|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | miR-145 improves metabolic inflammatory disease through multiple pathways显示文摘Chronic inflammation plays a pivotal role in insulin resistance and type 2 diabetes,yet the mechanisms are not completely understood.Here,we demonstrated that serum LPS levels were significantly higher in newly diagnosed diabetic patients than in normal control.miR-145 level in peripheral blood mononuclear cells decreased in type 2 diabetics.LPS repressed the transcription of miR-143/145 cluster and decreased miR-145 levels.Attenuation of miR-145 activity by anti-miR-145 triggered liver inflammation and increased serum chemokines in C57BL/6 J mice.Conversely,lentivirus-mediated miR-145 overexpression inhibited macrophage infiltration,reduced body weight,and improved glucose metabolism in db/db mice.And miR-145 overexpression markedly reduced plaque size in the aorta in ApoE−/−mice.Both OPG and KLF5 were targets of miR-145.miR-145 repressed cell proliferation and induced apoptosis partially by targeting OPG and KLF5.miR-145 also suppressed NF-κB activation by targeting OPG and KLF5.Our findings provide an association of the environment with the progress of metabolic disorders.Increasing miR-145 may be a new potential therapeutic strategy in preventing and treating metabolic diseases such as type 2 diabetes and atherosclerosis. | Min He Nan Wu Man Cheong Leong Weiwei Zhang Zi Ye Rumei Li Jinyang Huang Zhaoyun Zhang Lianxi Li Xiao Yao Wenbai Zhou Naijia Liu Zhihong Yang Xuehong Dong Yintao Li Lili Chen Qin Li Xuanchun Wang Jie Wen Xiaolong Zhao Bin Lu Yehong Yang Qinghua Wang Renming Hu | 2020 | Journal of Molecular Cell Biology2020，12，2： | 7 |
| 2 | Determination of dioxin-like polychlorinated biphenyls in soil and moss from Fildes Peninsula,Antarctica显示文摘Dioxin-like polychlorinated biphenyls(PCBs) are a class of toxic and persistent chemicals that are often found in the environment.The determination of dioxin-like PCBs in Fildes Peninsula,Antarctica,is reported in this paper.Dioxin-like PCBs were widely distributed in Antarctic soil and moss with concentration of 2.23-27.2 pg/g in soil and 10.4-812 pg/g in moss.The highest concentrations were found in the Ardley Island area and the lowest concentrations on the west coast.The contribution of PCB-118 to the ∑12PCBs ranged from 36.0% to 69.6% in soil,and 17.2% to 43.4% in moss.The congener specific patterns in soil and moss were similar.Long-range atmospheric transport is thought to be the main source of PCBs detected on King George Island.The ∑12PCBs toxic equivalent(TEQ) in soil was 0.400×10?3 to 516×10?3 pg(TEQ)/g with a mean value of 147×10?3 pg(TEQ)/g.PCB-126 had the largest contribution(81.1%) to the ∑12PCBs TEQ in soil.The ∑12PCBs TEQ in moss ranged from 2.90×10?3 to 1.19 pg/g with a mean value of 0.482 pg/g.PCB-126 was also the largest contributor(91.4%) to the ∑12PCBs TEQ in moss.The mean TEQ in moss was about 40 times that in soil. | WANG Qiang SHI YeHong HU JianXin YAO ZiWei FANG XueKun DONG YiAn | 2012 | Chinese Science Bulletin2012，57，9： | 3 |
| 3 | MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models显示文摘Mitogen-activated protein kinase(MAPK)phosphatase 1(MKP-1)is an essential negative regulator of MAPKs by dephosphorylating MAPKs at both tyrosine and threonine residues.Dysregulation of the MAPK signaling pathway has been associated with Alzheimer’s disease(AD).However,the role of MKP-1 in AD pathogenesis remains elusive.Here,we report that MKP-1 levels were decreased in the brain tissues of patients with AD and an AD mouse model.The reduction in MKP-1 gene expression appeared to be a result of transcriptional inhibition via transcription factor specificity protein 1(Sp1)cis-acting binding elements in the MKP-1 gene promoter.Amyloid-β(Aβ)-induced Sp1 activation decreased MKP-1 expression.However,upregulation of MKP-1 inhibited the expression of both Aβprecursor protein(APP)andβ-site APP-cleaving enzyme 1 by inactivating the extracellular signal-regulated kinase 1/2(ERK)/MAPK signaling pathway.Furthermore,upregulation of MKP-1 reduced Aβproduction and plaque formation and improved hippocampal long-term potentiation(LTP)and cognitive deficits in APP/PS1 transgenic mice.Our results demonstrate that MKP-1 impairment facilitates the pathogenesis of AD,whereas upregulation of MKP-1 plays a neuroprotective role to reduce Alzheimer-related phenotypes.Thus,this study suggests that MKP-1 is a novel molecule for AD treatment. | Yehong Du Yexiang Du Yun Zhang Zhilin Huang Min Fu Junjie Li Yayan Pang Peng Lei Yu Tian Wang Weihong Song Guiqiong He Zhifang Dong | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 4 | β-Cyclodextrin and Its Derivatives Functionalized Magnetic Nanoparticles for Targeting Delivery of Curcumin and Cell Imaging显示文摘 | Yehong Zhou Congli Wang Fei Wang Chenzhong Li Chuan Dong Shaomin Shuang | 2016 | Chinese Journal of Chemistry2016，34，6： | 2 |
