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| 1 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 2 | Frequency Control at the Power Sending Side for HVDC Asynchronous Interconnections Between Yunnan Power Grid and the Rest of CSG显示文摘For a large-scale high voltage direct current (HVDC)asynchronous interconnected power grid, the frequency issue atthe power sending side under DC faults is a crucial problem.To solve this problem, based on rotor motion equations, theeffect of unbalanced power on the system frequency under DCfaults is analyzed. The characteristics and dynamic developmentprocess of frequencies after the injection of disturbances areanalyzed. In addition, the actions and coordinated strategies ofvarious frequency control measures are also investigated. Basedon the testing projects of an asynchronous interconnection in theChina Southern Power Grid (CSG), the frequency features arestudied according to the measured PMU data. The outcome showsthat the frequency problem of the Yunnan Power Grid after anasynchronous interconnection can be solved and controlled. Italso shows that the frequency limit control (FLC) is importantfor the frequency regulation of large scale HVDC asynchronousinterconnected DC power grids. As demonstrated, DC FLC caneffectively suppress the deviation of the transient frequency.However, reasonable frequency regulation parameters shouldbe set and other area frequency control measures should becoordinated to maintain the frequency stability of the system. | Hong Rao Wei Wu Tian Mao Baorong Zhou Chao Hong Yongjun Liu Xiaoshan Wu | 2021 | CSEE Journal of Power and Energy Systems2021，7，1： | 4 |
| 3 | Modeling,analysis,and simulation of X-shape quasi-zero-stiffness-roller vibration isolators显示文摘Existing quasi-zero stiffness(QZS)isolators are reviewed.In terms of their advantages,a novel X-shape QZS isolator combined with the cam-roller-spring mechanism(CRSM)is proposed.Different from the existing X-shape isolators,oblique springs are used to enhance the negative stiffness of the system.Meanwhile,the CRSM is used to eliminate the gravity of the loading mass,while the X-shape structure leaves its static position.The existing QZS isolators are demonstrated and classified according to their nonlinearity mechanisms and classical shapes.It is shown that the oblique spring can realize negative stiffness based on the simplest mechanism.The X-shape has a strong capacity of loading mass,while the CRSM can achieve a designed restoring force at any position.The proposed isolator combines all these advantages together.Based on the harmonic balance method(HBM)and the simulation,the displacement transmissibilities of the proposed isolator,the X-shape isolators just with oblique springs,and the X-shape isolators in the traditional form are studied.The results show that the proposed isolator has the lowest beginning isolation frequency and the smallest maximum displacement transmissibility.However,it still has some disadvantages similar to the existing QZS isolators.This means that its parameters should be designed carefully so as to avoid becoming a bistable system,in which there are two potential wells in the potential energy curve and thus the isolation performance will be worsened. | Xiaoye MAO Mengmeng YIN Hu DING Xiaofeng GENG Yongjun SHEN Liqun CHEN | 2022 | Applied Mathematics and Mechanics(English Edition)2022，43，7： | 2 |
| 4 | Effects of short-term anoxic treatment on antioxidant ability and membrane integrity of postharvest kiwifruit during storage显示文摘 | Lili Song Haiyan Gao Hangjun Chen Jinlin Mao Yongjun Zhou Wenxuan Chen Yueming Jiang | 2008 | Food Chemistry2008，，： | 2 |
