancer cells than in normal cells. Mechanistically, anticarin-β potently impedes CCT4-mediated STAT3 maturation. Anticarin-β displays remarkable antitumor efficacy in orthotopic and patient-derived xenograft models of osteosarcoma.Collectively, our data uncover a key role of CCT4 in osteosarcoma, and propose a promising treatment strategy for osteosarcoma by disrupting CCT4 and proteostasis. | Gan Wang Min Zhang Ping Meng Chengbo Long Xiaodong Luo Xingwei Yang Yunfei Wang Zhiye Zhang James Mwangi Peter Muiruri Kamau Zhi Daic Zunfu Ke Yi Zhang Wenlin Chen Xudong Zhao Fei Ge Qiumin Lv Mingqiang Rong Dongsheng Li Yang Jin Xia Sheng Ren Lai | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 1 |
| 8 | A minute magneto hydro dynamic (MHD) stirrer显示文摘 | BAU HAIM H ZHONG JIHUA YI MINGQIANG | 2001 | Sensors and Actuators2001，79，： | 1 |
| 9 | A minute magneto hydro dynamic (MHD) mixer显示文摘 | Bau H H Jihua Zhong Mingqiang Yi | 2001 | Sensors and Actuators B2001，79，23： | 1 |
| 10 | Stem cell-derived hepatocyte therapy using versatile biomimetic nanozyme incorporated nanofiber-reinforced decellularized extracellular matrix hydrogels for the treatment of acute liver failure显示文摘Reactive oxygen species(ROS)-associated oxidative stress,inflammation storm,and massive hepatocyte necrosis are the typical manifestations of acute liver failure(ALF),therefore specific therapeutic interventions are essential for the devastating disease.Here,we developed a platform consisting of versatile biomimetic copper oxide nanozymes(Cu NZs)-loaded PLGA nanofibers(Cu NZs@PLGA nanofibers)and decellularized extracellular matrix(dECM)hydrogels for delivery of human adipose-derived mesenchymal stem/stromal cells-derived hepatocyte-like cells(hADMSCs-derived HLCs)(HLCs/Cu NZs@fiber/dECM).Cu NZs@PLGA nanofibers could conspicuously scavenge excessive ROS at the early stage of ALF,and reduce the massive accumulation of pro-inflammatory cytokines,herein efficiently preventing the deterioration of hepatocytes necrosis.Moreover,Cu NZs@PLGA nanofibers also exhibited a cytoprotection effect on the transplanted HLCs.Meanwhile,HLCs with hepatic-specific biofunctions and anti-inflammatory activity acted as a promising alternative cell source for ALF therapy.The dECM hydrogels further provided the desirable 3D environment and favorably improved the hepatic functions of HLCs.In addition,the pro-angiogenesis activity of Cu NZs@PLGA nanofibers also facilitated the integration of the whole implant with the host liver.Hence,HLCs/Cu NZs@fiber/dECM performed excellent synergistic therapeutic efficacy on ALF mice.This strategy using Cu NZs@PLGA nanofiber-reinforced dECM hydrogels for HLCs in situ delivery is a promising approach for ALF therapy and shows great potential for clinical translation. | Yuanyuan Jin Jiabin Zhang Yanteng Xu Ke Yi Fenfang Li Huicong Zhou Haixia Wang Hon Fai Chan Yeh-Hsing Lao Shixian Lv Yu Tao Mingqiang Li | 2023 | Bioactive Materials2023，，10： | 0 |
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