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| 1 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 2 | The High Energy X-ray telescope (HE) onboard the Insight-HXMT astronomy satellite显示文摘The Insight-Hard X-ray Modulation Telescope(Insight-HXMT) is a broadband X-ray and γ-ray(1-3000 ke V) astronomy satellite. One of its three main telescopes is the High Energy X-ray telescope(HE). The main detector plane of HE comprises 18 Na I(Tl)/Cs I(Na) phoswich detectors, where Na I(Tl) is used as the primary detector to measure ~ 20-250 ke V photons incident from the field of view(FOV) defined by collimators, and Cs I(Na) is used as the active shielding detector to Na I(Tl) by pulse shape discrimination. Additionally, Cs I(Na) is used as an omnidirectional γ-ray monitor. The HE collimators have a diverse FOV,i.e. 1.1°×5.7°(15 units), 5.7°×5.7°(2 units), and blocked(1 unit). Therefore, the combined FOV of HE is approximately5.7°×5.7°. Each HE detector has a diameter of 190 mm resulting in a total geometrical area of approximately 5100 cm2, and the energy resolution is ~15% at 60 ke V. For each recorded X-ray event by HE, the timing accuracy is less than 10 μs and the deadtime is less than 10 μs. HE is used for observing spectra and temporal variability of X-ray sources in the 20-250 ke V band either by pointing observations for known sources or scanning observations to unveil new sources. Additionally, HE is used for monitoring the γ-ray burst in 0.2-3 Me V band. This paper not only presents the design and performance of HE instruments but also reports results of the on-ground calibration experiments. | CongZhan Liu YiFei Zhang XuFang Li XueFeng Lu Zhi Chang ZhengWei Li AiMei Zhang YongJie Jin HuiMing Yu Zhao Zhang MinXue Fu YiBao Chen JianFeng Ji YuPeng Xu JingKang Deng RenCheng Shang GuoQing Liu FangJun Lu ShuangNan Zhang YongWei Dong TiPei Li Mei Wu YanGuo Li HuanYu Wang BoBing Wu YongJie Zhang Zhi Zhang ShaoLin Xiong Yuan Liu Shu Zhang HongWei Liu YiJung Yang Fan Zhang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 9 |
| 3 | Construction of heparin-based hydrogel incorporated with Cu_(5.4)O ultrasmall nanozymes for wound healing and inflammation inhibition显示文摘Excessive production of inflammatory chemokines and reactive oxygen species(ROS)can cause a feedback cycle of inflammation response that has a negative effect on cutaneous wound healing.The use of wound-dressing materials that simultaneously absorb chemokines and scavenge ROS constitutes a novel‘weeding and uprooting’treatment strategy for inflammatory conditions.In the present study,a composite hydrogel comprising an amine-functionalized star-shaped polyethylene glycol(starPEG)and heparin for chemokine sequestration as well as Cu_(5.4)O ultrasmall nanozymes for ROS scavenging(Cu_(5.4)O@Hep-PEG)was developed.The material effectively adsorbs the inflammatory chemokines monocyte chemoattractant protein-1 and interleukin-8,decreasing the migratory activity of macrophages and neutrophils.Furthermore,it scavenges the ROS in wound fluids to mitigate oxidative stress,and the sustained release of Cu_(5.4)O promotes angiogenesis.In acute wounds and impaired-healing wounds(diabetic wounds),Cu_(5.4)O@Hep-PEG hydrogels outperform the standard-of-care product Promogram®in terms of inflammation reduction,increased epidermis regeneration,vascularization,and wound closure. | Yuan Peng Danfeng He Xin Ge Yifei Lu Yuanhao Chai Yixin Zhang Zhengwei Mao Gaoxing Luo Jun Deng Yan Zhang | 2021 | Bioactive Materials2021，6，10： | 7 |