| 5 | Controlled Release of Curcumin via Folic Acid Conjugated Magnetic Drug Delivery System显示文摘 | SONG Shengmei LI Minglu GONG Xiaojuan HAN Hui ZHOU Yehong WANG Li SHUANG Shaomin DONG Chuan | 2018 | Chemical Research in Chinese Universities2018，34，2： | 1 |
| 6 | Simulation research on the influence of stress relaxation on plastic IC delamination during scrapped PCB disassembly 显示文摘 | LONG Danfeng XIANG Dong DONG Yehong | 2011 | International Journal of Environmental Technology and Management2011，14，56： | 1 |
| 7 | Review on Wind Power Development and Relevant Policies between China and Japan显示文摘China has abundant wind energy resources and huge development potential among developing countries.Japan is a developed country that planned to increase the use of renewable energy,especially wind energy.This research is aimed at reviewing the development of wind power and relevant policies between China and Japan.Firstly,we introduced the current status of global wind power development,such as the global installed capacity of wind power.The annual development of wind power generation in China and Japan is compared,and the distribution characteristics of wind resources are compared.Furthermore,the market share in China and Japan is introduced.Finally,according to the comparison of the government policies between China and Japan,we pointed out the existing problems in the wind power industry.In addition,we gave some suggestions on the development of wind power for China and Japan.These suggestions should be taken into account when designing national climate policies and have an important reference value for the future development of China’s wind energy industry. | Lei Wang Zekun Wang Yingjian Yang Shuni Zhou Yehong Dong Fanghong Zhang | 2021 | Energy Engineering2021，118，6： | 0 |
| 8 | Review on Research about Wake Effects of Offshore Wind Turbines显示文摘In recent years,the construction of offshore wind farms is developing rapidly.As the wake effect of the upstream wind turbines seriously affect the performance of the downstream wind turbines,the wake effect of offshore wind turbines has become one of the research hotspots.First,this article reviews the research methods of wake effects,including CFD numerical simulation method,wind turbine wake model based on roughness and engineering wake models.However,there is no general model that can be used directly.Then it puts forward some factors that affect the wake of offshore wind turbines.The turbulence intensity in offshore wind fields is lower than that in onshore wind fields.This makes the wake recovery length of offshore wind turbines longer than that of onshore wind turbines.Floating offshore wind turbines are simultaneously disturbed by wind loads and wave loads.Unsteady movement of the platform caused by wave loads.It affects the development and changes of the wake of wind turbines.In this regard,the focus of research on the wake effects of offshore wind farms will be the proposal of accurate prediction models for the wake effects of sea wind farms. | Yehong Dong Guangyin Tang Yan Jia Zekun Wang Xiaomin Rong Chang Cai Qingan Li Yingjian Yang | 2022 | Energy Engineering2022，119，4： | 0 |
| 9 | miR-429-3p mediates memory decline by targeting MKP-1 to reduce surface GluA1- containing AMPA receptors in a mouse model of Alzheimer’s disease显示文摘Alzheimer ’s disease(AD) is a leading cause of dementia in the elderly.Mitogen-activated protein kinase phosphatase 1(MKP-1) plays a neuroprotective role in AD.However,the molecular mechanisms underlying the effects of MKP-1 on AD have not been extensively studied.MicroRNAs(miRNAs) regulate gene expression at the post-transcriptional level,thereby repressing mRNA translation.Here,we reported that the microRNA-429-3p(miR-429-3p) was significantly increased in the brain of APP23/PS45 AD model mice and N2AAPPAD model cells.We further found that miR-429-3p could downregulate MKP-1 expression by directly binding to its 3’-untranslated region(3’ UTR).Inhibition of miR-429-3p by its antagomir(A-miR-429) restored the expression of MKP-1 to a control level and consequently reduced the amyloidogenic processing of APP and Aβ accumulation.More importantly,intranasal administration of A-miR-429 successfully ameliorated the deficits of hippocampal CA1 long-term potentiation and spatial learning and memory in AD model mice by suppressing extracellular signal-regulated kinase(ERK1/2)-mediated GluAl hyperphosphorylation at Ser831 site,thereby increasing the surface expression of GluAl-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors(AMPARs).Together,these results demonstrate that inhibiting miR-429-3p to upregulate MKP-1 effectively improves cognitive and synaptic functions in AD model mice,suggesting that miR-429/MKP-1 pathway may be a novel therapeutic target for AD treatment. | Man Luo Yayan Pang Junjie Li Lilin Yi Bin Wu Qiuyun Tian Yan He Maoju Wang Lei Xia Guiqiong He Weihong Song Yehong Du Zhifang Dong | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 10 | Lack of interferon regulatory factor 3 leads to anxiety/depression-like behaviors through disrupting the balance of neuronal excitation and