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| 1 | Redox status of thioredoxin-1 (TRX1) determines the sensitivity of human liver carcinoma cells (HepG2) to arsenic trioxide-induced cell death显示文摘细胞内部的氧化还原作用动态平衡在决定肿瘤房间的敏感到导致药的 apoptosis 起一个关键作用。这里,我们调查了 thioredoxin-1 (TRX1 ) 的角色,氧化还原作用规定的一个关键部件,在砷三氧化物(作为(2 ) O (3 )) 导致的 apoptosis。在 HepG ( 2 )房间的野类型的 TRX1 的在表示上导致了抑制当( 2 ) O ( 3 )导致了细胞色素 c ( cyto c ),释放, caspase 激活和 apoptosis ,并且由 RNAi 的 TRX1 表示的绒毛规定敏化 HepG ( 2 )房间到当( 2 ) O ( 3 )导致了 apoptosis 。有趣地,到重量的单位(32/35 ) 的从 Cys (32/35 ) 的 TRX1 的活跃地点的变化从一个 apoptotic 保护者把这个分子变换成一个 apoptotic 倡导者。以理解这变换的机制,我们从老鼠肝使用了孤立的线粒体并且发现了野类型的 TRX1 能保护的那重组体从 apoptotic 的线粒体变化。相反, TRX1 的变异的形式独自得到了线粒体相关的 apoptotic 变化,包括 mitochondrial 渗透转变毛孔(mPTP ) 洞, mitochondrial 膜潜力的损失,和 cyto 从线粒体的 c 版本。这些 apoptotic 效果被 cyclosporine A (CsA ) 禁止,显示指向到 mPTP 的那变异的 TRX1。到由 2,4-dinitrochlorobenzene (DNCB ) 的氧化形式体内的从它的减少的形式的 TRX1 的改变, TRX reductase 的一个特定的禁止者,也敏化的 HepG (2 ) 房间到当(2 ) O (3 ) 导致了 apoptosis。这些数据建议 TRX1 由任何一个变化在由堵住 cyto c 版本调整 apoptosis,并且在 TRX1 的激活起一个中央作用或活跃地点半胱氨酸的氧化可以敏化肿瘤房间到当(2 ) O (3 ) 导致了 apoptosis。 | Changhai Tian Ping Gao Yanhua Zheng Wen Yue Xiaohui Wang Haijing Jin Quan Chen | 2008 | Cell Research2008，18，4： | 7 |
| 2 | Determination of DNA single-strand breaks by low-energy heavy ion and analysis of dose-effect curves显示文摘Calf thymus DNA was exposed to low-energy heavy ions (N+) and 60Co-γ-rays, and the dose-effect on DNA single-strand breaks (SSB) has been investigated. The results indicate that the dose-effect curve by N+ irradiation is different from that of conventional ionizing radiation. While the curve from γ-irradiation follows exponential type, the effect curve produced by N+ ion is of 'saddle type'. The yield of DNASSB per dose unit per DNA unit remained at a certain level under different doses of γ-rays. In contrast, the DNASSB at low dosage region of N+ showed an obvious peak before it decreased rapidly to a lower level. | Yanhua Du Shenghai Huang Zheng Tan Yingzhi Lin Guanying Qiu | 1999 | Chinese Science Bulletin1999，44，8： | 5 |
| 3 | Chinese version of NCCN Clinical Practice Guidelines in Oncology officially authorized by NCCN显示文摘The publishing conference of the Chinese version of National Comprehensive Cancer Network(NCCN)Clinical Practice Guidelines in Oncology(hereinafter referred to as NCCN Guidelines)and the inaugural peer reviewer meeting of NCCN Clinical Practice Guidelines in Oncology:Digestive System Cancers(hereinafter referred to as NCCN Guidelines on Digestive System Cancers)were held | Yanhua Zheng Dingyao Xu Zhaode Bu | 2016 | Chinese Journal of Cancer Research2016，28，1： | 5 |
| 4 | Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-,and threonine-rich sequence(PEST)显示文摘Protein tyrosine phosphatase (PTP)-proline-,glutamate-,serine-,and threonine-rich sequence (PEST) is ubiquitously expressed and is a critical regulator of cell adhesion and migration.PTP-PEST activity can be regulated transcriptionally via gene deletion or mutation in several types of human cancers or via post-translational modifications,including phosphorylation,oxidation,and caspase-dependent cleavage.PTP-PEST interacts with and dephosphorylates cytoskeletal and focal adhesion-associated proteins.Dephos-phorylation of PTP-PEST substrates regulates their enzymatic activities and/or their interaction with other proteins and plays an essential role in the tumor cell migration process. | Yanhua Zheng Zhimin Lu | 2013 | Chinese Journal of Cancer2013，32，2： | 4 |
