|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Neomycin biosynthesis is regulated positively by AfsA-g and NeoR in Streptomyces fradiae CGMCC 4.7387显示文摘Neomycins are a group of aminoglycoside antibiotics with both clinical and agricultural applications.To elucidate the regulatory mechanism of neomycin biosynthesis,we completed draft genome sequencing of a neomycin producer Streptomyces fradiae CGMCC 4.7387 from marine sediments,and the neomycin biosynthesis gene cluster was identified.Inactivation of the afsA-g gene encoding a γ-butyrolactone(GBL) synthase in S.fradiae CGMCC 4.7387 resulted in a significant decrease of neomycin production.Quantitative RT-PCR analysis revealed that the transcriptional level of neoR and the aphA-neoGH operon were reduced in the afsA-g::aac(3)Ⅳ mutant.Interestingly,a conserved binding site of AdpA,a key activator in the GBL regulatory cascade,was discovered upstream of neoR,a putative regulatory gene encoding a protein with an ATPase domain and a tetratricopeptide repeat domain.When neoR was inactivated,the neomycin production was reduced about 40%in comparison with the WT strain.Quantitative RT-PCR analysis revealed that the transcriptional levels of genes in the aphA-neoGH operon were reduced clearly in the neoR::aac(3)Ⅳ mutant.Finally,the titers of neomycin were improved considerably by overexpression of qfsA-gand neoR in S.fradiae CGMCC 4.7387. | Xiangxi Meng Wenzhao Wang Zhoujie Xie Pengwei Li Yue Li Zhengyan Guo Yingjian Lu Jie Yang Kaile Guan Zhaoxin Lu Huarong Tan Yihua Chen | 2017 | Science China(Life Sciences)2017，60，9： | 7 |
| 2 | Can Fluorine-18 Fluoroestradiol Positron Emission Tomography–Computed Tomography Demonstrate the Heterogeneity of Breast Cancer In Vivo?显示文摘 | Zhongyi Yang Yifei Sun Yongping Zhang Jing Xue Mingwei Wang Wei Shi Beiling Zhu Silong Hu Zhifeng Yao Herong Pan Yingjian Zhang | 2013 | Clinical Breast Cancer2013，，： | 2 |
| 3 | Both Sp1and Smad participate in mediating TGF-beta1-induced HGF receptor expression on renal epithelial cells显示文摘 | Xianghong Zhang Junwei Yang Yingjian Li | 2005 | Am J Physiol Renal Physiol2005，288，： | 1 |
| 4 | Synthesis of amidie alginate derivatives and their application in microencapsulation of A - cyhalothrin biomacromolecules 显示文摘 | YANG JISHENG REN HAIBING XIE YINGJIAN | 2011 | Biomacromolecules2011，12，8： | 1 |
| 5 | Research progress on chemical modification of alginate:A review显示文摘 | Yang Jisheng Xie Yingjian He Wen | | 0，，01： | 1 |
| 6 | Can Fluorine-18 Fluoroestradiol Positron Emission Tomography–Computed Tomography Demonstrate the Heterogeneity of Breast Cancer In Vivo?显示文摘 | Zhongyi Yang Yifei Sun Yongping Zhang Jing Xue Mingwei Wang Wei Shi Beiling Zhu Silong Hu Zhifeng Yao Herong Pan Yingjian Zhang | 2013 | Clinical Breast Cancer2013，，： | 1 |
| 7 | A Review of Research Status and Scientific Problems of Floating Offshore Wind Turbines显示文摘With the continuous utilization of offshore wind resources,the installation depth and capacity of offshore wind turbines are increasing.In order to meet construction requirements of renewable energy,offshore wind farms are bound to develop further and deeper into the sea.As a result,a novel kind of power generation equipment,Floating Offshore Wind Turbines(FOWT),emerges as the times require.Consequently,this paper provides an objective comment on some key scientific difficulties.Firstly,The statistics and forecast of the market demand and installed capacity of offshore wind energy show a steady growth.After that,the advantages of constructing FOWT and most floating projects in various countries are summarized.And then,the reconstruction design of blades is reviewed under“Reynolds number”and“Froude number”similarity criterion,which is a prerequisite for achieving specific aerodynamic performance.So far,this paper focuses on aerodynamic researches,including aerodynamic forces and flow fields.On this basis,pitch angle control strategies are proposed to reduce aerodynamic forces on the premise of ensuring power generations.Finally,some other joint science problems to be solved are listed.Whether theoretical analysis,numerical simulations,ocean engineering basin tests,wind tunnel experiments or prototype sea measurements,FOWT is expected to break through various obstacles and finally achieve efficient and stable commercial operations. | Zhen Lei Xinbao Wang Shuni Zhou Zekun Wang Tengyuan Wang Yingjian Yang | 2022 | Energy Engineering2022，119，1： | 0 |
