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| 1 | Nitrification characteristics of nitrobacteria immobilized in waterborne polyurethane in wastewater of corn-based ethanol fuel production显示文摘A technology to achieve stable and high ammonia nitrogen removal rates for corn distillery wastewater (ethanol fuel production) treatment has been designed.The characteristics of nitrifying bacteria entrapped in a waterborne polyurethane (WPU) gel carrier were evaluated after acclimation.In the acclimation period,nitrification rates of WPU-immobilized nitrobacteria were monitored and polymerase chain reaction (PCR) was also carried out to investigate the change in ammonium-oxidizing bacteria.The results showed that the pellet nitrification rates increased from 21 to 228 mg-N/(L-pellet·hr) and the quantity of the ammonia oxidation bacteria increased substantially during the acclimation.A continuous ammonia removal experiment with the anaerobic pond effluent of a distillery wastewater system was conducted with immobilized nitrifying bacteria for 30 days using an 80 L airlift reactor with pellets at a fill ratio of 15% (V/V).Under the conditions of 75 mg/L influent ammonia,hydraulic retention time (HRT) of 3.7-5.6 hr,and dissolved oxygen (DO) of 4 mg/L,the effluent ammonia concentration was lower than 10 mg/L and the ammonia removal efficiency was 90%.While the highest ammonia removal rate,162 mg-N/(L-pellet·hr),was observed when the HRT was 1.3 hr. | Yamei Dong Zhenjia Zhang Yongwei Jin Jian Lut Xuehang Cheng Jun Li Yan-yan Deng Ya-nan Feng Dongning Chen | 2012 | Journal of Environmental Sciences2012，24，6： | 14 |
| 2 | A Vehicle Routing Problem Based on Intelligent Batteries Transfer Management for the EV Network显示文摘Batteries transfer management is one important aspect in electric vehicle(EV)network's intelligent operation management system.Batteries transfer is a special and much more complex VRP(Vehicle Routing Problem) which takes the multiple constraints such as dynamic multi-depots,time windows,simultaneous pickups and deliveries,distance minimization,etc.into account.We call it VRPEVB(VRP with EV Batteries).This paper,based on the intelligent management model of EV's battery power,puts forward a battery transfer algorithm for the EV network which considers the traffic congestion that changes dynamically and uses improved Ant Colony Optimization.By setting a reasonable tabv range,special update rules of the pheromone and path list memory functions,the algorithm can have a better convergence,and its feasibility is proved by the experiment in an EV's demonstration operation system. | XIA Yamei CHENG Bo | 2014 | China Communications2014，11，5： | 2 |
| 3 | Unravelling the critical role of surface Nafion adsorption in Ptcatalyzed oxygen reduction reaction by in situ electrical transport spectroscopy显示文摘Solid-state ionic conductor is a vital part in all electrochemical energy conversion devices. As a widely-applied protonconducting polymer and stabilizer for electrode preparation, Nafion has key applications in electrochemical devices operated under acidic conditions. Specific adsorption of Nafion on the catalyst surface is considered to result in partial loss of intrinsic activity in reactions such as oxygen reduction reaction(ORR), due to its comprehensive occupation of active sites. Many in situ characterization methods such as voltammetric fingerprinting and spectroscopic approaches have been used to explore the dynamic adsorption of Nafion on the electrode surface. However, most of current efforts have been focused on the behaviors of Nafion itself, with little attention paid to its effects on the adsorption of surface intermediates. Here, we employed the in situ electrical transport spectroscopy(ETS) to investigate Nafion adsorption on Pt catalysts and its effects on the ORR intermediates.Our findings suggest that specific adsorption of Nafion results in the increased coverage of oxygen intermediates with weaker adsorption strength, which in turn plays a critical role in the reaction selectivity. The successful application of ETS on the dynamic characterization of reaction intermediates provides a novel perspective for catalyst design in ORR-related applications in future sustainable chemistry. | Yamei Sun Jingyi Tian Zhangyan Mu Bailin Tian Qiulan Zhou Cheng Liu Shengtang Liu Qiang Wu Mengning Ding | 2022 | Science China Chemistry2022，65，11： | 1 |