| 5 | Solid-state intramolecular motions in continuous fibers driven by ambient humidity for fluorescent sensors显示文摘One striking feature of molecular rotors is their ability to change conformation with detectable optical signals through molecular motion when stimulated.However,due to the strong intermolecular interactions,synthetic molecular rotors have often relied on fluid environments.Here,we take advantage of the solid-state intramolecular motion of aggregation-induced emission(AIE)molecular rotors and one-dimensional fibers,developing highly sensitive optical fiber sensors that respond to ambient humidity rapidly and reversibly with observable chromatic fluorescence change.Moisture environments induce the swelling of the polymer fibers,activating intramolecular motions of AIE molecules to result in red-shifted fluorescence and linear response to ambient humidity.In this case,polymer fiber provides a process-friendly architecture and a physically tunable medium for the embedded AIE molecules to manipulate their fluorescence response characteristics.Assembly of sensor fibers could be built into hierarchical structures,which are adaptive to diverse-configuration for spatial-temporal humidity mapping,and suitable for device integration to build light-emitting sensors as well as touchless positioning interfaces for intelligence systems. | Yunmeng Jiang Yanhua Cheng Shunjie Liu Haoke Zhang Xiaoyan Zheng Ming Chen Michidmaa Khorloo Hengxue Xiang Ben Zhong Tang Meifang Zhu | 2021 | National Science Review2021，8，4： | 3 |
| 6 | Ther- mohydraulic transient studies of the Chinese 200 MWe HTR-PM for loss of forced cooling acci- dents显示文摘 | ZHENG Yanhua SHI Lei DONG Yujie | 2009 | Annals of Nuclear Energy2009，36，6： | 1 |
| 7 | Water-ingress analysis for the 200 MWe pebble-bedmodular high temperature gas-cooled reactor显示文摘 | ZHENG Yanhua SHI Lei WANG Yan | 2011 | Nuclear Engineering and Design2011，2，40： | 1 |
| 8 | Automatic software deployment using user-level virtualization for cloud-eompu ting显示文摘 | Zhang Youhui LI Yanhua Zheng Weimin | 2011 | Future Generation Computer Systems2011，，8： | 1 |
| 9 | High performance Au/Ag core/shell bipyramids for determination of thiram based on surface‐enhanced Raman scattering显示文摘 | Xia Zheng Yanhua Chen Yang Chen Ning Bi Haibo Qi Meihong Qin Dan Song Hanqi Zhang Yuan Tian | 2012 | J Raman Spectrosc2012，，10： | 1 |
| 10 | Identification of the protein–protein contact site and interaction mode of human VDAC1 with Bcl-2 family proteins显示文摘 | Yong Shi Jianjun Chen Changjiang Weng Rui Chen Yanhua Zheng Quan Chen Hong Tang | 2003 | Biochemical and Biophysical Research Communications2003，，4： | 1 |
| 11 | Determination of mercury(II) by surface-enhanced Raman scattering spectroscopy based on thiol-functionalized silver nanoparticles显示文摘 | Yang Chen Lihang Wu Yanhua Chen Ning Bi Xia Zheng Haibo Qi Meihong Qin Xue Liao Hanqi Zhang Yuan Tian | 2012 | Microchimica Acta2012，，3： | 1 |
| 12 | Study on step-up characteristics of hydraulic control rod driving system 显示文摘 | BO Hanliang ZHENG Yanhua ZHENG Wenxiang | 2002 | Nuclear Engineering and Design2002，216，： | 1 |
| 13 | A critical review of on-site inorganic arsenic screening methods显示文摘Approximately 94 to 220 million people worldwide are at risk of drinking well water containing arsenic > 10 μg/L, the WHO guideline value. To identify non-compliant domestic wells, assess health risks and reduce exposure, accurate and rapid on-site inorganic arsenic screening methods are desirable because all domestic wells worldwide need to be tested.Here, the principles, advantages and limitations of commonly used colorimetry, electrochemistry, and biosensing methods are critically reviewed, with the performance compared