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| 1 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 2 | The impact of climate change and human activities on streamflow and sediment load in the Pearl River basin显示文摘This paper uses monthly streamflow, suspended sediment concentration, and meteorological data to examine the impact of human activity and climate change on streamflow and sediment load in the Pearl River basin from the 1950s to the 2000s. The influences of climate change and human activities on hydrological processes were quantitatively evaluated using the Mann–Kendall abrupt change test and power rating curves. The results showed that:(1) abrupt changes and turning points in streamflow occurred in 1963, 1983, and 1991 which were found to be consistent with global ENSO events and volcanic eruptions. However, abrupt changes in sediment load showed significant spatial differences across the Pearl River basin. For the Xijiang River, an abrupt change in sediment load occurred in 2002, and after 2007 the change becomes significant at the 95% confidence level. At Beijiang and Dongjiang, abrupt changes in sediment load occurred in 1998 and 1988, respectively.(2) The time series of sediment load data was divided into four periods according to abrupt changes. The contribution of climate change and human activities is different in the different rivers. For the Xijiang River, compared with the first period, climate change and human activities contributed 83% and 17%, respectively, to the increasing sediment load during the second period. In the third period, the variation of sediment load followed a decreasing trend. The contribution from climate change and human activities also changed to t236% and -136%, respectively. In the fourth period, climate change and human activities contributed -32% and t132%, respectively. Meanwhile, For the Beijiang River, climate change and human activities contributed 90% and 10% in the second period, the contribution of climate change increased to t115% and human activities decreased to -15% in the third period. In the fourth period, the value for climate change decreased to t36% and human activities increased to t64%. For the Dongjiang River, the contribution of human activities was from 74.5% to 90%, and the values for climate change were from 11% to 25%. Therefore, the effect of human activity showed both spatial and temporal differences, and it seems likely that the decreased sediment load will continue to be controlled mainly by human activities in the future. | Chuangshou Wu Changchen Ji Benwei Shi Yaping Wang Jianhua Gao Yang Yang Jinbin Mu | 2019 | International Journal of Sediment Research2019，34，4： | 12 |
| 3 | High efficient gene targeting in rice field eel Monopterus albus by transcription activator-like effector nucleases显示文摘Genome editing plays an important role in the research of gene functions,gene correction and cell replacement therapy.Traditionally,genome editing is mainly dependent on the technology of homologous recombination(HR)and embryonic stem(ES)cell lines in mammals[1].However,genome editing is severely limited by the low efficiency of HR and lack of ES cell lines in most organisms.Recently,the development of zinc finger nucleases(ZFNs), | Ke Feng Hongrui Luo Yongming Li Ji Chen Yaping Wang Yonghua Sun Zuoyan Zhu Wei Hu | 2017 | Science Bulletin2017，62，3： | 9 |
| 4 | Review of Chinese atmospheric science research over the past 70 years: Synoptic meteorology显示文摘Synoptic meteorology is a branch of meteorology that uses synoptic weather observations and charts for the diagnosis,study,and forecasting of weather.Weather refers to the specific state of the atmosphere near the Earth’s surface during a short period of time.The spatial distribution of meteorological elements in the atmosphere can be represented by a variety of transient weather phenomena,which are caused by weather systems of different spatial and temporal scales.Weather is closely related to people’s life,and its development and evolution have always been the focus of atmospheric scientific research and operation.The development of synoptic meteorology is closely related to the development of observation systems,dynamical theories and numerical models.In China,observation networks have been built since the early 1950 s.Up to now,a comprehensive meteorological observation systembased on ground,air and space has been established.In particular,the development of a new generation of dense radar networks,the development of the Fengyun satellite series and the implementation of a series of large field experiments have brought our understanding of weather from large-scale environment to thermal dynamics,cloud microphysical structure and evolution characteristics of meso and micro-scale weather systems.The development of observation has also promoted the development of theory,numerical model