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| 1 | Eleven COVID-19 Outbreaks with Local Transmissions Caused by the Imported SARS-CoV-2 Delta VOC-China,July-August,2021显示文摘Starting from December 2019,Wuhan,China,encountered the first outbreak of coronavirus disease 2019(COVID-19)(1-2).The epidemic was successfully suppressed by strict containment so that the number of infected people was reduced to 0 on April 8,2020(3–4).After that,China experienced roughly 3 dozen outbreaks with local transmission caused by imported severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Lei Zhou Kai Nie Hongting Zhao Xiang Zhao Bixiong Ye Ji Wang Cao Chen Hong Wang Jiangli Di Jinsong Li Chao Li Zhixiao Chen Ruiqi Ren Peihua Niu Hui Chen Tao Chen Yali Wang Lili Li Bingxue Han Ruhan A Si Chen Dan Li Dan Li Chunxia Jin Xin Zhang Jiangmei Liu Chunyu Xu Yecheng Yao Yenan Feng Zhili Li Bike Zhang Yang Song Peter Hao Yanping Zhang Hao Li Qun Li George F.Gao Guoqing Shi Wenbo Xu | 2021 | China CDC weekly2021，3，41： | 13 |
| 2 | MiR-630 inhibits invasion and metastasis in esophageal squamous cell carcinoma显示文摘食道的有鳞的房间癌(ESCC ) 在最好攻击的恶意之中并且在中国有高发生。MicroRNAs (miRNAs ) 是调整多重 tumorigenic 过程的小内长的 RNA,包括增长,侵略,转移和预后。用 miRNA 表示 proling 分析,我们发现 miR-630 在配对的正常食道的纸巾与那相比在三件 ESCC 织物样品是显著地下面调整的。微分 miR-630 表示随后用量的即时 PCR 被证实。决定 miR-630 下面规定是否能被看作诊断指示物和不利预示的因素,我们与 ESCC 在病人调查了在 miR-630 和 clinicopathological 特征之间的协会。减少的 miR-630 表示总的来说与穷人被联系,这被发现在这些病人的幸存。另外,我们也由指向蛞蝓探索了 miR-630 的生物功能并且调查了在 miR-630 表示和上皮间充质的转变(EMT ) 之间的关联在 vivo 并且在 vitro 的前进。,宫外的 miR-630 表示能禁止增长,侵略和转移 miR-630 击倒的导致的增长,侵略,转移和 EMT 特点。总的来说,我们的学习在 ESCC 作为一个批评新奇调节的人为 miR-630 支持一个角色。 | Li Jin Jun Yi Yanping Gao Siqi Han Zhenyue He Longbang Chen Haizhu Song | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 11 |
| 3 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 4 | Effect of nitrogen fertilizer on distribution of starch granules in different regions of wheat endosperm显示文摘This study provided visual evidence of a nitrogen effect on starch granules(SGs) in wheat endosperm. Winter wheat(Titicum aestivum L.) cultivar Xumai 30 was cultured under no nitrogen(control) and 240 kg ha-1of nitrogen applied at the booting stage. The number, morphology, and size of Aand B-type SGs in subaleurone of dorsal endosperm(SDE), center of dorsal endosperm(CDE), modified aleurone(MA), subaleurone of ventral endosperm(SVE), and center of ventral endosperm(CVE) were observed under light and electron microscopes.(1) The distribution of SGs in SDE was similar to that in SVE, the distributions of SGs in CDE and CVE were similar, but the distribution of SGs in MA was different from those in the other four endosperm regions. The number of SGs in the five endosperm regions was in the order SDE > CDE > SVE > CVE > MA.(2) Nitrogen increased the number of Aand B-type SGs in SDE and SVE. Nitrogen also increased the number of B-type SGs but decreased the number of A-type SGs in CDE and CVE. Nitrogen decreased the numbers of A-type and B-type SGs in MA. The results suggest that increased N fertilizer application mainly increased the numbers of small SGs and decreased the numbers of large SGs, but that the results varied in different regions of the wheat endosperm. | Fei Xiong Xurun Yu Liang Zhou Jing Zhang Yanping Jin Dongliang Li Zhong Wang | 2014 | The Crop Journal2014，2，1： | 8 |
| 5 | Robust fault-tolerant controller design for linear time-invariant systems with actuator failures:an indirect adaptive method显示文摘In this paper,indirect adaptive state feedback control schemes are developed to solve the robust fault-tolerant control (FTC) design problem of actuator fault and perturbation compensations for linear time-invariant systems.A more general and practical model of actuator faults is presented.While both eventual faults on actuators and perturbations are unknown,the adaptive schemes are addressed to estimate the lower and upper bounds of actuator-stuck faults and perturbations online,as well as to estimate control effectiveness on actuators.Thus,on the basis of the information from adaptive schemes,an adaptive robust state feed-back controller is designed to compensate the effects of faults and perturbations automatically.According to Lyapunov stability theory,it is shown that the robust adaptive closed-loop systems can be ensured to be asymptotically stable under the influence of actuator faults and bounded perturbations.An example is provided to further illustrate the fault compensation effectiveness. | Xiaozheng JIN Guanghong YANG Yanping LI | 2010 | 控制理论与应用(英文版)2010，8，4： | 7 |
