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| 1 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 2 | Intraocular Pressure, Central Corneal Thickness, and Glaucoma in Chinese Adults: The Liwan Eye Study显示文摘 | Dandan Wang Wenyong Huang Yuetao Li Yingfeng Zheng Paul J. Foster Nathan Congdon Mingguang He | 2011 | American Journal of Ophthalmology2011，，3： | 2 |
| 3 | RFID- enabled real-time manufacturing information tracking infra- structure for extended enterprises显示文摘 | ZHANG Yingfeng JIANG Pingyu HUANG G | 2012 | Journal of Intelligent Manufacturing2012，23，6： | 1 |
| 4 | Two-stage hybrid batching flowshop scheduling with blocking and machine availability constraints using genetic algorithm显示文摘 | Luo Hao Huang G Q Zhang Yingfeng | 2009 | Robotics and Computer Integrated Manufacturing2009，25，： | 1 |
| 5 | Two-stage hy- brid batching flowshop scheduling with blocking and ma- chine availability constraints using genetic algorithm 显示文摘 | HAO Luo GEORGE Q HUANG Yingfeng | 2009 | Robotics and Computer Integrated Manufacturing2009，25，： | 1 |
| 6 | Refractive Error and Visual Impairment in School Children in Rural Southern China显示文摘 | Mingguang He Wenyong Huang Yingfeng Zheng Li Huang Leon B. Ellwein | 2007 | Ophthalmology2007，，2： | 1 |
| 7 | Refractive Error and Visual Impairment in School Children in Rural Southern China显示文摘 | Mingguang He Wenyong Huang Yingfeng Zheng Li Huang Leon B. Ellwein | 2007 | Ophthalmology2007，，2： | 1 |
| 8 | RFID-based wireless manufacturing for real-time management of job shop WIP inventories显示文摘 | HUANG Guoquan ZHANG Yingfeng JIANG Pingyu | 2008 | The International Journal of Advanced Manufacturing Technology2008，36，78： | 1 |
| 9 | RFID-based wireless manufacturing for walking-worker assembly islands with fixed-position layouts显示文摘 | HUANG Guoquan ZHANG Yingfeng JIANG Pingyu | 2007 | Robotics and Computer-Integrated Manufacturing2007，23，4： | 1 |
| 10 | RFID-based smart kanbans for just-in-time manufacturing显示文摘 | ZHANG Yingfeng JIANG Pingyu HUANG Guoquan | 2008 | International Journal of Materials and Product Technology2008，33，1： | 1 |
| 11 | RFID- Based Smart Kanbans for Just-In-Time Manufacturing显示文摘 | Zhang Yingfeng Jiang Pingyu Huang George | 2008 | International Journal of Materials and Product Technology2008，33，1： | 1 |
| 12 | A- gent-based smart objects management system for real-time u- biquitous manufacturing显示文摘 | ZHANG Yingfeng HUANG Guoquan QU Ting | 2011 | Robotics and Computer-Integrat- ed Manufacturing2011，27，3： | 1 |
| 13 | Computational Study of Ternary Devices: Stable, Low-Cost,and Efficient Planar Perovskite Solar Cells显示文摘Although perovskite solar cells with power conversion efficiencies(PCEs) more than 22% have been realized with expensive organic charge-transporting materials, their stability and high cost remain to be addressed. In this work, the perovskite configuration of MAPbX(MA = CH_3 NH_3,X = I_3, Br_3, or I_2Br) integrated with stable and low-cost Cu:Ni Oxhole-transporting material, ZnO electron-transporting material, and Al counter electrode was modeled as a planar PSC and studied theoretically. A solar cell simulation program(wx AMPS), which served as an update of the popular solar cell simulation tool(AMPS: Analysis of Microelectronic and Photonic Structures), was used. The study yielded a detailed understanding of the role of each component in the solar celland its effect on the photovoltaic parameters as a whole. The bandgap of active materials and operating temperature of the modeled solar cell were shown to influence the solar cell performance in a significant way. Further, the simulation results reveal a strong dependence of photovoltaic parameters on the thickness and defect density of the light-absorbing layers. Under moderate simulation conditions, the MAPb Br_3 and MAPbI _2 Br cells recorded the highest PCEs of 20.58 and 19.08%, respectively, while MAPbI_3 cell gave a value of 16.14%. | Sajid Sajid Ahmed Mourtada Elseman Jun Ji Shangyi Dou Dong Wei Hao Huang Peng Cui Wenkang Xi Lihua Chu Yingfeng Li Bing Jiang Meicheng Li | 2018 | Nano-Micro Letters2018，10，3： | 1 |
