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| 1 | Effects of Xinfeng capsule on pulmonary function based on treg-mediated notch pathway in a rat model of adjuvant arthritis显示文摘OBJECTIVE:To observe the impact of xinfeng xapsule(XFC) on pulmonary function in a rat model of adjuvant arthritis(AA) and to investigate the mechanism of action.METHODS:Forty rats were randomly divided into four groups of ten:normal control(NC);model control(MC);tripterygium glycosides tablet(TPT);and xinfeng capsule(XFC).Except for the NC group,AA was induced in all rats by intracutaneous injection of 0.1 mL Freund's complete adjuvant in the right paw on the 19th day.NC and MC groups were given(0.9%) physiological saline.The TPT and XFC groups were given TPT(10 mg/kg) and XFC(1.2 g/kg),respectively.Thirty days after administration,changes in paw edema(E),the arthritis index(AI),pulmonary function,levels of regulatory T-cells(Treg),ultrastructure of lung tissue,and expression of Notch receptors and ligands in lung tissue were observed.RESULTS:In the MC group,E and the AI were increased and pulmonary function significantly decreased;the structure of alveolar type-II cells was damaged;ratios of Treg in peripheral blood were reduced;and expression of Notch receptors such as Notch3 and Notch4 and ligands such as Delta1 in lung tissue were significantly increased whereas expression of Notch1,Jagged1 and Jagged2 were significantly decreased.After intervention with XFC,E and the AI were decreased;pulmonary function was enhanced;the structure of alveolar type-II cells was improved;and expression of Treg,Notch1,Jagged1,Jagged2 was elevated,whereas that of Notch3,Notch4 and Delta1 was reduced.CONCLUSION:XFC can not only inhibit E and the AI and improve joint symptoms,it can also improve pulmonary function and reduce inflammation in lung tissue.These actions could be carried out through increases in the expression of Treg,Notch receptors(Notch1) and ligands(Jagged1,Jagged2),and reductions in the expression of Notch3,Notch4 and Delta1.These phenomena would reduce the deposition of immune complexes and the inflammatory response in lung tissue,thereby improving joint symptoms and pulmonary function. | Lei Wan Jian Liu Chuanbing Huang Yuan Wang Xi Shen Wandong Zhang Guizheng Wang Haixia Fan Yao Ge Ruilian Chen Yunxiang Cao Ruikai Zong Li Lei | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 17 |
| 2 | Use of Xinfeng capsule to treat abarticular pathologic changes in patients with rheumatoid arthritis显示文摘OBJECTIVE: To observe the influence of Xinfengcapsule(XFC) on abarticular pathologic changes(APCs) and other indices of patients with rheumatoid arthritis(RA) and explore the mechanism of action of XFC in improving such changes.METHODS: Three-hundred RA patients were divided randomly into a treatment group(n=150) and control group(n=150). A normal control(NC)group(n=90) was also created. Changes in cardiac function, pulmonary function, anemia indices and platelet parameters of RA patients were measured.Curative effects of the two groups were compared,and comparison carried out with the NC group.RESULTS: In 300 RA patients, late diastolic peak flow velocity(A peak) was much higher(P<0.01)and early diastolic peak flow velocity(E peak), E/A,and left ventricular fraction shortening much lower(P<0.01) than those in the NC group. Vital capacity(VC), forced vital capacity in one second, forced vital capacity(FVC), maximal voluntary ventilation(MVV), maximal expiratory flow in 50% of VC(FEF50) and FEF75 were lowered remarkably(P<0.05 or P<0.01). Platelet count(PLT), plateletcrit(PCT) and mean platelet volume(MPV) increased markedly(P<0.05 or P<0.01), and hemoglobin(Hb)level decreased significantly(P<0.05). After XFC treatment, the A peak and PLT and PCT were much lower(P<0.05), and E/A and the number of red blood cells as well as Hb level were much higher(P<0.05), as were FVC, MVV and FEF50(P<0.05 or P<0.01), in the treatment group than those in the NC group. Total score of pain and swelling in joints,uric-acid level and high-sensitivity C-reactive protein level were much lower, and superoxide dismutase level as well as the number of CD4 +CD25+ regulation T cells(Treg) and CD4+CD25+CD127- Treg were much higher(P<0.05 or P<0.01)in the treatment group than those in the NC group.CONCLUSION: RA patients with pathologic changes in joints also suffer from lower cardiac and pulmonary functions and from parameters of anemia and platelet factors. XFC can improve the symptoms of RA patients, ameliorate their cardiac and pulmonary functions and reduce the parameters of anemia and platelet factors. XFC lowers the immune inflammatory reaction to improve APCs in RA patients. | Jian Liu Yunxiang Cao Chuanbing Huang Yuan Wang Xi Chen Wandong Zhang Guizhen Wang Haixia Fan Yao Ge Ruilian Chen Ruikai Zong Yajun Qi Yue Sun Yifei Liu Fang Wang | 2014 | Journal of Traditional Chinese Medicine2014，34，5： | 10 |
