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| 1 | A reversed CD4/CD8 ratio of tumor-infiltrating lymphocytes and a high percentage of CD4^(+)FOXP3^(+) regulatory T cells are significantly associated with clinical outcome in squamous cell carcinoma of the cervix显示文摘In this study,40 biopsy samples collected from cervical cancer patients at the First Affiliated Hospital of Xi’an Jiaotong University,China,were retrospectively assessed using immunohistochemistry for CD4^(+) and CD8^(+) tumor-infiltrating lymphocytes(TILs)and were analyzed for the expression of FOXP3,OX40,granzyme B(GrB)and perforin(Prf).The proliferating index of the TILs was determined by assessing Ki67 expression.We determined the prognostic value of low and high numbers of TILs on survival by performing Kaplan–Meier analysis using median values as the cut-off points.Except for the number of CD4^(+)FOXP3^(+) regulatory T cells(Tregs)and the CD4/CD8 ratio,none of the CD4^(+),CD8^(+),OX401,GrB^(+) or Prf^(+) TILs were associated with the overall 5-year survival rate.The 5-year survival rate was significantly lower in patients who had a high percentage of Tregs as compared with the those who had a lower percentage(35.3%versus 88.9%,P50.001),while the 5-year survival rate was significantly higher in patients with a high CD4/CD8 ratio as compared with patients who had a low CD4/CD8 ratio(82.4%versus 44.4%,P50.029).When we considered the deaths and surviving cases as separate groups,we found that both the number of CD4^(+) T cells and the CD4/CD8 ratio were significantly lower in patients who died as compared with those who survived(26.33±11.80 versus 47.79±38.18,P=0.023 and 0.60±0.25 versus 1.17±1.02,P=0.019,respectively).In conclusion,decreased proportions of tumor-infiltrating CD4^(+) T cells with high percentages of Tregs and reversed CD4/CD8 ratios were significantly associated with the clinical outcome of patients with cervical carcinoma. | Walayat Shah Xiaofei Yan Li Jing Yi Zhou Hongwei Chen Yili Wang | 2011 | Cellular & Molecular Immunology2011，8，1： | 24 |
| 2 | Federated Learning for 6G Communications:Challenges,Methods,and Future Directions显示文摘As the 5G communication networks are being widely deployed worldwide,both industry and academia have started to move beyond 5G and explore 6G communications.It is generally believed that 6G will be established on ubiquitous Artificial Intelligence(AI)to achieve data-driven Machine Learning(ML)solutions in heterogeneous and massive-scale networks.However,traditional ML techniques require centralized data collection and processing by a central server,which is becoming a bottleneck of large-scale implementation in daily life due to significantly increasing privacy concerns.Federated learning,as an emerging distributed AI approach with privacy preservation nature,is particularly attractive for various wireless applications,especially being treated as one of the vital solutions to achieve ubiquitous AI in 6G.In this article,we first introduce the integration of 6G and federated learning and provide potential federated learning applications for 6G.We then describe key technical challenges,the corresponding federated learning methods,and open problems for future research on federated learning in the context of 6G communications. | Yi Liu Xingliang Yuan Zehui Xiong Jiawen Kang Xiaofei Wang Dusit Niyato | 2020 | China Communications2020，17，9： | 21 |
