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| 1 | Propofol Attenuates a-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke显示文摘a-Synuclein is a soluble monomer abundant in the central nervous system. Aggregates of a-synuclein,consisting of higher-level oligomers and insoluble fibrils,have been observed in many chronic neurological diseases and are implicated in neurotoxicity and neurodegeneration.a-Synuclein has recently been shown to aggregate following acute ischemic stroke, exacerbating neuronal damage.Propofol is an intravenous anesthetic that is commonly used during intravascular embolectomy following acute ischemic stroke. While propofol has demonstrated neuroprotective properties following brain injury, the mechanism of protection in the setting of ischemic stroke is unclear. In this study, propofol administration significantly reduced the neurotoxic aggregation of a-synuclein, decreased the infarct area, and attenuated the neurological deficits after ischemic stroke in a mouse model. We then demonstrated that the propofol-induced reduction of a-synuclein aggregation was associated with increased mammalian target of rapamycin/ribosomal protein S6 kinase beta-1 signaling pathway activity and reduction of the excessive autophagy occurring after acute ischemic stroke. | Yuzhu Wang Dan Tian Changwei Wei Victoria Cui Huan Wang Yanbing Zhu Anshi Wu Yun Yue | 2020 | Neuroscience Bulletin2020，36，3： | 14 |
| 2 | Carbon nanotube-polypyrrole core-shell sponge and its application as highly compressible supercapacitor electrode显示文摘 | Peixu Li Enzheng Shi Yanbing Yang Yuanyuan Shang Qingyu Peng Shiting Wu Jinquan Wei Kunlin Wang Hongwei Zhu Quan Yuan Anyuan Cao Dehai Wu | 2014 | Nano Research2014，7，2： | 10 |
| 3 | Dimensional Synthesis of a 3-DOF Parallel Manipulator with Full Circle Rotation显示文摘Parallel robots are widely used in the academic and industrial fields. In spite of the numerous achievements in the design and dimensional synthesis of the low-mobility parallel robots, few research efforts are directed towards the asymmetric 3-DOF parallel robots whose end-effector can realize 2 translational and 1 rotational(2T1R) motion. In order to develop a manipulator with the capability of full circle rotation to enlarge the workspace, a new 2T1 R parallel mechanism is proposed. The modeling approach and kinematic analysis of this proposed mechanism are investigated. Using the method of vector analysis, the inverse kinematic equations are established. This is followed by a vigorous proof that this mechanism attains an annular workspace through its circular rotation and 2 dimensional translations. Taking the first order perturbation of the kinematic equations, the error Jacobian matrix which represents the mapping relationship between the error sources of geometric parameters and the end-effector position errors is derived. With consideration of the constraint conditions of pressure angles and feasible workspace, the dimensional synthesis is conducted with a goal to minimize the global comprehensive performance index. The dimension parameters making the mechanism to have optimal error mapping and kinematic performance are obtained through the optimization algorithm. All these research achievements lay the foundation for the prototype building of such kind of parallel robots. | NI Yanbing WU Nan ZHONG Xueyong ZHANG Biao | 2015 | Chinese Journal of Mechanical Engineering2015，28，4： | 8 |
| 4 | An option for green and sustainable future: Electrochemical conversion of ammonia into nitrogen显示文摘Green and sustainable options are needed to ease the current energy and environmental crisis, and alleviate the greenhouse effect and energy shortage. As an alternative carbon–neutral synthetic fuel, ammonia shows great potential due to its high energy density, non-toxic by-products, and mature related infrastructures. However, related practical applications have been severely hampered on ammoniaoxidation due to the high cost of catalysts and immature energy utilization systems. Here, we comprehensively summarized the efforts which