| 4 | 1000 Wh L^(-1)lithium-ion batteries enabled by crosslink-shrunk tough carbon encapsulated silicon microparticle anodes显示文摘Microparticulate silicon(Si),normally shelled with carbons,features higher tap density and less interfacial side reactions compared to its nanosized counterpart,showing great potential to be applied as high-energy lithium-ion battery anodes.However,localized high stress generated during fabrication and particularly,under operating,could induce cracking of carbon shells and release pulverized nanoparticles,significantly deteriorating its electrochemical performance.Here we design a strong yet ductile carbon cage from an easily processing capillary shrinkage of graphene hydrogel followed by precise tailoring of inner voids.Such a structure,analog to the stable structure of plant cells,presents‘imperfection-tolerance’to volume variation of irregular Si microparticles,maintaining the electrode integrity over 1000 cycles with Coulombic efficiency over 99.5%.This design enables the use of a dense and thick(3 m Ah cm^(-2))microparticulate Si anode with an ultra-high volumetric energy density of 1048 Wh L^(-1)achieved at pouch full-cell level coupled with a Li Ni_(0.8)Co_(0.1)Mn_(0.1)O_(2)cathode. | Fanqi Chen Junwei Han Debin Kong Yifei Yuan Jing Xiao Shichao Wu Dai-Ming Tang Yaqian Deng Wei Lv Jun Lu Feiyu Kang Quan-Hong Yang | 2021 | National Science Review2021，8，9： | 4 |
| 5 | Transient acquisition of cross-species infectivity during the evolution of SARS-CoV-2显示文摘Since the coronavirus disease 2019(COVID-19)pandemic began,its causative agent,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has spread worldwide.During the global transmission of SARS-CoV-2,mutations in the viral genome have gradually accumulated and have led to the emergence of variants.These emerging variants;including 501Y.V1,501Y.V2 and 501Y.V3(also called the alpha,beta and gamma variants,respectively),rapidly became the predominant epidemic strains and subsequently spread worldwide. | Qi Chen Xing-Yao Huang Meng-Xu Sun Rui-Ting Li Hongjing Gu Ying Tian Rong-Rong Zhang Dan Luo Chao Zhou Yifei Zhang Tianshu Cao Na-Na Zhang Yong-Qiang Deng Xiao-Feng Li Cheng-Feng Qin | 2021 | National Science Review2021，8，11： | 3 |
| 6 | Research progress of space non-pyrotechnic low-shock connection and separation technology(SNLT):A review显示文摘Space missions have become diversified in recent years, where connection and separation devices play a crucial role as key components of various spacecraft. Traditional pyrotechnic devices have the advantages of large carrying capacity, rapid motion and functional reliability. However,their shortcomings such as great release shock, poor safety, unrepeatability and other prominent defects make them unsuitable for new generation spacecraft such as microsatellites to separate at low shock or lock repeatedly, etc. Therefore, it is necessary to develop space non-pyrotechnic low-shock connection and separation devices(SNLD) which are required for advanced aerospace missions. In this paper, the progress of the research on space non-pyrotechnic low-shock connection and separation technology(SNLT) is summarized and reviewed. Proceed from the principle of reducing shock for non-pyrotechnic devices, present studies are classified from the perspective of actuating technology and systematic designing methods. For non-pyrotechnic actuating techniques,according to different driving sources, the separation devices are classified into several main categories: electric, magnetic, gas and thermal actuating devices. The actuation principle and application prospect of separation techniques are introduced and the working process, dimension and mechanical properties of typical devices are compared and evaluated. For the systematic designing method, the common mechanism types of SNLDs are summarized according to the designing concept of reducing shock. Then connection configurations are classified according to the structural forms of connection devices, of which the principles, bearing capacities and general applications are discussed. This paper systematically summarizes the key problems, puts forward the future development trend of SNLT, and points out the breakthrough direction for related scholars. | Honghao YUE Yifei YANG Yifan LU Fei YANG Jun WU Qi RUAN Zongquan DENG | 2022 | Chinese Journal of Aeronautics2022，35，11： | 3 |
