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| 1 | Stable classi?cation with limited sample: transferring a 30-m resolution sample set collected in 2015 to mapping 10-m resolution global land cover in 2017显示文摘As the world strives to reduce the impact of population growth, urbanization, agricultural expansion, and climate change on food security, energy and water shortage, resource over-exploration, biodiversity loss, environmental pollution, and ultimately human health, timely and higher resolution land cover information is urgently needed to achieve the sustainable development goals of the United Nations. | Peng Gong Han Liu Meinan Zhang Congcong Li Jie Wang Huabing Huang Nicholas Clinton Luyan Ji Wenyu Li Yuqi Bai Bin Chen Bing Xu Zhiliang Zhu Cui Yuan Hoi Ping Suen Jing Guo Nan Xu Weijia Li Yuanyuan Zhao Jun Yang Chaoqing Yu Xi Wang Haohuan Fu Le Yu Iryna Dronova Fengming Hui Xiao Cheng Xueli Shi Fengjin Xiao Qiufeng Liu Lianchun Song | 2019 | Science Bulletin2019，64，6： | 166 |
| 2 | PslG, a self-produced glycosyl hydrolase, triggers biofilm disassembly by disrupting exopolysaccharide matrix显示文摘Biofilms 是在细胞外的矩阵嵌入的微生物的联系表面的社区。Exopolysaccharide 是在维持 biofilm 建筑学并且保护居民 biofilm 细菌免受抗菌剂和主人免疫者攻击的伤害的细胞外的矩阵的一个批评部件。然而,指向矩阵 exopolysaccharides 的自我生产的因素,仍然糟糕被理解。这里,我们显示出那 PslG,在 Pseudomonas aeruginosa 涉及关键 biofilm 矩阵 exopolysaccharide Psl 的合成的蛋白质,阻止 biofilm 形成并且拆卸存在在外长地供应的在 nanomolar 集中的分钟以内的 biofilms。PslG 的水晶结构显示 endoglycosidase 的典型特征。PslG 主要破坏 Psl 矩阵从 biofilms 驱散细菌。PslG 处理显著地提高 biofilm 敏感到抗菌素和巨噬细胞房间,导致在一只老鼠的改进 biofilm 清理植入感染模型。而且, PslG 对大量 Pseudomonas 种类显示出 biofilm 抑制和拆卸活动,显示它在与 biofilm 相关的复杂并发症作斗争的大潜力。 | Shan Yu Tiantian Su Huijun Wu Shiheng Liu Di Wang Tianhu Zhao Zengjun Jin Wenbin Du Mei-Jun Zhu Song Lin Chua Liang Yang Deyu Zhu Lichuan Gu Luyan Z Ma | 2015 | Cell Research2015，25，12： | 13 |
| 3 | A polyoxometalate-functionalized two-dimensional titanium carbide composite MXene for effective cancer theranostics显示文摘作为一个新家庭二维(2D ) nanomaterials,因为高效, MXenes 最近包括精力在万用的应用吸引了许多注意存储和电气化学,而是他们到 biomedicine 的特定的申请很少被报导了特别为 theranostic nanomedicine,即,并发的诊断成像和治疗。这研究第一次显示出表面设计和 2D Ti 3 由 GdW 10-based polyoxometalates (POM ) 的集成的 C 2 MXene nanosheets。这些多功能的 GdW 10@Ti3 C 2 合成 nanosheets 向过高热的治疗提供磁性的回声(先生) 或计算断层摄影术(CT ) 向肿瘤房间或异种皮移植的成像指导。没有进一步的出现,一个肿瘤有效地在观察时期期间被根除。是综合的到 Ti 310 nanoclusters > C 2 nanosheets 被表明基于他们的唯一的作文为提高对比的 CT 和先生成像用作一个对比代理人,因此为诊断成像的指导显示出潜力并且为肿瘤过高热 nanotherapy 监视。在 GdW 10@Ti3 C 2 合成 nanosheets 被表明保证他们的随后的翻译进医疗。这研究为由表面工程和 multifunctionalization 拓宽 MXenes 的生物医学的应用提供新奇策略,它被期望在 nanotheranostics 支持 MXenes 的生物医学的应用的进一步的探索。 | Luyan Zong Huixia Wu Han Lin Yu Chen | 2018 | Nano Research2018，11，8： | 9 |
| 4 | Effects of Cracks on the Mass Transfer of Polymer Electrolyte Membrane Fuel Cell with High Performance Membrane Electrode Assembly显示文摘A two-dimensional geometric model is developed for a polymer electrolyte based on the liquid water penetration mechanism in the membrane electrode assemblies under the action of capillary pressure.The effects of the diameter,number,and distribution of cracks in the micro-pore layers(MPLs)of the modeled MEA on the performance of the PEMFC are simulated to investigate the influence of mass transfer across the membrane.The results indicate that liquid water in the catalyst layer(CL)of the MEA can be discharged to gas channels through the cracks in MEA under the action of capillary pressure,thereby alleviating the flooding in the CL and enhancing the diffusion of oxygen to the CL.When the proportion of the total area of cracks in the active area of the MEA was 8%-12%,crack diameter was 20-30μm,and cracks were distributed uniformly.MEAs with and without cracks were prepared,fuel cells were assembled,and their performance was measured.The effects of cracks on mass transfer were then verified.This study helps prepare MEAs with controllable cracks. | 施金蓉 詹志刚 ZHANG Di YU Yuan YANG Xiaoxiang HE Luyan PAN Mu | 2021 | Journal of Wuhan University of Technology(Materials Science)2021，36，3： | 1 |