| 8 | Review on Wind Power Development and Relevant Policies between China and Japan显示文摘China has abundant wind energy resources and huge development potential among developing countries.Japan is a developed country that planned to increase the use of renewable energy,especially wind energy.This research is aimed at reviewing the development of wind power and relevant policies between China and Japan.Firstly,we introduced the current status of global wind power development,such as the global installed capacity of wind power.The annual development of wind power generation in China and Japan is compared,and the distribution characteristics of wind resources are compared.Furthermore,the market share in China and Japan is introduced.Finally,according to the comparison of the government policies between China and Japan,we pointed out the existing problems in the wind power industry.In addition,we gave some suggestions on the development of wind power for China and Japan.These suggestions should be taken into account when designing national climate policies and have an important reference value for the future development of China’s wind energy industry. | Lei Wang Zekun Wang Yingjian Yang Shuni Zhou Yehong Dong Fanghong Zhang | 2021 | Energy Engineering2021，118，6： | 0 |
| 9 | Optimal Configuration of an Off-Grid Hybrid Wind-Hydrogen Energy System: Comparison of Two Systems显示文摘Due to the uncertainty of renewable energy power generation and the non-linearity of load demand,it becomes complicated to determine the capacity of each device in hybrid renewable energy power generation systems.This work aims to optimize the capacity of two types of the off-grid hybrid wind-hydrogen energy system.We considered the maximum profit of the system and the minimum loss of power supply probability as optimization goals.Firstly,we established steady-state models of the wind turbine,alkaline electrolyzer,lead-acid battery,and proton exchange membrane fuel cell in matrix laboratory software to optimize the capacity.Secondly,we analyzed the operating mode of the system and determined two system structures(system contains batteries whether or not).Finally,according to the wind speed and load in the sample area,we compared the economics of the two systems and selected the optimal configuration for the area.In the same calculation example data,the non-dominated sorting genetic algorithm-II(NSGA-II)is used to optimize the capacity of each device in the two systems.The results showed that the profit of the without battery-equipped system is 32.38%higher than another system.But the power supply reliability is the opposite.To avoid the contingency of the calculation results,we used the traditional genetic algorithm(GA)and ant colony optimization(ACO)to calculate the same example.The results showed that NSGA-II is significantly better than GA and ACO in terms of iteration steps and calculation results.The required architecture for the System-I composes of 3 numbers of 10 kW wind turbines,61 sets of 12 V·240 Ah leadacid batteries,8 kW electrolytic cell,and 6 kW PEMFC.The net profit and LPSP are ¥44,315 and 0.01254 respectively.The required architecture for the System-II composes of 2 numbers of 10 kW wind turbines,24 kW electrolytic cells,and 18 kW PEMFC.Net profit and LPSP are ¥58,663 and 0.03244,respectively.This paper provided two schemes for the optimal configuration of the hybrid wind-hydrogen energy system in islanding mode,which provided a theoretical basis for practical engineering applications. | Zekun Wang Yan Jia Yingjian Yang Chang Cai Yinpeng Chen | 2021 | Energy Engineering2021，118，6： | 0 |
