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| 1 | CD147 regulates antitumor CD8^(+)T-cell responses to facilitate tumor-immune escape显示文摘Negative regulation of antitumor T-cell-immune responses facilitates tumor-immune escape.Here,we show that deletion of CD147,a type I transmembrane molecule,in T cells,strongly limits in vivo tumor growth of mouse melanoma and lung cancer in a CD8^(+)T-cell-dependent manner.In mouse tumor models,CD147 expression was upregulated on CD8^(+)tumor-infiltrating lymphocytes(TILs),and CD147 was coexpressed with two immune-checkpoint molecules,Tim-3 and PD-1.Mining publicly available gene-profiling data for CD8^(+)TILs in tumor biopsies from metastatic melanoma patients showed a higher level of CD147 expression in exhausted CD8^(+)TILs than in other subsets of CD8^(+)TILs,along with expression of PD-1 and TIM-3.Additionally,CD147 deletion increased the abundance of TILs,cytotoxic effector function of CD8^(+)T cells,and frequency of PD-1^(+)CD8^(+)TILs,and partly reversed the dysfunctional status of PD-1^(+)Tim-3^(+)CD8^(+)TILs.The cytotoxic transcription factors Runx3 and T-bet mediation enhanced antitumor responses by CD147^(-/-)CD8^(+)T cells.Moreover,CD147 deletion in T cells increased the frequency of TRM-like cells and the expression of the T-cell chemokines CXCL9 and CXCL10 in the tumor microenvironment.Analysis of tumor tissue samples from patients with non-small-cell lung cancer showed negative correlations between CD147 expression on CD8^(+)TILs and the abundance of CD8^(+)TILs,histological grade of the tumor tissue samples,and survival of patients with advanced tumors.Altogether,we found a novel function of CD147 as a negative regulator of antitumor responses mediated by CD8^(+)TILs and identified CD147 as a potential target for cancer immunotherapy. | Yatong Chen Jing Xu Xiaodong Wu Hui Yao Zhou Yan Ting Guo Wenjing Wang Peixiao Wang Yu Li Xiangmin Yang Hao Li Huijie Bian Zhi-Nan Chen | 2021 | Cellular & Molecular Immunology2021，18，8： | 4 |
| 2 | Difficult and complicated oral ulceration:an expert consensus guideline for diagnosis显示文摘The complexity of oral ulcerations poses considerable diagnostic and therapeutic challenges to oral specialists.The expert consensus was conducted to summarize the diagnostic work-up for difficult and complicated oral ulcers,based on factors such as detailed clinical medical history inquiry,histopathological examination,and ulceration-related systemic diseases screening.Not only it can provide a standardized procedure of oral ulceration,but also it can improve the diagnostic efficiency,in order to avoid misdiagnosis and missed diagnosis. | Xin Zeng Xin Jin Liang Zhong Gang Zhou Ming Zhong Wenmei Wang Yuan Fan Qing Liu Xiangmin Qi Xiaobing Guan Zhimin Yan Xuemin Shen Yingfang Wu Lijie Fan Zhi Wang Yuan He Hongxia Dan Jiantang Yang Hui Wang Dongjuan Liu Hui Feng Kai Jiao Qianming Chen | 2022 | International Journal of Oral Science2022，14，2： | 2 |
| 3 | Comparison of pixel-based and object-oriented image classification approaches—a case study in a coal fire area, Wuda, Inner Mongolia, China显示文摘 | Gao Yan J. -F. Mas B. H. P. Maathuis Zhang Xiangmin P. M. Van Dijk | 2006 | International Journal of Remote Sensing2006，，18： | 1 |
| 4 | Large-bore parti-cle-entrapped monolithic precolumns prepared by asol-gel method for on-line peptides trapping and pre-concentration in multidimensional liquid chromatogra-phy system for proteome analysis显示文摘 | Gu Xue Wang Yan Zhang Xiangmin | 2005 | J Chromatogr A2005，1072，2： | 1 |
| 5 | Developing a strong anion exchange/RP (SAX/RP) 2D LC system for high‐abundance proteins depletion in human plasma显示文摘 | Shaochun Zhu Xueyang Zhang Mingxia Gao Guangfeng Hong Guoquan Yan Xiangmin Zhang | 2012 | Proteomics (-)2012，，23： | 1 |
| 6 | Large-bore parti- cle-entrapped monolithic precolumns prepared by a so|- gel method for on-line peptides trapping and preconcen- tration in multidimensional liquid chromatography system for proteome analysis显示文摘 | Gu Xue Wang Yan Zhang Xiangmin | 2005 | J Chromatogr A2005，1072，2： | 1 |
| 7 | Application of Biotechnology on Apple Breeding显示文摘Modern biotechnology is a kind of potential technology. The advantages of this method have aroused much attention. Recently, biotechnology has evolved very fast in apple tree, and has got much progress in production and breeding of seedlings. This paper summarized the advances in tissue culture, molecular marker and gene engineering. The emphases and direction which need further investigation were also discussed. | Xueying LI Jie HAO Xinmin YAN Xian'ge WANG Jianzhong FENG Xiangmin SUO | 2019 | Agricultural Biotechnology2019，8，2： | 0 |