have been made in recent years with the aim of providing a deep sight into the development and deficiencies in this territory and trying to establish a simple framework of basic knowledge for researchers. The exploration of mechanism is discussed first and then the relevant catalysts studied in recent years are summarized. Besides, the progress of direct ammonia fuel cells(DAFCs) is also presented and the challenges as well as perspectives on future developments of electrocatalysts for ammonia electro-oxidation and its practical application are provided at the end. | Bo Zhou Nana Zhang Yujie Wu Weijun Yang Yanbing Lu Yanyong Wang Shuangyin Wang | 2021 | Journal of Energy Chemistry2021，30，9： | 5 |
| 5 | A 5'-flanking region polymorphism in toll-like receptor 4 is associated with gastric cancer in a Chinese population显示文摘Objective:Inflammation induced by H.pylori colonization in the stomach is related to the development of gastric cancer and the genetic variations of the genes involved in the immune responses modify the host response to the infection. The aim of this study was to evaluate whether polymorphisms in the toll-like receptor 4 (TLR4) gene, a key regulator of both innate and adaptive immunity, were related to the susceptibility togastric cancer in a Chinese population. Methods: Two variations in the 5'-flanking region of TLR4 (rs1927914 T>C and rs10759932 T>C) were genotyped by using the PCR-restriction fragment length polymorphism (RFLP) assay in a case-control study of 1,053 incident gastric cancer cases and 1,100 cancer-free controls in a Chinese population. Results: Individuals carrying the C allele of rs10759932 had a significantly reduced risk of gastric cancer (adjusted OR=0.81; 95%CI=0.67-0.96), compared with the wild-type homozygote (TT), and the protective effect was not significantly different among subgroups stratified by age, sex, smoking, drinking and H.pylori infection status (P for heterogeneity >0.05). No significant association was observed between rs1927914 and gastric cancer risk in this study population. Conclusion: The T to C allele substitution of rs10759932 may play a protective role in gastric carcinogenesis in a Chinese population. Large studies with different ethnic populations are warranted to confirm these findings. | Hua Huang Juan Wu Guangfu Jin Hanze Zhang Yanbing Ding Zhaolai Hua Yan Zhou Yan Xue Yan Lu Zhibin Hu Yaochu Xu Hongbing Shen | 2010 | The Journal of Biomedical Research2010，24，2： | 5 |
| 6 | A regulated digital currency显示文摘The decentralized digital currency Bitcoin is an anonymous alternative to the centralized banking system and enjoys widespread and increasing adoption. Since Bitcoin created, many other electronic currencies have been developed. We propose a protocol for an electronic currency for making anonymous payments that can be supervised by an auditor, who has sole access to the transaction history. Other electronic currencies provide only anonymity, which is convenient for making illegal transactions without regulation. For users, miners, and banks, the transactions of our electronic currency are anonymous, and only auditors can see how it is used. We make use of POW(prove-of-work) technique that allows for distributed decisionmaking within a network, namely the Bitcoin blockchain protocol. We combine the POW and blockchain technology of Bitcoin to give better protection against double-spending attacks. | Yanbing WU Haining FAN Xiaoyun WANG Guangnan ZOU | 2019 | Science China(Information Sciences)2019，62，3： | 4 |
| 7 | Propofol Protects Regulatory T Cells, Suppresses Neurotoxic Astrogliosis, and Potentiates Neurological Recovery After Ischemic Stroke显示文摘Dear Editor,Emergency intravascular thrombectomy is the best treatment for acute ischemic stroke [1]. However, it is controversial whether the use of general anesthesia during emergency intravascular thrombectomy affects patient recovery. | Yuzhu Wang Dan Tian Yushang Zhao Mengyao Qu Yuhualei Pan Changwei Wei Yanbing Zhu Anshi Wu | 2021 | Neuroscience Bulletin2021，37，5： | 3 |