| 5 | Choline acetate enhanced the catalytic performance of Candida rogusa lipase in AOT reverse micelles 显示文摘 | Xue Luyan Zhao Yin Yu Lijie | 2013 | Colloids and Surfaces B: Biointerfaces2013，105，： | 1 |
| 6 | HPLC method lactone dehydrogenase Muxiang in the content显示文摘 | Xu Yu Fang Luyan Tan Hong | 2004 | Chinese Herbal Medicine2004，35，12： | 1 |
| 7 | Dual functions:A coumarin–chalcone conjugate inhibits cyclic-di-GMP and quorum-sensing signaling to reduce biofilm formation and virulence of pathogens显示文摘Antibiotic resistance or tolerance of pathogens is one of the most serious global public health threats.Bacteria in biofilms show extreme tolerance to almost all antibiotic classes.Thus,use of antibiofilm drugs without bacterial-killing effects is one of the strategies to combat antibiotic tolerance.In this study,we discovered a coumarin–chalcone conjugate C9,which can inhibit the biofilm formation of three common pathogens that cause nosocomial infections,namely,Pseudomonas aeruginosa,Staph-ylococcus aureus,and Escherichia coli,with the best antibiofilm activity against P.aeruginosa.Further investigations indicate that C9 decreases the synthesis of the key biofilm matrix exopolysaccharide Psl and bacterial second messenger cyclic-di-GMP.Meanwhile,C9 can interfere with the regulation of the quorum sensing(QS)system to reduce the virulence of P.aeruginosa.C9 treatment enhances the sensitivity of biofilm to several antibiotics and reduces the survival rate of P.aeruginosa under starvation or oxidative stress conditions,indicating its excellent potential for use as an antibiofilm-forming and anti-QS drug. | Yu Zhang Pramod Bhasme Dinesh S.Reddy Dejian Liu Zhaoxiao Yu Tianhu Zhao Yaqian Zheng Amit Kumar Haiying Yu Luyan Z.Ma | 2023 | mLife2023，2，3： | 0 |
| 8 | Chemical compositions and biological activities of Flos lonicerae显示文摘Flos lonicerae is the dry flower bud of Lonicera japonica Thunb,and it is a very important Chinese herbal medicine in China.In ancient times,it was widely used to treat the exopathogenic wind-heat,epidemic febrile diseases,sores,carbuncles and some infectious diseases.Modern pharmacological research has indicated that it has anti-inflammatory,anti-bacterial,anti-viral and anti-oxidation activities.This paper reviews the chemical compositions and biological activities of Flos lonicerae in order to provide reference for its application in clinical practice in the future. | Yi’an Shi Luming Pan Luyan Yang Jing Sun Meng Zhang Yu Chen | 2023 | Asian Journal of Traditional Medicines2023，18，2： | 0 |
| 9 | Cell division factor ZapE regulates Pseudomonas aeruginosa biofilm formation by impacting the pqs quorum sensing system显示文摘Pseudomonas aeruginosa is one of the leading nosocomial pathogens that causes both severe acute and chronic infections.The strong capacity of P.aeruginosa to form biofilms can dramatically increase its antibiotic resistance and lead to treatment failure.The biofilm resident bacterial cells display distinct gene expression profiles and phenotypes compared to their free-living counterparts.Elucidating the genetic determinants of biofilm formation is crucial for the development of antibiofilm drugs.In this study,a highthroughput transposon-insertion site sequencing(Tn-seq)approach was employed to identify novel P.aeruginosa biofilm genetic determinants.When analyzing the novel biofilm regulatory genes,we found that the cell division factor ZapE(PA4438)controls the P.aeruginosa pqs quorum sensing system.The ΔzapE mutant lost fitness against the wild-type PAO1 strain in biofilms and its production of 2-heptyl-3-hydroxy-4(1H)-quinolone(PQS)had been reduced.Further biochemical analysis showed that ZapE interacts with PqsH,which encodes the synthase that converts 2-heptyl-4-quinolone(HHQ)to PQS.In addition,site-directed mutagenesis of the ATPase active site of ZapE(K72A)abolished the positive regulation of ZapE on PQS signaling.As ZapE is highly conserved among the Pseudomonas group,our study suggests that it is a potential drug target for the control of Pseudomonas infections. | Xi Liu Minlu Jia Jing Wang Hang Cheng Zhao Cai Zhaoxiao Yu Yang Liu Luyan ZMa Lianhui Zhang Yingdan Zhang Liang Yang | 2023 | mLife2023，2，1： | 0 |
