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| 1 | Autophagy in bone homeostasis and the onset of osteoporosis显示文摘Autophagy is an evolutionarily conserved intracellular process,in which domestic cellular components are selectively digested for the recycling of nutrients and energy.This process is indispensable for cell homeostasis maintenance and stress responses.Both genetic and functional studies have demonstrated that multiple proteins involved in autophagic activities are critical to the survival,differentiation,and functioning of bone cells,including osteoblasts,osteocytes,and osteoclasts.Dysregulation at the level of autophagic activity consequently disturbs the balance between bone formation and bone resorption and mediates the onset and progression of multiple bone diseases,including osteoporosis.This review aims to introduce the topic of autophagy,summarize the understanding of its relevance in bone physiology,and discuss its role in the onset of osteoporosis and therapeutic potential. | Xing Yin Chenchen Zhou Jingtao Li Renkai Liu Bing Shi Quan Yuan Shujuan Zou | 2019 | Bone Research2019，7，4： | 25 |
| 2 | Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference显示文摘Mesenchymal stem cells(MSCs)are multipotent stem cells and capable of differentiating into multiple cell types including osteoblastic,chondrogenic and adipogenic lineages.We previously identified BMP9 as one of the most potent BMPs that induce osteoblastic differentiation of MSCs although exact molecular mechanism through which BMP9 regulates osteogenic differentiation remains to be fully understood.Here,we seek to develop a recombinant adenovirus system to optimally silence mouse BMP9 and then characterize the important role of BMP9 in osteogenic differentiation of MSCs.Using two different siRNA bioinformatic prediction programs,we design five siRNAs targeting mouse BMP9(or simB9),which are expressed under the control of the converging H1 and U6 promoters in recombinant adenovirus vectors.We demonstrate that two of the five siRNAs,simB9-4 and simB9-7,exhibit the highest efficiency on silencing exogenous mouse BMP9 in MSCs.Furthermore,simB9-4 and simB9-7 act synergistically in inhibiting BMP9-induced expression of osteogenic markers,matrix mineralization and ectopic bone formation from MSCs.Thus,our findings demonstrate the important role of BMP9 in osteogenic differentiation of MSCs.The characterized simB9 siRNAs may be used as an important tool to investigate the molecular mechanism behind BMP9 osteogenic signaling.Our results also indicate that recombinant adenovirus-mediated expression of siRNAs is efficient and sustained,and thus may be used as an effective delivery vehicle of siRNA therapeutics. | Shujuan Yan Ruyi Zhang Ke Wu Jing Cui Shifeng Huang Xiaojuan Ji Liping An Chengfu Yuan Cheng Gong Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Bo Liu Rex C.Haydon Michael J.Lee Russell R.Reid Jennifer Moriatis Wolf Qiong Shi Hue H.Luu Tong-Chuan He Yaguang Weng | 2018 | Genes & Diseases2018，5，2： | 8 |
| 3 | New ancient DNA sequences suggest high genetic diversity for the woolly mammoth (Mammuthus primigenius)显示文摘细胞色素 b 基因(mtDNA ) 的部分 DNA 序列成功地从从 Xiguitu 县(Yakeshi ) 收集的 Mammuthus primigenius 的迟了的更新世石块骨头被检索,内部蒙古自治区域并且从 Zhaodong,在北中国的 Heilongjiang 省的哈尔滨。二古老的 DNA 碎片(109 bp 和 124 bp ) 被可再现的实验与另外的 Elephantidae 税在二个不同实验室并且由种系发生的分析证实一。用在分开或联合的数据集的这些序列和出版数据的种系发生的分析在毛茸茸的猛犸和二头生活大象之中显示不稳定的关系, Elephas 和 Laxodonta。除了过去常尝试 Elephantidae 终端的长独立的进化的短序列征税一,我们建议高 intra 特定的差异在 Mammuthus primigeniuscrossing 存在空间、时间的范围,为 DNA 导致建筑群和分叉的基因背景到目前为止定序恢复。在绝灭的毛茸茸的猛犸的高基因的差异能解释 Elephantidae 税的明显的不稳定性一上分子的种系发生的树和罐头关于未解决的 Elephantidae 三分法调解明显的悖论。 | YANG Shujuan LAI Xulong SHI Suhua CHENG Shenghong ZHOU Xiugao YANG Xiujuan YANG Hong | 2006 | Progress in Natural Science:Materials International2006，16，4： | 5 |