| 4 | DCLK1 autoinhibition and activation in tumorigenesis显示文摘Doublecortin-like kinase 1(DCLK1)is upregulated in many tumors and is a marker for tumor stem cells.Accumulating evidence suggests DCLK1 constitutes a promising drug target for cancer therapy.However,the regulation of DCLK1 kinase activity is poorly understood,particularly the function of its autoinhibitory domain(AID),and,moreover,no physiological activators of DCLK1 have presently been reported.Here we determined the first DCLK1 kinase structure in the autoinhibited state and identified the neuronal calcium sensor HPCAL1 as an activator of DCLK1.The C-terminal AID functions to block the ATP-binding site and is competitive with ATP.HPCAL1 binds directly to the AID in a Ca^(2+)-dependent manner,which releases the autoinhibition.We also analyzed cancer-associated mutations occurring in the AID and elucidate how these mutations disrupt DCLK1 autoinhibition to elicit kinase activity upregulation.Our results present a molecular mechanism for autoinhibition and activation of DCLK1 kinase activity and provide insights into DCLK1-associated tumorigenesis. | Linna Cheng Zejing Yang Wenhao Guo Chengyong Wu Shufang Liang Aiping Tong Zhongwei Cao Rick F.Thorne Sheng-Yong Yang Yamei Yu Qiang Chen | 2022 | The Innovation2022，3，1： | 1 |
| 5 | Forebrain-dominant deficit in cerebrovascular reactivity in Alzheimer’s disease显示文摘 | Uma S. Yezhuvath Jinsoo Uh Yamei Cheng Kristin Martin-Cook Myron Weiner Ramon Diaz-Arrastia Matthias van Osch Hanzhang Lu | 2012 | Neurobiology of Aging2012，，1： | 1 |
| 6 | Morphological and skeletal comparison and ecological adaptability of Mandarin fish Siniperca chuatsi and big-eye Mandarin fish Siniperca kneri显示文摘Most of the closely related fish species are similar in appearance,with slight differences.This study evaluated 35 morphological characteristic parameters and the number,shape,and spatial location of bones in the skull and vertebrae of the mandarin fish Siniperca chuatsi and big-eye mandarin fish Siniperca kneri.We can understand their ecological adaptability,compare their morphological and skeletal differences,and elucidate the relationship between their phenotypic trait differences and skeletal characteristics.The results were as follows:1.The Student’s t-test results revealed significant differences between S.chuatsi and S.kneri in terms of head depth,head back length,snout length,interorbital distance,distance of the eyes from the oral fissure,and width between the posterior trunk and base of the caudal fin.Principal component and discriminant analysis showed that the main morphological differences between S.chuatsi and S.kneri were in the eye position,head hump and body shape.2.There was no significant difference in the number and shape of the skull and vertebrae between S.chuatsi and S.kneri,but they differed in spatial position.The terminus of the maxilla in S.chuatsi is located at the lower border of the postorbital bone,but at the anterior in S.kneri.The size of head hump is closely related to the spatial location of the splanchnocranium in S.chuatsi and S.kneri.The angles between the caudal vertebrae centrum and each of the following:the neural arch and spine;haemal arch and spine of S.chuatsi are larger than those of S.kneri.In conclusion,the morphological differences between S.chuatsi and S.kneri are closely related to the spatial position of skeleton.These phenotypic differences reflect the ecological adaptation of mandarin fish to different natural environments. | XiaoYing Cao JinLiang Zhao ChenHong Li ShuQin Zhu YueYue Hao YaMei Cheng HongYan Wu | 2021 | Aquaculture and Fisheries2021，6，5： | 1 |