| 10 | The Inhibitory Effects of PSS-Loaded Nanoparticles on the Dysfunction of Cardiac Microvascular Endothelia in Rats with Diabetic Cardiomyopathy显示文摘Propylene glycol alginate sodium sulfate-loaded nanoparticles(PSS-NP) has been shown potential to prevent the microvascular endothelial injuries caused by diabetic cardiomyopathy(DCM). In this study, we aimed to investigate the effects of PSS-NP on the dysfunction of cardiac microvascular endothelia in streptozotocin(STZ)-induced DCM rat model. Echocardiographic measurements showed a significant improvement of cardiac function in the PSS-NP-treated group. Our results revealed that the abnormalities of cardiac systolic and diastolic functions were suppressed by the treatments of prostaglandin E1(PGE1), low molecular weight heparin(LMWH), PSS and PSS-NP. Our comparison analysis indicated that PSS-NP showed the strongest inhibitory effects on microvascular endothelial injuries. Transmission electron microscopy analysis demonstrated that PSS-NP protected the cardiac microvascular endothelium and further improved endothelium dysfunction in DCM rats. ELISA and Western blot assays further showed a high efficiency of improving cardiac microvascular endothelial dysfunction with PSS-NP. Our results demonstrated that PSS-NP increased the protein expression of phosphatidylinositol 3-kinase(PI3K)-p85 and vascular endothelial growth factor(VEGF)-A, and the phosphorylation of protein kinase B(Akt) and endothelial nitric oxide synthase(eNOS), which were involved in the amelioration of cardiac microvascular endothelial dysfunction. These data suggest that PSS-NP may be a novel approach to the treatment the coronary microcirculation disorder diseases such as DCM. | AN Nina YU Luyan HU Yi FENG Wenjing SHI Shujuan CHEN Honghua MAO Yongjun | 2019 | Journal of Ocean University of China2019，18，1： | 0 |
| 11 | Chemical constituents and pharmacological effects of Croton crassifolius显示文摘Croton crassifolius(CC)is a kind of traditional Chinese medicine rich in terpenoids,with among which diterpene species are the most.CC had biological activities in the treatment of cancer,inflammation,ulcerative colitis,osteoporosis and Alzheimer’s disease.This study reviews the chemical compositions and pharmacological activities of CC to provide reference for further research. | Luyan Yang Yibo Wang Xinyao Wang Xiaoxia Xu Yunpeng Yang Meng Zhang Yu Chen | 2024 | Asian Journal of Traditional Medicines2024，19，2： | 0 |
| 12 | Stimulated Brillouin interaction between guided phonons and photons in a lithium niobate waveguide显示文摘The Brillouin scattering is one of the strongest nonlinear optical effects in dielectrics[1].In particular,the backward Brillouin scattering(BBS)provides an efficient method to achieve low-noise optical gain for active photonics[2]and the coherent interconnects between 10 GHz phonons and photons[3].However,previous studies on BBS are primarily limited to the unconfined phonons[1]or phonon confined in suspended structures[4-6]. | Yuan-Hao Yang Jia-Qi Wang Zheng-Xu Zhu Xin-Biao Xu Qiang Zhang Juanjuan Lu Yu Zeng Chun-Hua Dong Luyan Sun Guang-Can Guo Chang-Ling Zou | 2024 | Science China(Physics,Mechanics & Astronomy)2024，67，1： | 0 |
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