| 6 | Inner Envelope CHLOROPLAST MANGANESE TRANSPORTER 1 Supports Manganese Homeostasis and Phototrophic Growth in Arabidopsis显示文摘 | Bin Zhang Chi Zhang Congge Liu Yanping Jing Yuan Wang Ling Jin Lei Yang Aigen Fu Jisen Shi Fugeng Zhao Wenzhi Lan Sheng Luan | 2018 | Molecular Plant2018，11，7： | 6 |
| 7 | High spatial and temporal resolution synthetic aperture phase microscopy显示文摘A new optical microscopy technique,termed high spatial and temporal resolution synthetic aperture phase microscopy(HISTR-SAPM),is proposed to improve the lateral resolution of wide-field coherent imaging.Under plane wave illumination,the resolution is increased by twofold to around 260 nm,while achieving millisecond-level temporal resolution.In HISTR-SAPM,digital micromirror devices are used to actively change the sample illumination beam angle at high speed with high stability.An off-axis interferometer is used to measure the sample scattered complex fields,which are then processed to reconstruct high-resolution phase images.Using HISTR-SAPM,we are able to map the height profiles of subwavelength photonic structures and resolve the period structures that have 198 nm linewidth and 132 nm gap(i.e.,a full pitch of 330 nm).As the reconstruction averages out laser speckle noise while maintaining high temporal resolution,HISTR-SAPM further enables imaging and quantification of nanoscale dynamics of live cells,such as red blood cell membrane fluctuations and subcellular structure dynamics within nucleated cells.We envision that HISTR-SAPM will broadly benefit research in material science and biology. | Cheng Zheng Di Jin Yanping He Hongtao Lin Juejun Hu Zahid Yaqoo Peter T.C.So Renjie Zhou | 2020 | Advanced Photonics2020，2，6： | 5 |
| 8 | Effects of rotor structure on performance of small size axial flow fans显示文摘Small size axial flow fans are used as a cooling component for computers,electronic equipment and other electronic components.With the increasing power of electrical equipment,the demand for lower noise and higher ventilation of cooling fan is also increasing.Traditional methods of improving ventilation by raising the fan's rotation speed causes a decrease in efficiency and an increase in noise.In this paper,different structures of fans were simulated,and as a result,the counter-rotating fan can achieve higher pressure,efficiency and facilitate ventilation in a smaller space.Furthermore,some other conclusions are as follows:(1) Higher pressure rise can be obtained by a counter-rotating fan than by the two-stage rotor fan in the same axial length.Meanwhile,the counter-rotating fan has a broader work scope.(2) The main noise type of the counter-rotating fan is rotating noise;the small peak pulse caused by vortex noise mainly due to the eddy current produced by small eddies.(3) When the distance of counter-rotating fans is smaller than 2 times the chord,the greater distance the greater total pressure of the circum-averages and along the axial direction,the total pressure begin to decline until the distance is three times the chord,so there is an optimal distance between rotors.The simulation results are of important significance to the quantitative analysis and optimization design of the counter-rotating fan. | Pin Liu Yingzi Jin Yanping Wang | 2011 | Journal of Thermal Science2011，20，3： | 5 |
