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| 1 | Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopathologic features in human hepatocellular carcinoma显示文摘BACKGROUND: Angiogenesis is known to be essential to the survival, growth, invasion, and metastasis of tumor cells. Vascular endothelial growth factor (VEGF) are an important angiogenic factor regulating tumor angiogenesis, but its significance and tumor pathologic features are un- clear in hepatocellular carcinoma (HCC). In the present study, we analyzed expression of tissue VEGF, alteration of microvascular density (MVD) in microvessel angiogenesis, development and metastasis of HCC, and level of serum VEGF in differential diagnosis of benign and malignant liv- er diseases. METHODS: Tumor specimens were prospectively collected from HCC patients undergoing resection. Total RNAs were extracted and the expression levels were detected from different parts of HCC tissues. The cellular distributions of VEGF and MVD of liver tumors and their paracancerous and distal cancerous tissues were investigated by streptavi- din peroxidase (S-P) immunohistochemistry, respectively. The VEGF levels of circulating blood and hepatoma tissues were measured by enzyme-linked immunosorbent assay. RESULTS: The incidence of VEGF expression was 63.9% in HCCs (23/36 cases), 78.3% in non-encapsulated HCCs (18/23), and 90.9% in HCCs with extrahepatic metastasis (10/11), respectively. The VEGF expression was tightly correlated with MVD (P <0.01). The MVD in HCC with metastasis, low differentiation or non-encapsulation was significantly higher than that in HCC with intact capsule, high differentiation, or no metastasis. No significant diffe- rence was found between VEGF, MVD, tumor size, and hepatitis virus infection. The level of total RNA in HCC tis- sues was significantly lower but the VEGF level significantly higher than those in paracancerous or distal cancerous ones (P<0.01). The abnormal expression levels of VEGF in sera of HCC patients were directly correlated with the me- tastasis and recurrence of tumors. CONCLUSION: The high expression of VEGF and abnor- mality of tissue MVD are useful predictors for vascular inva- sion and metastasis of liver tumors. | Deng-Fu Yao, Xin-Hua Wu, Yong Zhu, Gong-Sheng Shi, Zhi-Zhen Dong, Deng-Bing Yao, Wei Wu, Li-Wei Qiu and Xian-Yong Meng Nantong, China Research Center of Clinical Molecular Biology , Department of Pathology and Department of Gastroenterology , Affiliated Hos- pital of Nantong University Department of Diagnostics , and Institute of Neurosciences , Nantong University Nantong 226001, China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，2： | 81 |
| 2 | China Stroke Statistics 2019:A Report From the National Center for Healthcare Quality Management in Neurological Diseases,China National Clinical Research Center for Neurological Diseases,the Chinese Stroke Association,National Center for Chronic and Non-communicable Disease Control and Prevention,Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations显示文摘China faces the greatest challenge from stroke in the world.The death rate for cerebrovascular diseases in China was 149.49 per 100000,accounting for 1.57 million deaths in 2018.It ranked third among the leading causes of death behind malignant tumours and heart disease.The age-standardised prevalence and incidence of stroke in 2013 were 1114.8 per 100000 population and 246.8 per 100000 person-years,respectively.According to the Global Burden of Disease Study 2017,the years of life lost(YLLs)per 100000 population for stroke increased by 14.6%;YLLs due to stroke rose from third highest among all causes in 1990 to the highest in 2017.The absolute numbers and rates per 100000 population for all-age disability-adjusted life years(DALYs)for stroke increased substantially between 1990 and 2017,and stroke was the leading cause of all-age DALYs in 2017.The main contributors to cerebrovascular diseases include behavioural risk factors(smoking and