|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Current Situation on Major Depressive Disorder in China:Research on Mechanisms and Clinical Practice显示文摘Depression is the most disabling disorder worldwide that accounts for the highest proportion of global burden attributable to mental disorders. Major depressive disorder(MDD) is characterized by deep sadness, reduced energy,vegetative nervous system dysregulation, cognitive dysfunction, and even a high suicidal tendency. Although other treatment choices are available, antidepressant medication is the front-line treatment option for MDD. Regarding clinical efficacy, only ~50% of patients respond to frontline antidepressants, and <33% obtain remission. Currently, objective indexes to guide clinical decisions are still lacking. Furthermore, knowledge about the neurobiological mechanisms underlying discrepant antidepressant outcomes is still also fragmentary. In the present review, we discuss the current research progress and clinical opinions on MDD in China. | Zhenghua Hou Wenhao Jiang Yingying Yin Zhijun Zhang Yonggui Yuan | 2016 | Neuroscience Bulletin2016，32，4： | 16 |
| 2 | Achieving the nitrite pathway using FA inhibition and process control in UASB-SBR system removing nitrogen from landfill leachate显示文摘An up-flow sludge blanket(UASB) and sequencing batch reactor(SBR) system was introduced to remove organics and nitrogen from landfill leachate.The synergetic effect of free ammonia(FA) inhibition and process control was used to achieve the nitrite pathway in the SBR.In previous research,inhibition of FA on nitrite oxidizing bacteria(NOB) activity has been revealed and the process control parameters(DO,ORP and pH) exactly indicate the end-point of nitritation.The method was implemented in the SBR achieving stable nitrogen removal via the nitrite pathway from landfill leachate.The degree of nitrite accumulation during the nitritation was monitored along with the simultaneous and advanced removal of organics and nitrogen in the UASB-SBR system.The nitrifying bacteria community was quantitatively analyzed by fluorescence in situ hybridization(FISH) techniques.Batch tests were carried out to investigate the denitritation kinetics of microbial bacteria in the SBR.Experimental results showed that the nitrite pathway could be repeatedly and reliably achieved by synergetic effect of FA inhibition and process control.FISH analysis showed the dominant nitrifying bacteria were ammonia-oxidizing β-Proteobacteria. Relationship between nitrite concentration and nitrite reduction rate followed the Monod-type equation.The maximum specific nitrite utilization rate(k) and half-velocity constant(Ks) were calculated as 0.44 gN gVSS-1d-1and 15.8 mg L-1,respectively. | Sun, HongWei Yang, Qing Dong, GuoRi Hou, HongXun Zhang, ShuJun Yang, YingYing Peng, YongZhen | 2010 | Science China Chemistry2010，53，5： | 8 |
| 3 | Virtual 5G Network Embedding in a Heterogeneous and Multi-Domain Network Infrastructure显示文摘The pursuit of the higher performance mobile communications forces the emergence of the fifth generation mobile communication(5G). 5G network, integrating wireless and wired domain, can be qualified for the complex virtual network work oriented to the cross-domain requirement. In this paper, we focus on the multi-domain virtual network embedding in a heterogeneous 5G network infrastructure, which facilitates the resource sharing for diverse-function demands from fixed/mobile end users. We proposed the mathematical ILP model for this problem.And based on the layered-substrate-resource auxiliary graph and an effective six-quadrant service-type-judgment method, 5G embedding demands can be classified accurately to match different user access densities. A collection of novel heuristic algorithms of virtual 5G network embedding are proposed. A great deal of numerical simulation results testified that our algorithm performed better in terms of average blocking rate, routing latency and wireless/wired resource utilization, compared with the benchmark. | Cunqian Yu Weigang Hou Yingying Guan Yue Zong Pengxing Guo | 2016 | China Communications2016，13，10： | 6 |
