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| 1 | Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma显示文摘Background:Resistance to ferroptosis,a regulated cell death caused by irondependent excessive accumulation of lipid peroxides,has recently been linked to lung adenocarcinoma(LUAD).Intracellular antioxidant systems are required for protection against ferroptosis.The purpose of the present studywas to investigate whether and how extracellular system desensitizes LUAD cells to ferroptosis.Methods:Established human lung fibroblasts MRC-5,WI38,and human LUAD H1650,PC9,H1975,H358,A549,and H1299 cell lines,tumor and matched normal adjacent tissues of LUAD,and plasma from healthy individuals and LUAD patients were used in this study.Immunohistochemistry and immunoblotting were used to analyze protein expression,and quantitative reverse transcription-PCR was used to analyze mRNA expression.Cell viability,cell death,and the lipid reactive oxygen species generationwere measured to evaluate the responses to ferroptosis.Exosomes were observed using transmission electron microscope.The localization of arachidonic acid(AA)was detected using click chemistry labeling followed by confocal microscopy.Interactions between RNAs and proteins were detected using RNA pull-down,RNA immunoprecipitation and photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation methods.Proteomic analysis was used to investigate RNA-regulated proteins,and metabolomic analysis was performed to analyze metabolites.Cellderived xenograft,patient-derived xenograft,cell-implanted intrapulmonary LUAD mouse models and plasma/tissue specimens from LUAD patients were used to validate the molecular mechanism.Results:Plasma exosome from LUAD patients specifically reduced lipid peroxidation and desensitized LUAD cells to ferroptosis.A potential explanation is that exosomal circRNA_101093(cir93)maintained an elevation in intracellular cir93 in LUAD to modulate AA,a poly-unsaturated fatty acid critical for ferroptosisassociated increased peroxidation in the plasma membrane.Mechanistically,cir93 interacted with and increased fatty acid-binding protein 3(FABP3),which transported AA and facilitated its reaction with taurine.Thus,global AA was reduced,whereas N-arachidonoyl taurine(NAT,the product of AA and taurine)was induced.Notably,the role of NAT in suppressing AA incorporation into the plasma membrane was also revealed.In pre-clinical in vivo models,reducing exosome improved ferroptosis-based treatment.Conclusion:Exosome and cir93 are essential for desensitizing LUAD cells to ferroptosis,and blocking exosome may be helpful for future LUAD treatment. | Xiao Zhang Yunhua Xu Lifang Ma Keke Yu Yongjie Niu Xin Xu Yi Shi Susu Guo Xiangfei Xue Yikun Wang Shiyu Qiu Jiangtao Cui Hong Wang Xiaoting Tian Yayou Miao Fanyu Meng Yongxia Qiao Yongchun Yu Jiayi Wang | 2022 | Cancer Communications2022，42，4： | 10 |
| 2 | Review of heterogeneous photochemical reactions of NOy on aerosol-A possible daytime source of nitrous acid (HONO) in the atmosphere显示文摘As an important precursor of hydroxyl radical, nitrous acid (HONO) plays a key role in the chemistry of the lower atmosphere. Recent atmospheric measurements and model calculations show strong enhancement for HONO formation during daytime, while they are inconsistent with the known sources in the atmosphere, suggesting that current models are lacking important sources for HONO. In this article, heterogeneous photochemical reactions of nitric acid/nitrate anion and nitrogen oxide on various aerosols were reviewed and their potential contribution to HONO formation was also discussed. It is demonstrated that HONO can be formed by photochemical reaction on surfaces with deposited HNO3 , by photocatalytic reaction of NO2 on TiO2 or TiO2 -containing materials, and by photochemical reaction of NO2 on soot, humic acids or other photosensitized organic surfaces. Although significant uncertainties still exist in the exact mechanisms and the yield of HONO, these additional sources might explain daytime observations in the atmosphere. | Jinzhu Ma Yongchun Liu Chong Han Qingxin Ma Chang Liu Hong He | 2013 | Journal of Environmental Sciences2013，25，2： | 8 |
| 3 | A case study of Asian dust storm particles:Chemical composition,reactivity to SO_2 and hygroscopic properties显示文摘Mineral dust comprises a great fraction of the global aerosol loading,but remains the largest uncertainty in predictions of the future climate due to its complexity in composition and physico-chemical properties.In this work,a case study characterizing Asian dust storm particles was conducted by multiple analysis methods,including SEM-EDS,XPS,FT-IR,BET,TPD/mass and Knudsen cell/mass.The morphology,elemental fraction,source distribution,true uptake coefficient for SO 2,and hygroscopic behavior were studied.The major components of Asian dust storm particles are aluminosilicate,SiO 2 and CaCO 3,with organic compounds and inorganic nitrate coated on the surface.It has a low reactivity towards SO 2 with a true uptake coefficient,5.767×10-6,which limits the conversion of SO 2 to sulfate during dust storm periods.The low reactivity also means that the heterogeneous reactions of SO 2 in both dry and humid air conditions have little effect on the hygroscopic behavior of the dust particles. | Qingxin Ma Yongchun Liu Chang Liu Jinzhu Ma Hong He | 2012 | Journal of Environmental Sciences2012，24，1： | 7 |