| 3 | Evaluation of Two Momentum Control Variable Schemes and Their Impact on the Variational Assimilation of Radar Wind Data:Case Study of a Squall Line显示文摘Different choices of control variables in variational assimilation can bring about different influences on the analyzed atmospheric state.Based on the WRF model's three-dimensional variational assimilation system,this study compares the behavior of two momentum control variable options—streamfunction velocity potential(ψ–χ) and horizontal wind components(U–V)—in radar wind data assimilation for a squall line case that occurred in Jiangsu Province on 24 August 2014.The wind increment from the single observation test shows that the ψ–χ control variable scheme produces negative increments in the neighborhood around the observation point because streamfunction and velocity potential preserve integrals of velocity.On the contrary,the U–V control variable scheme objectively reflects the information of the observation itself.Furthermore,radial velocity data from 17 Doppler radars in eastern China are assimilated.As compared to the impact of conventional observation,the assimilation of radar radial velocity based on the U–V control variable scheme significantly improves the mesoscale dynamic field in the initial condition.The enhanced low-level jet stream,water vapor convergence and low-level wind shear result in better squall line forecasting.However,the ψ–χ control variable scheme generates a discontinuous wind field and unrealistic convergence/divergence in the analyzed field,which lead to a degraded precipitation forecast. | Xin LI Mingjian ZENG Yuan WANG Wenlan WANG Haiying WU Haixia MEI | 2016 | Advances in Atmospheric Sciences2016，33，10： | 10 |
| 4 | O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an “O-Follow-N” rule显示文摘Dear Editor,Severe acute respiratory syndrome coronavirus-2(SARS-CoV-2),the causative agent of coronavirus disease 2019(COVID-19),emerged in late 2019 and has since caused a pandemic.Although there have been extensive studies worldwide,our understanding of this newly emerged pathogen is far from sufficient.The pathogenesis of the SARS-CoV-2 infection is not fully understood,although a“two-stage”hypothesis was proposed in our previous study. | Wenmin Tian Delin Li Nan Zhang Guijie Bai Kai Yuan Haixia Xiao Feng Gao Yang Chen Catherine C.L.Wong George Fu Gao | 2021 | Cell Research2021，31，10： | 9 |
| 5 | The long rather than the short allele of 5-HTTLPR predisposes Han Chinese to anxiety and reduced connectivity between prefrontal cortex and amygdala显示文摘The short allele of the serotonin-transporter gene is associated with higher risk for anxiety and depression in Caucasians, but this association is still unclear in Asians. Here, we addressed this issue using behavioral and multi-modal MRI approaches in a large group of healthy Han Chinese participants (n = 233). In contrast to findings in Caucasians, we found that long-allele (L) carriers had higher anxiety scores. In another group (n = 64) experiencing significant levels of depression or anxiety, the L-allele frequency was also significantly higher. In healthy participants, L-carriers had reduced functional and anatomical connectivity between the amygdala and prefrontal cortex (PFC), which was correlated with anxiety or depression scores. Our findings demonstrated that in Chinese Han participants, in contrast to Caucasians, the L-allele confers vulnerability to anxiety or depression and weakens top-down emotional control between the PFC and amygdala. Therefore, ethnic background should be taken into account in gene-related studies and their potential clinical applications. | Haixia Long Bing Liu Bing Hou Chao Wang Jin Li Wen Qin Dawei Wang Yuan Zhou Keith M. Kendrick Chunshui Yu Tianzi Jiang | 2013 | Neuroscience Bulletin2013，29，1： | 9 |