| 8 | Orbital ordering and fluctuations in a kagome superconductor CsV_(3)Sb_(5)显示文摘Recently,competing electronic instabilities,including superconductivity and density-wave-like order,have been discovered in vanadium-based kagome metals AV_(3)Sb_(5)(A=K,Rb,Cs)with a nontrivial band topology.This finding stimulates considerable interest to study the interplay of these competing electronic orders and possible exotic excitations in the superconducting state.Here,we performed51V and133Cs nuclear magnetic resonance(NMR)measurements on a CsV_(3)Sb_(5)single crystal to clarify the nature of density-wave-like transition in these kagome superconductors.A first-order structural transition is unambiguously revealed below T_(s)~94 K by observing the sudden splitting of Knight shift in^(51)V NMR spectrum.Moreover,combined with^(133)Cs NMR spectrum,the present result confirms a three-dimensional structural modulation.By further analyzing the anisotropy of Knight shift and 1/T_(1)T at^(51)V nuclei,we proposed that the orbital order is the primary electronic order induced by the firstorder structural transition,which is supported by further analysis on electric field gradient at^(51)V nuclei.In addition,the evidence for possible orbital fluctuations is also revealed above T_(s).The present work sheds light on a rich orbital physics in kagome superconductors AV_(3)Sb_(5). | DianWu Song LiXuan Zheng FangHang Yu Jian Li LinPeng Nie Min Shan Dan Zhao ShunJiao Li BaoLei Kang ZhiMian Wu YanBing Zhou KuangLv Sun Kai Liu XiGang Luo ZhenYu Wang JianJun Ying XianGang Wan Tao Wu XianHui Chen | 2022 | Science China(Physics,Mechanics & Astronomy)2022，65，4： | 2 |
| 9 | Direct fabrication of carbon nanotube-graphene hybrid films by a blown bubble method显示文摘有 graphene 的碳 nanotubes (CNT ) 的杂交提供集成两材料的属性的一个有希望的工具,从而创新的普遍申请。这里,我们在场直接由一个吹的水泡方法装配混合 CNT-graphene 电影的一个方法与选择底层退火结合了。我们把 polymethylmethacrylate (PMMA ) 用作聚合矩阵吹包含自我装配的多围的 CNT 数组的水泡,然后由在 Cu 底层上的热退火把水泡电影转变成一部 CNT-graphene 混合电影;PMMA 为在 CNT 网络之中对很少层 graphene 变得单个直到担任碳来源一连续地, hybridized 结构被形成。比作赤裸(non-hybridized ) CNT 联网,混合电影展览改进了电的电导率和结构的完整。我们的方法也启用一节多围的 CNT-Si 太阳能电池的制造,它有高力量变换效率,通过混合 CNT-graphene 结构的集会。 | Shiting Wu Enzheng Shi Yanbing Yang Wenjing Xu Xinyang Li Anyuan Cao | 2015 | Nano Research2015，8，5： | 2 |
| 10 | Localization and cellular distribution of CPNE5 in embryonic mouse brain显示文摘 | Ding Xuefeng Jin Yanbing Wu Yan | 2008 | Brain Res2008，1224，： | 1 |
| 11 | Effects of kisspeptin-10 on progesterone secretion in cultured chicken ovarian granulosa cells from preovulatory (F 1 –F 3 ) follicles显示文摘 | Yunqi Xiao Yingdong Ni Yanbing Huang Jing Wu Roland Grossmann Ruqian Zhao | 2011 | Peptides2011，，10： | 1 |
| 12 | Hydrogen bond network and local structure of liquid water: an atom-in-molecules perspective 显示文摘 | Lu Haigang Wang Yuekui Wu Yanbe | 2008 | J Chem Phys2008，129，： | 1 |
| 13 | A compact liquid chromatography-mass spectrometry instrument for the quantitation of immunosuppressants显示文摘Liquid chromatography tandem mass spectrometry(LC-MS/MS) plays an important role in clinical diagnostics. Although LC-MS/MS is superior in terms of accurately quantifying molecules in complex matrices,instrument footprint, operation and maintenance complexity also hinder its expansion as the analytical technique of choice. In this study, a compact LC-MS instrument was developed, in which an assembled liquid chromatograph was coupled with a miniature ion trap mass spectrometer. The overall instrument has a footprint of 69 cm × 31 cm × 31 cm, and it requires no gas supply as well as minimum maintenance. Furthermore, the use of LC-MS is in accord with conventional clinical diagnostic protocols, and the choice of ion trap offers tandem MS performance. The results showed that the use of LC could improve both mixture analysis capability and detection sensitivity of the miniature mass spectrometer. After optimization, feasibility of this instrument in clinical practice was demonstrated by the quantitation of four widely used immunosuppressants in blood samples. Relatively good linearities were obtained, which spanned the reference ranges of effective therapeutic concentrations of each immunosuppressant. Intraday and inter-day accuracy and precision of analytical method were also assessed. This work showed that a compact LC-MS instrument could be used in clinical diagnosis, either to replace conventional lab-scale instruments or to be used in POCT applications. | Hao Gu Guoxin Dai Siyu Liu Yanbing Zhai Qian Xu Hongqiang Wu Wei Xu | 2023 | Chinese Chemical Letters2023，34，4： | 1 |