| 4 | Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages显示文摘 | Xianfa Yang Boqiang Hu Yu Hou Yunbo Qiao Ran Wang Yingying Chen Yun Qian Su Feng Jun Chen Chang Liu Guangdun Peng Fuchou Tang Naihe Jing | 2018 | Cell Research2018，28，5： | 5 |
| 5 | Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis显示文摘Dear Editor,The axolotl,Ambystoma mexicanum,has extraordinary capability to fully recover multiple tissues after lost,whereas such capability has disappeared in mammals.Thus,deci-phering detailed mechanisms underlying axolotl regenera-tion could provide valuable lessons for regenerative medicine.However,many questions,such as the origin of essential progenitor cells and key responses of individual types of cells for regeneration remain elusive(Haas and Whited,2017).Newly developed single-cell RNA sequenc-ing(scRNA-seq)method enables researchers to observe cellular and molecular dynamics in axolotl regeneration at the single-cell resolution(Gerber et al.,2018;Leigh et al.,2018),but the reported transcriptome landscapes are only for certain cell types or in certain regenerative stages.A complete overview of the regeneration process for all cell types is still lacking. | Hanbo Li Xiaoyu Wei Li Zhou Weiqi Zhang Chen Wang Yang Guo Denghui Li Jjianyang Chen Tianbin Liu Yingying Zhang Shuai Ma Congyan Wang Fujian Tan Jiangshan Xu Yang Liu Yue Yuan Liang Chen Qiaoran Wang Jing Qu Yue Shen Shanshan Liu Guangyi Fan Longqi Liu Xin Liu Yong Hou Guang-Hui Liu Ying Gu Xun Xu | 2021 | Protein & Cell2021，12，1： | 3 |
| 6 | Accessing Alignments of Ontologies via IoT Based on SKOS Data Model显示文摘Many ontologies are provided to representing semantic sensors data.However,heterogeneity exists in different sensors which makes some service operators of Internet of Thing(IoT) difficult(such as such as semantic inferring,non-linear inverted index establishing,service composing) .There is a great deal of research about sensor ontology alignment dealing with the heterogeneity between the different sensor ontologies,but fewer solutions focus on exploiting syntaxes in a sensor ontology and the pattern of accessing alignments.Our solution infers alignments by extending structural subsumption algorithms to analyze syntaxes in a sensor ontology,and then combines the alignments with the SKOS model to construct the integration sensor ontology,which can be accessed via the IoT.The experiments show that the integration senor ontology in the SKOS model can be utilized via the IoT service,and the accuracy of our prototype,in average,is higher than others over the four real ontologies. | Xiulei Liu Xia Hou Junyang Yu Ying Gao Yue Zhang Yingying Zhang | 2017 | China Communications2017，14，6： | 3 |
| 7 | Quercetin promotes human epidermal stem cell proliferation through the estrogen receptor/β-catenin/c-Myc/cyclin A2 signaling pathway显示文摘Skin epidermal stem cells(EpSCs)play an important role in wound healing.Quercetin is a phytoestrogen reported to accelerate skin wound healing,but its effect on EpSCs is unknown.In this study,we investigated the effect of quercetin on human EpSC proliferation and explored the underlying mechanisms.We found that quercetin at 0.1~1μM significantly promoted EpSC proliferation and increased the number of cells in S phase.The pro-proliferative effect of quercetin on EpSCs was confirmed in cultured human skin tissue.Mechanistic studies showed that quercetin significantly upregulated the expressions ofβ-catenin,c-Myc,and cyclins A2 and E1.Inhibitor forβ-catenin or c-Myc significantly inhibited quercetin-induced EpSC proliferation.Theβ-catenin inhibitor XAV-939 suppressed quercetin-induced expressions ofβ-catenin,c-Myc,and cyclins A2 and E1.The c-Myc inhibitor 10058-F4 inhibited the upregulation of c-Myc and cyclin A2 by quercetin.Pretreatment of EpSCs with estrogen receptor(ER)antagonist ICI182780,but not the G protein-coupled ER1 antagonist G15,reversed quercetin-induced cell proliferation and upregulation ofβ-catenin,c-Myc,and cyclin A2.Collectively,these results indicate that quercetin promotes EpSC proliferation through ER-mediated activation ofβ-catenin/c-Myc/cyclinA2 signaling pathway and ER-independent upregulation of cyclin E1 and that quercetin may accelerate skin wound healing through promoting EpSC proliferation.As EpSCs are used not only in clinic to treat skin wounds but also as seed cells in skin tissue engineering,quercetin is a useful reagent to expand EpSCs for basic research,skin wound treatment,and skin tissue engineering. | Zhaodong Wang Guangliang Zhang Yingying Le Jihui Ju Ping Zhang Dapeng Wan Qiang Zhao Guangzhe Jin Hao Su Jinwei Liu Jiaxuan Feng Yi Fu Ruixing Hou | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 3 |
