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| 1 | Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds显示文摘最近,我们报导了一条化学途径从老鼠成纤维细胞产生 pluripotent 干细胞。然而,是否化学上导致了 pluripotent 干细胞(CiPSCs ) ,能从要示威的另外的房间类型遗体被导出。用系跟踪,这里,我们首先从成纤维细胞验证 CiPSCs 的产生。下次,我们证明从外胚层的神经干细胞(NSC ) 和从内胚叶的小肠的上皮的房间(IEC ) 能是化学上 reprogrammed 进 pluripotent 干细胞。CiPSCs 源于 NSC 和 IEC 类似于老鼠处于增长率,全球基因表示侧面, epigenetic 地位,自强和区别能力的胚胎的干细胞,和 germline 传播才能。有趣地, pluripotency 基因 Sall4 从不同房间类型,和一样的核心在化学 reprogramming 过程在起始的阶段被表示小分子为 reprogramming 被要求,在从这些多样的房间类型位于化学 reprogramming 下面的分子的机制建议保存。我们的分析也证明这些小分子的使用应该被调整从不同房间类型满足 reprogramming 的要求。一起,这些调查结果证明那条完整的化学 reprogramming 途径能在不同织物起源的房间被使用并且建议化学 reprogramming 是有要延长到更起始的类型的潜力的有希望的策略。 | Junqing Ye Jian Ge Xu Zhang Lin Cheng Zhengyuan Zhang Shan He Yuping Wang Hua Lin Weifeng Yang Junfang Liu Yang Zhao Hongkui Deng | 2016 | Cell Research2016，26，1： | 19 |
| 2 | Characteristics of paleoflood deposits archived in unit T0403 of Yuxi Site in the Three Gorges reservoir areas,China显示文摘Based on the detailed analyses,multi-proxies such as AMS 14 C dating,grain size,component and morphology of heavy minerals,micromorphology of zircon,magnetic susceptibility,Rb/Sr and Hg content are used to research the paleoflood sediments archived in the Yuxi Site.The research indicates that, since 7.6 kaBP,at least 16 times of paleoflood with water level above Wusong Elevation 147.024 m(a.s.l.) left deposits in the Neolithic layers of unit T0403 from the Yuxi Site.The results are induced from the following aspects:(1)The plaeoflood sediments take on great similarities with modern flood sediments in the Yuxi Site and Zhongba Site in probability cumulative curves which mainly show a pattern of 3 segments in fluvial pattern.(2)There is some resemblance between the heavy mineral components and the zircon shape characteristics of paleoflood deposits and those of modern flood deposits.(3) Magnetic susceptibility values(40.44―70.10SI)are lower than those of sediments from cultural layers (59.59―188.68SI).(4)Hg values(290.71―742.51 ng/g)are lower than those of sediments from cultural layers(344.16―10518.17 ng/g).(5)Rb/Sr values are higher than those of sediments from cultural layers, while those of the 4th,5th,6th,7th,8th cultural layers are high,which shows that they are inundated by paleoflood.The reason for many flood deposits existing is related to the site situated on the first terrace where the Yuxi River joins with the Yangtze River.As there are some similarities between the plaeoflood sediments and those of the Zhongba Site,it is feasible to confirm the existence of paleoflood sediments based on the above points. | ZHU Cheng MA ChunMei XU WeiFeng BAI JiuJiang ZHENG ChaoGui ZHU GuangYao WANG HuiLin CHEN Ye LU XueFeng | 2008 | Chinese Science Bulletin2008，53，S1： | 16 |
| 3 | Proanthocyanidins Inhibit Seed Germination by Maintaining a High Level of Abscisic Acid in Arabidopsis thaliana显示文摘Proanthocyanidins (PAs) are the main products of the flavonoid biosynthetic pathway in seeds, but their biological function during seed germination is still unclear. We observed that seed germination is delayed with the increase of exogenous PA concentration in Arabidopsis. A similar inhibitory effect occurred in peeled Brassica napus seeds, which was observed by measuring radicle elongation. Using abscisic acid (ABA), a biosynthetic and metabolic inhibitor, and gene expression analysis by real-time polymerase chain reaction, we found that the inhibitory effect of PAs on seed germination is due to their promotion of ABA via de novo biogenesis, rather than by any inhibition of its degradation. Consistent with the relationship between PA content and ABA accumulation in seeds, PA-deficient mutants maintain a lower level of ABA compared with wild-types during germination. Our data suggest that PA distribution in the seed coat can act as a doorkeeper to seed germination. PA regulation of seed germination is mediated by the ABA signaling pathway. | Liguo Jia Qiuyu Wu Nenghui Ye Rui Liu Lu Shi Weifeng Xu Hui Zhi A. N. M. Rubaiyath Bin Rahman Yiji Xia Jianhua Zhang | 2012 | Journal of Integrative Plant Biology2012，54，9： | 9 |