| 3 | Spatial pattern and decadal change of agro-meteorological disasters in the main wheat production area of China during 1991-2009显示文摘Agro-meteorological disasters(AMD) have become more frequent with climate warming. In this study, the temporal and spatial changes in the occurrence frequency of major meteorological disasters on wheat production were firstly explored by analyzing the observed records at national agro-meteorological stations(AMS) of China from 1991 to 2009. Furthermore, impact of climate change on AMD was discussed by comparing the warmer decade(2000–2009) with another decade(1991–2000). It was found that drought was the most frequent disaster during the last two decades, with a highest proportion of 79%. And the frequency of AMD increased significantly with climate change. Specifically, the main disasters occurred more frequently in the reproductive period than in the vegetative period. Besides, the spatial changes in the AMD frequency were characterized by region-specific. For example, the wheat cultivation areas located on the Loess Plateau and the middle-lower reaches of the Yellow River suffered mainly from drought. All these results were strongly linked to climate change in China. Therefore, sound adaptation options should be taken based on the latest changes of AMD under global warming to reduce agricultural damages. | ZHANG Zhao WANG Pin CHEN Yi ZHANG Shuai TAO Fulu LIU Xiaofei | 2014 | Journal of Geographical Sciences2014，24，3： | 19 |
| 4 | Tissue clearing of both hard and soft tissue organs with the PEGASOS method显示文摘织物空地技术由转织物在 3 尺寸(3-D ) 启用不透明的机关和纸巾的可视化透明。当前的组织空地方法被能与每个单个协议被清除的纸巾的有限类型限制,它不可避免地导致了存在在整个身体或身体部分成像以内盲点。包括骨头和牙齿的难纸巾仍然是要清除的最困难的机关。另外,内长的荧光的损失为基于溶剂的空地方法仍然是一颗主要担心。这里,我们发展了聚乙烯乙二醇(木钉) 联系了溶剂系统(PEGASOS ) ,它将近显示了纸巾的所有类型透明、保存的内长的荧光。骨头和牙齿能被转在变清以后将近不可见。PEGASOS 方法转了透明的整个成年老鼠身体,我们对一个成年老鼠头骨头,牙齿,大脑,肌肉,和其它填写了的图象有能力没有盲目区域的纸巾。难织物透明性使我们能重建在 3-D 的未经触动的上颚,牙齿,腿节,或膝关节。另外,我们在长距离上在亚 cellular 分辨率并且到踪迹个人神经原和轴突管理了未经触动的鼠标大脑到图象。我们也通过 vertebrae 直接设想了背面的根中心。最后,我们在长骨头的髓空间以内在 3-D 揭示了神经网络的分发模式。这些结果建议 PEGASOS 方法是为一般生物医学的研究的一个有用工具。 | Dian Jing Shiwen Zhang Wenjing Luo Xiaofei Gao Yi Men Chi Ma Xiaohua Liu Yating Yi Abhijit Bugde Bo O. Zhou Zhihe Zhao Quan Yuan Jian Q. Feng Liang Gao Woo-Ping Ge Hu Zhao | 2018 | Cell Research2018，28，8： | 18 |
| 5 | Consensus on the application of negative pressure wound therapy of diabetic foot wounds显示文摘Because China is becoming an aging society,the incidence of diabetes and diabetic foot have been increasing.Diabetic foot has become one of the main health-related killers due to its high disability and mortality rates.Negative pressure wound therapy(NPWT)is one of the most effective techniques for the treatment of diabetic foot wounds and great progress,both in terms of research and its clinical application,has been made in the last 20 years of its development.However,due to the complex pathogenesis and management of diabetic foot,irregular application of NPWT often leads to complications,such as infection,bleeding and necrosis,that seriously affect its treatment outcomes.In 2020,under the leadership of Burns,Trauma and Tissue Repair Committee of the Cross-Straits Medicine Exchange Association,the writing group for‘Consensus on the application of negative pressure wound therapy of diabetic foot wounds’was established with the participation of scholars from the specialized areas of burns,endocrinology,vascular surgery,orthopedics and wound repair.Drawing on evidence-based practice suggested by the latest clinical research,this consensus proposes the best clinical practice guidelines for the application and prognostic evaluation of NPWT for diabetic foot.The consensus aims to support the formation of standardized treatment schemes that clinicians can refer to when treating cases of diabetic foot. | Shizhao Ji Xiaobin Liu Jie Huang Junmin Bao Zhaohong Chen Chunmao Han Daifeng Hao Jingsong Hong Dahai Hu Yufeng Jiang Shang Ju Hongye Li Zongyu Li Guangping Liang Yan Liu Gaoxing Luo Guozhong Lv Xingwu Ran Zhongmin Shi Juyu Tang Aiping Wang Guangyi Wang Jiangning Wang Xin Wang Bing Wen Jun Wu Hailin Xu Maojin Xu Xiaofei Ye Liangxi Yuan Yi Zhang Shichu Xiao Zhaofan Xia | 2021 | Burns & Trauma2021，9，1： | 17 |