| 7 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 8 | Efficacy and Safety of Traditional Chinese Medicine (Shenqi Particle) for Patients With Idiopathic Membranous Nephropathy: A Multicenter Randomized Controlled Clinical Trial显示文摘 | Yiping Chen Yueyi Deng Zhaohui Ni Nan Chen Xiangmei Chen Wei Shi Yongli Zhan Fahuan Yuan Wei Deng Yifei Zhong | 2013 | American Journal of Kidney Diseases2013，，： | 1 |
| 9 | Therapeutic use of traditional Chinese herbal medications for chronic kidney diseases显示文摘 | Yifei Zhong Yueyi Deng Yiping Chen | 2013 | Kidney International2013，84，6： | 1 |
| 10 | Efficacy and Safety of Traditional Chinese Medicine (Shenqi Particle) for Patients With Idiopathic Membranous Nephropathy: A Multicenter Randomized Controlled Clinical Trial显示文摘 | Yiping Chen Yueyi Deng Zhaohui Ni Nan Chen Xiangmei Chen Wei Shi Yongli Zhan Fahuan Yuan Wei Deng Yifei Zhong | 2013 | American Journal of Kidney Diseases2013，，： | 1 |
| 11 | Electron-ion collider in China显示文摘Lepton scattering is an established ideal tool for studying inner structure of small particles such as nucleons as well as nuclei.As a future high energy nuclear physics project,an Electron-ion collider in China(EicC)has been proposed.It will be constructed based on an upgraded heavy-ion accelerator,High Intensity heavy-ion Accelerator Facility(HIAF)which is currently under construction,together with a new electron ring.The proposed collider will provide highly polarized electrons(with a po-larization of 80%)and protons(with a polarization of 70%)with variable center of mass energies from 15 to 20 GeV and the luminosity of(2–3)×1033 cm^(−2)·s^(−1).Polarized deuterons and Helium-3,as well as unpolarized ion beams from Carbon to Uranium,will be also available at the EicC.The main foci of the EicC will be precision measurements of the structure of the nucleon in the sea quark region,including 3D tomography of nucleon;the partonic structure of nuclei and the parton interaction with the nuclear environment;the exotic states,especially those with heavy flavor quark contents.In addition,issues fundamental to understanding the origin of mass could be addressed by measurements of heavy quarkonia near-threshold production at the EicC.In order to achieve the above-mentioned physics goals,a hermetical detector system will be constructed with cutting-edge technologies.This document is the result of collective contributions and valuable inputs from experts across the globe.The EicC physics program complements the ongoing scientific programs at the Jefferson Laboratory and the future EIC project in the United States.The success of this project will also advance both nuclear and particle physics as well as accelerator and detector technology in China. | Daniele PAnderle Valerio Bertone Xu Cao Lei Chang Ningbo Chang Gu Chen Xurong Chen Zhuojun Chen Zhufang Cui Lingyun Dai Weitian Deng Minghui Ding Xu Feng Chang Gong Longcheng Gui Feng-Kun Guo Chengdong Han Jun He Tie-Jiun Hou Hongxia Huang Yin Huang KrešImir KumeričKi LPKaptari Demin Li Hengne Li Minxiang Li Xueqian Li Yutie Liang Zuotang Liang Chen Liu Chuan Liu Guoming Liu Jie Liu Liuming Liu Xiang Liu Tianbo Liu Xiaofeng Luo Zhun Lyu Boqiang Ma Fu Ma Jianping Ma Yugang Ma Lijun Mao Cédric Mezrag HervéMoutarde Jialun Ping Sixue Qin Hang Ren Craig DRoberts Juan Rojo Guodong Shen Chao Shi Qintao Song Hao Sun PawełSznajder Enke Wang Fan Wang Qian Wang Rong Wang Ruiru Wang Taofeng Wang Wei Wang Xiaoyu Wang Xiaoyun Wang Jiajun Wu Xinggang Wu Lei Xia Bowen Xiao Guoqing Xiao Ju-Jun Xie Yaping Xie Hongxi Xing Hushan Xu Nu Xu Shusheng Xu Mengshi Yan Wenbiao Yan Wencheng Yan Xinhu Yan Jiancheng Yang Yi-Bo Yang Zhi Yang Deliang Yao Zhihong Ye Peilin Yin C-PYuan Wenlong Zhan Jianhui Zhang Jinlong Zhang Pengming Zhang Yifei Zhang Chao-Hsi Chang Zhenyu Zhang Hongwei Zhao Kuang-Ta Chao Qiang Zhao Yuxiang Zhao Zhengguo Zhao Liang Zheng Jian Zhou Xiang Zhou Xiaorong Zhou Bingsong Zou Liping Zou | 2021 | Frontiers of physics2021，16，6： | 1 |