| 10 | Construction of UHVAC Test Base显示文摘The construction of the UHVAC test base of SGCC is an important component of the pilot project on UHVAC power transmission and transformation in China. This paper introduces the layout, technical requirements and main test functions of the UHVAC test base as well as difficulties during construction. It lays stress on the characterization of a 1 000-kV single-circuit test line, a 1 000-kV one-tower double-circuit test line, a full voltage test site for UHV equipment, a climate laboratory, a corona cage and a long-wave-front impulse voltage generator. | Yang Yingjian,Hu Yi,Wu Xiong,Wu Zhirong,Wan Qifa,Liu Xianjin and Cai Wei State Grid Electric Power Research Institute | 2009 | Electricity2009，20，4： | 0 |
| 11 | Review on Research about Wake Effects of Offshore Wind Turbines显示文摘In recent years,the construction of offshore wind farms is developing rapidly.As the wake effect of the upstream wind turbines seriously affect the performance of the downstream wind turbines,the wake effect of offshore wind turbines has become one of the research hotspots.First,this article reviews the research methods of wake effects,including CFD numerical simulation method,wind turbine wake model based on roughness and engineering wake models.However,there is no general model that can be used directly.Then it puts forward some factors that affect the wake of offshore wind turbines.The turbulence intensity in offshore wind fields is lower than that in onshore wind fields.This makes the wake recovery length of offshore wind turbines longer than that of onshore wind turbines.Floating offshore wind turbines are simultaneously disturbed by wind loads and wave loads.Unsteady movement of the platform caused by wave loads.It affects the development and changes of the wake of wind turbines.In this regard,the focus of research on the wake effects of offshore wind farms will be the proposal of accurate prediction models for the wake effects of sea wind farms. | Yehong Dong Guangyin Tang Yan Jia Zekun Wang Xiaomin Rong Chang Cai Qingan Li Yingjian Yang | 2022 | Energy Engineering2022，119，4： | 0 |
| 12 | Hepatic Zbtb18 (Zinc Finger and BTB Domain Containing 18) alleviates hepatic steatohepatitis via FXR (Farnesoid X Receptor)显示文摘A lasting imbalance between fatty acid synthesis and consumption leads to non-alcoholic fatty liver disease(NAFLD),coupled with hepatitis and insulin resistance.Yet the details of the underlying mechanisms are not fully understood.Here,we unraveled that the expression of the transcription factor Zbtb18 is markedly decreased in the livers of both patients and murine models of NAFLD.Hepatic Zbtb18 knockout promoted NAFLD features like impaired energy expenditure and fatty acid oxidation(FAO),and induced insulin resistance.Conversely,hepatic Zbtb18 overexpression alleviated hepato-steatosis,insulin resistance,and hyperglycemia in mice fed on a high-fat diet(HFD)or in diabetic mice.Notably,in vitro and in vivo mechanistic studies revealed that Zbtb18 transcriptional activation of Farnesoid X receptor(FXR)mediated FAO and Clathrin Heavy Chain(CLTC)protein hinders NLRP3 inflammasome activity.This key mechanism by which hepatocyte’s Zbtb18 expression alleviates NAFLD and consequent liver fibrosis was further verified by FXR’s deletion and forced expression in mice and cultured mouse primary hepatocytes(MPHs).Moreover,CLTC deletion significantly abrogated the hepatic Zbtb18 overexpression-driven inhibition of NLRP3 inflammasome activity in macrophages.Altogether,Zbtb18 transcriptionally activates the FXR-mediated FAO and CLTC expression,which inhibits NLRP3 inflammasome’s activity alleviating inflammatory stress and insulin resistance,representing an attractive remedy for hepatic steatosis and fibrosis. | Lei Zhang Jiabing Chen Xiaoying Yang Chuangpeng Shen Jiawen Huang Dong Zhang Naihua Liu Chaonan Liu Yadi Zhong Yingjian Chen Kaijia Tang Jingyi Guo Tianqi Cui Siwei Duan Jiayu Li Shangyi Huang Huafeng Pan Huabing Zhang Xiaoqiang Tang Yongsheng Chang Yong Gao | 2024 | Signal Transduction and Targeted Therapy2024，9，2： | 0 |