| 4 | Rhizosheath formation and involvement in foxtail millet(Setaria italica) root growth under drought stress显示文摘The rhizosheath, a layer of soil particles that adheres firmly to the root surface by a combination of root hairs and mucilage, may improve tolerance to drought stress. Setaria italica(L.) P. Beauv.(foxtail millet), a member of the Poaceae family, is an important food and fodder crop in arid regions and forms a larger rhizosheath under drought conditions. Rhizosheath formation under drought conditions has been studied, but the regulation of root hair growth and rhizosheath size in response to soil moisture remains unclear. To address this question, in this study we monitored root hair growth and rhizosheath development in response to a gradual decline in soil moisture. Here, we determined that a soil moisture level of 10%–14%(w/w)stimulated greater rhizosheath production compared to other soil moisture levels. Root hair density and length also increased at this soil moisture level, which was validated by measurement of the expression of root hair-related genes.These findings contribute to our understanding of rhizosheath formation in response to soil water stress. | Tie-Yuan Liu Nenghui Ye Tao Song Yunying Cao Bei Gao Di Zhang Fuyuan Zhu Moxian Chen Yingjiao Zhang Weifeng Xu Jianhua Zhang | 2019 | Journal of Integrative Plant Biology2019，61，4： | 6 |
| 5 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science2013，，6146： | 4 |
| 6 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science . 2013 (6146)2013，，： | 2 |
| 7 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | Science2013，，6146： | 2 |
| 8 | Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds显示文摘 | Pingping Hou Yanqin Li Xu Zhang Chun Liu Jingyang Guan Honggang Li Ting Zhao Junqing Ye Weifeng Yang Kang Liu Jian Ge Jun Xu Qiang Zhang Yang Zhao Hongkui Deng | 2013 | 2013 (6146)2013，，6146： | 1 |
| 9 | Department of U- rology of hospital infection characteristic analysis显示文摘 | Zhang Guomin Ye Weifeng Shao Xiaobin | 2009 | Chinese Journal of hospital pharmacy2009，15，22： | 1 |
| 10 | Photoluminescence and photocatalytic properties of SrSnO3perovskite显示文摘 | Zhang Weifeng Tang Junwang Ye Jinhua | 2006 | Chemical Physics Letters2006，418，10： | 1 |
| 11 | Based on rough set and fuzzy clustering of MRI brain segmentation显示文摘 | Yang Zhang Shufan Ye Weifeng Ding | 2017 | International Journal of Biomathematics2017，10，2： | 1 |
| 12 | Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism显示文摘Primary biliary cholangitis(PBC) is an autoimmune disease involving dysregulation of a broad array of homeostatic and metabolic processes. Although considerable single-nucleotide polymorphisms have been unveiled, a large fraction of risk factors remains enigmatic. Candidate genes with rare mutations that tend to confer more deleterious effects need to be identified. To help pinpoint cellular and developmental mechanisms beyond common noncoding variants, we integrate whole exome sequencing with integrative network analysis to investigate genes harboring de novo mutations. Prominent convergence has been revealed on a network of disease-specific co-expression comprised of 55 genes associated with homeostasis and metabolism. The transcription factor gene MEF2 D and the DNA repair gene PARP2 are highlighted as hub genes and identified to be up-and down-regulated, respectively, in peripheral blood data set. Enrichment analysis demonstrates that altered expression of MEF2 D and PARP2 may trigger a series of molecular and cellular processes with pivotal roles in PBC pathophysiology. Our study identifies genes with de novo mutations in PBC and suggests that a subset of genes in homeostasis and metabolism tend to act in synergy through converging on co-expression network, providing novel insights into the etiology of PBC and expanding the pool of molecular candidates for discovering clinically actionable biomarkers. | Lu Wang Jinchen Li Chan Wang Ruqi Tang Jialong Liang Yuhua Gong Yaping Dai Ningling Ding Jian Wu Na Dai Lei Liu Yi Zhao Youlin Shao Weifeng Zhao Peng Jiang Xingjuan Shi Weichang Chen Ye Tian Xiangdong Liu Xiong Ma Zhongsheng Sun | 2022 | Journal of Genetics and Genomics2022，49，2： | 1 |