| 12 | Development Geography for exploring solutions to promote regional development显示文摘Development Geography is a branch of geography which studies the socioeconomic development of different countries and regions worldwide.Its related research provides informative ideas for promoting regionally co-ordinated development.This study introduces the basic connotation and theory of Development Geography re-search,and clarifies its primary indicators and core approaches to provide solutions for regional development.Finally,the application in regional development research under globalization is proposed.It is considered that the systematically integrated geography paradigm highlights the advantages of Development Geography in re-gional development research.As a result of its“differentiation characteristics-diffusion state-convergence mode”,an important theoretical basis and methodological paradigm are provided to explore the features of regional de-velopment.Since the development gaps among regions exist long throughout the world,Development Geography research ought to focus on new characteristics and challenges of regional development,to provide a theoretical basis for synergy management of sustainable development goals and international cooperation.This contributes to high-quality regional development. | Xiangzheng Deng Yifei Wang Malin Song | 2023 | Geography and Sustainability2023，4，1： | 1 |
| 13 | Irrigation decision model for tomato seedlings based on optimal photosynthetic rate显示文摘Soil moisture is a major environmental factor that influences tomato growth and development.Suitable soil moisture not only increases tomato production but also saves irrigation water.In this study,an irrigation decision model was developed,which called soil moisture regulation model,for optimizing growth of tomato seedlings while saving water.The data used for modeling were collected from a multi-gradient nested experiment,in which temperature,photosynthetic photon flux density(PPFD),carbon dioxide(CO2)concentration and soil moisture were variables and the corresponding photosynthetic rate was measured.Subsequently,a prediction model of tomato photosynthetic rate was constructed using support vector regression(SVR)algorithm.With photosynthetic rate prediction model as fitness function,genetic algorithm(GA)was used to find the optimal soil moisture under each combination of the above environmental factors.Finally,back propagation neural network(BPNN)algorithm was used to establish a decision model of tomato irrigation,which could provide the optimal soil moisture under current environment.For the soil moisture regulation model constructed here,the coefficient of determination was 0.9738,the mean square error of the test set was 1.51×10-5,the slope of the verified straight line was 0.9752,and the intercept was 0.00916.This model demonstrated high precision,which thereby provides a theoretical basis for accurate irrigation control in the greenhouse facility environment. | Xiangbei Wan Bin Li Danyan Chen Xingyue Long Yifei Deng Huarui Wu Jin Hu | 2021 | International Journal of Agricultural and Biological Engineering2021，14，5： | 1 |
| 14 | Visual knowledge guided intelligent generation of Chinese seal carving显示文摘We digitally reproduce the process of resource collaboration,design creation,and visual presentation of Chinese seal-carving art.We develop an intelligent seal-carving art-generation system(Zhejiang University Intelligent Seal-Carving System,http://gffzz71002f4557414951hvvxpouufoufb6vcb.ffgz.tsg.suse.edu.cn/seal/;the website of the seal-carving search and layout system is http://gffzz71002f4557414951hvvxpouufoufb6vcb.ffgz.tsg.suse.edu.cn/seal/search_app/)to deal with the difficulty in using a visual knowledge guided computational art approach.The knowledge base in this study is the Qiushi Seal-Carving Database,which consists of open datasets of images of seal characters and seal stamps.We propose a seal character generation method based on visual knowledge,guided by the database and expertise.Furthermore,to create the layout of the seal,we propose a deformation algorithm to adjust the seal characters and calculate layout parameters from the database and knowledge to achieve an intelligent structure.Experimental results show that this method and system can effectively deal with the difficulties in the generation of seal carving.Our work provides theoretical and applied references for the rebirth and innovation of seal-carving art. | Kejun ZHANG Rui ZHANG Yehang YIN Yifei LI Wenqi WU Lingyun SUN Fei WU Huanghuang DENG Yunhe PAN | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，10： | 0 |