and simulation.In the early days,China mainly used foreign numerical models.Lately,China has developed numerical model systems with independent intellectual property rights.Based on the results of high-resolution numerical simulations,in-depth understanding of the initiation and evolution mechanism and predictability of weather at different scales has been obtained.Synoptic meteorology has gradually changed from an initially independent development to a multidisciplinary approach,and the interaction between weather and the change of climate and environment has become a hot and frontier topic in atmospheric science.This paper reviews the important scientific and technological achievements made in China over the past 70 years in the fields of synoptic meteorology based on the literatures in China and abroad,from six aspects respectively including atmospheric dynamics,synoptic-scale weather,typhoon and tropical weather,severe convective weather,numerical weather prediction and data assimilation,weather and climate,atmospheric physics and atmospheric environment. | Zhiyong MENG Fuqing ZHANG Dehai LUO Zhemin TAN Juan FANG Jianhua SUN Xueshun SHEN Yunji ZHANG Shuguang WANG Wei HAN Kun ZHAO Lei ZHU Yongyun HU Huiwen XUE Yaping MA Lijuan ZHANG Ji NIE Ruilin ZHOU Sa LI Hongjun LIU Yuning ZHU | 2019 | Science China Earth Sciences2019，62，12： | 7 |
| 5 | The integration characteristics of the exogenous growth hormone gene in a transgenic common carp(Cyprinus carpio L.) with fast-growth performance显示文摘The genetic stability and expression efficiency of exogenous genes in transgenic animals are closely related to integration site and copy number. In our laboratory, by transgenic manipulation and subsequent test crosses, we established an ‘‘all-fish'' growth hormone(GH)transgenic common carp family that exhibits fast growth.In this present study, genome walking, real-time quantitative polymerase chain reaction, and fluorescence in situ hybridization techniques were applied to identify the integration characteristics of the exogenous grass carp GH gene in the transgenic common carp. The exogenous GH genes, in the form of two complete and one incomplete tandem repeats, were found to have integrated into an ATrich region near the end of a chromosome pair. We hypothesize that the high efficiency of exogenous GH gene expression might be due to the low copy number in the genome and the AT-rich integration site. | Ji Chen Qing Luo Hairong Bao Lanjie Liao Yongming Li Zuoyan Zhu Yaping Wang Wei Hu | 2015 | Science Bulletin2015，60，19： | 3 |
| 6 | Anomalous Pore-Density Dependence in Nanofluidic Osmotic Power Generation显示文摘 | Jianjian Su Danyan Ji Jialiang Tang Hao Li Yaping Feng Liuxuan Cao Lei Jiang Wei Guo | 2018 | Chinese Journal of Chemistry2018，36，5： | 3 |
| 7 | Photocatalytic degradating methyl orange in water phase by UV-irradiated CdS carried by carbon nanotubes显示文摘A new candidate for photocatalytic degradating organic dyes,CdS carried by car-bon nanotubes(CdS/CNTs) ,is reported. The degradation ratio curves of methyl orange in water phase show that the capability for degradating organic molecules of CdS/CNTs is obviously higher than that of separated CdS. The degradation ca-pability enhances as the increase of the amount of net CdS catalyst,the ratio of carbon nanotubes to CdS,and the area of the template,and is influenced by the pH value and the temperature of aqueous solution. These results suggest that the photocatalyst of CdS/CNTs is very suitable for potential applications in organic waste removal from water. | LI ChenSha TANG YaPing KANG BoNan WANG BinSong ZHOU Feng MA Qiang XIAO Ji WANG DaZhi LIANG Ji | 2007 | Science China(Technological Sciences)2007，50，3： | 2 |
| 8 | The opposing effects of intracerebroventricularly injected norepinephrine on oxytocin and vasopressin neurons in the paraventricular nucleus of the rat显示文摘 | Mei Jun Lu Shaogang | 1998 | Neurosci Lett1998，244，1： | 1 |
| 9 | Overexpression of NYGGF4 (PID1) induces mitochondrial impairment in 3T3-L1 adipocytes显示文摘 | Yaping Zhao Chunmei Zhang Xiaohui Chen Chunlin Gao Chenbo Ji Fukun Chen Chun Zhu Jingai Zhu Jialin Wang Lingmei Qian Xirong Guo | 2010 | Molecular and Cellular Biochemistry (-)2010，，1： | 1 |
| 10 | No Relationship between Maternal Iron Status and Postpartum Depression in Two Samples in China显示文摘 | Rinat Armony-Sivan Jie Shao Ming Li Gengli Zhao Zhengyan Zhao Guobing Xu Min Zhou Jianying Zhan Yang Bian Chai Ji Xing Li Yaping Jiang Zhixiang Zhang Blair J. Richards Twila Tardif Betsy Lozoff Laura Murray-Kolb | 2012 | Journal of Pregnancy2012，，： | 1 |
| 11 | Bone biomechanical and histomorphometrical investment in type 2 diabetic Goto-Kakizaki rats显示文摘 | Liping Zhang Yaping Liu Dong Wang Xinbo Zhao Zhanjun Qiu Hong Ji Haiqin Rong | 2009 | Acta Diabetologica2009，，2： | 1 |
| 12 | Behavioral training-induced c-fos expression in the rat nuceus basalis of meynert during aging显示文摘 | Zhang Yuqiu Ji Yaping Mei Jun | | 0，，： | 1 |