| 9 | Numerical and Experimental Study on Aerodynamic Performance of Small Axial Flow Fan with Splitter Blades显示文摘To improve the aerodynamic performance of small axial flow fan, in this paper the design of a small axial flow fan with splitter blades is studied. The RNG k-ε turbulence model and SIMPLE algorithm were applied to the steady simulation calculation of the flow field, and its result was used as the initial field of the large eddy simulation to calculate the unsteady pressure field. The FW-H noise model was adopted to predict aerodynamic noise in the six monitoring points. Fast Fourier transform algorithm was applied to process the pressure signal. Experiment of noise testing was done to further investigate the aerodynamic noise of fans. And then the results obtained from the numerical simulation and experiment were described and analyzed. The results show that the static characteristics of small axial fan with splitter blades are similar with the prototype fan, and the static characteristics are improved within a certain range of flux. The power spectral density at the six monitoring points of small axial flow fan with splitter blades have decreased to some extent. The experimental results show sound pressure level of new fan has reduced in most frequency bands by comparing with prototype fan. The research results will provide a proof for parameter optimization and noise prediction of small axial flow fans with high performance. | Zhu Lifu Jin Yingzi Li Yi Jin Yuzhen Wang Yanping Zhang Li | 2013 | Journal of Thermal Science2013，22，4： | 4 |
| 10 | Influence of Tip End-plate on Noise of Small Axial Fan显示文摘In this work, tip end-plate is used to improve the noise performance of small axial fans. Both numerical simulations and experimental methods were adopted to study the fluid flow and noise level of axial fans. Four modified models and the prototype are simulated. Influences of tip end-plate on static characteristics, internal flow field and noise of small axial fans are analyzed. The results show that on basis of the prototype, the model with the tip end-plate of 2 mm width and changed length achieved best noise performance. The overall sound pressure level of the model with the tip end-plate of 2 mm width and changed length is 2.4 dB less than that of the prototype at the monitoring point in specified far field. It is found that the mechanism of noise reduction is due to the decrease of vorticity variation on the surface of blades caused by the tip end-plate. Compared with the prototype, the static pressure of the model with the tip end-plate of 2 mm width and changed length at design flow rate decreases by 2 Pa and the efficiency decreases by 0.8%. It is concluded that the method of adding tip end-plate to impeller blades has a positive influence on reducing noise, but it may diminish the static characteristics of small axial fan to some extent. | MAO Hongya WANG Yanping LIN Peifeng JIN Yingzi Toshiaki Setoguchi Heuy Dong Kim | 2017 | Journal of Thermal Science2017，26，1： | 4 |
| 11 | Single Nucleotide Polymorphism of FSHβ Gene Associated with Reproductive Traits in Japanese Flounder (Paralichthys olivaceus)显示文摘Follicle stimulating hormone β (FSHβ) of Japanese flounder (Paralichthys olivaceus) plays a key role in the regulation of gonadal development.This study aimed to investigate molecular genetic characteristics of the FSHβ gene and elucidate the effects of single nucleotide polymorphisms (SNPs) of FSHβ on reproductive traits in Japanese flounder.We used polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) and sequencing of the FSHβ gene in 60 individuals.We identified only an SNP (T/C) in the coding region of exon3 of FSHβ.The SNP (T/C) did not lead to amino acid changes at the position 340 bp of FSHβ gene.Statistical analysis showed that the SNP was significantly associated with testosterone (T) level and gonadosomatic index (GSI) (P<0.05).Individuals with genotype TC of the SNP had significantly higher serum T levels and GSI (P<0.05) than that of genotype CC.Therefore, FSHβ gene could be a useful molecular marker in selection for prominent reproductive trait in Japanese Flounder. | HE Feng WEN Haishen YU Dahui LI Jifang SHI Bao CHEN Caifang ZHANG Jiaren JIN Guoxiong CHEN Xiaoyan Shi Dan Yang Yanping | 2010 | Journal of Ocean University of China2010，9，4： | 4 |