| 6 | Arsenic trioxide alleviates acute graft-versus-host disease by modulating macrophage polarization显示文摘This study aimed to explore macrophage polarization in acute graft-versus-host disease after hematopoietic stem cell transplantation, and investigated if arsenic trioxide(ATO) could correct this imbalance. In the colon of GVHD mice, we found that the number of F4/80+iNOS+ cells as well as the expression intensity of TNF-α and IL-1β was greater in the GVHD group than in the BM group, whereas the number of F4/80+CD206+ cells and the expression intensity of IL-10 and TGF-β was greater in the BM group than in the GVHD group. We investigated the effect of ATO on GVHD mice, and found that ATO treatment clearly improved the survival of the mice and reduced the severity of GVHD. In addition, ATO reduced the number of F4/80+iNOS+ cells, and increased the number of F4/80+CD206+ cells in the colon of GVHD mice. Furthermore, ATO sharply decreased CD86 and CD80 expression, and increased CD163 and CD206 expression in macrophages induced from aGVHD patients. Therefore,ATO can modulate the M1 and M2 phenotype in GVHD mice or in macrophages from aGVHD patients. Our data suggest that macrophage polarization is involved in the pathogenesis of aGVHD, and ATO treatment modulates macrophage polarization toward an M2 phenotype. | Xiao Liu Yan Su Xueyan Sun Haixia Fu Qiusha Huang Qi Chen Xiaodong Mo Meng Lv Yuan Kong Lanping Xu Xiaojun Huang Xiaohui Zhang | 2020 | Science China(Life Sciences)2020，63，11： | 6 |
| 7 | Photocatalytic degradation of 4-tert-octylphenol in a spiral photoreactor system显示文摘A spiral photoreactor system(SPS) was developed for the degradation of 4-tert-octylphenol(4-t-OP) in aqueous phase.4-t-OP was previously considered as a endocrine disrupting compound frequently present in water.The direct photodegradation reaction caused by the SPS was found to accord with the characteristic of apparent first-order reaction with reaction rate constant k = 4.8 × 10-2 min-1.However,the direct photodegradation reaction could not make the 4-t-OP mineralized.The photodegradation efficiency increased from 88% to 91.2% in 45 min irradiation period after the internal surface of SPS was sintered with TiO2 thin film as catalyst.Catalyst concentration,number of catalyst coating layers and initial concentration of 4-t-OP were proven to be the factors affecting the photocatalytic degradation performance of the SPS on aqueous 4-t-OP.The degradation mechanism was investigated and the byproducts were analyzed using total organic carbon analyzer(TOC) and LC-MS.The possible chemical structures of the products were suggested.SPS with single layer of TiO2 prepared by sintering 13.6% of TiO2 precursor was proven to be more efficient than most of previous systems for removal of 4-t-OP from aqueous phase.28.3% of the 4-t-OP was mineralized in 45 min according to the decreased amount of TOC value. | Yanlin Wu Haixia Yuan Xiaoxuan Jiang Guanran Wei Chunlei Li Wenbo Dong | 2012 | Journal of Environmental Sciences2012，24，9： | 3 |
| 8 | History of and suggestions for China’s biosafety legislation显示文摘Biosafety has attracted an unprecedented amount of attention from the global community as an important element in national security.All biosafety issues are related to laws and therefore must be regulated accordingly.A preliminary biosafety legislation system based on and suitable for China’s actual conditions has been established.The provisions of numerous laws have provided legislative tools to manage biosafety issues.The State Council and relevant ministries have also exercised their respective functions and drafted codes and regulations concerning biosafety protection.These laws and regulations play important roles,but our nation still lacks a law solely dedicated to biosafety regulation,and the supervisory system is incomplete.To remedy this situation,relevant biotechnologies must be developed,issues related to biosafety must be thoroughly examined,and the best practices of other nations should be introduced,all of which will improve biosafety legislation in China. | Liang Huigang Xiang Xiaowei Ma Haixia Yuan Zhiming | 2019 | Journal of Biosafety and Biosecurity2019，1，2： | 3 |
| 9 | ZIC1 Is a Putative Tumor Suppressor in Thyroid Cancer by Modulating Major Signaling Pathways and Transcription Factor FOXO3a显示文摘 | Wei Qiang Yuan Zhao Qi Yang Wei Liu Haixia Guan Siqing Lv Meiju Ji Bingyin Shi Peng Hou | 2014 | The Journal of Clinical Endocrinology & Metabolism2014，，7： | 2 |