| 8 | Analysis of Short-Shoot Fuji Apple Tree Structure and Correlative Factors显示文摘In order to clarify the correlation between short-shoot Fuji apple tree structure and different factors under different trimming and pruning modes,we investigate the trunk taperingness of free-spindle short-shoot Fuji and slender-spindle short-shoot Fuji,respectively,as well as the total thickness,average thickness,total length and average length of small main branches in the standard demonstration apple garden in Xingtang County of Hebei Province. By SPSS analysis,we study the correlation between trunk taperingness of trees with different shapes and the growth indices of their small main branches. The results show that the trunk taperingness of free-spindle short-shoot Fuji apple is negatively correlated with the total thickness,average thickness,total length and average length of small main branches,but the correlation is not significant; the trunk taperingness of slender-spindle short-shoot Fuji apple is negatively correlated with the total thickness but positively correlated with other factors,and the correlation with average length reaches a significant level. The results of this study can provide a scientific basis for guiding the high-density dwarf rootstock short-shoot Fuji apple tree trimming technology. | Jie HAO Xiangmin SUO Xueying LI Liang WEI Xinmin YAN Xian’ge WANG Jianzhong FENG | 2017 | Asian Agricultural Research2017，9，6： | 0 |
| 9 | Analysis on Free Spindle Pruning Mode and Related Factors in Fuji Apple显示文摘In order to clarify the correlations between the free spindle pruning mode and various factors in Fuji apple,the growth data of the free spindle-shaped short branch Fuji apple Tianhong No. 2 and the free spindle-shaped long branch Fuji apple Changfu No. 2 in the Apple Demonstration Park of Xingtang County,Hebei Province were investigated. Using SPSS statistical software,the correlations between the stem tapering grade and various growth traits were analyzed. The results showed that in Tianhong No. 2,the stem tapering grade was negatively correlated with various growth traits of the central shaft,and the correlation coefficients between the stem tapering grade and the central shaft total thickness,the central shaft average thickness,the central shaft total length and the central shaft average length were-0. 228,-0. 033,-0. 411 and-0. 430,respectively; and in Changfu No. 2,the stem tapering grade was positively correlated with various growth traits of the central shaft,and the correlation coefficients between the stem tapering grade and the central shaft total thickness,the central shaft average thickness,the central shaft total length and the central shaft average length were 0. 475,0. 181,0. 120 and 0. 258,respectively. This paper can provide a scientific basis for guiding the construction of free spindle pruning mode in densely planted dwarf apple trees. | Jie HAO Xian ge WANG Xueying LI Xiangmin SUO Liang WEI Xinmin YAN Jianzhong FENG | 2018 | Asian Agricultural Research2018，10，9： | 0 |
| 10 | Analysis on Factors Related with Slender Spindle Shaped Apple Trees显示文摘[Objectives] This study was to determine the correlations of stem taperingness with small central shaft total roughness,average roughness,total length,and average length by slender spindle pruning mode on different apple cultivars. [Methods]A total of 2 tree structures were selected,namely,the slender spindleshaped Zhongqiuwang from Shen County of Hebei Province and slender spindle-shaped short shoot Fuji from Xingtang County of Hebei Province,to investigate the growth indicators of the small central shafts. SPSS analysis was used to compare the correlations between the taperingness with the growth factors of the small central shafts. [Results]The stem taperingness on slender spindle-shaped Zhongqiuwang was positively correlated with the various growth factors of the small central shaft,and the difference in the positive correlation with average roughness reached the extremely significant level. The stem taperingness of slender spindle-shaped short shoot Fuji was negatively correlated with the total roughness of small central shaft,but was positively correlated with the average roughness,total length and average length. [Conclusions] The results provided scientific and theoretical basis for guiding the dense planting of dwarfing apple tree pruning technology. | Jie HAO Xiange WANG Xueying LI Xiangmin SUO Liang WEI Xinmin YAN Jianzhong FENG | 2019 | Agricultural Biotechnology2019，8，1： | 0 |