| 6 | Impact of chilling injury and global warming on rice yield in Heilongjiang Province显示文摘这研究为米饭集中于索引在 Heilongjiang 省的寒心的损害在 19602009 期间。第一,我们比较了由与传统的方法种密度的米饭加权的一个新导出的气候数据,并且发现新的是更合理的在庄稼收益上估计气候变化的影响。就在第二,寒心的索引由气象学、国家、国际的层次定义的省寒心的米饭的频率和紧张而言被估计。,结果证明气象学的标准对延期类型损害合适国际的,在阀值(GDDn ) 下面种度白天的所谓的和,描绘的最好为米饭的无菌类型的寒心的损害。当二个独立变量到达了约 92% ,包括两损害的米饭收益时间系列模型的解释能力打字(p < 0.05 ) 。最后,我们断定到米饭收益的人和天气因素的贡献率是大约87.2%和12.8%分别地,并且作为光增加的趋势因为无菌类型的寒心的损害在在最近的年里出发到流动时期期间被发现,为在未来在 Heilongjiang 省种的米饭显示高寒心的风险全球温暖。 | LIU Xiaofei ZHANG Zhao SHUAI Jiabing WANG Pin SHI Wenjiao TAO Fulu CHEN Yi | 2013 | Journal of Geographical Sciences2013，23，1： | 16 |
| 7 | Study on preparation and properties of CeO_2/epoxy resin composite coating on sintered NdFeB magnet显示文摘The CeO_2/epoxy resin composite coating was deposited on NdFeB substrate by cathode electrophoresis method for enhancing the anticorrosion and anti-wear performances. The morphologies and structures were characterized by a scanning electron microscope and an X-ray diffractometer. The micro hardness of the composite coating was evaluated by a microhardness tester. The corrosive behaviors of the coatings were studied by potentiodynamic polarization curve, electrochemical impedance spectroscopy and neutral salt spray tests. The concentration of CeO_2 nanoparticles(NPs) in the electrophoresis bath was optimized according to the coating structures and anticorrosion performances. The results show that CeO_2 NPs can enhance the microhardness of the composite coatings. Moreover, the nanoparticles disperse uniformly in the matrix when the concentration is lower than 30 g/L. The microhardness of CeO_2/epoxy resin(30 g/L) composite coating is about 63% higher than that of the blank epoxy resin coating. And the NSS time of the CeO_2/epoxy resin(30 g/L) composite coated sample can reach 1248 h.Meanwhile, the composite coatings possess no deteriorate influence on the magnetic properties of NdFeB substrates. The anticorrosion mechanisms of the composite coatings on the NdFeB substrate are deeply discussed. | Pengjie Zhang Minggang Zhu Wei Li Guangqing Xu Xiulian Huang Xiaofei Yi Jingwu Chen Yucheng Wu | 2018 | Journal of Rare Earths2018，36，5： | 8 |
| 8 | Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis显示文摘 | Xu Xiaojie Fan Zhongyi Kang Lei Han Juqiang Jiang Chengying Zheng Xiaofei Zhu Ziman Jiao Huabo Lin Jing Jiang Kai Ding Lihua Zhang Hao Cheng Long Fu Hanjiang Song Yi Jiang Ying Liu Jiahong Wang Rongfu Du Nan Ye Qinong | 2013 | Journal of Clinical Investigation2013，，2： | 7 |
| 9 | Azithromycin enhances anticancer activity of TRAIL by inhibiting autophagy and up-regulating the protein levels of DR4/5 in colon cancer cells in vitro and in vivo显示文摘Background:Azithromycin is a member of macrolide antibiotics,and has been reported to inhibit the proliferation of cancer cells.However,the underlying mechanisms are not been fully elucidated.Tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)selectively targets tumor cells without damaging healthy cells.In the present study,we examined whether azithromycin is synergistic with TRAIL,and if so,the underlying mechanisms in colon cancers.Methods:HCT-116,SW480,SW620 and DiFi cells were treated with azithromycin,purified TRAIL,or their combina-tion.A sulforhoddamine B assay was used to examine cell survival.Apoptosis was examined using annexin V-FITC/PI staining,and autophagy was observed by acridine orange staining.Western blot analysis was used to detect protein expression levels.In mechanistic experiments,siRNAs were used to knockdown death receptors(DR4,DR5)and LC-3B.The anticancer effect of azithromycin and TRAIL was also examined in BALB/c nude mice carrying HCT-116 xenografts.Results:Azithromycin decreased the proliferation of HCT-116 and SW480 cells in a dose-dependent manner.Combination of azithromycin and TRAIL inhibited tumor growth in a manner that could not be explained by additive effects.Azithromycin increased the expressions of DR4,DR5,p62 and LC-3B proteins and potentiated induction of apoptosis by TRAIL.Knockdown of DR4 and DR5 with siRNAs increased cell survival rate and decreased the expression of cleaved-PARP induced by the combination of azithromycin and TRAIL.LC-3B siRNA and CQ potentiated the anti-proliferation activity of TRAIL alone,and increased the expressions of DR4 and DR5.Conclusion:The synergistic antitumor effect of azithromycin and TRAIL mainly relies on the up-regulations of DR4 and DR5,which in turn result from LC-3B-involved autophagy inhibition. | Xinran Qiao Xiaofei Wang Yue Shang Yi Li Shu-zhen Chen | 2018 | Cancer Communications2018，38，1： | 5 |