alcohol use)and pre-existing conditions(hypertension,diabetes mellitus,dyslipidaemia and atrial fibrillation(AF)).The most prevalent risk factors among stroke survivors were hypertension(63.0%-84.2%)and smoking(31.7%-47.6%).The least prevalent was AF(2.7%-7.4%).The prevalences for major risk factors for stroke are high and most have increased over time.Based on the latest national epidemiological data,26.6%of adults aged≥15 years(307.6 million adults)smoked tobacco products.For those aged≥18 years,age-adjusted prevalence of hypertension was 25.2%;adjusted prevalence of hypercholesterolaemia was 5.8%;and the standardised prevalence of diabetes was 10.9%.For those aged≥40 years,the standardised prevalence of AF was 2.31%.Data from the Hospital Quality Monitoring System showed that 3010204 inpatients with stroke were admitted to 1853 tertiary care hospitals during 2018.Of those,2466785(81.9%)were ischaemic strokes(ISs);447609(14.9%)were intracerebral haemorrhages(ICHs);and 95810(3.2%)were subarachnoid haemorrhages(SAHs).The average age of patients admitted was 66 years old,and nearly 60%were male.A total of 1555(0.1%),2774(0.6%)and 1347(1.4%)paediatric strokes(age<18 years)were identified among IS,ICH and SAH,respectively.Over one-third(1063892(35.3%))of the patients were covered by urban resident basic medical insurance,followed by urban employee basic medical insurance(699513(23.2%))and new rural cooperative medical schema(489361(16.3%)).The leading risk factor was hypertension(67.4%for IS,77.2%for ICH and 49.1%for SAH),and the leading comorbidity was pneumonia or pulmonary infection(10.1%for IS,31.4%for ICH and 25.2%for SAH).In-hospital death/discharge against medical advice rate was 8.3%for stroke inpatients,ranging from 5.8%for IS to 19.5%for ICH.The median and IQR of length of stay was 10.0(7.0-14.0)days,ranging from 10.0(7.0-13.0)in IS to 14.0(8.0-22.0)in SAH.Data from the Chinese Stroke Center Alliance demonstrated that the composite scores of guideline-recommended key performance indicators for patients with IS,ICH and SAH were 0.77±0.21,0.72±0.28 and 0.59±0.32,respectively. | Yong-Jun Wang Zi-Xiao Li Hong-Qiu Gu Yi Zhai Yong Jiang Xing-Quan Zhao Yi-Long Wang Xin Yang Chun-Juan Wang Xia Meng Hao Li Li-Ping Liu Jing Jing Jing Wu An-Ding Xu Qiang Dong David Wang Ji-Zong Zhao On behalf of China Stroke Statistics 2019 Writing Committee | 2020 | Stroke & Vascular Neurology2020，5，3： | 181 |
| 3 | The adsorption behavior of metals in aqueous solution by microplastics effected by UV radiation显示文摘Microplastics are considered as the carrier to heavy metals in the environment.But the sorption ability of microplastics influenced by photo-aging is remaining unclear.In the present study,the sorption of two kinds of metal ions(Cu^2+ and Zn^2+)in the aqueous solution by both the virgin and aged microplastics was investigated.Polyethylene terephthalate(PET)debris,one of the typical kinds of microplastics was chosen in this study.Photo-aging of microplastics in environment was simulated using UV radiation in the laboratory.Date analysis indicated that the aged microplastics had higher adsorption capacity of heavy metals than original ones.This could be related to the increased surface area and oxygen containing function appeared in the surface of aged microplastics after UV radiation.When prolonging the time of radiation,the enhanced adsorption capacities of microplastics appeared for Cu^2+ and Zn^2+.These results showed a great interaction between the aging degree of plastics and sorption capacity to heavy metals.Meanwhile,external conditions including temperature and pH value were also showed great influence to the adsorption behavior. | Qiongjie Wang Yong Zhang Xiaoxue Wangjin Yulai Wang Guanhua Meng Yihua Chen | 2020 | Journal of Environmental Sciences2020，32，1： | 47 |