| 4 | Ischemic stroke susceptibility gene in a Northern Han Chinese population显示文摘Interleukin-18 gene promoter polymorphisms are potential risk factors for ischemic cerebrovascular disease, and the -607C allele may increase ischemic stroke risk in the Han Chinese population. In the present study, we recruited 291 patients with ischemic cerebrovascular disease from the Affiliated Hospital of Qingdao University Medical College, China, and 226 healthy controls. Both patients and controls were from the Han population in northern China. Immunoresonance scattering assays detected increased serum amyloid A protein, C-reactive protein, and interleukin-18 levels in ischemic cerebrovascular disease patients compared with healthy controls. Analysis of the -607C/A (rs1946518) polymorphism in the interleukin-18 gene promoter showed ischemic cerebrovascular disease patients exhibited increased frequencies of the CC genotype and C alleles than healthy controls. Genotype and allele frequencies of the interleukin-18 -137G/C (rs187238) polymorphism and the -13T/C (rs11024595) polymorphism in the 5'-flanking region of serum amyloid A, showed no significant difference between the two groups. Multivariate logistic regression analysis on the interleukin-18 promoter A/C genetic locus, for correction of age, gender, history of smoking, hypertension, diabetes mellitus, hypercholesteremia, and an ischemic stroke family history, showed ischemic cerebrovascular disease risk in individuals without the A allele (C homozygotes) was 2.2-fold greater than in A allele carriers. Overall, our findings suggest that the -13T/C (rs11024595) polymorphism in the 5′-flanking region of serum amyloid A has no correlation with ischemic cerebrovascular disease, but the C allele of the -607C/A (rs1946518) polymorphism in the interleukin-18 promoter is a high-risk factor for ischemic cerebrovascular disease in the Han population of northern China. In addition, the A allele is likely a protective gene for ischemic cerebrovascular disease. | Haiping Wang Shujuan Shi Wenjing Yan Yan Song Jingjing Zhan Chen Zhang Haiji Wang | 2013 | Neural Regeneration Research2013，8，20： | 4 |
| 5 | A New Robust Watermarking Algorithm for Vector Data显示文摘Because the existing vector data watermarking algorithm is insufficiently robust for compression and cropping,and has no sufficient control on map deformation,a new watermarking algorithm was proposed in this paper.Its main features are:① it selected feature points and non-feature points from the sequence of Douglas,and then embedded watermarking points by wavelet transform,which is based on layer segmentation;② it enhanced the map deformation control design.Furthermore,it increased the map graphic deformation control design.The algorithm was applied to experimental data,and the test results showed that the algorithm had good robustness on graphics geometric transformation,the addition,deletion and cropping of points in graph layers.Also,the graph distortion had been well controlled. | ZHANG Lei YAN Dashun JIANG Shujuan SHI Tingting | 2010 | Wuhan University Journal of Natural Sciences2010，15，5： | 2 |
| 6 | A near-infrared phosphorescent probe for F^- based on a cationic iridium(Ⅲ) complex with triarylboron moieties显示文摘In this work, a near-infrared (NIR) phosphorescent probe for F- based on a cationic Ir(Ⅲ) complex [Ir(Bpq)2(quqo)]PF6 (1) with dimesitylboryl (Mes2B) groups on the cyclometalated C^N ligands (Bpq) and 2-(quinolin-2-yl)quinoxaline (quqo) as N^N ligand was designed and synthesized. The excited state properties of 1 were investigated in detail using molecular orbital cal- culations and experimental methods. Upon excitation, complex 1 shows NIR phosphorescent emission around 680 nm. Inter- estingly, the complex can be excited