| 5 | Effects of grain boundary diffusion of PrCu alloy on microstructure and coercivity of hot deformed(Nd,Ce)-Fe-B magnets显示文摘The technology of using high abundance rare earth element Ce in permanent magnets has attracted many concerns.In this work,the magnetic properties and microstructures of hot deformed(Nd_(1-x)Ce_(x))_(13.8)Fe_(76.1)Co_(4)Ga_(0.5)B_(5.6) magnets and a selective magnet treated with PrCu grain boundary diffusion process(GBDP) were investigated systematically.It is found that Ce is beneficial to improving the plastic deformation ability of NdFeB magnets.The strongest c-axis orientation is achieved in the HD magnets with Ce concentration of x=0.3,resulting in good comprehensive magnetic properties of B_(r)=13.00 kGs,H_(cj)=10.12 kOe,(BH)_(max)=38.42 MGOe.Based on that,the GBDP was implemented on the magnets with the best orientation using Pr_(68)Cu_(32) ribbons and the magnetic properties of B_(r)=12.87 kGs,H_(cj)=15.65 kOe,(BH)_(max)=37.48 MGOe were obtained.The results of composition distribution and Curie temperature test of the GBDPed magnets illustrate that Pr diffuses into the(Nd,Ce)_(2)(Fe,Co)_(14)B grains to substitute Ce,which not only improves the Curie temperature of the grains,but also enhances the magnetic performance of the magnets.Through GBDP,the thermal stability of magnets has also been improved. | Haijun Peng Dunbo Yu Xinyuan Bai Xiao Lin Yongjun Mao Zilong Wang Yang Luo | 2021 | Journal of Rare Earths2021，39，8： | 1 |
| 6 | Design and fabrication of erbium doped photosensitive fibers显示文摘A kind of erbium doped photosensitive fiber(EDPF) was proposed and fabricated,whose core was made of double layers named photosensitive layer and erbium doped layer.The double-layer core de-sign can overcome difficulties in fabrication of EDPF with single core design,i.e.the conflict between the high consistency rare earth doping and high consistency germanium doping.A sample was fabri-cated through the modified chemical vapor deposition method combined with solution doping tech-nique.The peak absorption coefficient was 48.80 dB/m at 1.53 μm,the background loss was lower than 0.1 dB/m,and the reflectivity of the fiber Brag gratings(FBG) written directly on the sample fiber was up to 97.3% by UV-writing technology.Moreover,a C band tunable fiber laser was fabricated using the sample fiber,in which a uniform FBG was written directly on EDPFs as a reflector.A single wavelength lasing with a maximum wavelength tuning range of 1555.2―1558.0 nm was achieved experimentally.Within this tuning range,the full-width at half maximum(FWHM) of the laser output was smaller than 0.015 nm and the side mode suppression ratio(SMSR) was better than 50 dB. | LI Jian LIU Peng LU ShaoHua WANG Jing MAO XiangQiao WEI Huai FU YongJun ZHENG Kai NING TiGang LI TangJun JIAN ShuiSheng | 2009 | Science China(Technological Sciences)2009，52，5： | 1 |
| 7 | Combined 3 D-QSAR modeling and molecular docking study on azacycles CCR5 antagonists 显示文摘 | Ji Yongjun Shu Mao Lin Yong | 2013 | Journal of Molecular Structure2013，1045，3： | 1 |
| 8 | Combined 3D-QSAR modeling and molecular docking study on azacycles CCR5 antagonists 显示文摘 | JI Yongjun Mao Shu Yong Lin | 2013 | Journal of Molecular Structure2013，1045，： | 1 |
| 9 | Preparation of alumina-carbon composites with phloroglucinol-formaldehyde resin and their application in asymmetric hydrogenation显示文摘To overcome the shortcomings of single component carrier supported platinum(Pt)-based catalysts,herein,we demonstrate the fabrication of alumina combined mesoporous carbon to prepare a series of alumina-carbon composites and their corresponding Pt-based catalysts.The alumina-carbon composites Al@PhFC are synthesized by using phloroglucinol-formaldehyde resin as carbon source and aluminum acetylacetone as the aluminum source.Further,the effect of alumina content on the properties of the composites is investigated.The composites and catalysts are characterized by using XRD,XPS,N2 sorption,and TEM.The Pt/Al@PhFC-1.8 composite with appropriate amounts of alumina,pore diameter,and moderate Pt nanoparticle size,resulted in 99.5%of conversion efficiency and 77.4%of optical selectivity in the asymmetric hydrogenation of ethyl 2-oxo-4-phenylbutanoate(EOPB).Intere stingly,this composite can be used more than 20 times without a significant decrease in its performance. | Wenrui Cai Renjie Xiong Cong Mao Meitian Xiao Yongjun Liu Ranjith Kumar Kankala Xueqin Zhang | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