| 4 | Unconventional Natural Gas Accumulations in Stacked Deposits:A Discussion of Upper Paleozoic Coal-Bearing Strata in the East Margin of the Ordos Basin, China显示文摘The Upper Paleozoic(Carboniferous to Permian) succession in the east margin of the Ordos Basin in the North China Craton has a potential to contain significant hydrocarbon resources, though attention have been mainly attracted for its successful development of coalbed methane(CBM). To improve the previous resource estimates and evaluate the hydrocarbon play possibilities, this study incorporated new discoveries of hydrocarbon units and their stratigraphic relation with source rocks, hydrocarbon migration and trapping configurations. Continuous hydrocarbon accumulation units were identified within the Upper Paleozoic, including the Taiyuan, Shanxi and Xiashihezi formations with great tight gas potential, and the Taiyuan and Shanxi formations also containing shale gas and CBM. Different strata combinations are identified with coal deposition and favour for continuous gas accumulations, including the tidal flat, deltaic and fluvial systems distributed in most of the study areas. Methane was not only generated from the thick coal seams in the Taiyuan and Shanxi formations, but also from shale and dark mudstones. The coal, shale and tight sandstones are proved of remarkable gas content and hydrocarbon indications, and the gas saturation of tight sandstones decreases upward. The stacked deposit combinations vary isochronally in different areas, while the coal seams were developed stably showing good gas sources. Two key stages control the hydrocarbon enrichment, the continuous subsidence from coal forming to Late Triassic and the anomalous paleo-geothermal event happened in Early Cretaceous, as indicated by the fluid inclusions evidence. Extensive areas show good hydrocarbon development potential presently, and more works should be focused on the evaluation and selection of good reservoir combinations. | LI Yong YANG Jianghao PAN Zhejun MENG Shangzhi WANG Kai NIU Xinlei | 2019 | Acta Geologica Sinica(English Edition)2019，93，1： | 32 |
| 5 | Temperature variation of a thermionic cathode during electron emission显示文摘It is necessary to know the actual temperature of a thermionic cathode that works as the electron source in a microwave tube. It has been found that the temperature of the cathode drops markedly during the thermionic emission. For example, the temperature could fall by about 30oC under a current density of 2.92 A/cm2. Using the molecular thermodynamics, the dependence of the cathode temperature on the emission current density has been obtained. It has been theoretically pointed out that several factors, such as heating model and temperature coefficient of resis-tance of heater, can influence the cathode temperature. These theoretical conclu-sions were supported by the experimental results. | LIU YanWen TIAN Hong HAN Yong XU ZhenYing MENG MingFeng ZHANG HongLai | 2008 | Science China(Technological Sciences)2008，51，9： | 22 |
| 6 | Influencing factors of seismic signals generated by un-tuned large volume airgun array in a land reservoir显示文摘Un-tuned large volume airgun array in a water reservoir is recently proposed as a new way to generate seismic waves on land. It can be used to explore the earth velocity structure and its temporal variations as well.However, the characteristics of seismic signals(especially far-field signals) from an airgun array in a reservoir and its affecting factors(firing pressure, airgun towing depth,water level of the reservoir, etc.) has not been adequately studied. We analyzed the seismic data collected from field experiments at Binchuan Transmitting Seismic Station in2011 and 2013 and found that(1) The similarity of seismic signals decrease with distance, which is most likely induced by the decay of signal amplitude and signal to noise ratio(SNR);(2) The amplitudes of far-field airgun signals are almost linearly proportional to the firing pressure;(3) The towing depth of airgun has less effects on the far-field signals;(4) The amplitudes of far-field airgun signals are proportional to the water level of the reservoir. | Meng Chen Wei Yang Weitao Wang Baoshan Wang Hongkui Ge Li Chen Yansheng Ding Jiyan Qiao Yong Chen | 2014 | Earthquake Science2014，27，4： | 19 |