with long wavelength around 610 nm. Such long-wavelength excitation can reduce the background emission interference and improve the signal-to-noise ratio. Furthermore, the selective binding between boron at- om and F- can give rise to the quenching of emission and realize the near-infrared phosphorescent sensing for F-. We wish that the results reported herein will be helpful for the further design of excellent near-infrared phosphorescent probes based on heavy-metal complexes. | XU WenJuan LIU ShuJuan ZHAO Qiang MA TingChun SUN Shi ZHAO XinYan HUANG Wei | 2011 | Science China Chemistry2011，54，11： | 2 |
| 7 | Environmental pollution status assessment of water and soil in Langfang City显示文摘 | Jinzhong GONG Shujuan SHI Sichao JIN Jinsheng WANG | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 2 |
| 8 | Comparisons between Movement Speed of Main Types of Dunes:A Case Study of Desert Areas in Hexi Region of Gansu Province显示文摘In desert areas in Hexi region,11 barchan dunes,6 chains of barchan dunes,6 pyramid dunes,6 parabolic dunes and 6 accumulated sand-belts were chosen to study their movement speed based on images obtained by Google Earth in various periods.The results show that among the dunes,the movement of the barchan dunes was the fastest,followed by the chains of barchan dunes,and only the tops of the pyramid dunes swayed,while the parabolic dunes and accumulated sand-belts hardly moved forward.The higher the barchan dunes(or the chains of barchan dunes) were,the slower the movement was.On the contrary,the higher the pyramid dunes were,the faster the swing was.There was a positive correlation between the movement speed of the barchan dunes and the average wind speed of sandstorms. | CHANG Zhaofeng ZHU Shujuan SHI Xuegang ZHANG Jinhu LI Ya WANG Qi ZHANG Dekui DUAN Xiaofeng | 2016 | Journal of Landscape Research2016，8，6： | 2 |
| 9 | Effect of inoculum/substrate ratio on methane yield and orthophosphate release from anaerobic digestion of Microcystis spp显示文摘 | Zeng Shujuan Yuan Xianzheng Shi Xiaoshuang | | 0，，1： | 1 |
| 10 | An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC) has a high mortality rate. To determine the molecular basis of ESCC development, this study sought to identify characteristic genome-wide alterations in ESCC, including exonic mutations and structural alterations. The clinical implications of these genetic alterations were also analyzed. Exome sequencing and verification were performed for nine pairs of ESCC and the matched blood samples, followed by validation with additional samples using Sanger sequencing. Whole-genome SNP arrays were employed to detect copy number alteration(CNA) and loss of heterozygosity(LOH) in 55 cases, including the nine ESCC samples subjected to exome sequencing. A total of 108 non-synonymous somatic mutations(NSSMs) in102 genes were verified in nine patients. The chromatin modification process was found to be enriched in our gene ontology(GO) analysis. Tumor genomes with TP53 mutations were significantly more unstable than those without TP53 mutations. In terms of the landscape of genomic alterations, deletion of 9p21.3 covering CDKN2A/2B(30.9%), amplification of 11q13.3 covering CCND1(30.9%), and TP53 point mutation(50.9%) occurred in two-thirds of the cases. These results suggest that the deregulation of the G1 phase during the cell cycle is a key event in ESCC.Furthermore, six minimal common regions were found to be significantly altered in ESCC samples and three of them, 9p21.3, 7p11.2, and 3p12.1, were associated with lymph node metastasis. With the high correlation of TP53 mutation and genomic instability in ESCC, the amplification of CCND1, the deletion of CDKN2A/2B, and the somatic mutation of TP53 appear to play pivotal roles via G1 deregulation and therefore helps to classify this cancer into different genomic subtypes.These findings provide clinical significance that could be useful in future molecular diagnoses and therapeutic targeting. | Qiyan Wang Jian Bai Amir Abliz Ying Liu Kenan Gong Jingjing Li Wenjie Shi Yaqi Pan Fangfang Liu Shujuan Lai Haijun Yang Changdong Lu Lixin Zhang Wei Chen Ruiping Xu Hong Cai Yang Ke Changqing Zeng | 2015 | Genomics, Proteomics & Bioinformatics2015，13，4： | 1 |