| 10 | Combined 3D-QSAR modeling and molecular docking study on azacycles CCR5 antagonists显示文摘 | Yongjun Ji Mao Shu Yong Lin | 2013 | Journal of Molecular Structure2013，1045，： | 1 |
| 11 | 短期氮处理(缺氧处理)对采后猕猴桃贮藏过程中抗氧化能力和质膜完整性的影响显示文摘将猕猴桃用氮气处理6 h后,在(1±1)℃、相对湿度为95%~100%条件下贮藏35 d,最后在20℃下放置3 d,测定果实硬度、质膜透性、硫代巴比妥酸反应产物(TBARS)、过氧化氢含量、超氧阴离子生成速率、脂氧合酶(LOX)、超氧化物歧化酶(SOD)和过氧化物酶(POD)的活性。 | Lili Song Haiyan Gao Hangjun Chen Jinlin Mao Yongjun Zhou Wenxuan Chen Yueming Jiang | 2010 | 保鲜与加工2010，10，6： | 1 |
| 12 | Study on pure silica core optical fibers显示文摘An optimal refractive index profile of pure silica core optical fiber (PSCF) was de- signed, in combination with the characters of the modified chemical vapor deposi- tion (MCVD) process. Techniques of preform fabrication by a new furnace round heating MCVD process and fiber drawing process were reviewed. Difficulties in doping fluorine in silica, widening the depressed-index cladding and maintaining the index of fiber core were discussed. Methods used to overcome these difficulties were given at the same time. Additionally, the optimal refractive index profiles of PSCF were presented. | LI Jian ZHENG Kai CHANG DeYuan WEI Huai NING TiGang FU YongJun MAO XiangQiao YAN FengPing JIAN Wei JIAN ShuiSheng | 2008 | Science China(Technological Sciences)2008，51，1： | 1 |
| 13 | Combined 3D- QSAR modeling and molecular docking study on aza- cydes CCR5 antagonists 显示文摘 | Yongjun Ji Mao Shu Yong Lin | 2013 | Journal of Mdecular Structure2013，，1045： | 1 |
| 14 | Immobilization of GOX on PEG/fluoresence functionalized nanographene oxide to describe fluctuation of glucose level显示文摘Enzyme,produced and worked in all living things,could work as macromolecular biological catalysts in diverse biochemical processes with particular specificity,like glucose oxidase(GOX).The efficient use of enzyme properties has great importance in pharmaceutics and therapeutics.In this work,we could fabricate naive and effective electrochemical biosensors in the determination of glucose levels via utilizing GOX.Graphene oxide,as a water-soluble derivative of graphene,has shown great promise in a variety of biomedical applications including biosensors.Thus,we established a new-type special platform for GOX immobilization to perform its prosperities,in which nanographene oxide(nGO)was employed as an ideal base and poly(ethylene glycol)(PEG)was conjugated on the edge of nGO sheets to enhance its biocompatibility.Additionally,preferable functional dyes(Rhodamine B/fluorescein isothiocyanate)were also introduced to the platform.Enzyme-nanocomposites were then provided by locating GOX on the platform,i.e.,GOX@nGO-PEG-RhB and GOX@nGO-PEG-FITC.The microstructure and composite of platforms and enzyme-nanocomposites were confirmed by diverse characterizations.Finally,on account of corresponding cyclic voltammetric and typical ready-state amperometric curves,it was informed that GOX@nGO-PEG-RhB and GOX@nGO-PEG-FITC could effectively respond to the fluctuation of glucose level as electrochemical biosensor.The present work presents special platforms for the immobilization of enzymes like GOX and provides new-type biosensors in the detection of glucose levels. | Wenhao Qian Tao Song Mao Ye Xiaoyu Huang Yongjun Li Bingjie Hao | 2023 | Journal of Materials Science & Technology2023，，33： | 0 |
| 15 | Construct a 3D microsphere of HMX/B/Al/PTFE to obtain the high energy and combustion reactivity显示文摘Metal(aluminum and boron)based energetic materials have been wildly applied in various fields including aerospace,explosives and micro-devices due to their high energy density.Unfortunately,the low combustion efficiency and reactivity of metal fuels,especially boron(B),severely limit their practical applications.Herein,multi-component 3D microspheres of HMX/B/Al/PTFE(HBA)have been designed and successfully prepared by emulsion and solvent evaporation method to achieve superior energy and combustion reactivity.The reactivity and energy output of HBA are systematically measured by ignitionburning test,constant-volume explosion vessel system and bomb calorimetry.Due to the increased interfacial