| 7 | Interactive effects of wind speed,vegetation coverage and soil moisture in controlling wind erosion in a temperate desert steppe,Inner Mongolia of China显示文摘The rapid desertification of grasslands in Inner Mongolia of China poses a significant ecological threaten to northern China. The combined effects of anthropogenic disturbances(e.g., overgrazing) and biophysical processes(e.g., soil erosion) have led to vegetation degradation and the consequent acceleration of regional desertification. Thus, mitigating the accelerated wind erosion, a cause and effect of grassland desertification, is critical for the sustainable management of grasslands. Here, a combination of mobile wind tunnel experiments and wind erosion model was used to explore the effects of different levels of vegetation coverage, soil moisture and wind speed on wind erosion at different positions of a slope inside an enclosed desert steppe in the Xilamuren grassland of Inner Mongolia. The results indicated a significant spatial difference in wind erosion intensities depending on the vegetation coverage, with a strong decreasing trend from the top to the base of the slope. Increasing vegetation coverage resulted in a rapid decrease in wind erosion as explained by a power function correlation. Vegetation coverage was found to be a dominant control on wind erosion by increasing the surface roughness and by lowering the threshold wind velocity for erosion. The critical vegetation coverage required for effectively controlling wind erosion was found to be higher than 60%. Further, the wind erosion rates were negatively correlated with surface soil moisture and the mass flux in aeolian sand transport increased with increasing wind speed. We developed a mathematical model of wind erosion based on the results of an orthogonal array design. The results from the model simulation indicated that the standardized regression coefficients of the main effects of the three factors(vegetation coverage, soil moisture and wind speed) on the mass flux in aeolian sand transport were in the following order: wind speed>vegetation coverage>soil moisture. These three factors had different levels of interactive effects on the mass flux in aeolian sand transport. Our results will improve the understanding of the interactive effects of wind speed, vegetation coverage and soil moisture in controlling wind erosion in desert steppes, and will be helpful for the design of desertification control programs in future. | MENG Zhongju DANG Xiaohong GAO Yong REN Xiaomeng DING Yanlong WANG Meng | 2018 | Journal of Arid Land2018，10，4： | 19 |
| 8 | The Frattini Subalgebra of Restricted Lie Superalgebras显示文摘在现在的论文,我们学习限制谎言 superalgebra 的 Frattini subalgebra (L,[p ]) 。我们首先看那是否 L = A 1 鈯? A 2 鈯?鈯? A n 一,然后? p (L)=? p (一 1 )+? p (一 2 )+?+? p ( n ),在每 A i 是 L 的 p 鈥搃d eal 的地方。我们然后获得二结果:F (L)=?(L)= J (L)= L (1 ) 如果并且仅当 L 是 nilpotent;如果 L 是可解决的, F p (L) 和 F (L) 是 L 的 nilpotent 理想。另外,必要、足够的条件被作出对有利的裁决 ? p 鈥揻r ee 限制了谎言 superalgebras。最后,我们讨论 E 鈥損鈥搑e stricted 谎言 superalgebras 和 E 鈥搑e stricted 谎言 superalgebras 的关系。关键词限制了谎言 superalgebras - E 鈥損鈥搑e stricted 谎言 superalgebras - Frattini p 鈥搒u balgebra -蠁 p 鈥揻r ee - p 鈥揺l ementary 先生(2000 ) 题目分类 17B40 - 17B50 由中国(资助号码 10271076 ) | Liang Yun CHEN Dao Ji MENG Yong Zheng ZHANG | 2006 | Acta Mathematica Sinica,English Series2006，22，5： | 18 |