| 11 | Value of Coronary Sinus During Computed Tomography Pulmonary Angiography for Predicting Pulmonary Hypertension in Patients with Acute Pulmonary Embolism显示文摘Objective:Computed tomography pulmonary angiography(CTPA)parameters are valuable for predicting pulmonary hypertension(PH)in patients with pulmonary embolism(PE).However,few studies have used the coronary sinus ostium area(CSOA),derived from CTPA,to detect PH.This study aimed to compare the prognostic values of the CSOA,coronary sinus ostium diameter(CSOD),and right ventricular(RV)/left ventricular(LV)ratio for PH.Methods:This study retrospectively analyzed 78 patients(mean age,(51.94±12.33)years;53.8%male)with acute PE confirmed by CTPA at the Sixth and Eighth Medical Centers of the People’s Liberation Army General Hospital between June 2018 and June 2020.Patients were categorized into 2 groups using a pulmonary artery systolic pressure(PASP)cut-off of 30 mmHg.CTPA parameters were compared between these groups.Results:Patients with PASP>30 mmHg(n=22)had a larger CSOA,CSOD,RV diameter,RV/LV ratio,and inferior vena cava diameter compared with patients with PASP≤30 mmHg(n=56).The CSOA had an area under the receiver-operating characteristic curve(AUC,0.84;95%confidence interval(CI),0.74–0.94;P<0.001)similar to that of the RV/LV ratio(AUC,0.85;95%CI,0.73–0.99;P<0.001),while that of the CSOD was smaller(AUC,0.66;95%CI,0.51–0.81;P<0.05).Conclusion:Both CSOA and CSOD demonstrated a good ability to predict PH,while CSOA better predicted PASP>30 mmHg. | Chuang Zhang Qian Xin Hongling Xu Xiangyu Wang Zhiqiang Yan Shengtao Sun Xiangmin Shi Mei Tian | 2023 | Cardiology Discovery2023，3，2： | 0 |
| 12 | Technical Regulations for Production of Apple ‘Jiping 1’显示文摘Apple‘Jiping 1’is a new early maturing apple variety bred by Shijiazhuang Pomology Institute,Hebei Academy of Agriculture and Forestry Sciences.To further normalize the standardized production technology of‘Jiping 1’,realize improvement and upgrading of fruit quality,and improve sustainable development of apple industry,according to national and industrial standards,specific requirements on selection of production orchard,planting,soil,fertilizer and water management,shaping and pruning,flower and fruit management,pest control,and fruit harvesting of‘Jiping 1’are put forward,and technical regulation for production of‘Jiping 1’(standard number:DB 13/T 5167-2020)is made.The regulation has important guiding significance for the production of early maturing apple in Hebei Province. | Xiangmin SUO Jinxin WANG Jingmiao HUANG Jie HAO Jianzhong FENG Xinmin YAN Jianming LI Xiange WANG Xueying LI | 2021 | Asian Agricultural Research2021，13，9： | 0 |
| 13 | Application of Ultrasonic Measurement Technology in Breeding of Beef Cattle and Its Evaluation before Slaughtering显示文摘The live cattle eye muscle area,back-fat thickness,height of eye muscle and intramuscular fat content were determined by ultrasonic technology. The prediction model for meat production performance was established. The numerical value had high reliability and accuracy,which reached extremely significant difference via analysis of variance. The study provides scientific basis for breeding and meat evaluation of beef cattle. | Zhang Yang Yan Xiangmin Zhou Zhenyong Zhang Jinshan Li Hongbo Li Na Yuan Lixing | 2015 | Animal Husbandry and Feed Science2015，7，2： | 0 |
| 14 | Impacts of Bad Weathers in Growing Season on Apples and Post-disaster Management Measures显示文摘Apple cultivation has special requirements for climatic conditions. The period from May to August is a key period for apple growth.During this period,extreme weather occurs frequently,such as extreme high temperature,strong wind,hail,and floods. This paper introduced these extreme weathers and came up with some corresponding management measures. | Xueying LI Jie HAO Jianzhong FENG Xinmin YAN Xian'ge WANG Wenzhang JI Xuehua LI Xiangmin SUO | 2018 | Asian Agricultural Research2018，10，12： | 0 |
| 15 | Protoplast Culture and Its Application in Fruit Breeding显示文摘The progress in protoplast technology and its application in fruit breeding were summarized,and the existing problems and application prospect were also discussed. | Xiangmin SUO Jie HAO Xinmin YAN Xiange WANG Jianzhong FENG Xueying LI | 2019 | Agricultural Biotechnology2019，8，3： | 0 |
| 16 | Investigation on Occurrence of Lithocolletis ringoniella Adults in New and Aged Apple Orchards in Shijiazhuang Area显示文摘[Objective]The paper was to investigate the occurrence of Lithocolletis ringoniella adults in aged and new apple orchards in Shijiazhuang area.[Method]The growth and decline dynamics of L.ringoniella adults in 3a apple orchard and 17a apple orchard in Shijiazhuang were monitored by sex attractant trapping method.Meantime,the trapping effects of sex attractant on L.ringoniella were compared with that of sweet-sour liquor.[Result]L.ringoniella occurred five generations annually in Shijiazhuang area.The adults emerged in April,and entered into peak occurrence period during May and June,with overlapping generations.Comparison between sex attractant and sweet-sour liquor tests showed that the trapping effect of sweet-sour liquor received little effect,but was expensive.Therefore,it is not recommended to use sweet-sour liquor for prevention and treatment of L.ringoniella in production.[Conclusion]In the actual production,sex attractant trapping should be combined with appropriate agricultural control measures to control the damage of L.ringoniella. | Suo Xiangmin Wang Jinxin Hao Jie Huang Jingmiao Feng Jianzhong Yan Xinmin Wang Xiange Li Xueying | 2020 | Plant Diseases and Pests2020，11，5： | 0 |
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