with laboratory-based benchmark methods. Most commercial kits are based on the classic Gutzeit reaction. Despite being semi-quantitative, the more recent and more expensive products display improved and acceptable accuracy and shorter testing time (~10 min). Carried out by trained professionals, electrochemical methods are also feasible for on-site analysis, although miniaturization is desirable yet challenging. Biosensing using whole bacterial cells or bio-engineered materials such as aptamers is promising, if incorporated with function specific nanomaterials and biomaterials. Since arsenic is frequently found as arsenite in reducing groundwater and subject to oxidation during sampling, transportation and storage, on-site separation and sample preservation are feasible but the specific methods should be chosen based on sample matrix and tested before use. To eliminate arsenic exposure among hundreds of millions of mostly rural residents worldwide, we call for concerted efforts in research community and regulatory authority to develop accurate, rapid, and affordable tests for on-site screening and monitoring of arsenic in drinking water. Access to affordable testing will benefit people who are socioeconomically disadvantaged. | Yi He Jingyu Liu Yanhua Duan Xiaofei Yuan Lulu Ma Ratan Dhar Yan Zheng | 2023 | Journal of Environmental Sciences2023，，3： | 1 |
| 14 | Reactivity Accident in a High Temperature Gas-Cooled Reactor Due to Inadvertent Withdrawal of Control Rod 显示文摘 | Zheng Yanhua Shi Lei | 2011 | Journal of Engineering for Gas Turbines and Power2011，133，： | 1 |
| 15 | Emerging roles of phosphoinositide-associated membrane trafficking in plant stress responses显示文摘Eukaryotic cells are confined by membranes that create hydrophobic barriers for substance and information exchange between the inside and outside of the cell.These barriers are formed by assembly of lipids and protein in aqueous environments.Lipids not only serve as building blocks for membrane construction,but also possess regulatory functions in cellular activities.These regulatory lipids are non-uniformly distributed in membrane systems;their temporal and spatial accumulation in specific membranes decodes environmental cues and changes cellular activity accordingly.Phosphoinositides(PIs)are phospholipids that exert regulatory effects.In recent years,research on PIs roles in regulating plant growth,development,and responses to environmental stress is increasing.Several reviews have been published on the composition of PIs,intermolecular transferring of PIs by lipid kinases(phosphatases)or PI-PLCs,subcellular localization,and specially their functions in plant developments.Herein,we review the crucial regulatory functions of PIs in plant stress responses,with a particular focus on PIs involved in membrane trafficking. | Feng Lin Junming Zheng Yanhua Xie Wen Jing Qun Zhang Wenhua Zhang | 2022 | Journal of Genetics and Genomics2022，49，8： | 1 |
| 16 | Multiomics approach reveals the ubiquitination-specific processes hijacked by SARS-CoV-2显示文摘The Coronavirus Disease 2019(COVID-19)caused by Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2)is a global pandemic that seriously threatens health and socioeconomic development,but the existed antiviral drugs and vaccines still cannot yet halt the spread of the epidemic.Therefore,a comprehensive and profound understanding of the pathogenesis of SARS-CoV-2 is urgently needed to explore effective therapeutic targets.Here,we conducted a multiomics study of SARS-CoV-2-infected lung epithelial cells,including transcriptomic,proteomic,and ubiquitinomic.Multiomics