| 7 | CCGD-ESCC: A Comprehensive Database for Genetic Variants Associated with Esophageal Squamous Cell Carcinoma in Chinese Population显示文摘Esophageal squamous-cell carcinoma(ESCC) is one of the most lethal malignancies in the world and occurs at particularly higher frequency in China. While several genome-wide association studies(GWAS) of germline variants and whole-genome or whole-exome sequencing studies of somatic mutations in ESCC have been published, there is no comprehensive database publically available for this cancer. Here, we developed the Chinese Cancer Genomic Database-Esophageal Squamous Cell Carcinoma(CCGD-ESCC) database, which contains the associations of 69,593 single nucleotide polymorphisms(SNPs) with ESCC risk in 2022 cases and 2039 controls, survival time of 1006 ESCC patients(survival GWAS) and gene expression(expression quantitative trait loci,eQTL) in 94 ESCC patients. Moreover, this database also provides the associations between8833 somatic mutations and survival time in 675 ESCC patients. Our user-friendly database is a resource useful for biologists and oncologists not only in identifying the associations of genetic variants or somatic mutations with the development and progression of ESCC but also in studying the underlying mechanisms for tumorigenesis of the cancer. CCGD-ESCC is freely accessible at http://gffzzdf7d528e3a264cb9hn055fcpo60v56906.ffgz.tsg.suse.edu.cn/ccgd/ESCCdb. | Linna Peng Sijin Cheng Yuan Lin Qionghua Cui Yingying Luo Jiahui Chu Mingming Shao Wenyi Fan Yamei Chen Ai Lin Yiyi Xi Yanxia Sun Lei Zhang Chao Zhang Wen Tan Ge Gao Chen Wu Dongxin Lin | 2018 | Genomics, Proteomics & Bioinformatics2018，16，4： | 1 |
| 8 | Effects of salinity and alkalinity on fatty acids, free amino acids and related substance anabolic metabolism of Nile tilapia显示文摘A 56-day experiment was conducted to investigate the effects of ambient salinity and alkalinity on fatty acids,free amino acids and related anabolic metabolisms of Nile tilapia.The fatty acid and free amino acid contents in the muscle of tilapia cultured in saline water(SW),alkaline water(AW),saline-alkaline water(SAW)and fresh water(FW)conditions were analyzed and compared.The mRNA levels and enzymatic activities of fatty acyl desaturase(FADS2),elongation of very long-chain fatty acids(ELOVL5),Δ1-pyrroline-5-carboxylate synthase(P5CS),ornithine-δ-aminotransferase(δ-OAT),and proline dehydrogenase(PDH)were also determined.The contents of saturated and monounsaturated fatty acids were significantly higher in the AW and SAW groups than those in the SW group,and those of eicosapentaenoic acid(EPA)and docosahexaenoic acid(DHA)were the highest in the SAW group.The contents of flavor amino acids in the SAW and AW groups were significantly higher than that in the SW group,and that of proline in the SW,AW,and SAW groups was 3.58-,4.11-,and 4.15-times higher than that in the FW group.The mRNA levels and enzyme activities of FADS 2,ELOVL5,PDH and P5CS were found to differ among the different groups.The results suggested that ambient salinity and alkalinity could effectively improve flesh quality of tilapia by regulating lipid and proline metabolism pathways. | Yamei Cheng Jinliang Zhao Christian Larbi Ayisi Xiaoying Cao | 2022 | Aquaculture and Fisheries2022，7，4： | 0 |
| 9 | Evidence of aircraft activity impact on local air quality: A study in the context of uncommon airport operation显示文摘Wuhan Tianhe International Airport (WUH) was suspended to contain the spread of COVID-19,while Shanghai Hongqiao International Airport (SHA) saw a tremendousflight reduction.Closure of a major international airport is extremely rare and thus represents a unique opportunity to straightforwardly observe the impact of airport emissions on local air quality.In this study,a series of statistical tools were applied to analyze the variations in air pollutant levels in the vicinity of WUH and SHA.The results of bivariate polar plots show that airport SHA and WUH are a major source of nitrogen oxides.NOx,NO_(2)and NO diminished by 55.8%,44.1%,76.9%,and 40.4%,33.3% and 59.4% during the COVID-19 lockdown compared to those in the same period of 2018 and 2019,under a reduction in aircraft activities by 58.6%and61.4%.The concentration of NO_(2),SO_(2)and PM_(2.5)decreased by 77.3%,8.2%,29.5%,right after the closure of airport WUH on 23 January 2020.The average concentrations of NO,NO_(2)and NOxscatter plots at downwind of SHA after the lockdown were 78.0%,47.9%,57.4%and 62.3%,34.8%,41.8%lower than those during the same period in 2018 and 2019.However,a significant increase in O_(3)levels by 50.0% and 25.9%at WUH and SHA was observed,respectively.These results evidently show decreased nitrogen oxides concentrations in the airport vicinity due to reduced aircraft activities,while amplified O_(3)pollution due to a lower titration by NO under strong reduction in NOxemissions. | Hao Xu Kai Xiao Jun Pan Qingyan Fu Xiaodong Wei Junrui Zhou Yamei Yu Xue Hu Huarui Ren Jinping Cheng Shitao Peng Ningning Hong Yin Ye Ning Su Zehui He Tao Hu | 2023 | Journal of Environmental Sciences2023，，3： | 0 |