| 13 | Understanding the Moon's internal structure through moonquake observations and remote sensing technologies显示文摘Explorations for the interior structure of the Moon mainly involve three technologies: the early gravitational observations via circumlunar satellites, the moonquake observations during the Apollo period, and the recent high-resolution remote sensing observations. Based on these technologies, we divided the development of the moon's interior structure into three stages. The first stage is the discovery of high-density anomalous masses(mascons) on the lunar surface with the low-order gravitational field models, which were obtained by observing perturbations of the early lunar orbital satellites. The second stage is the preliminary understanding of the layer structure with the help of moonquake observations during the Apollo period. The third stage is the deep understanding of the structure of the lunar crust, mantle, and core, with the use of high-resolution remote sensing data and the reassessment of moonquake data from the Apollo's mission. This paper gave detailed introduction and comments on different observation technologies, gathered data, and data processing techniques used at the three stages. In addition, this paper analyzed the current issues in the researches on the Moon's internal structure and discussed the prospects for future explorations. | Weifeng HAO Fei LI Chi XIAO Jianguo YAN Mao YE | 2018 | Science China Earth Sciences2018，61，8： | 1 |
| 14 | Improving antibody affinity through in vitro mutagenesis in complementarity determining regions显示文摘High-affinity antibodies are widely used in diagnostics and for the treatment of human diseases.However,most antibodies are isolated from semi-synthetic libraries by phage display and do not possess in vivo affinity maturation,which is triggered by antigen immunization.It is therefore necessary to engineer the affinity of these antibodies by way of in vitro assaying.In this study,we optimized the affinity of two human monoclonal antibodies which were isolated by phage display in a previous related study.For the 42A1 antibody,which targets the liver cancer antigen glypican-3,the variant T57H in the second complementarity-determining region of the heavy chain(CDR-H2)exhibited a 2.6-fold improvement in affinity,as well as enhanced cell-binding activity.For the I4A3 antibody to severe acute respiratory syndrome coronavirus 2,beneficial single mutations in CDR-H2 and CDR-H3 were randomly combined to select the best synergistic mutations.Among these,the mutation S53P-S98T improved binding affinity(about 3.7 fold)and the neutralizing activity(about 12 fold)compared to the parent antibody.Taken together,single mutations of key residues in antibody CDRs were enough to increase binding affinity with improved antibody functions.The mutagenic combination of key residues in different CDRs creates additive enhancements.Therefore,this study provides a safe and effective in vitro strategy for optimizing antibody affinity. | Wei Ye Xiaoyu Liu Ruiting He Liming Gou Ming Lu Gang Yang Jiaqi Wen Xufei Wang Fang Liu Sujuan Ma Weifeng Qian Shaochang Jia Tong Ding Luan Sun Wei Gao | 2022 | The Journal of Biomedical Research2022，36，3： | 0 |
| 15 | Low-threshold and narrow-emission random lasing in a self-assembly TiN nanoparticle-doped carbon quantum dot/DCM nanowire composite显示文摘The random lasing in quantum dot systems is in anticipation for widespread applications in biomedical therapy and image recognition,especially in random laser devices with high brightness and high monochromaticity.Herein,low-threshold,narrowband emission,and stable random lasing is realized in carbon quantum dot(CQD)/DCM nanowire composite-doped TiN nanoparticles,which are fabricated by the mixture of carbon quantum dots and self-assembly DCM dye molecules.The F?rster resonance energy transfer process results in a high luminescence efficiency for the composite of carbon dots and DCM nanowires,allowing significant random lasing actions to emerge in CQD/DCM composite as TiN particles are doped that greatly enhance the emission efficiency through the plasmon resonance and random scattering.Thus,sharp and low-threshold random lasing is finally realized and even strong single-mode lasing occurs under higher pumping energy in the TiN-doped CQD/DCM composite.This work provides a promising way in high monochromaticity random laser applications. | JING LYU XINYU ZHANG LEI CAI LI TAO WEIFENG MA AN LI YE TIAN YUNSONG YIN DENAN KONG WEN YI XIANSHUANG WANG RUIBIN LIU | 2022 | Photonics Research2022，10，9： | 0 |