| 14 | Agent- based workflow management for RFID-enabled reagtime reconfigurable manufacturing 显示文摘 | ZHANG Yingfeng HUANG G Q QU Ting | 2010 | International Journal of Computer Integrated Manufacturing2010，23，2： | 1 |
| 15 | Agent- based smart objects management system for ubiquitous mahu facturing 显示文摘 | ZHANG Yingfeng HUANG G Q QU Ting | 2011 | International Journal of Robotics and Comput er Integrated Manufacturing2011，27，3： | 1 |
| 16 | Development of an Agrobacterium-mediated CRISPR/Cas9 system in pea(Pisum sativum L.)显示文摘Pea(Pisum sativum L.)is an annual cool-season legume crop.Owing to its role in sustainable agriculture as both a rotation and a cash crop,its global market is expanding and increased production is urgently needed.For both technical and regulatory reasons,neither conventional nor transgenic breeding techniques can keep pace with the demand for increased production.In answer to this challenge,CRISPR/Cas9 genome editing technology has been gaining traction in plant biology and crop breeding in recent years.However,there are currently no reports of the successful application of the CRISPR/Cas9 genome editing technology in pea.We developed a transient transformation system of hairy roots,mediated by Agrobacterium rhizogenes strain K599,to validate the efficiency of a CRISPR/Cas9 system.Further optimization resulted in an efficient vector,PsU6.3-tRNA-PsPDS3-en35S-PsCas9.We used this optimized CRISPR/Cas9 system to edit the pea phytoene desaturase(PsPDS)gene,causing albinism,by Agrobacterium-mediated genetic transformation.This is the first report of successful generation of gene-edited pea plants by this route. | Guan Li Rong Liu Rongfang Xu Rajeev KVarshney Hanfeng Ding Mengwei Li Xin Yan Shuxian Huang Juan Li Dong Wang Yishan Ji Chenyu Wang Junguang He Yingfeng Luo Shenghan Gao Pengcheng Wei Xuxiao Zong Tao Yang | 2023 | The Crop Journal2023，11，1： | 0 |
| 17 | The Tianlai Cylinder Pathfinder array: System functions and basic performance analysis显示文摘The Tianlai Cylinder Pathfinder is a radio interferometer array designed to test techniques for 21 cm intensity mapping in the post-reionization Universe,with the ultimate aim of mapping the large scale structure and measuring cosmological parameters such as the dark energy equation of state.Each of its three parallel cylinder reflectors is oriented in the north-south direction,and the array has a large field of view.As the Earth rotates,the northern sky is observed by drift scanning.The array is located in Hongliuxia,a radio-quiet site in Xinjiang,and saw its first light in September 2016.In this first data analysis paper for the Tianlai cylinder array,we discuss the sub-system qualification tests,and present basic system performance obtained from preliminary analysis of the commissioning observations during 2016-2018.We show typical interferometric visibility data,from which we derive the actual beam profile in the east-west direction and the frequency band-pass response.We describe also the calibration process to determine the complex gains for the array elements,either using bright astronomical point sources,or an artificial on site calibrator source,and discuss the instrument response stability,crucial for transit interferometry.Based on this analysis,we find a system temperature of about 90 K,and we also estimate the sensitivity of the array. | JiXia Li ShiFan Zuo FengQuan Wu YouGang Wang JuYong Zhang ShiJie Sun YiDong Xu ZiJie Yu Reza Ansari YiChao Li Albert Stebbins Peter Timbie YanPing Cong JingChao Geng Jie Hao QiZhi Huang JianBin Li Rui Li DongHao Liu YingFeng Liu Tao Liu John PMarriner ChenHui Niu Ue-Li Pen Jeffery BPeterson HuLi Shi Lin Shu YaFang Song HaiJun Tian GuiSong Wang QunXiong Wang RongLi Wang WeiXia Wang Xin Wang KaiFeng Yu Jiao Zhang BoQin Zhu JiaLu Zhu XueLei Chen | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，12： | 0 |