| 8 | Laser-induced Janus graphene/poly(p-phenylene benzobisoxazole)fabrics with intrinsic flame retardancy as flexible sensors and breathable electrodes for fire-fighting field显示文摘Conventional firefighting clothing and fire masks can protect firemen’s safety to a certain extent,whereas cannot perceive environmental hazards and monitor their physical status in real time.Herein,we fabricated two kinds of Janus graphene/poly(pphenylene benzobisoxazole)(PBO)fabrics by laser direct writing approach and evaluated their performance as intelligent firefighting clothes and fire masks.The results showed that the Janus graphene/PBO fabrics were virtually non-combustible and achieved the highest thermal protection time of 18.91 s ever reported in flame,which is due to the intrinsic flame-retardant nature of PBO fibers.The graphene/PBO woven fabrics-based sensor showed good repeatability and stability in human motion monitoring and NO_(2)gas detection.Furthermore,the piezoelectric fire mask was assembled with graphene/PBO nonwoven fabric as electrode layer and polyvinylidene fluoride(PVDF)electrostatic direct writing film as piezoelectric layer.The filtration efficiency of the fire mask reaches 95%for PM_(2.5)and 100%for PM_(3.0),indicating its effective filtration capability for smoke particles in fires.The respiratory resistance of the piezoelectric fire mask(46.8 Pa)was lower than that of commercial masks(49 Pa),showing that it has good wearing comfort.Besides,the piezoelectric fire mask can be sensitive to the speed and intensity of human breathing,which is essential for indirectly reflecting the health of the human body.Consequently,this work provides a facile approach to fabricate next-generation intrinsic flame-retardant smart textiles for smart firefighting. | Yu Luo Yaping Miao Huimin Wang Kai Dong Lin Hou Yanyan Xu Weichun Chen Yao Zhang Yingying Zhang Wei Fan | 2023 | Nano Research2023，16，5： | 2 |
| 9 | Effect of tumor necrosis factor inhibitors on rheumatoid arthritis-induced peripheral neuropathy A cohort study显示文摘In this historical cohort study,236 patients with primary rheumatoid arthritis were treated with the tumor necrosis factor inhibitors,etanercept or infliximab(n = 80),or by conventional methods(n = 156).Results revealed that 11 patients developed varying types of peripheral neuropathy at 1-2 years post-treatment(mean 16 months).The incidence of peripheral neuropathy in the tumor necrosis factor inhibitors treatment group was 8.8%(7/80),which was significantly higher than the conventional treatment group(2.6%;4/156).The relative risk of developing peripheral neuropathy in the tumor necrosis factor inhibitors treatment group was 3.41(95% confidence interval:1.03-11.31).Comparison of the tumor necrosis factor inhibitors revealed that etanercept and infliximab had no significant difference in terms of inducing peripheral neuropathy.Experimental findings indicate that tumor necrosis factor inhibitors may increase the risk of peripheral neuropathy. | Naizhi Wang Yingying Guo Lili Yang Wenyi Fu Yanbing Xu Linxin Hou Shuai Zhao Ning Zhang | 2012 | Neural Regeneration Research2012，7，11： | 2 |