| 10 | Adaptive Cascaded High-Resolution Source Localization Based on Collaboration of Multi-UAVs显示文摘Effective information fusion is very important in hybrid source localization. In this paper, the performance analysis of conventional joint direction of arrival(DOA) and time difference of arrival(TDOA) system is derived and it is shown that this hybrid system may inferior to the single system when the ratio of angular measurements error to distance measurements error exceeds a threshold. To avoid this problem, an effective DOA/TDOA adaptive cascaded(DTAC) technique is presented. The rotation feature of UAVs and spatial filtering technique are applied to gain the signal-to-noise ratio(SNR), which leads to more accurate estimation of time delay by using DOAs. Nevertheless, the time delay estimation precision is still limited by the sampling frequency, which is constrained by the finite load of UAV. To break through the limitation, an enhanced self-delay-compensation(SDC) method is proposed, which aims at detecting the overlooked time delay within the sampling interval by adding a tiny time delay. Finally, the position of the source is estimated by the Chan algorithm. Compared to DOA-only algorithm, TDOA-only algorithm and joint DOA/TDOA(JDT) algorithm, the proposed method shows better localization accuracy regardless of different SNRs and sampling frequencies. Numerical simulations are presented to validate the effectiveness and robustness of the proposed algorithm. | Yi He Jianfeng Li Xiaofei Zhang | 2020 | China Communications2020，17，4： | 4 |
| 11 | Coercivity enhancement mechanism of grain boundary diffused Nd-Fe-B sintered magnets by magnetic domain evolution observation显示文摘The grain boundary diffusion(GBD) technology was used to prepare high performance Nd-Fe-B sintered magnets by NdH3 and TbH3 nanoparticle diffusion.The factors affecting the coercivity of GBD magnets include distribution of rare earth rich grain boundary phase and substitution of the heavy rare earth.In order to distinguish the influence of various factors on the coercivity,the microstructure and magnetic domain evolution of the original,reference,Nd-diffused,and Tb-diffused magnets were analyzed.The core-shell structure formed by heavy rare earth substitution is the main factor of coercivity enhancement,and it can transform the magnetic domain reversal mode from easy-nucleation(EN) to difficultnucleation(DN).With increasing the diffusion depth,the shell of the core-shell structure gradually becomes thinner,DN grains gradually decrease while the EN grains gradually increase,indicating that the magnetic domain reversal mode is directly related to the core-shell structure. | Weiqiang Liu Yi Li Dan Wu Ming Yue Zhanjia Wang Shanshun Zha Youhao Liu Xiaofei Yi Yihui Du | 2021 | Journal of Rare Earths2021，39，6： | 2 |
| 12 | Effects of bias voltage on coating structures and anticorrosion performances of PA-PVD Al coated NdFeB magnets显示文摘Al coated NdFeB magnets were prepared by plasma-assisted-physical-vapor-deposition(PA-PVD)method fo r enhancing the corro sion resistance.Mo rphologies and structures were characterized by an Xray diffractometer and a scanning electron microscope.Corrosion behaviors of the samples with different bias voltages were studied by electrochemical methods and neutral salt spray test,respectively.The bias voltage during the deposition process was optimized according to the coating structures and corrosion resistances.The