| 9 | GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats显示文摘Hydrogen sulfide(H_2S) is a gasotransmitter that regulates cardiovascular functions.The present study aimed to determine the protective effect of slow-releasing H_2S donor GYY4137 on myocardial ischemia and reperfusion(I/R) injury and to investigate the possible signaling mechanisms involved.Male Sprague-Dawley rats were treated with GYY4137 at 12.5 mg/(kg·day),25 mg/(kg·day) or 50 mg/(kg·day) intraperitoneally for7 days.Then,rats were subjected to 30 minutes of left anterior descending coronary artery occlusion followed by reperfusion for 24 hours.We found that GYY4137 increased the cardiac ejection fraction and fractional shortening,reduced the ischemia area,alleviated histological injury and decreased plasma creatine kinase after myocardial I/R.Both H_2S concentration in plasma and cystathionine-γ-lyase(CSE) activity in the myocardium were enhanced in the GYY4137 treated groups.GYY4137 also decreased malondialdehyde and myeloperoxidase levels in serum,attenuated superoxide anion level and suppressed phosphorylation of mitogen activated protein kinases in the myocardium after I/R.Meanwhile,GYY4137 increased the expression of Bcl-2 but decreased the expression of Bax,caspase-3 activity and apoptosis in the myocardium.The data suggest that GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis. | Guoliang Meng Jing Wang Yujiao Xiao Wenli Bai Liping Xie Liyang Shan Philip K Moore Yong Ji | 2015 | The Journal of Biomedical Research2015，29，3： | 18 |
| 10 | The mortality of lung cancer attributable to smoking among adults in China and the United States during 1990–2017显示文摘Background:Statistical data on the burden and relevant risk factors of lung cancer are valuable for policy-making.This study aimed to compare the mortality of lung cancer attributable to smoking stratified by sex and age among adults in China and the United States(US).Methods:We extracted age-standardized mortality rates of lung cancer during 1990-2017 using the comparative risk assessment framework of the 2017 Global Burden of Disease study.We performed an age-period-cohort analysis to estimate time trend of lung cancer mortality attributable to smoking.Results:During 1990-2017,the age-standardized mortality rate of lung cancer was increasing in China but decreasing in the US for both sexes.The mortality attributable to smoking in China showed a generally increasing trend,while a continuous decrease was observed in the US.The age-period-cohort analysis showed a similar trend of age effect among adults between China and the US:the mortality substantially increased from the 30-34 to 80-84 age group and subsequently decreased in the 90-94 age group.However,the period effect rapidly increased in Chinese adults during 1990-2017,while it tended to be stable in the US although it was still slightly increasing in women.The cohort effect generally peaked in the earlier cohort born in 1902-1906 in the two countries.Conclusions:During 1990-2017,the lung cancer mortality attributable to smoking and the period effect are generally increasing in Chinese adults;the mortality attributable to smoking is decreasing in the US adults,but the period effect tends to be stable.The rapid aging and prevalence of smoking may intensify the increasing mortality of lung cancer in China. | Xiaoxue Liu Yong Yu Minsheng Wang Sumaira Mubarik Fang Wang Yafeng Wang Runtang Meng Chuanhua Yu | 2020 | Cancer Communications2020，40，11： | 17 |
| 11 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 12 | The LA-ICP-MS zircons U-Pb ages and geochemistry of the Baihua basic igneous complexes in Tianshui area of West Qinling显示文摘Baihua meta-igneous complex consists mainly of pyroxenite-gabbro(diorite)-diorite-quartz diorite. They form a complete comagmatic evolutionary series. The geochemical characteristics of basic-interme- diate basic igneous rocks indicate that they belong to a tholeiite suite. The REE distribution pattern is nearly flat type and LREE is slightly enriched type, and their primitive mantle-normalized and MORB-normalized trace element spider diagrams are generally similar; the LIL elements (LILE) Cs, Ba, Sr, Th and U are enriched, but Rb, K and the HFSEs Nb, P, Zr, Sm, Ti and Y are relatively depleted. All these show comagmatic evolution and origin characteristics. The tectonics environment discrimination of trace element reveals that these igneous complexes formed in an island-arc setting. The LA-ICP-MS single-zircons U-Pb age of Baihua basic igneous complex is 434.6±1.5 Ma (MSWD = 1.3), which proves that the formation time of the island-arc type magmatite in the northern zone of West Qinling is Late Ordovician or Early Silurian, also reveals that the timing of subduction of paleo-ocean basin represented by the Guanzizhen ophiolite and resulting island-arc-type magmatic activities is probably Middle-Late Ordovician to Early Silurian. | PEI XianZhi DING SaPing ZHANG GuoWei LIU HuiBin LI ZuoChen LI GaoYang LIU ZhanQing MENG Yong | 2007 | Science China Earth Sciences2007，50，z2： | 15 |