| 11 | A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants显示文摘The current COVID-19 pandemic has heavily burdened the global public health system and may keep simmering for years.The frequent emergence of immune escape variants have spurred the search for prophylactic vaccines and therapeutic antibodies that confer broad protection against SARS-CoV-2 variants.Here we show that the bivalency of an affinity maturated fully human singledomain antibody(n3113.1-Fc)exhibits exquisite neutralizing potency against SARS-CoV-2 pseudovirus,and confers effective prophylactic and therapeutic protection against authentic SARS-CoV-2 in the host cell receptor angiotensin-converting enzyme 2(ACE2)humanized mice.The crystal structure of n3113 in complex with the receptor-binding domain(RBD)of SARS-CoV-2,combined with the cryo-EM structures of n3113 and spike ecto-domain,reveals that n3113 binds to the side surface of up-state RBD with no competition with ACE2.The binding of n3113 to this novel epitope stabilizes spike in up-state conformations but inhibits SARS-CoV-2 S mediated membrane fusion,expanding our recognition of neutralization by antibodies against SARS-CoV-2.Binding assay and pseudovirus neutralization assay show no evasion of recently prevalent SARS-CoV-2 lineages,including Alpha(B.1.1.7),Beta(B.1.351),Gamma(P.1),and Delta(B.1.617.2)for n3113.1-Fc with Y58L mutation,demonstrating the potential of n3113.1-Fc(Y58L)as a promising candidate for clinical development to treat COVID-19. | Zhenlin Yang Yulu Wang Yujia Jin Yuanfei Zhu Yanling Wu Cheng Li Yu Kong Wenping Song Xiaolong Tian Wuqiang Zhan Ailing Huang Shanshan Zhou Shuai Xia Xiaoxu Tian Chao Peng Cuicui Chen Yibing Shi Gaowei Hu Shujuan Du Yuyan Wang Youhua Xie Shibo Jiang Lu Lu Lei Sun Yuanlin Song Tianlei Ying | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 1 |
| 12 | Effect of inoculum/substrate ratio on methane yield and or- thophosphate release from anaerobic digestion of Microcystis spp 显示文摘 | Shujuan Zeng Xianzheng Yuan Xiaoshuang Shi | 2010 | Journal of Hazardous Materials2010，178，： | 1 |
| 13 | Simple conjugated polymers with on-chain phosphorescent iridium ( iii ) complexes : Toward ratiometric chemodosimeters for detecting trace amounts of mercury(ii) 显示文摘 | SHI Huifang LIU Shujuan SUN Huibin | 2010 | Chem-Eur J2010，16，12： | 1 |
| 14 | Dissipative Particle Dynamics Study on Platycodin's Solubilization Enhancing Effect Towards Five Drug Components显示文摘In this study,a dissipative particle dynamics mehtod was used to study the solubilization enhancing effect of platycodin towards 5 different drug components.Two factors were mainly considered,including the ,XlogP value of drug components and the sugar chain length of platycodin.As a result,it was found that there was an optimal drug XlogP value for the solubilization enhancing effect of platycodin,and it was different between the drug's own XlogP value and the optimal drug XlogP value of platycodin that determines the solubilization enhancing effect. | WU Zhimin DING Haiou YANG Chang GUO Shujuan DAI Xingxing SHI Xinyuan | 2019 | Chemical Research in Chinese Universities2019，35，1： | 0 |