| 12 | Factors Affecting Small Axial Cooling Fan Performance显示文摘Many factors such as outer diameter,hub ratio,blade numbers,shape and stagger angle affect the performance of small cooling fans.A small cooling fan was simulated using CFD software for three blade stagger angles (30.5°,37.5°,44.5°)and obtained the internal flow field and the static characteristics.Research indicated that the stagger angle has an obvious effect on the static characteristics of a fan.For flow rates below 0.0104 m3/s,total pressure is the greatest when the stagger angle is 37.5°;flow rates higher than 0.0104 m3/s,the total pressure is greatest when the stagger angle is 44.5° For the same flow rates,the velocity at inlet of pressure surface increases with increasing stagger angle,but the change of velocity on the suction surface is very small.For one model,vortices and the speed of revolution surfaces decrease with tip clearance increasing.But for other three models,increasing the stagger angle,the vortex intensity and speed of revolution surfaces at same height tip clearance increases,simultaneously,the position of vortex offset from the top of the rotor blade to the suction surface. | Lihong Wang,Yingzi Jin,Baoling Cui,Yuzhen Jin,Jin Lin,Yanping Wang and Chuanyu Wu College of Mechanical Engineering & Automation,Zhejiang Sci-Tech University,Xiasha Education Zone,Hangzhou 310018,China | 2010 | Journal of Thermal Science2010，19，2： | 4 |
| 13 | Curcumin’s prevention of inflammation-driven early gastric cancer and its molecular mechanism显示文摘Worldwide,gastric cancer is the second leading cause of cancer deaths and the fifth most common malignant tumor.Gastric cancer is believed to be caused by a variety of factors,such as genetics,epigenetics,and environmental influences.Among the pathogenic factors,inflammation has been considered as one of the main risk factors for gastric cancer.There are currently limited ways to prevent gastric cancer.Although the combined application of aspirin and non-steroidal anti-inflammatory drugs can reduce the risk,it has great side effects and can easily cause gastric perforation or gastric bleeding.Therefore,an alternative plan is urgently needed.Curcumin is the yellow pigment in the rhizome of the plant turmeric.Current studies have found that curcumin has a protective effect on gastric mucosal damage caused by non-steroidal anti-inflammatory drugs,gastric mucosal damage in rats,and gastric mucosal damage caused by stress bleeding and Helicobacter pylori infection.Curcumin shows significant antiinflammatory and anti-cancer activities by regulating DNA methylation,histone modification,nuclear factor erythrocyte 2 related factor 2 and other related signal pathways.In this article,the latest evidence of curcumin for epigenetic changes in gastric cancer and its potential contribution to gastric cancer were discussed. | Wensen Zhang Na Cui Jin Ye Bingyou Yang Yanping Sun Haixue Kuang | 2022 | Chinese Herbal Medicines2022，14，2： | 3 |
| 14 | Electrochemistry during efficient copper recovery from complex electronic waste using ammonia based solutions显示文摘 | Zhi Sun Hongbin Cao Prakash Venkatesan Wei Jin Yanping Xiao Jilt Sietsma Yongxiang Yang | 2017 | Frontiers of Chemical Science and Engineering2017，11，3： | 3 |