contact and reaction area,HBA shows higher flame propagation rate,faster pressurization rate and larger combustion heat of 29.95 cm/s,1077 kPa/s,and 6164.43 J/g,which is 1.5 times,3.5 times,and 1.03 times of the physical mixed counterpart(HBA-P).Meanwhile,HBA also shows enhanced energy output and reactivity than 3D microspheres of HMX/B/PTFE(HB)resulting from the high reactivity of Al.The reaction mechanism of 3D microspheres is comprehensively investigated through combustion emission spectral and thermal analysis(TG-DSC-MS).The superior reactivity and energy of HBA originate from the surface etching of fluorine to the inert shell(Al_(2)O_(3) and B_(2)O_(3))and the initiation effect of Al to B.This work offers a promising approach to design and prepare high-performance energetic materials for the practical applications. | Jian Wang Jie Chen Yaofeng Mao Yongjun Deng Wei Cao Fude Nie Jun Wang | 2024 | Defence Technology(防务技术)2024，32，2： | 0 |
| 16 | Association between GABRG2 rs211037 polymorphism and febrile seizures:a metaanalysis显示文摘Background:Emerging evidence has implied that the GABRG2 gene play a role in the mechanism of febrile seizure(FS),however,the relationship between GABRG2 rs211037 polymorphism and the risk of FS remains controversial.This meta-analysis was conducted to investigate the relationship of GABRG2 rs211037 polymorphism with the susceptibility to FS.Methods:MEDLINE,Embase,Cochrane Library and CNKI databases were searched(until April 6,2019)for eligible studies on the relationship between GABRG2 rs211037 polymorphism and FS.We calculated the odds ratios(ORs)by a fixed or random model with the STATA 15.0 software.Subgroup analyses for the ethnicity,the source of the control,and age and sex matching of controls were conducted.Results:A total of 8 studies consisting of 775 FS patients and 5162 controls were included in this study.Based on the overall data,he GABRG2 rs211037 polymorphism was not significantly associated with the risk of FS(TT+CT vs CC:OR=0.95,95%CI 0.64–1.41,P=0.80).Notably,the GABRG2 rs211037 variant was significantly associated with decreased risk of FS in Asian populations(TT vs CT+CC:OR=0.63,95%CI 0.45–0.88,P=0.006),but increased risk in Caucasian populations(CT vs CC:OR=1.56,95%CI 1.14–2.15,P=0.006).Significant associations were also detected when healthy controls out of the whole controls were employed for comparison(TT vs CT+CC:OR=0.59,95%CI 0.45–0.77,P<0.001)and when data from studies with age-and sex-matched controls were used(TT+CT vs CC:OR=0.60,95%CI 0.43–0.86,P=0.001).Conclusion:The GABRG2 rs211037 polymorphism may decrease the risk of FS in Asian populations,while increasing the risk in Caucasian populations.Further well-designed studies with large sample sizes are essential to verify the conclusions in other ethnicities. | Xiaohui Yang Jing Chi Xiaomeng Wang Hongyun Wei Xueping Zheng Yi Hu Song Hu Yongjun Mao Xiaosa Chi | 2021 | Acta Epileptologica2021，3，1： | 0 |
| 17 | The Inhibitory Effects of PSS-Loaded Nanoparticles on the Dysfunction of Cardiac Microvascular Endothelia in Rats with Diabetic Cardiomyopathy显示文摘Propylene glycol alginate sodium sulfate-loaded nanoparticles(PSS-NP) has been shown potential to prevent the microvascular endothelial injuries caused by diabetic cardiomyopathy(DCM). In this study, we aimed to investigate the effects of PSS-NP on the dysfunction of cardiac microvascular endothelia in streptozotocin(STZ)-induced DCM rat model. Echocardiographic measurements showed a significant improvement of cardiac function in the PSS-NP-treated group. Our results revealed that the abnormalities of cardiac systolic and diastolic functions were suppressed by the treatments of prostaglandin E1(PGE1), low molecular weight heparin(LMWH), PSS and PSS-NP. Our comparison analysis indicated that PSS-NP showed the strongest inhibitory effects on microvascular endothelial injuries. Transmission electron microscopy analysis demonstrated that PSS-NP protected the cardiac microvascular endothelium and further improved endothelium dysfunction in DCM rats. ELISA and Western blot