| 15 | The Inhibitory Effects of PSS-Loaded Nanoparticles on the Dysfunction of Cardiac Microvascular Endothelia in Rats with Diabetic Cardiomyopathy显示文摘Propylene glycol alginate sodium sulfate-loaded nanoparticles(PSS-NP) has been shown potential to prevent the microvascular endothelial injuries caused by diabetic cardiomyopathy(DCM). In this study, we aimed to investigate the effects of PSS-NP on the dysfunction of cardiac microvascular endothelia in streptozotocin(STZ)-induced DCM rat model. Echocardiographic measurements showed a significant improvement of cardiac function in the PSS-NP-treated group. Our results revealed that the abnormalities of cardiac systolic and diastolic functions were suppressed by the treatments of prostaglandin E1(PGE1), low molecular weight heparin(LMWH), PSS and PSS-NP. Our comparison analysis indicated that PSS-NP showed the strongest inhibitory effects on microvascular endothelial injuries. Transmission electron microscopy analysis demonstrated that PSS-NP protected the cardiac microvascular endothelium and further improved endothelium dysfunction in DCM rats. ELISA and Western blot assays further showed a high efficiency of improving cardiac microvascular endothelial dysfunction with PSS-NP. Our results demonstrated that PSS-NP increased the protein expression of phosphatidylinositol 3-kinase(PI3K)-p85 and vascular endothelial growth factor(VEGF)-A, and the phosphorylation of protein kinase B(Akt) and endothelial nitric oxide synthase(eNOS), which were involved in the amelioration of cardiac microvascular endothelial dysfunction. These data suggest that PSS-NP may be a novel approach to the treatment the coronary microcirculation disorder diseases such as DCM. | AN Nina YU Luyan HU Yi FENG Wenjing SHI Shujuan CHEN Honghua MAO Yongjun | 2019 | Journal of Ocean University of China2019，18，1： | 0 |
| 16 | Lattice vibrational modes and phonon thermal conductivity of singlelayer GaGeTe显示文摘Exploring the vibrational properties of experimental or theoretical finding of new phase twodimensional(2D)materials is one key to expand their promising application.The GaGeTe monolayer with high carrier mobility,tunable band structure,and low cleavage energy attracts rapidly growing interests in electronics.However,their vibrational modes and phonon properties are not explored.Based on first-principles calculations within the framework of density functional perturbation theory,we systematically study the lattice vibrational modes as well as phonon thermal conductivity of single-layer GaGeTe,which could be exfoliated from the experimentally synthesized GaGeTe crystal.We find that the frequencies and intensities of A1g and Eg Raman modes,contributing to the main peaks in Raman spectra of monolayer GaGeTe,show distinct responses to different external strains.The calculated lattice thermal conductivity of GaGeTe is about 58 Wm-1 K1,which is comparable to that of MoS2(around 52 Wm1K1)and two orders of magnitude lower than that of graphene(2000 Wm1K1)at room temperature.This is mainly due to the partial couple for acoustic branches and low frequency optic phonon branches,moderate group velocity,strong anharmonic ZA phonon branch.Moreover,atom substitution at tellurium could be as an effective strategy to further decrease lattice thermal conductivity.Our findings fill in the gap about the thermal transport properties of GaGeTe monolayer and trigger for further experimental verification of the predicted properties. | Jingyu Li Peng-Fei Liu Chi Zhang Xiaobo Shi Shujuan Jiang Weizhen Chen Huabing Yin Bao-Tian Wang | 2020 | Journal of Materiomics2020，6，4： | 0 |
| 17 | Votalization of selenium in selenium-rich black rock series in Yutangba显示文摘 | Shujuan SHI Yuegang TANG | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 0 |