| 15 | Synthesis,characterization and cell imaging properties of rare earth compounds based on hydroxamate ligand显示文摘Six binuclear rare earth compounds were synthesized through the ligand of 4-Bromo-N-hydroxy-Nmethyl-benzamide(sH_2 bha). Compounds 1-3 are isomorphous, and compound 1 is crystallized in the monoclinic system with the P2_1/c space group. Compounds 4 and 5 are isomorphous, and compound 4 is crystallized in the triclinic system with the P-1 space group. Compound 6 is crystallized in the triclinic system with the P-1 space group. The compounds were characterized by thermogravimetric analysis(TGA) and IR spectroscopy. The fluorescence spectrum in the visible area shows characteristic peaks of Eu, Tb, and Dy compounds. The efficiency of Eu compound on the viability of PC3 cells was assessed using CCK8 assays. From the CCK8 results, ionic concentration may have a great effect on PC3 cells' proliferation. Eu compound shows red fluorescence in the cytoplasm of PC3 cell. As for Eu compound, it might have potential application in cell imaging technology. | Linyan Yang Yanping Zhang Liwei Hu Yunhe Zong Ruili Zhao Tianming Jin Wen Gu | 2018 | Journal of Rare Earths2018，36，4： | 3 |
| 16 | External application of a Nocardia rubra cell wall skeleton in the treatment of diabetic foot ulcers显示文摘Diabetic foot ulcers are one of the most severe complications of diabetes that have imposed great financial and psychological burdens on diabetic patients.A Nocardia rubra cell wall skeleton(Nr-CWS)can be externally applied to accelerate wound healing.However,its clinical application has not yet been reported.Herein,we report two patients with diabetic foot ulcers treated with Nr-CWS.After wound debridement,the wound was covered with a sterile cotton ball infiltrated with an Nr-CWS that was diluted with 2.0 mL of saline.The covers were changed every two days until complete wound healing occurred.The two wounds healed after 3 and 12 weeks,respectively.This article aims to provide a new treatment for diabetic foot ulcers,with the hope that physicians may consider an Nr-CWS as a complementary method for the treatment of chronic wounds. | Caiqi Shen Wuhan Wei Aijun Zhang Changbo Tao Xueyang Li Yanping Guo Hanxiao Wei Qiang Li Peisheng Jin | 2022 | Chinese Journal Of Plastic and Reconstructive Surgery2022，4，1： | 2 |
| 17 | Simulation and Experiment Research of Aerodynamic Performance of Small Axial Fans with Struts显示文摘Interaction between rotor and struts has great effect on the performance of small axial fan systems.The small axial fan systems are selected as the studied objects in this paper,and four square struts are downstream of the rotor.The cross section of the struts is changed to the cylindrical shapes for the investigation:one is in the same hydraulic diameter as the square struts and another one is in the same cross section as the square struts.Influence of the shape of the struts on the static pressure characteristics,the internal flow and the sound emission of the small axial fans are studied.Standard K-ε turbulence model and SIMPLE algorithm are applied in the calculation of the steady fluid field,and the curves of the pressure rising against the flow rate are obtained,which demonstrates that the simulation results are in nice consistence with the experimental data.The steady calculation results are set as the initial field in the unsteady calculation.Large eddy simulation and PISO algorithm are used in the transient calculation,and the Ffowcs Williams-Hawkings model is introduced to predict the sound level at the eight monitoring points.The research results show that:the static pressure coefficients of the fan with cylindrical struts increase by about 25%compared to the fan with square struts,and the efficiencies increase by about 28.6%.The research provides a theoretical guide for shape optimization and noise reduction of small axial fan with struts. | CHU Wei LIN Peifeng ZHANG Li JIN Yingzi WANG Yanping Heuy Dong Kim Toshiaki Setoguchi | 2016 | Journal of Thermal Science2016，25，3： | 2 |