inhibition in mice显示文摘Disrupting the balance of neuronal excitation and inhibition (E/I) is an important pathogenic mechanism of anxiety and depression. Interferon regulatory factor 3 (IRF3) plays a key role in the innate immune response, and activation of IRF3 triggers the expression of type I interferons and downstream interferon-stimulated genes, which are associated with anxiety and depression. However, whether IRF3 participates in the pathogenesis of anxiety/depression by regulating E/I balance remains poorly understood. Here, we reported that global knockout (KO) of IRF3 (IRF3^(−/−)) significantly increased anxiety/depression-like behaviors, but did not affect normal spatial learning and memory. Compared with wild type (WT) control mice, the E/I balance was disrupted, as reflected by enhanced glutamatergic transmission and decreased GABAergic transmission in the neurons of hippocampal CA1 and medial prefrontal cortex (mPFC) in IRF3-KO mice. Importantly, genetic rescue of IRF3 expression by adeno-associated virus (AAV) was sufficient to alleviate anxiety/depression-like behaviors and restore the neuronal E/I balance in IRF3-KO mice. Taken together, our results indicate that IRF3 is critical in maintaining neuronal E/I balance, thereby playing an essential role in ensuring emotional stability. | Junjie Li Yayan Pang Yehong Du Lei Xia Mulan Chen Yepeng Fan Zhifang Dong | 2023 | Genes & Diseases2023，10，3： | 0 |
| 11 | Sanitary and Phytosanitary Measures in China:Efficiency and Challenge:A Case Study of Swine Industry显示文摘The Sanitary and Phytosanitary( SPS) measures are technical regulations,standards,and requirements closely related to food safety,plant and animal health,and environmental safety,aiming to prevent disease,pests,pathogens and other alien risk from entering China.Pork is favorite meat for Chinese consumers; its safety directly concerns the safety of whole food supply chain with rapid increasing of pork import. This paper analyzed SPS management system of swine and pork import,and evaluated SPS efficiency of swine industry in China from SPS notification number,swine health situation,and pork import standard. The study found that as for SPS notification number and chemical residue control standard,China's SPS protection level is relatively high,while the control level of swine diseases is still low. In China,SPS management system has the problem of involving multiple authorities and poor coordination among them,leading to some standards lacking scientific basis and low enforcement. | Yinguo DONG Yehong LU | 2015 | Asian Agricultural Research2015，7，11： | 0 |
| 12 | Glutamate and GABAA receptor crosstalk mediates homeostatic regulation of neuronal excitation in the mammalian brain显示文摘Maintaining a proper balance between the glutamate receptor-mediated neuronal excitation and the A type of GABA receptor(GABAAR)mediated inhibition is essential for brain functioning;and its imbalance contributes to the pathogenesis of many brain disorders including neurodegenerative diseases and mental illnesses.Here we identify a novel glutamate-GABAAR interaction mediated by a direct glutamate binding of the GABAAR.In HEK293 cells overexpressing recombinant GABAARs,glutamate and its analog ligands,while producing no current on their own,potentiate GABA-evoked currents.This potentiation is mediated by a direct binding at a novel glutamate binding pocket located at theα+/β−subunit interface of the GABAAR.Moreover,the potentiation does not require the presence of aγsubunit,and in fact,the presence ofγsubunit significantly reduces the potency of the glutamate potentiation.In addition,the glutamate-mediated allosteric potentiation occurs on native GABAARs in rat neurons maintained in culture,as evidenced by the potentiation of GABAAR-mediated inhibitory postsynaptic currents and tonic currents.Most importantly,we found that genetic impairment of this glutamate potentiation in knock-in mice resulted in phenotypes of increased neuronal excitability,including decreased thresholds to noxious stimuli and increased seizure susceptibility.These results demonstrate a novel cross-talk between excitatory transmitter glutamate and inhibitory GABAAR.Such a rapid and short feedback loop between the two principal excitatory and inhibitory neurotransmission systems may play a critical homeostatic role in fine-tuning the excitation-inhibition balance(E/I balance),thereby maintaining neuronal excitability in the mammalian brain under both physiological and pathological conditions. | Ya Wen Zhifang Dong Jun Liu Peter Axerio-Cilies Yehong Du Junjie Li Long Chen Lu Zhang Lidong Liu Jie Lu Ning Zhou Dong Chuan Wu Yu Tian Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，11： | 0 |
| 13 | Studies on the Interaction Between Vanillin and β-Amyloid Protein via Fluorescence Spectroscopy and Atomic Force Microscopy显示文摘 | SONG Shengmei MA Xuewen ZHOU Yehong XU Maotian SHUANG Shaomin DONG Chuan | 2016 | Chemical Research in Chinese Universities2016，32，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员