| 13 | Sex differences in spinal processing of transient and inflammatory colorectal stimuli in the rat显示文摘 | Yaping Ji Bin Tang Dong-Yuan Cao Gexin Wang Richard J. Traub | 2012 | Pain2012，，9： | 1 |
| 14 | Modulatory effects of estrogen and progesterone on colorectal hyperalgesia in the rat显示文摘 | Yaping Ji Tang B Traub R J | 2005 | Pain2005，117，3： | 1 |
| 15 | Estrogen Modulates the Visceromctor Reflex and Responses of Spinal Dorsal Hom Neurons to Colorectal Stimulation inthe Bat显示文摘 | Yaping Ji Anne Z Murphy | 2003 | The Journal of Neuroscience2003，23，9： | 1 |
| 16 | A pH-responsive mesoporous silica nanoparticles-based multi-drug delivery system for overcoming multi-drug resistance显示文摘 | Qianjun He Yu Gao Lingxia Zhang Zhiwen Zhang Fang Gao Xiufeng Ji Yaping Li Jianlin Shi | 2011 | Biomaterials2011，，30： | 1 |
| 17 | Author Correction: 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘In the initial published version of this article, there was a mistake in the P value for the correlation between gene-expression changes and 5 hmC changes in tumors. The correct P value should be same as the P value shown in Fig. S6A: 9.8?×?10?6 (mistakenly shown as “9.8?×?106” in the main text). This correction does not affect the description of results or the conclusions of this study, since the range of P value is between 0 and 1. | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2019 | Cell Research2019，29，7： | 1 |
| 18 | Spectrum-shaped Si-perovskite hybrid photodetectors for hyperspectral bioimaging显示文摘Hyperspectral imaging(HSI)with rich spectral and spatial information holds potential for applications ranging from remote sensing to biomedicine.However,charge-coupled device(CCD)detectors used in conventional HSI systems suffer from inferior and unbalanced responsivity in the visible region,which is not a perfect choice for high-performance visible HSI.That is,conventional Si-based CCDs exhibit poor responsivity at short wavelengths(e.g.,400–600 nm)compared with that at longer wavelengths due to the nature of the indirect bandgap in silicon of around 1.1 e V.To solve this challenge,we introduce a Cs Pb Br_(3) perovskite layer to shape the spectrum of a Si/PEDOT:PSS heterojunction photodetector(PD),resulting in a fabricated Si-Cs Pb Br_(3) hybrid PD with enhanced responsivity at 400–600 nm.This results in an approximately flat spectral responsivity curve in the visible region(400–800 nm).Therefore,the stable Si-Cs Pb Br_(3) hybrid PD with a flat spectrum overcomes the shortcomings of traditional Si-based PDs and makes it more suitable for HSI.Further,we set up a first perovskite HSI system with high spectrum resolution and demonstrate potential applications for tumor detection and tissue identification.We believe that this perovskite optimization can be integrated into modern CCD,thus becoming a step in future CCD fabrication processes,which is a milestone for high-performance HSI systems. | YUJIN LIU ZHONG JI YAPING LI HONG JIN FAN WENJIE MAI | 2021 | Photonics Research2021，9，9： | 1 |
| 19 | Switchable half-metallicity in A-type antiferromagnetic NiI_(2)bilayer coupled with ferroelectric In_(2)Se_(3)显示文摘Electrically controlled half-metallicity in antiferromagnets is of great significance for both fundamental research and practical application.Here,by constructing van der Waals heterostructures composed of two-dimensional(2D)A-type antiferromagnetic NiI_(2)bilayer(bi-NiI_(2))and ferroelectric In_(2)Se_(3)with different thickness,we propose that the half-metallicity is realizable and switchable in the bi-NiI_(2)proximate to In_(2)Se_(3)bilayer(bi-In_(2)Se_(3)).The polarization flipping of the bi-In_(2)Se_(3)successfully drives transition between half-metal and semiconductor for the bi-NiI_(2).This intriguing phenomenon is attributed to the joint effect of polarization field-induced energy band shift and interfacial charge transfer.Besides,the easy magnetization axis of the bi-NiI_(2)is also dependent on the polarization direction of the bi-In_(2)Se_(3).The half-metallicity and magnetic anisotropy energy of the bi-NiI_(2)in heterostructure can be effectively manipulated by strain.These findings provide not only a feasible strategy to achieve and control half-metallicity in 2D antiferromagnets,but also a promising candidate to design advanced nanodevices. | Yaping Wang Xinguang Xu Xian Zhao Weixiao Ji Qiang Cao Shengshi Li Yanlu Li | 2022 | npj Computational Materials2022，，1： | 1 |
| 20 | Concomitant chemoradiotherapy using pemetrexed and carboplatin for unresectable stage III non-small cell lung cancer (NSCLC): Preliminary results of a phase II study显示文摘 | Yaping Xu Shenglin Ma Yongling Ji Xiaojiang Sun Hao Jiang Jianxiang Chen Xianghui Du Yuanda Zheng Guoqin Qiu | 2010 | Lung Cancer2010，，3： | 1 |
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