| 18 | Corrigendum to “Characterization of the essential role of bone morphogenetic protein 9 (BMP9) in osteogenic differentiation of mesenchymal stem cells (MSCs) through RNA interference” [Genes & Diseases 5(2018):172–184]显示文摘The authors regret having several image assembly errors.Specifically,in Figure 3A panel b,the image for 'AdsimB9-4 only'group was erroneously duplicated with an overlapping image from the'AdRFp'group;and the image for'AdsimB9-1+BMP9'groupwas erroneouslyduplicatedwithan overlapping image from'AdsimB9-8+BMP9'group.In Figure 4Apanel a,the images for'BMP9'group and 'BMP9+simB9-4'group were erroneously duplicated with an overlapping image from'simB9-4'group.In Figure 5A,the image for'BMP9+simB9-4/Day3'group was erroneously duplicated with an overlapping image from'BMP9+simB9-7/Day3'group;and the image for'BMP9+simB9-4/Day5'group was erroneously duplicated with an overlapping image from an unrelated experiment.In Figure 6B,the image for'BMP9+simB9-7/Day 11'group was erroneously duplicated with an overlapping image from the'BMP9+simB9-4/Day 11'group. | Shujuan Yan Ruyi Zhang Ke Wu Jing Cui Shifeng Huang Xiaojuan Ji Liping An Chengfu Yuan Cheng Gong Linghuan Zhang Wei Liu Yixiao Feng Bo Zhang Zhengyu Dai Yi Shen Xi Wang Wenping Luo Bo Liu Rex C. Haydon Michael J. Lee Russell R. Reid Jennifer Moriatis Wolf Qiong Shi Hue H. Luu Tong-Chuan He Yaguang Weng | 2023 | Genes & Diseases2023，10，2： | 0 |
| 19 | Organic Ligand-Free Hydroformylation with Rh Particles as Catalyst显示文摘Summary of main observation and conclusion An efficient and organic ligand-free heterogeneous catalytic system for hydroformylation of olefins is highly desirable for both academy and industry.In this study,simple Rh black was employed as a heterogeneous catalyst for hydroformylation of olefins in the absence of organic ligand.The Rh black catalyst showed good catalytic activity for a broad substrate scope including the aliphatic and aromatic olefins,affording the desired aldehydes in good yields.Taking the hydroformylation of ethylene as an example,86%yield of propanal and TOF of 200 h-1 were obtained,which was superior to the reported homogeneous catalytic systems.In addition,the catalyst could be reused five times without loss of activity under identical reaction conditions,and the Rh leaching was negligible after each cycle. | Shujuan Liu Xingchao Dai Hongli Wang Xinzhi Wang Feng Shi | 2020 | Chinese Journal of Chemistry2020，38，2： | 0 |
| 20 | Computational prediction of Mo_(2)@g-C_(6)N_(6) monolayer as an efficient electrocatalyst for N_(2) reduction显示文摘Electrocatalytic nitrogen reduction reaction(NRR)is an environmentally friendly method for sustainable ammonia synthesis under ambient conditions.Searching for efficient NRR electrocatalysts with high activity and selectivity is currently urgent but remains great challenge.Herein,we systematically investigate the NRR catalytic activities of single and double transition metal atoms(TM=Fe,Co,Ni and Mo)anchored on g-C_(6)N_(6) monolayers by performing first-principles calculation.Based on the stability,activity,and selectivity analysis,Mo_(2)@g-C_(6)N_(6) monolayer is screened out as the most promising candidate for NRR.Further exploration of the reaction mechanism demonstrates that the Mo dimer anchored on g-C_(6)N_(6) can sufficiently activate and efficiently reduce the inert nitrogen molecule to ammonia through a preferred distal pathway with a particularly low limiting potential of -0.06 V.In addition,we find that Mo_(2)@g-C_(6)N_(6) has excellent NRR selectivity over the competing hydrogen evolution reaction,with the Faradaic efficiency being 100%.Our work not only predicts a kind of ideal NRR electrocatalyst but also encouraging more experimental and theoretical efforts to develop novel double-atom catalysts(DACs)for NRR. | Jiajun Wang Mengyao Shi Guolin Yi Lu Wang Shulai Lei Ke Xu Shujuan Li Jianshuai Mu | 2022 | Chinese Chemical Letters2022，33，10： | 0 |
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