| 18 | A durable 4-1BB-based CD19 CAR-T cell for treatment of relapsed or refractory non-Hodgkin lymphoma显示文摘Objective:Previous studies reported that 4-1BB-based CD19 chimeric antigen receptor(CAR)-T cells were more beneficial for the clinical outcomes than CD28-based CAR-T cells,especially the lower incidence rate of severe adverse events.However,the median progression-free survival(mPFS)of 4-1BB-based product Kymriah was shorter than that of CD28-based Yescarta(2.9 months vs.5.9 months),suggesting that Kymriah was limited in the long-term efficacy.Thus,a safe and durable 4-1BB-based CD19 CAR-T needs to be developed.Methods:We designed a CD19-targeted CAR-T(named as IM19)which consisted of an FMC63 scFv,4-1BB and CD3ζintracellular domain and was manufactured into a memory T-enriched formulation.A phase I/II clinical trial was launched to evaluate the clinical outcomes of IM19 in relapsed or refractory(r/r)B cell non-Hodgkin lymphoma(B-NHL).Dose-escalation investigation(at a dose of 5×10^(5)/kg,1×10^(6)/kg and 3×106/kg)was performed in 22 r/r B-NHL patients.All patients received a single infusion of IM19 after 3-day conditional regimen.Results:At month 3,the overall response rate(ORR)was 59.1%,the complete response rate(CRR)was 50.0%.The mPFS was 6 months and the 1-year overall survival rate was 77.8%.Cytokine release syndrome(CRS)occurred in 13 patients(59.1%),with 54.5%of grade 1−2 CRS.Only one patient(4.5%)experienced grade 3 CRS and grade 3 neurotoxicity.Conclusions:These results demonstrated the safety and durable efficacy of a 4-1BB-based CD19 CAR-T,IM19,which is promising for further development and clinical investigation. | Zhitao Ying Ting He Shanzhao Jin Xiaopei Wang Wen Zheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Weiping Liu Lijuan Deng Yanping Ding Xuelian Hu Bing Bu Xin’an Lu Yuqin Song Jun Zhu | 2022 | Chinese Journal of Cancer Research2022，34，1： | 2 |
| 19 | Traditional Chinese Medicine guidelines for coronavirus disease 2019显示文摘OBJECTIVE:To summarize the evidence from Traditional Chinese Medicine(TCM)practice in the treatment of coronavirus disease 2019(COVID-19)and provide timely clinical practice guidance.METHODS:The guidelines were developed in accordance with the World Health Organization rapid guideline process.The evidence on TCM for COVID-19 from published guidelines,direct and indirect published clinical evidence,first hand clinical data,and expert experience and consensus were collected.The grading of recommendations assessment,development and evaluation(GRADE)method was used to grade the evidence and make the recommendations.RESULTS:Based on the available evidence,the guidelines recommended 17 Chinese medicines for COVID-19:2 Chinese herbal granules,7 Chinese patent medicines,and 8 Chinese herbal injections.CONCLUSION:As the literature search was conducted on March,any subsequent versions of these guidelines require an up-to-date literature review.We hope that the evidence summary in these guidelines will be helpful in global efforts to address COVID-19. | Liang Ning Ma Yanfang Wang Jingya Li Huizhen Wang Xiaohui Jiao Liwen Liu Bin Ma Yan Zhao Chen Luo Xufei Zhao Siya Lu Meng Cao Jin Hu Wenpin Zhang Hairong Liu Guoxiu Lu Cheng Liu Mengyu Li Li Han Xuejie Liu Yuqi Wang Liying Zhao Xueyao Wei Dongfeng Bai Jing Sun Mingyu Yang Yong Wu Xiaodan Chen Yaolong Shi Nannan Wang Yanping Wang Yongyan | 2020 | Journal of Traditional Chinese Medicine2020，40，6： | 2 |
| 20 | Identification of two novel missense WFS1 mutations,H696Y and R703H,in patients with non-syndromic low-frequency sensorineural hearing loss显示文摘Non-syndromic 低频率的 sensorineural 听觉损失(LFSNHL ) 是听见在频率, 2000 Hz 主要被影响的损失的一种不平常的类型。迄今为止,在二基因, DIAPH1 和 WFS1 的不同变化,被发现了与 LFSNHL 被联系。这里,我们与 postlingual 和进步 LFSNHL 报导一个五产生的中国家庭。我们在在标记 SNP_A-2167174 和 D4S431 之间的染色体 4p16 上印射疾病地点到 2.5 Mb 区域,与 DFNA6/14/38 地点重叠。候选人基因定序揭示了异质接合的 c.2086C > 在 exon 的 T 替换 8 WFS1,在 Wolframin (WFS1 ) 的 C 终点导致 p.H696Y 替换。另外,我们执行了在 37 个分散的病人, WFS1 屏蔽的 mutational 750 岁,与 LFSNHL。我们检测了异质接合的 c.2108G > 在 exon 的替换 8 WFS1,在一个病人导致 p.R703H 替换。在 WFS1 的 H696 和 R703 高度越过种类被保存,包括人,猩猩,老鼠,老鼠,和青蛙(Xenopus ) 。顺序分析表明了 c.2086C 的缺席 > T 或 c.2108G > 在在中国背景的 200 个无关的控制题目之中的 WFS1 基因的 A 替换,支持他们代表的假设原因的变化,和不稀罕的多型性。我们的数据为为 LFSNHL 建立更好的 genotypephenotype 关联提供另外的分子、临床的信息。 | Yi Sun Jing Cheng Yanping Lu Jianzhong Li Yu Lu Zhanguo Jin Pu Dai Rongguang Wang Huijun Yuan | 2011 | Journal of Genetics and Genomics2011，38，2： | 2 |
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