| 10 | Correlation between the genetic variants of base excision repair (BER) pathway genes and neuroblastoma susceptibility in eastern Chinese children显示文摘Dear Editor,Neuroblastoma is the most common non-central nerve system(CNS)solid tumor in pediatrics[1].Neuroblastoma accounts for approximately 8%of all pediatric cancers but disproportionally causes a high cancer mortality(15%)in children[2].Pediatric patients with low-risk neuroblastoma witness a 5-year overall survival rate>90%,whereas the 5-year overall survival rate in high-risk neuroblastoma pediatric patients is<40%[3]. | Zhenjian Zhuo Chunlei Zhou Yuan Fang Jinhong Zhu Hongting Lu Haixia Zhou Haiyan Wu Yizhen Wang Jing He | 2020 | Cancer Communications2020，40，11： | 2 |
| 11 | Genetic and Phylogenetic Characterization of a Chikungunya Virus Imported into Shenzhen, China显示文摘Dear Editor,Chikungunya virus(CHIKV)is a mosquito-borne virus belonging to the family Togaviridae,genus Alphavirus,and was first isolated in Tanzania in the 1950s(Silva and Dermody 2017;Weaver and Lecuit 2015).Human infections with CHIKV typically result in a rapid-onset febrile disease,with symptoms that include fever,headache,rash,severe joint and muscle pain,as well as prolonged periods of disability in some patients(Weaver and Lecuit 2015;Silva and Dermody 2017). | Yang Yang Zhixiang Xu Haixia Zheng Jingdong Song Ying Wu Zhou Tong Jing Yuan Gary Wong William J.Liu Yuhai Bi Yingxia Liu George F.Gao | 2020 | Virologica Sinica2020，35，1： | 2 |
| 12 | Design and Analysis of Spatial Modulation Based Orthogonal Time Frequency Space System显示文摘In this paper,we design a spatial modulation based orthogonal time frequency space(SMOTFS)system to achieve improved transmission reliability and meet the high transmission rate and highspeed demands of future mobile communications,which fully utilizes the characteristics of spatial modulation(SM)and orthogonal time frequency space(OTFS)transmission.The detailed system design and signal processing of the SM-OTFS system have been presented.The closed-form expressions of the average symbol error rate(ASER)and average bit error rate(ABER)of the SM-OTFS system have been derived over the delay-Doppler channel with the help of the union bounding technique and moment-generating function(MGF).Meanwhile,the system complexity has been evaluated.Numerical results verify the correctness of the theoretical ASER and ABER analysis of the SM-OTFS system in the high signal-to-noise ratio(SNR)regions and also show that the SM-OTFS system outperforms the traditional SM based orthogonal frequency division multiplexing(SM-OFDM)system with limited complexity increase under mobile conditions,especially in high mobility scenarios. | Yingchao Yang Zhiquan Bai Ke Pang Piming Ma Haixia Zhang Xinghai Yang Dongfeng Yuan | 2021 | China Communications2021，18，8： | 2 |
| 13 | Novel study on PAPR reduction in wavelet-based multiearrier modulation systems显示文摘 | Zhang Haixia Yuan Dongfeng Matthias Patzold | 2007 | Digital Signal Processing2007，17，1： | 1 |
| 14 | The preliminary study on the antithrombotic mechanism of glycosaminoglycan from Mactra Veneriformis显示文摘 | Qingman Cui Haixia Wang Chunying Yuan | 2014 | Blood Coagulation & Fibrinolysis2014，25，1： | 1 |
| 15 | Quality-of-Service Driven Power and Sub-Carrier Allocation Policy for Vehicular Communication Networks显示文摘 | ZHANG Haixia MA Yanbo YUAN Dongfeng | 2011 | IEEE Journal on Selected Areas in Communications2011，29，1： | 1 |
| 16 | A new room temperature ionic liquid 1-butyl-3-trimethylsilylimidazolium hexafluorophosphate as a solvent for extraction and preconcentration of mercury with determination by cold vapor atomic absorption spectrometry显示文摘 | Zaijun Li Qin Wei Rui Yuan Xia Zhou Huizhen Liu Haixia Shan Qijun Song | 2006 | Talanta2006，，1： | 1 |
| 17 | High performance Cu-doped vanadium oxide (Cu2V2O5 ) prepared by rapid precipitation method for rechargeable batteries显示文摘 | Haixia Li Lifang Jiao Huatang Yuan | 2007 | Materials Letters2007，61，： | 1 |
| 18 | Micronization of atorvastatin calcium by antisolvent precipitation process显示文摘 | Zhang Haixia Wang Jiexin Zhang Zhibing Le Yuan Shen Zhigang Chen Jianfeng | | 0，，1： | 1 |
| 19 | Fire per- formance and mechanical properties of phenolic foams modi- fied by phosphorus-containing polyethers显示文摘 | YANG Hongyu WANG Xin YUAN Haixia | 2012 | Journal of Poly- mer Research2012，19，3： | 1 |
| 20 | A new temperature ionic liquid 1-butyl-3-trimethylsilylimidazolium hexafluorophosphate as a solvent for extraction and preconcentration of mercury with determination by cold vapor atomic absorption spectrometry显示文摘 | Li zaijun Wei Qin Zhou Xia Yuan Rui Liu Huizhen Shan Haixia Song Qijun | 2007 | Talanta2007，71，1： | 1 |
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