analysis showed that SARS-CoV-2-infected lung epithelial cells activated strong innate immune response,including interferon and inflammatory responses.Ubiquitinomic further reveals the underlying mechanism of SARS-CoV-2 disrupting the host innate immune response.In addition,SARS-CoV-2 proteins were found to be ubiquitinated during infection despite the fact that SARS-CoV-2 itself didn’t code any E3 ligase,and that ubiquitination at three sites on the Spike protein could significantly enhance viral infection.Further screening of the E3 ubiquitin ligases and deubiquitinating enzymes(DUBs)library revealed four E3 ligases influencing SARS-CoV-2 infection,thus providing several new antiviral targets.This multiomics combined with high-throughput screening study reveals that SARS-CoV-2 not only modulates innate immunity,but also promotes viral infection,by hijacking ubiquitination-specific processes,highlighting potential antiviral and anti-inflammation targets. | Gang Xu Yezi Wu Tongyang Xiao Furong Qi Lujie Fan Shengyuan Zhang Jian Zhou Yanhua He Xiang Gao Hongxiang Zeng Yunfei Li Zheng Zhang | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 1 |
| 17 | Automatic software deployment using user-level virtualization for cloud-computing显示文摘 | Youhui Zhang Yanhua Li Weimin Zheng | 2013 | Future Generation Computer Systems2013，，1： | 1 |
| 18 | Activated IL- 23/IL-17 pathway closely correlates with increased Foxp3 expression in livers of chronic hepatitis B patients显示文摘 | Wang Qinghong Zheng Yanhua Huang Zemin | 2011 | BMC Immunol2011，12，： | 1 |
| 19 | Single-cell transcriptomic profiling reveals the tumor heterogeneity of small-cell lung cancer显示文摘Small-cell lung cancer(SCLC)is the most aggressive and lethal subtype of lung cancer,for which,better understandings of its biology are urgently needed.Single-cell sequencing technologies provide an opportunity to profile individual cells within the tumor microenvironment(TME)and investigate their roles in tumorigenic processes.Here,we performed high-precision single-cell transcriptomic analysis of~5000 individual cells from primary tumors(PTs)and matched normal adjacent tissues(NATs)from 11 SCLC patients,including one patient with both PT and relapsed tumor(RT).The comparison revealed an immunosuppressive landscape of human SCLC.Malignant cells in SCLC tumors exhibited diverse states mainly related to the cell cycle,immune,and hypoxic properties.Our data also revealed the intratumor heterogeneity(ITH)of key transcription factors(TFs)in SCLC and related gene expression patterns and functions.The non-neuroendocrine(non-NE)tumors were correlated with increased inflammatory gene signatures and immune cell infiltrates in SCLC,which contributed to better responses to immune checkpoint inhibitors.These findings indicate a significant heterogeneity of human SCLC,and intensive crosstalk between cancer cells and the TME at single-cell resolution,and thus,set the stage for a better understanding of the biology of SCLC as well as for developing new therapeutics for SCLC. | Yanhua Tian Qingqing Li Zhenlin Yang Shu Zhang Jiachen Xu Zhijie Wang Hua Bai Jianchun Duan Bo Zheng Wen Li Yueli Cui Xin Wang Rui Wan Kailun Fei Jia Zhong Shugeng Gao Jie He Carl MGay Jianjun Zhang Jie Wang Fuchou Tang | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 1 |
| 20 | Thermal hydraulic analysis of a pebble-bed modular high temperature gas-cooled reactor with ATTICA3D and THERMIX codes显示文摘 | ZHENG Yanhua LAPINS J LAURIEN E | 2012 | Nuclear Engineering and Design2012，246，： | 1 |
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