| 10 | On the deformation behavior of heterogeneous microstructure and its effect on the mechanical properties of die cast AZ91D magnesium alloy显示文摘Both a conventional flow distributer and an improved one with a flow buffer were applied respectively during the high pressure die casting(HPDC)process,and samples of AZ91D magnesium alloy with different microstructure mainly consisting ofα-Mg grains,β-phase and porosities were obtained.According to the grain orientation analysis,the predominant deformation behavior inα-Mg grains was dislocation slip,supplemented by deformation twinning.Dislocation slip was more difficult to occur in the samples with the improved flow distributer on account of the fact that the size ofα-Mg grains in the microstructure was finer and more uniform.During the in situ tensile deformation test,cracks were observed to initiate from gas-shrinkage pore and island-shrinkage,and two main crack propagation mechanisms,porosity growth and coalescence were found accordingly.When the crack was in contact with theβ-phase,it would pass through and fracture the networkβ-phase,whereas bypass the islandβ-phase by detaching it from the surroundingα-Mg grains.Mechanical property tests showed that the samples with relatively more homogeneous microstructure would perform higher mechanical properties,which was the combined effect of matrixα-Mg grains,β-phase,and porosities. | Mengwu Wu Yingying Hou Lin Hua Huijuan Ma Xiaobo Li Shoumei Xiong | 2022 | Journal of Magnesium and Alloys2022，10，7： | 1 |
| 11 | Rapid, sensitive and on-line measurement of chemical oxygen demand by novel optical method based on UV photolysis and chemiluminescence显示文摘 | Yingying Su Xiaohong Li He Chen Yi Lv Xia- odeng Hou | 2007 | Microchemical Journal2007，，87： | 1 |
| 12 | Establishment of customized mouse stem cell lines by sequential nuclear transfer显示文摘治疗学的克隆,胚胎的干细胞(转换字符) 由此从原子转移(NT ) 被导出胚胎,可以在再生药的新时代起一个主要作用。Inthis 学习我们建立了四十原子转移 -- 从不同施主房间类型或段落的 NTembryos 被导出的转换字符(NT 转换字符) 线。我们发现 NT 转换字符能够形成胚胎植物或动物身体。另外, NT 转换字符表示了 pluripotency 干细胞标记试管内并且能区分进胚胎的纸巾体内。从施主房间能形成完整的术语的早经过 R1 的 NT 胚胎开发了小狗,而那些为为实时出生是必要的 reprogramming 从迟了的经过 R1 ES 施主房间失去了潜力。我们随后建立了近来从 NT 胚囊被开发的 sequentialNT-R1-ESC 线经过 R1 转换字符施主。然而,当在他们的早段落用作原子转移施主时,这些 NT-R1-ESC 排队,没能导致实时小狗。这显示用顺序的 NT 转换字符的治疗学的克隆过程不能救居住在以前的施主代的发展缺乏。 | Chunli Zhao Ruqiang Yao Jie Hao Chenhui Ding Yong Fan Xiangpeng Dai Wei Li Tang Hai Zichuan Liu Yang Yu Yingying Wang Xiaojun Hou Weizhi Ji Qi Zhou Alice Jouneau Fanyi Zeng Liu Wang | 2007 | Cell Research2007，17，1： | 1 |
| 13 | Sodium-based dual-ion batteries via coupling high-capacity selenium/graphene anode with high-voltage graphite cathode显示文摘Dual ion batteries(DIBs) exhibit broad application prospects in the field of electrical energy storage(EES)devices with excellent properties,such as high voltage,high energy density,and low cost.In the graphitebased DIBs,high voltage is needed to store enough anions with the formation of anion intercalation compound XCn(X=AlCl4-,PF6-,TFSI-,etc.).Hence,it is difficult for graphite-based DIBs to match proper anodes and electrolytes.Here,an Se/graphene composite is prepared via a convenient method,and assembled into a dual-ion full battery(DIFB) as anode with graphite cathode and 1 mol/L NaPF6 in EC:EMC(1:1,v:v).This DIFB has achieved a high discharge capacity of 75.9 mAh/g and high medium output voltage of 3.5 V at 0.1 A/g.Actually,the suitable anode materials,such as the present Se/graphene composite,are extremely important for the development and application of graphite-based DIBs.This study is enlightening for the design of future low-cost EES devices including graphite-based DIBs. | Xiankun Hou Wenhao Li Yingying Wang Shaofang Li Yunfeng Meng Haiyue Yu Baokuan Chen Xinglong Wu | 2020 | Chinese Chemical Letters2020，31，9： | 1 |
| 14 | The fusion protein of HSP65 with tandem repeats of β-hCG acting as a potent tumor vaccine in suppressing hepatocarcinoma显示文摘 | Hu Xiangbing Zhang Yankai Lin Ming Lu Yong Zhang Yu Zhang Huiyong Chen Yingying Hou Jing Xing Yun Jin Liang Cao Rongyue Liu Jingjing | 2009 | International Immunopharmacology2009，，： | 1 |
| 15 | SARS-CoV-2 infection and the antiviral innate immune response显示文摘The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)outbreak be-gan in December 2019,causing the illness known as the novel coronavirus disease 2019(COVID-19).The virus spread rapidly worldwide to become a global public health emergency.As of November 15,2020,more than 53 million confirmed cases and over 1 million deaths worldwide have been reported(World Health Organization,2020). | Hui Yang Yingying Lyu Fajian Hou | 2020 | Journal of Molecular Cell Biology2020，12，12： | 1 |