| 10 | Outcomes of allograft from donor kidney microthrombi and secondary recipient thrombotic microangiopathy: should we consider loosening the belt?显示文摘There is currently a huge worldwide demand for donor kidneys for organ transplantation.Consequently,numerous marginal donor kidneys,such as kidneys with microthrombi,are used to save patients'lives.While some studies have shown an association between the presence of microthrombi in donor kidneys and an increased risk for delayed graft function(DGF)(McCall et al.,2003;Gao et al.,2019),other studies have demonstrated that microthrombi negatively impact the rate of DGF(Batra et al.,2016;Hansen et al.,2018),but not graft survival rate(McCall et al.,2003;Batra et al.,2016;Gao et al.,2019).In contrast,Hansen et al.(2018)concluded that fibrin thrombi were not only associated with reduced graft function six months posttransplantation but also with increased graft loss within the first year of transplantation.On the other hand,Batra et al.(2016)found no significant differences in the DGF rate or one-year graft function between recipients in diffuse and focal microthrombi groups.To date,however,the overall influence of donor kidney microthrombi and the degree of influence on prognosis remain controversial,necessitating further research. | Yamei CHENG Luying GUO Xue REN Zhenzhen YANG Junhao LV Huiping WANG Wenhan PENG Hongfeng HUANG Jianyong WU Jianghua CHEN Rending WANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，6： | 0 |
| 11 | Molecule-based vertical transistor via intermolecular charge transport throughπ-πstacking显示文摘Theπ-πstacking is a well-recognized intermolecular interaction that is responsible for the construction of electron hopping channels in numerous conducting frameworks/aggregates.However,the exact role ofπ-to-πchannels within typical single crystalline organic semiconductors remains unclear as the orientations of these molecules are diverse,and their control usually requires additional side chain groups that misrepresent the intrinsic properties of the original semiconducting molecules.Therefore,the construction of conduction channels with intrinsicπ-πstacking in the molecule-based device is crucial for the utilization of their unique transport characteristics and understanding of the transport mechanism.To this end,we present a molecular intercalation strategy that integrates two-dimensional layered materials with functional organic semiconductor molecules for functional molecule-based electronics.Various organic semiconductor molecules can be effectively intercalated into the van der Waals gaps of semi-metallic TaS_(2) withπ-πstacking configuration and controlled intercalant content.Our results show that the vertical charge transport in the stacking direction shows a tunneling-dominated mechanism that strongly depends on the molecular structures.Furthermore,we demonstrated a new type of molecule-based vertical transistor in which TaS_(2) andπ-πstacked organic molecules function as the electrical contact and the active channel,respectively.On/off ratios as high as 447 are achieved under electrostatic modulation in ionic liquid,comparable to the current state-of-the-art molecular transistors.Our study provides an ideal platform for probing intrinsic charge transport acrossπ-πstacked conjugated molecules and also a feasible approach for the construction of high-performance molecule-based electronic devices. | Cheng Liu Cheng Fu Lingyu Tang Jianghua Wu Zhangyan Mu Yamei Sun Yanghang Pan Bailin Tian Kai Bao Jing Ma Qiyuan He Mengning Ding | 2024 | Nano Research2024，17，5： | 0 |
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