| 14 | Label-free photoelectric sensor for lactic acid determination in human sweat显示文摘A label-free lactic acid sensor has been successfully developed by using a Dysprosium single crystal-based photoelectric potential technique via Dy-SCN/FTO electrode. Interestingly, the proposed sensor demonstrated excellent performance for L-lactic acid analysis with a wide linear range of 0.0196~16.31 mmol/L,the detection limit of as low as 3.20 μmol/L as well as an advisable stability. The feasibility of this strategy was also verified by practical application towards human sweat samples. The mechanism studies indicated that lactic acid molecules specifically bind to the surface of semiconductor materials, which alters the charge distribution of the electrode surface and subsequently results in band bending/photoelectric potential changes. The theoretical formula for this photoelectric chemistry(PEC) strategy was then derived according to charge balance theory. We believe that the proposed Dy-SCN/FTO sensor would open a new way for rapid, non-invasive L-lactic acid level evaluation during human physical condition monitoring. | Hao Gu Guoxin Dai Siyu Liu Yanbing Zhai Qian Xu Hongqiang Wu Wei Xu | 2023 | Chinese Chemical Letters2023，34，4： | 1 |
| 15 | Induction of TGF-β and IL-10 production in dendritic cells using astilbin to inhibit dextran sulfate sodium-induced colitis显示文摘 | Yanbing Ding Yu Liang Bin Deng Ahui Qiao Keyan Wu Weiming Xiao Weijuan Gong | 2014 | Biochemical and Biophysical Research Communications2014，，： | 1 |
| 16 | White spot syndrome virus envelope protein VP124 involved in the virus infection显示文摘White spot syndrome virus(WSSV)is one of the major shrimp pathogens causing large economic losses to shrimp farming.In an attempt to identify the envelope proteins involved in the virus infection,purified WSSV virions were mixed with three antisera against WSSV envelope proteins(VP39,VP124 and VP187),individually.And then they were injected intramuscularly into crayfish(Procambarus clarkii)to conduct in vivo neutralization assays.The results showed that for groups injected with virions only and groups injected with the mixture of virions and antiserum against VP124,the crayfish mortalities were 100% and 60% on the 8th day postinfection,individually.The virus infection could be delayed or neutralized by antibody against the envelope protein VP124.Quantitative PCR was used to further investigate the influence of three antisera described above on the virus infection.The results showed that the antiserum against VP124 could restrain the propagation of WSSV in crayfish.All of the results suggested that the viral envelope protein VP124 played a role in WSSV infection. | ZHU Yanbing WU Chenglin YANG Feng | 2008 | Acta Oceanologica Sinica2008，27，4： | 0 |
| 17 | Magnetic-field-induced electronic instability of Weyl-like fermions in compressed black phosphorus显示文摘Revealing the role of Coulomb interaction in topological semimetals with Dirac/Weyl-like band dispersion shapes a new frontier in condensed matter physics.Topological node-line semimetals(TNLSMs),anticipated as a fertile ground for exploring electronic correlation effects due to the anisotropy associated with their node-line structure,have recently attracted considerable attention.In this study,we report an experimental observation for correlation effects in TNLSMs realized by black phosphorus(BP)under hydrostatic pressure.By performing a combination of nuclear magnetic resonance measurements and band calculations on compressed BP,a magnetic-field-induced electronic instability of Weyl-like fermions is identified under an external