| 16 | A linear DNA template-based framework for site-specific unnatural amino acid incorporation显示文摘Site-specific incorporation of unnatural amino acids(UNAAs)into proteins using an orthogonal translation system(OTS)has expanded the scope of protein-coding chemistry.The key factor affecting UNAA embedding efficiency is the orthogonality of the OTS.Compared to traditional cell systems,cell-free systems are more convenient to control the reaction process and improve the utilization rate of UNAA.In this study,a linear DNA template-based cell-free unnatural protein synthesis system for rapid high-throughput screening and evolution was proposed.A total of 14 cell extracts were selected for screening out cell extract with high expression level.The result showed that EcAR7ΔAΔSer cell extract was optimal for the cell-free system.In addition,the screening results of four UNAAs,p-propargyloxy-l-phenylalanine(pPaF),p-azyl-phenylalanine(pAzF),p-acetyl-l-phenylalanine(pAcF),and p-benzoyl-l-phenylalanine(pBpF),showed that o-aaRS and o-tRNA of pPaF had good orthogonality.A new pair of corresponding o-aaRS and o-tRNA for pBpF was screened out.These results proved that this method could speed up the screening of optimal OTS components for UNAAs with versatile functions. | Xinjie Chen Yingying Liu Jiaqi Hou Yuan Lu | 2021 | Synthetic and Systems Biotechnology2021，6，3： | 1 |
| 17 | Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development显示文摘Primary germ layers have the potential to form all tissues in the mature organism,and their formation during gastrulation requires precise epigenetic modulation of both proximal and distal regulatory elements.Previous studies indicated that spatial and temporal patterns of gene expression in the gastrula predispose individual regions to distinct cell fates.However,the underlying epigenetic mechanisms remain largely unexplored.Here,we profile the spatiotemporal landscape of the epigenome and transcriptome of the mouse gastrula.We reveal the asynchronous dynamics of proximal chromatin states during germ layer formation as well as unique gastrula-specific epigenomic features of regulatory elements,which have strong usage turnover dynamics and clear germ layerspecific signatures.Importantly,we also find that enhancers around organogenetic genes,which are weakly expressed at the gastrulation stage,are frequently pre-marked by histone H3 lysine 27 acetylation(H3K27ac)in the gastrula.By using the transgenic mice and genome editing system,we demonstrate that a pre-marked enhancer,which is located in the intron of a brain-specific gene 25W009E07Rik,exhibits specific enhancer activity in the ectoderm and future brain tissue,and also executes important function during mouse neural differentiation.Taken together,our study provides the comprehensive epigenetic information for embryonic patterning during mouse gastrulation,demonstrates the importance of gastrula pre-marked enhancers in regulating the correct development of the mouse embryo,and thus broadens the current understanding of mammalian embryonic development and related diseases. | Xianfa Yang Boqiang Hu Jiaoyang Liao Yunbo Qiao Yingying Chen Yun Qian Su Feng Fang Yu Ji Dong Yu Hou He Xu Ran Wang Guangdun Peng Jinsong Li Fucnou Tang Naihe Jing | 2019 | Cell Research2019，29，11： | 1 |
| 18 | Dose rate effects on shape memory epoxy resin during 1 Me V electron irradiation in air显示文摘The effects of 1 Me V electron irradiation in air at a fixed accumulated dose and dose rates of 393.8,196.9,78.8,and 39.4 Gy s^(-1)on a shape memory epoxy(SMEP)resin were studied.Under low-dose-rate irradiation,accelerated degradation of the shape memory performance was observed;specifically,the shape recovery ratio decreased exponentially with increasing irradiation time(that is,with decreasing dose rate).In addition,the glass transition temperature of the SMEP,as measured by dynamic mechanical analysis,decreased overall with decreasing dose rate.The dose rate effects of 1 Me V electron irradiation on the SMEP were confirmed by structural analysis using electron paramagnetic resonance(EPR)spectroscopy and Fourier transform infrared(FTIR)spectroscopy.The EPR spectra showed that the concentration of free radicals increased exponentially with increasing irradiation time.Moreover,the FTIR spectra showed higher intensities of the peaks at 1660 and 1720 cm^(-1),which