| 15 | Comparative coherence between layered and traditional semiconductors: unique opportunities for heterogeneous integration显示文摘As Moore’s law deteriorates,the research and development of new materials system are crucial for transitioning into the post Moore era.Traditional semiconductor materials,such as silicon,have served as the cornerstone of modern technologies for over half a century.This has been due to extensive research and engineering on new techniques to continuously enrich silicon-based materials system and,subsequently,to develop better performed silicon-based devices.Meanwhile,in the emerging post Moore era,layered semiconductor materials,such as transition metal dichalcogenides(TMDs),have garnered considerable research interest due to their unique electronic and optoelectronic properties,which hold great promise for powering the new era of next generation electronics.As a result,techniques for engineering the properties of layered semiconductors have expanded the possibilities of layered semiconductor-based devices.However,there remain significant limitations in the synthesis and engineering of layered semiconductors,impeding the utilization of layered semiconductor-based devices for mass applications.As a practical alternative,heterogeneous integration between layered and traditional semiconductors provides valuable opportunities to combine the distinctive properties of layered semiconductors with well-developed traditional semiconductors materials system.Here,we provide an overview of the comparative coherence between layered and traditional semiconductors,starting with TMDs as the representation of layered semiconductors.We highlight the meaningful opportunities presented by the heterogeneous integration of layered semiconductors with traditional semiconductors,representing an optimal strategy poised to propel the emerging semiconductor research community and chip industry towards unprecedented advancements in the coming decades. | Zhuofan Chen Xiaonan Deng Simian Zhang Yuqi Wang Yifei Wu Shengxian Ke Junshang Zhang Fucheng Liu Jianing Liu Yingjie Liu Yuchun Lin Andrew Hanna Zhengcao Li Chen Wang | 2023 | International Journal of Extreme Manufacturing2023，5，4： | 0 |
| 16 | High-performance and stable AgSbTe_(2)-based thermoelectric materials for near room temperature applications显示文摘AgSbTe_(2)-based ternary chalcogenides show excellent thermoelectric performance at low-and middletemperature ranges,yet their practical applications are greatly limited by their intrinsic poor thermodynamic stability.In this work,we demonstrate that AgSbTe_(2)-based ternary chalcogenides can be stabilized for service below their decomposition threshold.A series of AgxSb_(2-x)Te_(3-x)(x=1.0,0.9,0.8 and 0.7)samples have been prepared by the melt-quenching method.Among them,phase pure Ag0.9Sb1.1Te2.1 is verified by comprehensive structural characterizations from macroscale by X-ray diffraction to microscale by energy-dispersive spectroscopy and then to sub-nanometer scale by atom probe tomography.This composition is further chosen for the stability investigation.The decomposition threshold of Ag_(0.9)Sb_(1.1)Te_(2.1)appears around 473 K.Below this temperature,the chemical compositions and thermoelectric properties are barely changed even after 720 h annealing at 473 K.The figure-of-merit(zT)value of Ag_(0.9)Sb_(1.1)Te_(2.1)below the decomposition threshold is very competitive for real applications even compared with Bi_(2)Te_(3-)based alloys.The average zT of Ag_(0.9)Sb_(1.1)Te_(2.1)at 300e473 K reaches 0.84,which is higher than most other thermoelectric materials in a similar temperature range,promising applications in miniaturized refrigeration and power generation near room temperature. | Yi Wu Pengfei Qiu Yuan Yu Yifei Xiong Tingting Deng Oana Cojocaru-Miredin Matthias Wuttig Xun Shi Lidong Chen | 2022 | Journal of Materiomics2022，8，6： | 0 |