magnetic field parallel to the so-called nodal ring in the reciprocal space.Anomalous spin fluctuations serving as the fingerprint of electronic instability are observed at low temperatures,and they are observed to maximize at approximately 1.0 GPa.This study presents compressed BP as a realistic material platform for exploring the rich physics in strongly coupled Weyl-like fermions. | Lixuan Zheng Kaifa Luo Zeliang Sun Dan Zhao Jian Li Dianwu Song Shunjiao Li Baolei Kang Linpeng Nie Min Shan Zhimian Wu Yanbing Zhou Xi Dai Hongming Weng Rui Yu Tao Wu Xianhui Chen | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，11： | 0 |
| 18 | Investigation on the radioactivity levels of seawater,sediments,and biota in Daya Bay,China显示文摘Objective:To investigate the radioactivity levels of seawater,sediments,and biota in the Daya Bay sea area,China,in order to establish the radioactivity baseline values,and provide basic data for the assessment of potential radiological risks that might result from the application of nuclear technology or human activities.Methods:Samples of seawater,sediments,and biota were collected from the Daya Bay sea area and analyzed.Their radioactivity baseline data were then compared with information from other regions in China and around the world reported in related literature.Results:For the seawater samples,the activity concentrations of natural radionuclide ^(40)K were 9.9-10.4 Bq/L,while ^(238)U,226Ra,^(210)Pb,^(137)Cs,and ^(110)Ag^(m) were below the minimum detectable activity(MDA).Regarding the sediment samples,the activity concentrations of ^(238)U,^(228)Ra,^(226)Ra,^(210)Pb,^(40)K,and ^(137)Cs were 38.1-40.4,49.1-53.7,32.6-38.6,59-95,590-650,and 0.48-0.88 Bq/(kg dry weight),respectively,while ^(110)Agm was below the MDA.For the marine shrimps in the biota samples,the activity concentrations of ^(228)Ra,^(226)Ra,^(40)K,and ^(137)Cs were 1.14-2.75,0.17-0.43,63-76,and 0.038-0.045 Bq/(kg wet weight),respectively,while ^(238)U,^(210)Pb,and ^(110)Agm were all below the MDA.Furthermore,for the marine fishes in the biota samples,the activity concentrations of ^(228)Ra,^(226)Ra,^(210)Pb,^(40)K,and ^(137)Cs were 2.1-19.7,0.32-3.78,<2.2-2.8,59-70,and<0.007-0.026 Bq/(kg wet weight),respectively,while ^(238)U and ^(110)Ag^(m) were all below the MDA.^(228)Ra was found to be concentrated in Osteomugil ophuyseni with 19.7 Bq/(kg wet weight).Conclusions:The radioactivity levels of seawater and marine sediments in the Daya Bay sea area are within the range of the normal background values.Osteomugil ophuyseni exhibited higher concentrations of ^(228)Ra than other species in this study,while the other species in the biota show no significant difference in the radioactivity levels from data in relevant literature. | Fan Cui Honghui Huang Yi Shen Zhan Tan Pengxiang Qu Ming Dai Hongwei Yu Weixu Huang Zixiang Wu Huifeng Chen Weizhen Guo Yuxin Jia Yanbing Liu | 2023 | Radiation Medicine and Protection2023，4，3： | 0 |
| 19 | Liquid-phase Chemistry of Pa(Ⅴ)显示文摘In the previous work, we have studied the extraction of Pa with PMBP, TBP and Aliquat336.The most suitable conditions of Pa extraction by using the extraction reagents was found. The extraction mechanism was also discussed. In order to identify similarities with the extraction pattern of Db and thereby unraveling some of the chemistry of Db, it is necessary to study further the extraction pattern of Pa with different types of extracting agents. | Ding Huajie, Niu Yanning, Yang Weifan, Xu Yanbing Yuan Shuanggui, Qin Zhi and Wu Xiaolei | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 20 | Constrained Edge Dynamic Deleting in CD-TIN Based on Influence Domain Retriangulation of Virtual Point显示文摘抑制 Delaunay triangulated 不规则的网络是在地球科学使用的一个种动态数据结构。关于在 CD 听的点和边插入的研究是它的申请的基础。与点和抑制的边插入的算法作比较,有很关于在 CD 听的抑制的边删除的一些研究。基于抑制的边的多型性的分析,虚拟点被用来描述抑制的边的交叉。一个新算法被介绍,作为影响领域 retriangulating 要求了虚拟点(IDRVP ) ,与虚拟点抑制了边删除。算法在拓扑学是完全的。最后,算法被一些应用盒子测试。 | WANG Yanbing WU Lixin SHI Wenzhong | 2007 | Geo-Spatial Information Science2007，10，3： | 0 |
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