are attributed to stretching vibrations of amide C=O and ketone/acid C=O,at lower dose rates.The intensities of the IR peaks at 1660 and 1720 cm^(-1) increased exponentially with increasing irradiation time,and the relative intensity of the IR peak at 2926 cm^(-1)decreased exponentially with increasing irradiation time.The solid-state13 C nuclear magnetic resonance(NMR)spectra of the SMEP before and after 1 Me V electron irradiation at a dose of 1970 k Gy and a dose rate of 78.8 Gy s^(-1) indicated damage to the CH_(2)–N groups and aliphatic isopropanol segment.This result is consistent with the detection of nitrogenous free radicals,a phenoxy-type free radical,and several types of pyrolytic carbon radicals by EPR.During the subsequent propagation process,the free radicals produced at lower dose rates were more likely to react with oxygen,which was present at higher concentrations,and form the more destructive peroxy free radicals and oxidation products such as acids,amides,and ketones.The increase in peroxy free radicals at lower dose rates was thought to accelerate the degradation of the macroscopic performance of the SMEP. | Longyan Hou Yiyong Wu Debin Shan Bin Guo Yingying Zong | 2021 | Journal of Materials Science & Technology2021，，8： | 1 |
| 19 | Split graphs whose half-strong endomorphisms form a monoid显示文摘In this paper,the half-strong,the locally strong and the quasi-strong endomorphisms of a split graph are investigated.Let X be a split graph and let End(X),hEnd(X),lEnd(X) and qEnd(X) be the endomorphism monoid,the set of all half-strong endomorphisms,the set of all locally strong endomorphisms and the set of all quasi-strong endomorphisms of X,respectively.The conditions under which hEnd(X) forms a submonoid of End(X) are given.It is shown that lEnd(X) = qEnd(X) for any split graph X.The conditions under which lEnd(X)(resp.qEnd(X)) forms a submonoid of End(X) are also given.In particular,if hEnd(X) forms a monoid,then lEnd(X)(resp.qEnd(X)) forms a monoid too. | LUO YanFeng ZHANG WenTing QIN YingYing HOU HaiLonga | 2012 | Science China Mathematics2012，55，6： | 1 |
| 20 | Angiopoietin-like 4 promotes epidermal stem cell proliferation and migration and contributes to cutaneous wound re-epithelialization显示文摘Proliferation and migration of epidermal stem cells(EpSCs)are essential for epithelialization during skin wound healing.Angiopoietin-like 4(ANGPTL4)has been reported to play an important role in wound healing,but the mechanisms involved are not fully understood.Here,we investigate the contribution of ANGPTL4 to full-thickness wound re-epithelialization and the underlying mechanisms using Angptl4-knockout mice.Immunohistochemical staining reveals that ANGPTL4 is significantly upregulated in the basal layer cells of the epidermis around the wound during cutaneous wound healing.ANGPTL4 deficiency impairs wound healing.H&E staining shows that ANGPTL4 deficiency significantly reduces the thickness,length and area of the regenerated epidermis postwounding.Immunohistochemical staining for markers of EpSCs(α6 integrin andβ1 integrin)and cell proliferation(PCNA)shows that the number and proliferation of EpSCs in the basal layer of the epidermis are reduced in ANGPTL4-deficient mice.In vitro studies show that ANGPTL4 deficiency impedes EpSC proliferation,causes cell cycle arrest at the G1 phase and reduces the expressions of cyclins D1 and A2,which can be reversed by ANGPTL4 overexpression.ANGPTL4 deletion suppresses EpSC migration,which is also rescued by ANGPTL4 overexpression.Overexpression of ANGPTL4 in EpSCs accelerates cell proliferation and migration.Collectively,our results indicate that ANGPTL4 promotes EpSC proliferation by upregulating cyclins D1 and A2 expressions and accelerating the cell cycle transition from G1 to S phase and that ANGPTL4 promotes skin wound re-epithelialization by stimulating EpSC proliferation and migration.Our study reveals a novel mechanism underlying EpSC activation and re-epithelialization during cutaneous wound healing. | Yuan Yang Chenghao Yu Yingying Le Weijuan Gong Jihui Ju Guangliang Zhang Pengxiang Ji Rui Zuo Zhe Liu Ping Zhang Ruixing Hou Yi Fu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员