| 17 | N-acetyldopamine dimer inhibits neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 pathways显示文摘Neuroinflammation mediated by microglia is an important pathophysiological mechanism in neurodegenerative diseases.However,there is a lack of effective drugs to treat neuroinflammation.N-acetyldopamine dimer(NADD)is a natural compound from the traditional Chinese medicine Isaria cicada.In our previous study,we found that NADD can attenuate DSS-induced ulcerative colitis by suppressing the NF-κB and MAPK pathways.Does NADD inhibit neuroinflammation,and what is the target of NADD?To answer this question,lipopolysaccharide(LPS)-stimulated BV-2 microglia was used as a cell model to investigate the effect of NADD on neuroinflammation.Nitric oxide(NO)detection,reactive oxygen species(ROS)detection and enzyme-linked immunosorbent assay(ELISA)results show that NADD attenuates inflammatory signals and proinflammatory cytokines in LPS-stimulated BV-2 microglia,including NO,ROS,tumor necrosis factor(TNF)-α,interleukin(IL)-1βand interleukin-6(IL-6).Western blot analysis show that NADD inhibits the protein levels of Toll-like receptor 4(TLR4),nuclear factor kappa-B(NF-κB),NOD-like receptor thermal protein domain associated protein 3(NLRP3),ASC and cysteinyl aspartate specific proteinase(Caspase)-1,indicating that NADD may inhibit neuroinflammation through the TLR4/NF-κB and NLRP3/Caspase-1 signaling pathways.In addition,surface plasmon resonance assays and molecular docking demonstrate that NADD binds with TLR4 directly.Our study reveals a new role of NADD in inhibiting the TLR4/NF-κB and NLRP3/Caspase-1 pathways,and shows that TLR4-MD2 is the direct target of NADD,which may provide a potential therapeutic candidate for the treatment of neuroinflammation. | Lijun Huang Leiqiang Gong Xueyan Huo Lirong Lei Qi Zhang Yunjie Hu Qixuan Kuang Yu Gui Yifei Dai Yucheng Gu Yun Deng Dong Wang Dale Guo | 2023 | Acta Biochimica et Biophysica Sinica2023，55，1： | 0 |
| 18 | Dual ultrasound-guided totally implantable venous access ports via the right internal jugular vein in pediatric patients with cancer:a preliminary experience in a single institution显示文摘Objective To assess the efficacy and safety of dual ultrasound-guided(DUG)totally implantable venous access port(TIVAP)implantation(namely,using ultrasoundguided percutaneous puncture with transesophageal echocardiography-guided catheterization)via the right internal jugular vein(IJV)in pediatric patients with cancer.Methods Fifty-five children with cancer requiring chemotherapy underwent DUG-TIVAP implantation via the right IJV.Clinical data were recorded,including the procedure success rate,first attempt success rate,and perioperative and postoperative complications.Results All 55 cases were successfully operated on.The first puncture success rate was 100%.The operation time was 22–41min,with a mean time of 30.8±5.5min.The mean TIVAP implantation time was 253±145 days(range 42–520 days).There were no perioperative complications.The postoperative complication rate was 5.4%(3/55),including skin infections around the port in one case,catheter-related infection in one case,and fibrin sheath formation in one case.The ports were all preserved after anti-infection or thrombolytic therapy.No unplanned port withdrawal was recorded in this study.Conclusions DUG-TIVAP implantation is a technique with a high success rate and a low complication rate;therefore,it provides an alternative for children with cancer.Further randomized controlled studies are needed to confirm the efficacy and safety of DUG-TIVAP via the right IJV in children. | Xiao Bin Deng Liang Peng Jun Zhang Xiangru Kong Zhenzhen Zhao Shan Wang Changchun Li Yifei Du Jianwu Zhou Lifei Liu Chao Yang | 2023 | World Journal of Pediatric Surgery2023，6，3： | 0 |
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