| 13 | Impact of body mass index,weight gain,and metabolic disorders on survival and prognosis in patients with breast cancer who underwent chemotherapy显示文摘Background: Weight gain during chemotherapy in patients with breast cancer contributes to their poor prognosis. However, a growing number of studies have found that metabolic disorders seem to play a more important role in breast cancer prognosis than weight gain. This study aimed to explore the prognostic effects of body mass index (BMI), weight gain, and metabolic disorders on the overall survival (OS) and prognosis of patients with breast cancer who underwent chemotherapy.Methods: Data from the inpatient medical records of patients with breast cancer who underwent chemotherapy at the Beijing Cancer Hospital Breast Cancer Center from January to December 2010 were retrospectively collected, and the patients were followed up until August 2020.Results: A total of 438 patients with stages I to III breast cancer met the inclusion and exclusion criteria. Forty-nine (11.19%) patients died, while 82 (18.72%) patients had tumor recurrence and metastasis at the last follow-up (August 2020). From the time of diagnosis until after chemotherapy, no significant differences were observed in the body weight (t=4.694,P<0.001), BMI categories (χ^(2)=19.215,P=0.001), and incidence of metabolic disorders (χ^(2)=24.841,P<0.001);the BMI categories and weight change had no effect on the OS. Both univariate (χ^(2)=6.771,P=0.009) and multivariate survival analyses (hazard ratio=2.775, 95% confidence interval [CI]: 1.326-5.807,P=0.007) showed that low high-density lipoprotein cholesterol (HDL-C) levels at diagnosis had a negative impact on the OS. The multivariate logistic regression analysis showed that the HDL-C level at diagnosis (odds ratio [OR]=2.200, 95% CI: 0.996-4.859,P=0.051) and metabolic disorders after chemotherapy (OR=1.514, 95% CI: 1.047-2.189,P=0.028) are risk factors for poor prognosis in patients with breast cancer.Conclusions: Chemotherapy led to weight gain and aggravated the metabolic disorders in patients with breast cancer. Low HDL-C levels at diagnosis and metabolic disorders after chemotherapy may have negative effects on the OS and prognosis of patients with breast cancer. | Ping Yang Yingjian He Xinying Yu Baohua Liu Xuemei Wang Xiangping Li Peiyu Wang | 2022 | Chinese Medical Journal2022，，13： | 0 |
| 14 | Research on Representative Engineering Applications of Anemometer Towers Location in Complex TopographyWind Resource Assessment显示文摘The typical location and number of anemometer towers in the assessed area are the key to the accuracy of wind resource assessment in complex topography.As calculation examples,this paper used two typical complex topography wind farms in Guangxi,Yunnan province in China.Firstly,we simulated the wind resource status of the anemometer tower in the Meteodyn WT software.Secondly,we compared the simulated wind resource with the actual measured data by the anemometer tower in the same situation.Thirdly,we analyzed the influence of anemometer tower location and quantity in the accuracy of wind resource assessment through the comparison results.The results showed that the range which the anemometer tower can represent is limited(<5 kilometers),and the prediction error more than 5%.Besides,the anemometer towers in special terrain areas(such as wind acceleration areas)cannot be used as a representative choice.The relative error of the simulated average annual wind speed by choose different number of anemometer towers is about 4%,and the grid-connected power generation more than 6%.The representative effect of anemometer towers is of crucial for improving the accuracy of wind resource assessment in engineering applications. | Hao Liu Xiaoyang Zhang Zhongjie Yan Yingjian Yang Qing’an Li Chang Cai | 2023 | Energy Engineering2023，120，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员