assays further showed a high efficiency of improving cardiac microvascular endothelial dysfunction with PSS-NP. Our results demonstrated that PSS-NP increased the protein expression of phosphatidylinositol 3-kinase(PI3K)-p85 and vascular endothelial growth factor(VEGF)-A, and the phosphorylation of protein kinase B(Akt) and endothelial nitric oxide synthase(eNOS), which were involved in the amelioration of cardiac microvascular endothelial dysfunction. These data suggest that PSS-NP may be a novel approach to the treatment the coronary microcirculation disorder diseases such as DCM. | AN Nina YU Luyan HU Yi FENG Wenjing SHI Shujuan CHEN Honghua MAO Yongjun | 2019 | Journal of Ocean University of China2019，18，1： | 0 |
| 18 | Unconventional piezoelectric coefficients in perovskite piezoelectric ceramics显示文摘Piezoelectric ceramics exhibit three conventional piezoelectric coefficients,i.e.,d33,d31,d15,due to their∞mm crystal symmetry.Unconventional piezoelectric coefficients,such as d11,d12,d13,d14,d16,etc.,can only be extracted from piezoelectric single crystals of special symmetry with specific cut direction.Here we demonstrate a rotated poling method to realize unconventional piezoelectric coefficients in perovskite piezoelectric ceramics.This method is elaborated in theory and experimentally proven to be effective.Full nonzero piezoelectric coefficients in the 36 piezoelectric coefficients matrix can be obtained by combining these“quasi(effective)piezoelectric coefficients”with the conventional piezoelectric coefficients,which would expand applications in a wide variety of piezoelectric devices. | Jingen Wu Zhongqiang Hu Xiangyu Gao Miaomiao Cheng Xinger Zhao Wei Su Liqian Wang Mengmeng Guan Yongjun Du Ruohao Mao Zhiguang Wang Ziyao Zhou Shuxiang Dong Ming Liu | 2021 | Journal of Materiomics2021，7，2： | 0 |
| 19 | Functionalized nanographene oxide/PEG/rhodamine B/gold nanocomposite for electrochemical determination of glucose显示文摘Diabetes,one of the most serious metabolism diseases,has continually plagued human beings so that timely monitored blood glucose level is very necessary.Gold nanoparticles(Au NPs)have been considered as potential substitutes for non-enzymatic sensors,due to their unusual physicochemical property and efficient catalytic activity.Herein,we prepared a facial platform for Au NPs to maintain good dispersity and inherent physicochemical property.In this special platform(SH-n GO-PEG-Rh B),nanographene oxide(n GO)was employed as an ideal base,which provided adequate carboxyls for conjugating with poly(ethylene glycol)(PEG),and enough epoxy groups for thiol active site.A functional dye(rhodamine B)with preferable fluorescence properties was also introduced into this platform.Au NPs were then aptly in situ grown on the platform via reduction of HAuCl_(4) under mild conditions,providing Au NPs@SHn GO-PEG-Rh B.The nanocomposite was cast on a glassy carbon electrode(GCE)conveniently,yielding GCE/Au NPs@SH-n GO-PEG-Rh B.Reasonably,as shown by cyclic voltammetry(CV)and ready-state amperometry,GCE/Au NPs@SH-n GO-PEG-Rh B was capable of electrochemical determination of glucose so as to provide an efficient sensor for glucose determination with dye tracer. | Wenhao Qian Tao Song Mao Ye Xiaoyu Huang Yongjun Li Bingjie Hao | 2022 | Journal of Materials Science & Technology2022，，27： | 0 |
| 20 | Pd-catalyzed cascade cyclization of allenylethylene carbonates and indandiones: Synthesis of tetracyclic dihydrocyclopentaindenofuranone derivatives显示文摘A palladium-catalyzed cascade cyclization of allenylethylene carbonates with 1,3-indandiones was developed, providing biologically interesting tetracyclic dihydrocyclopentaindenofuranone derivatives having three contiguous quaternary carbon centers in moderate to high yields with excellent diastereoselectivities. In this reaction, the allene moiety was fully fused into the cyclopentene ring. | Yujie Dong Jun Liu Xing Gao Ting Pan Biming Mao Songcheng Yu Yongjun Wu Cheng Zhang Hongchao Guo | 2023 | Chinese Chemical Letters2023，34，10： | 0 |
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