density and flatness of Al coating increase with increasing the bias voltage,and at the same time the thickness decreases.The coating density and thickness turn to be stable when bias voltage is 1800 V.Also,the corrosion behaviors of PA-PVD Al coatings in different media,such as NaOH,HNO_(3) and NaCl solutions,were studied.The self-corrosion potentials(E_(corr)) of PA-PVD Al coatings almost keep constant in NaOH and HNO_(3) solutions with diffe rent concentrations.However,the self-corrosion current densities(J_(corr)) decrease with the increasing concentrations.E_(corr) shifts to negative potential and J_(corr)decreases gradually when increasing the concentration of NaCl solution.The corrosion mechanisms of Al coatings are discussed based on the corrosion behaviors in different media. | Yujie Cao Pengjie Zhang Wei Sun Weifeng Zhang Hanzhong Wei Jiquan Wang Bingshan Li Xiaofei Yi Guangqing Xu Yucheng Wu | 2021 | Journal of Rare Earths2021，39，6： | 2 |
| 13 | 17β-Estradiol attenuates blood–brain barrier disruption induced by cerebral ischemia–reperfusion injury in female rats显示文摘 | Ran Liu Yi Wen Evelyn Perez Xiaofei Wang Arthur L. Day James W. Simpkins Shao-Hua Yang | 2005 | Brain Research2005，，1： | 1 |
| 14 | MicroRNA-193b regulates proliferation, migration and invasion in human hepatocellular carcinoma cells显示文摘 | Chengwang Xu Shanshan Liu Hanjiang Fu Shuai Li Yi Tie Jie Zhu Ruiyun Xing Yinghua Jin Zhixian Sun Xiaofei Zheng | 2010 | European Journal of Cancer2010，，15： | 1 |
| 15 | Correlation of mechanical anisotropy with fine grain strengthening for Sm_(2)Co_(17)-type sintered permanent magnets显示文摘The as-solution-treated Sm_(2)Co_(17)-type magnets exhibiting a single 1:7 H phase with different average grain sizes(D) were designed.Anisotropy of bending strength(R_(bb))and compressive strength(R_(mc)) of the magnets were investigated.Moreover,the R_(bb) increases from 86 to 173 MPa with D decreasing from~52 to~18 μm for group c//h samples.The Hall-Petch correlation was employed to reveal the effect of grain size on mechanical properties of the magnets,giving deep understanding of the mechanical anisotropy characteristics.The relatively high Hall-Petch coefficient K^(Rbb)(0.79 MPa·m^(1/2)) gives rise to the largest R_(bb)(173 MPa) for group c//h samples.The mechanical anisotropy of the samples is well explained based on crystal structure and grain size features(grain boundaries).Grain refinement is an effective way to enhance the mechanical properties of Sm_(2)Co_(17)-type sintered magnets. | Lei Wang Chao Wang Qiangfeng Li Youhao Liu Yikun Fang Xiaofei Yi Wei Li | 2022 | Journal of Rare Earths2022，40，10： | 1 |
| 16 | Identification of human fetal liver miRNAs by a novel method显示文摘 | Hanjiang Fu Yi Tie Chengwang Xu Zhuoyuan Zhang Jie Zhu Yingxu Shi Hong Jiang Zhixian Sun Xiaofei Zheng | 2005 | FEBS Letters2005，，17： | 1 |
| 17 | Spatial and temporal changes of agro-meteorological disasters affecting maize production in China since 1990显示文摘 | Zhao Zhang Yi Chen Pin Wang Shuai Zhang Fulu Tao Xiaofei Liu | 2014 | Natural Hazards2014，，3： | 1 |
| 18 | A novel method for ionizing radiation-induced RNA damage detection by poly(A)-tailing RT-PCR显示文摘Ionizing radiation (IR) causes severe cellular damage both directly and indirectly and disrupts RNA integrity. RNA strand breaks are the most frequent type of damage caused by IR. RNA damage is involved in the development of degenerative diseases, including Alzheimer’s disease and Parkinson’s disease. However, the mechanism of mRNA damage and any resulting pathophysiological outcomes are poorly understood. This is partly because there is a lack of sensitive tools to monitor damage randomly occurring in RNA, especially RNA strand break damage in a given RNA. In this work, a method using the reverse transcription polymerase chain reaction (RT-PCR) after poly(A) addition to 3′-end of RNA to determine RNA strand break damage in a specific RNA by poly(A) polymerase has been developed. The levels of damage in specific mRNAs, including ABL1, TP53, GADD45A and ATR from IR-treated HeLa cells were examined. Strand breaks were detected in all mRNAs examined. The study provides a novel and sensitive method based on 3 -end poly(A)-tailing RT-PCR to monitor RNA strand break damage. | TIE Yi HU Zheng LU GuiXiang FU HanJiang XING RuiYun ZHU Jie SUN ZhiXian HENG XiaoFei | 2011 | Chinese Science Bulletin2011，56，30： | 1 |