| 18 | Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment显示文摘Enzyme-driven micro/nanomotors consuming in situ chemical fuels have attracted lots of attention for biomedical applications.However,motor systems composed by organism-derived organics that maximize the therapeutic efficacy of enzymatic products remain challenging.Herein,swimming proteomotors based on biocompatible urease and human serum albumin are constructed for enhanced antitumor therapy via active motion and ammonia amplification.By decomposing urea into carbon dioxide and ammonia,the designed proteomotors are endowed with self-propulsive capability,which leads to improved internalization and enhanced penetration in vitro.As a glutamine synthetase inhibitor,the loaded L-methionine sulfoximine further prevents the conversion of toxic ammonia into non-toxic glutamine in both tumor and stromal cells,resulting in local ammonia amplification.After intravesical instillation,the proteomotors achieve longer bladder retention and thus significantly inhibit the growth of orthotopic bladder tumor in vivo without adverse effects.We envision that the as-developed swimming proteomotors with amplification of the product toxicity may be a potential platform for active cancer treatment. | Hao Tian Juanfeng Ou Yong Wang Jia Sun Junbin Gao Yicheng Ye Ruotian Zhang Bin Chen Fei Wang Weichang Huang Huaan Li Lu Liu Chuxiao Shao Zhili Xu Fei Peng Yingfeng Tu | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 19 | Effect of Comprehensive Nursing Intervention on Intestinal Preparation Quality of Hospitalized Patients undergoing Colonoscopy显示文摘Objective:To explore the impact of comprehensive nursing intervention on the quality of intestinal preparation in the process of intestinal preparation for hospitalized patients undergoing colonoscopy.Methods:A total of 320 patients underwent colonoscopy in our department from January to June 2021.They were grouped by random number table.There were 160 cases in the control group and 160 cases in the observation group.The adverse reactions of intestinal preparation and the cleanliness of intestinal preparation were analyzed.Results:Through comprehensive nursing intervention,it can be found that the incidence of adverse reactions in the preparation of colonoscopy in the control group was 24.38%,and that in the observation group was 13.48%.The results showed that the incidence of adverse reactions in the preparation of colonoscopy was significantly lower than that in the control group(P<0.05),which indicates that the difference was statistically significant.In the control group,105 people qualified in intestinal cleanliness score(>5 points)during enteroscopy preparation,and the cleanliness qualification rate was 65.63%.In the observation group,139 people qualified in intestinal cleanliness score(>5 points)during enteroscopy preparation,and the cleanliness qualification rate was 86.88%.The cleanliness qualification rate of enteroscopy preparation was significantly higher than that of the control group,and P<0.05,which indicates that the difference was statistically significant.Conclusion:Comprehensive nursing intervention can promote the quality of preparation of patients for colonoscopy,improve the compliance of patients and improve the accuracy of examination effect. | Li Liu Fang Fang Yingfeng Huang | 2021 | Journal of Clinical and Nursing Research2021，5，6： | 0 |
| 20 | KDM4C与ATF4协同作用转录调控氨基酸代谢显示文摘组蛋白赖氨酸甲基转移酶(KNITs)和去甲基化酶(KDMs)通过控制组蛋白赖氨酸的甲基化状态,在转录调控中起着重要的作用。 | Erhu Zhao Jane Ding Yingfeng Xia Mengling Liu Bingwei Ye Jeong-Hyeon Choi Chunhong Yan Zheng Dong Shuang Huang Yunhong Zha Liqun Yang 崔红娟 Han-Fei Ding | 2017 | 科学新闻2017，19，4： | 0 |
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