| 13 | Dermoscopy in China: current status and future prospective显示文摘Objective: Dermoscopy is a useful technique for improving the diagnostic accuracy of various types of skin disorders. In China, dermoscopy has been widely accepted, and domestic researchers have made tremendous progress in the field of dermoscopy. The main purpose of this review is to summarize the current status of dermoscopy in China and identify its future directions. Data sources: Articles included in this review were obtained by searching the following databases: Wanfang, China National Knowledge Infrastructure, PubMed, and the Web of Science. We focused on research published before 2019 with keywords including dermoscopy, dermoscopic, dermoscope and trichoscopy. Study selection: A total of 50 studies were selected. Of these studies, 20 studies were in Chinese and 30 in English, research samples of all the studies were collected from Chinese populations. Results: Since 2000, more than 380 articles about dermoscopy have been published in domestic or foreign journals. Dermoscopy can improve the diagnostic accuracy of neoplastic diseases, evaluating the therapeutic effect of treatment, and determining the treatment endpoint, and it can also assist in the differential diagnosis of inflammatory diseases and in the assessment of the severity of the disease. In addition, researches about the applications of dermoscopy during surgical treatment have been published. Training courses aiming to improve the diagnostic ability of dermatologists, either face-to-face or online, have been offered. The Chinese Skin Image Database, launched in 2017 as a work platform for dermatologists, has promoted the development of dermoscopy in China. Computer-aided diagnostic systems based on the Chinese population are ready for use. In the future, cooperation, resource sharing, talent development, image management, and computer-aided diagnosis will be important directions for the development of dermoscopy in China. Conclusion: Dermoscopy has been widely used and developed in China, however, it still needs to address more challenges in the future. | Xue Shen Rui-Xing Yu Chang-Bing Shen Cheng-Xu Li Yan Jing Ya-Jie Zheng Zi-Yi Wang Ke Xue Feng Xu Jian-Bin Yu Ru-Song Meng Yong Cui | 2019 | Chinese Medical Journal2019，，17： | 15 |
| 14 | Long Distance Transmission of SARS-CoV-2 from Contaminated Cold Chain Products to Humans——Qingdao City,Shandong Province,China,September 2020显示文摘Summary What is already known about this topic?Though coronavirus disease 2019(COVID-19)has largely been controlled in China,several outbreaks of COVID-19 have occurred from importation of cases or of suspected virus-contaminated products.Though several outbreaks have been traced to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)isolated on the outer packaging of cold chain products,live virus has not been obtained. | Huilai Ma Zhaoguo Wang Xiang Zhao Jun Han Yong Zhang Hong Wang Cao Chen Ji Wang Fachun Jiang Jie Lei Jingdong Song Shaofeng Jiang Shuangli Zhu Huihui Liu Dongyan Wang Yao Meng Naiying Mao Yanhai Wang Zhen Zhu Zhixiao Chen Bingling Wang Qinqin Song Haijun Du Qun Yuan Dong Xia Zhiqiang Xia Peipei Liu Yuchao Wu Zijian Feng Ruqin Gao George F.Gao Wenbo Xu | 2021 | China CDC weekly2021，3，30： | 13 |