| 16 | Effective strategies to promote Z(S)-scheme photocatalytic water splitting显示文摘Artificial Z(S)-scheme photocatalytic water splitting systems have attracted extensive attention due to their advantages such as wide light absorption range,high charge separation efficiency and strong carrier redox ability.However,it is still challenging to design and prepare Z(S)-scheme photocatalysts with low-cost and highly stability for efficiently photocatalytic overall water splitting using solar energy.This review mainly introduces various strategies to improve the photocatalytic water splitting performance of Z(S)-scheme systems.These strategies mainly focus on enhancing or extending the range of light absorption,promoting charge separation,and enhancing surface redox reaction in Z(S)-scheme systems.Finally,the main challenges of Z(S)-scheme photocatalytic water splitting systems and their future development directions are pointed out.This review would be beneficial to understanding the challenges and opportunities faced by the research field of Z(S)-scheme photocatalytic systems,and has important guiding significance for the development and utilization of high-performance Z(S)-scheme photocatalytic reaction system in the future. | Ye Yuan Junan Pan Weinan Yin Haoxuan Yu Fengshun Wang Weifeng Hu Longlu Wang Dafeng Yan | 2024 | Chinese Chemical Letters2024，35，3： | 0 |
| 17 | Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis显示文摘Primary biliary cholangitis(PBC)is an autoimmune liver disease characterized by the destruction of intrahepatic small bile ducts and progressive cholestasis,eventually leading to liver cirrhosis and hepatic failure without appropriate treatment(Terziroli Beretta-Piccoli et al.,2019). | Peng Jiang Chan Wang Mingming Zhang Ye Tian Weifeng Zhao Junyi Xin Yexi Huang Zhibin Zhao Wenjuan Sun Jie Long Ruqi Tang Fang Qiu Xingjuan Shi Yi Zhao Li Zhu Na Dai Lei Liu Xudong Wu Jinshan Nie Bo Jiang Youlin Shao Yueqiu Gao Jianjiang Yu Zhigang Hu Zhidong Zang Yuhua Gong Yaping Dai Lan Wang Ningling Ding Ping Xu Sufang Chen Lu Wang Jing Xu Luyao Zhang Junyan Hong Ruonan Qian Hu Li Xuan Jiang Congwei Chen Wenyan Tian Jian Wu Yuzhang Jiang Chongxu Han Kui Zhang Hong Qiu Li Li Hong Fan Liming Chen Jianqiong Zhang Zhongsheng Sun Xiao Han Zhenhua Dai Erguang Li M.Eric Gershwin Zhexiong Lian Xiong Ma Michael F.Seldin Weichang Chen Meilin Wang Xiangdong Liu | 2023 | Journal of Genetics and Genomics2023，50，10： | 0 |
| 18 | Fabrication of recyclable Fe^(3+) chelated aminated polypropylene fiber for efficient clean-up of phosphate wastewater显示文摘Herein,a Fe^(3+)-loaded aminated polypropylene fiber has been reported as an efficient phosphate adsorbent.The remarkable phosphate removal ability of the fiber is due to Fe^(3+)immobilization,and it demonstrates a maximum adsorption capacity of 33.94 mg·P·g^(–1).Adsorption experiments showed that the fiber is applicable over a wide pH range from 2 to 9.Furthermore,the adsorption kinetics and isotherm data were consistent with the pseudo-second-order and Langmuir adsorption models,respectively.The adsorption equilibrium of the fiber for phosphate was reached within 60 min,indicating an efficient monolayer chemisorption process.Moreover,the adsorbent maintained prominent phosphate removal in the presence of competitive ions such as NO_(3)^(–)and Cl^(–),exhibiting high selectivity.More importantly,the fiber demonstrated excellent reusability(5 times)and low adsorption limit below 0.02 mg·P·g^(–1).In addition,the phosphate removal efficiency of the fiber can exceed 99%under continuous flow conditions.The adsorption mechanism was studied by X-ray photoelectron spectroscopy,showing that the adsorption of phosphate on the fiber mainly depended on the chemical adsorption of the modified Fe^(3+).Overall,this study proves that the fiber possesses many advantages for phosphate removal,including high adsorption efficiency,lower treatment limit,good recyclability,and environmental friendliness. | Shangyuan Zhao Fangjia Wang Rui Zhou Peisen Liu Qizhong Xiong Weifeng Zhang Chaochun Zhang Gang Xu Xinxin Ye Hongjian Gao | 2023 | Frontiers of Chemical Science and Engineering2023，17，7： | 0 |
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