| 19 | Correlation of microRNAs responding to high dose γ-irradiation with predicted target mRNAs in HeLa cells using microarray analyses显示文摘An increasing data indicates that altered microRNAs(miRNAs)participate in the radiation-induced DNA damage response.However,a correlation of mRNA and miRNA profiles across the entire genome and in response to irradiation has not been thoroughly assessed.We analyzed miRNA microarray data collected from HeLa cells after ionizing radiation(IR),quantified the expression profiles of mRNAs and performed comparative analysis of the data sets using target prediction algorithms,Gene Ontology(GO)analysis,pathway analysis,and gene network construction.The results showed that the altered miRNAs were involved in regulation of various cellular functions.miRNA-gene network analyses revealed that miR-186,miR-106b,miR-15a/b,CCND1and CDK6 played vital role in the cellular radiation response.Using qRT-PCR,we confirmed that twenty-two miRNAs showed differential expression in HeLa cells treated with IR and some of these miRNAs affected cell cycle progression.This study demonstrated that miRNAs influence gene expression in the entire genome during the cellular radiation response and suggested vital pathways for further research. | HU Zheng TIE Yi Lü GuiXiang FU HanJiang XING RuiYun ZHU Jie SUN ZhiXian ZHENG XiaoFei | 2013 | Chinese Science Bulletin2013，58，36： | 1 |
| 20 | A critical review of on-site inorganic arsenic screening methods显示文摘Approximately 94 to 220 million people worldwide are at risk of drinking well water containing arsenic > 10 μg/L, the WHO guideline value. To identify non-compliant domestic wells, assess health risks and reduce exposure, accurate and rapid on-site inorganic arsenic screening methods are desirable because all domestic wells worldwide need to be tested.Here, the principles, advantages and limitations of commonly used colorimetry, electrochemistry, and biosensing methods are critically reviewed, with the performance compared with laboratory-based benchmark methods. Most commercial kits are based on the classic Gutzeit reaction. Despite being semi-quantitative, the more recent and more expensive products display improved and acceptable accuracy and shorter testing time (~10 min). Carried out by trained professionals, electrochemical methods are also feasible for on-site analysis, although miniaturization is desirable yet challenging. Biosensing using whole bacterial cells or bio-engineered materials such as aptamers is promising, if incorporated with function specific nanomaterials and biomaterials. Since arsenic is frequently found as arsenite in reducing groundwater and subject to oxidation during sampling, transportation and storage, on-site separation and sample preservation are feasible but the specific methods should be chosen based on sample matrix and tested before use. To eliminate arsenic exposure among hundreds of millions of mostly rural residents worldwide, we call for concerted efforts in research community and regulatory authority to develop accurate, rapid, and affordable tests for on-site screening and monitoring of arsenic in drinking water. Access to affordable testing will benefit people who are socioeconomically disadvantaged. | Yi He Jingyu Liu Yanhua Duan Xiaofei Yuan Lulu Ma Ratan Dhar Yan Zheng | 2023 | Journal of Environmental Sciences2023，，3： | 1 |
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