| 15 | A wave energy resource assessment in the China's seas based on multi-satellite merged radar altimeter data显示文摘Wave energy resources are abundant in both offshore and nearshore areas of the China's seas. A reliable assessment of the wave energy resources must be performed before they can be exploited. First, for a water depth in offshore waters of China, a parameterized wave power density model that considers the effects of the water depth is introduced to improve the calculating accuracy of the wave power density. Second, wave heights and wind speeds on the surface of the China's seas are retrieved from an AVISO multi-satellite altimeter data set for the period from 2009 to 2013. Three mean wave period inversion models are developed and used to calculate the wave energy period. Third, a practical application value for developing the wave energy is analyzed based on buoy data. Finally, the wave power density is then calculated using the wave field data. Using the distribution of wave power density, the energy level frequency, the time variability indexes, the total wave energy and the distribution of total wave energy density according to a wave state, the offshore wave energy in the China's seas is assessed. The results show that the areas of abundant and stable wave energy are primarily located in the north-central part of the South China Sea, the Luzon Strait, southeast of Taiwan in the China's seas; the wave power density values in these areas are approximately 14.0–18.5 k W/m. The wave energy in the China's seas presents obvious seasonal variations and optimal seasons for a wave energy utilization are in winter and autumn. Except for very coastal waters, in other sea areas in the China's seas, the energy is primarily from the wave state with 0.5 m≤H s≤4 m, 4 s≤T e≤10 s where H s is a significant wave height and T e is an energy period; within this wave state, the wave energy accounts for 80% above of the total wave energy. This characteristic is advantageous to designing wave energy convertors(WECs). The practical application value of the wave energy is higher which can be as an effective supplement for an energy consumption in some areas. The above results are consistent with the wave model which indicates fully that this new microwave remote sensing method altimeter is effective and feasible for the wave energy assessment. | WAN Yong ZHANG Jie MENG Junmin WANG Jing | 2015 | Acta Oceanologica Sinica2015，34，3： | 13 |
| 16 | Chinese Medicine Sequential Therapy Improves Pregnancy Outcomes after Surgery for Endometriosis-Associated Infertility: A Multicenter Randomized Double-blind Placebo Parallel Controlled Clinical Trial显示文摘Objective:To evaluate the efficacy and safety of Chinese medicine(CM)improving pregnancy outcomes after surgery for endometriosis-associated infertility.Methods:A multicenter,randomized,doubleblind placebo parallel controlled clinical trial was designed.A total of 202 patients who had laparoscopy for endometriosis-associated infertility with qi stagnation and blood stasis syndrome were included and randomly divided into the CM treatment group and placebo control group at a ratio of 1:1 using a central block randomization from May 2014 to September 2017,101 patients in each group.The two groups received continuous intervention at 1–5 days after surgery,for 6 menstrual cycles.Before ovulation,the CM group was treated Huoxue Xiaoyi Granule(活血消异颗粒);after ovulation,Bushen Zhuyun Granule(补肾助孕颗粒)was involved.The control group was treated with placebo.Transvaginal ultrasonography was performed every menstrual cycle during the treatment,and female hormone levels in the follicular and luteal phases were measured during the 1 st,3 rd and 6 th menstrual cycles.The analysis was continued until pregnancy.The primary outcomes were clinical pregnancy rate and pregnancy outcome,and the secondary outcomes were follicular development and endometrial receptivity.Safety evaluations were performed before and after treatment.Results:(1)Clinical pregnancy and live birth rates:the clinical pregnancy and live birth rates of the CM group were significantly higher than those of the placebo group[44.6%(45/101)vs.29.7%(30/101),34.7%(35/101)vs.20.8%(21/101),both P<0.05].(2)Follicle development:the incidence of dominant follicles,rate of cumulative cycle ovulation,and rate of cumulative cycle mature follicle ovulation were significantly higher in the CM group than those in the placebo group[93.8%(350/373)vs.89.5%(341/381),80.4%(275/342)vs.69.1%(253/366),65.8%(181/275)vs 56.1%(142/253),P<0.05 or P<0.01]).The incidence of cumulative cycle luteinized unruptured follicle syndrome was significantly lower in the CM group than in the placebo group[11.7%(40/342)vs.17.8%(65/366),P<0.05).(3)Endometrial receptivity:after treatment,both endometrial types and endometrial blood flow types in the CM group were mainly types A and B,while those in the placebo group were mainly types B and C,with a significant difference between the two groups(both P<0.05).(4)Adverse events:the incidence of adverse events between the two groups was not significantly different(P>0.05).Conclusion:Strategies for activating blood circulation-regulating Gan(Liver)-tonifying Shen(Kidney)sequential therapy can effectively improve the clinical pregnancy rate and live birth rate of endometriosis-associated infertility with qi stagnation and blood stasis after laparoscopy,improve follicular development,promote ovulation,improve endometrial receptivity,while being a safe treatment option.(Trial registration No.NCT02676713). | ZHAO Rui-hua LIU Yong LU Dan WU Ying WANG Xiao-yun LI Wei-li ZENG Cheng MENG Qing-wei LIAN Feng-mei ZHOU Jun SHI Yun SUN Wei-wei HAN Qian TANG Yi SHI Guang | 2020 | Chinese Journal of Integrative Medicine2020，26，2： | 13 |
| 17 | Reuse of waste frying oil for production of rhamnolipids using Pseudomonas aeruginosa zju.u1M显示文摘In this work,rhamnolipid production was investigated using waste frying oil as the sole carbon source. By culture in shaking flasks,a naturally isolated strain synthesized rhamnolipid at concentration of 12.47 g/L and its mutant after treatment by UV light increased this productivity to 24.61 g/L. Fermentation was also conducted in a 50 L bioreactor and the productivity reached over 20 g/L. Hence,with a stable and high productive mutant strain,it could be feasible to reuse waste frying oil for rhamnolipid production on industrial scale. | ZHU Yong GAN Jun-jiang ZHANG Guo-liang YAO Bin ZHU Wen-jie MENG Qin | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，9： | 12 |
| 18 | Expression and alterations of different molecular form γ-glutamyl transferase and total RNA concentration during the carcinogenesis of rat hepatoma显示文摘INTRODUCTIONCarcinogenesisiscloselyrelatedwithDNAsynthesisandhypermetabolismofnucleicacid.γglutamyltransferase(GGT,EC2.3.2.2... | TANG Qi Yun, YAO Deng Fu, LU Jian Xin, WU Xin Hua and MENG Xian Yong | 1999 | World Journal of Gastroenterology1999，5，4： | 12 |
| 19 | Expression of nucleostemin in prostate cancer and its effect on the proliferation of PC-3 cells显示文摘背景:Nucleostemin 为茎和癌症细胞的增长和幸存是必要的,但是这个最新识别的分子是否涉及前列腺癌症致病,是未知的。方法:全部的 RNA 和蛋白质从前列腺癌症纸巾被提取, PC-3, LNCap 和 DU145 房间排队。nucleostemin mRNA 和蛋白质表示被 RT-PCR 和西方的污点测量。Immunohistochemistry 也被用来在前列腺癌症纸巾和 PC-3 房间检测 nucleostemin 蛋白质表示。nucleostemin 特定的、短发卡 RNA,表示原生质标志习惯于 transfect PC-3 房间。nucleostemin 基因的变化被检测,房间的增生的能力是坚定的。结果:Nucleostemin 高度在前列腺癌症纸巾和房间线被表示。在 silencer 的 Nucleostemin 表示水平组织显著地减少的 PC-3 房间。silencer 组 PC-3 房间的增长率减少了, G1 阶段房间的百分比增加了。在 silencer 组 PC-3 房间的裸体老鼠形成能力的瘤显著地减少了。结论:Nucleostemin 高度在前列腺癌症纸巾和房间线被表示。PC-3 房间的增生的能力显著地在 silencing nucleostemin 基因表示以后被减少。 | LIU Ran-lu ZHANG Zhi-hong ZHAO Wei-ming WANG Meng QI Shi-yong LI Jing ZHANG Yue LI Sheng-zhi XU Yong | 2008 | Chinese Medical Journal2008，，4： | 12 |
| 20 | Functional organization of complex brain networks modulated by acupuncture at different acupoints belonging to the same anatomic segment显示文摘 | CHEN Shang-jie MENG Lan YAN Hao BAI Li-jun WANG Fang HUANG Yong LI Jian-ping PENG Xu-ming SHI Xue-min | 2012 | Chinese Medical Journal2012，，15： | 12 |
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