| 4 | Distinct potential aerosol masses under different scenarios of transport at a suburban site of Beijing显示文摘In order to evaluate the secondary aerosol formation potential at a suburban site of Beijing,in situ perturbation experiments in a potential aerosol mass(PAM) reactor were carried out in the winter of 2014.The variations of secondary aerosol formation as a function of time,OH exposure,and the concentrations of gas phase pollutants and particles were reported in this study.Two periods with distinct secondary aerosol formation potentials,marked as Period Ⅰ and Period Ⅱ,were identified during the observation.In Period Ⅰ,the secondary aerosol formation potential was high,and correlated well to the air pollutants,i.e.,SO_2,NO_2,and CO.The maximal secondary aerosol formation was observed with an aging time equivalent to about 3 days of atmospheric oxidation.In period Ⅱ,the secondary aerosol formation potential was low,with no obvious correlation with the air pollutants.Meanwhile,the aerosol mass decreased,instead of showing a peak,with increasing aging time.Backward trajectory analysis during the two periods confirmed that the air mass in Period Ⅰwas mainly from local sources,while it was attributed mostly to long distance transport in Period Ⅱ.The air lost its reactivity during the long transport and the particles became highly aged,resulting in a low secondary aerosol formation potential.Our experimental results indicated that the in situ measurement of the secondary aerosol formation potential could provide important information for evaluating the contributions of local emission and long distance transport to the aerosol pollution. | Biwu Chu Yongchun Liu Qingxin Ma Jinzhu Ma Hong He Gang Wang Shuiyuan Cheng Xinming Wang | 2016 | Journal of Environmental Sciences2016，28，1： | 5 |
| 5 | In situ DRIFTS study of hygroscopic behavior of mineral aerosol显示文摘In situ difflusion reflectance infrared Fourier transform spectroscopy was used to study the water adsorption on mineral oxides(SiO2,α-Al2O3,MgO,Fe2O3,TiO2).The results showed that all the water adsorption isotherms were well fitted with the Brunauer-EmmettTeller(BET)-Ⅲ type equation,with the calculated monolayers occurring at 24%-30% relative humidity.It showed that about 1-5 layers of water adsorbed on oxides surfaces in ambient relative humidity(20%-90%).The measured deliquescence relative humidity of NaCl was(74 ± 1)%,which demonstrated that DRIFTS is a useful method for the study the hygroscopic behavior of mineral dust.In addition,the limits of DRIFTS were also discussed. | Qingxin Ma,Hong He,Yongchun Liu State Key Laboratory of Environmental Chemistry and Ecotoxicology,Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences,Beijing 100085,China. | 2010 | Journal of Environmental Sciences2010，22，4： | 5 |
| 6 | Differences of the oxidation process and secondary organic aerosol formation at low and high precursor concentrations显示文摘Current atmospheric quality models usually underestimate the level of ambient secondary organic aerosol(SOA), one of the possible reasons is that the precursors at different concentrations may undergo different oxidation processes and further affect SOA formation. Therefore, there is a need to perform more chamber studies to disclose the influence. In this work, SOA formation over a wide range of initial precursor concentrations(tens of ppb to hundreds of ppb levels) was investigated in a 30 m3 indoor smog chamber,and mainly through the analysis of multiple generations of VOCs detected from HR-To FPTRMS to expound the difference in the oxidation process between low and high precursor concentrations. Compared to high initial concentrations, gas-phase intermediates formed at low concentrations had a higher intensity by about one order of magnitude, and the lowvolatility compounds also had a higher formation potential due to the competition between semi-volatile intermediates and precursors with oxidants. In addition, the formed SOA was more oxidized with higher f44 value(0.14 ± 0.02) and more relevant to real atmosphere than that formed at high concentrations. This work should help to deeply understand SOA formation and improve the performance of air quality models for SOA simulation. | Tianzeng Chen Yongchun Liu Biwu Chu Changgeng Liu Jun Liu Yanli Ge Qingxin Ma Jinzhu Ma Hong He | 2019 | Journal of Environmental Sciences2019，31，5： | 4 |
| 7 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 8 | Secondary aerosol formation and oxidation capacity in photooxidation in the presence of Al_2O_3 seed particles and SO_2显示文摘To investigate the sensitivity of secondary aerosol formation and oxidation capacity to NOx in homogeneous and heterogeneous reactions, a series of irradiated toluene/NOx/air and ?-pinene/NOx/air experiments were conducted in smog chambers in the absence or presence of Al2O3 seed particles. Various concentrations of NOx and volatile organic compounds(VOCs) were designed to simulate secondary aerosol formation under different scenarios for NOx. Under 'VOC-limited' conditions, the increasing NOx concentration suppressed secondary aerosol formation, while the increasing toluene concentration not only contributed to the increase in secondary aerosol formation, but also led to the elevated oxidation degree for the organic aerosol. Sulfate formation was suppressed with the increasing NOx due to a decreased oxidation capacity of the photooxidation system. Secondary organic aerosol(SOA) formation also decreased with the presence of high concentration of NOx, because organo-peroxy radicals(RO2) react with NOx instead of with peroxy radicals(RO2 or HO2), resulting in the formation of volatile organic products. The increasing concentration of NOx enhanced the formation of sulfate, nitrate and SOA under 'NOx-limited' conditions, in which the heterogeneous reactions played an important role. In the presence of Al2O3 seed particles, a synergetic promoting effect of mineral dust and NOx on secondary aerosol formation in heterogeneous reactions was observed in the photooxidation. This synergetic effect strengthened the positive relationship between NOx and secondary aerosol formation under 'NOx-limited' conditions but weakened or even overturned the negative relationship between NOx and secondary aerosol formation under 'VOC-limited' conditions. Sensitivity of secondary aerosol formation to NOx seemed different in homogeneous and heterogeneous reactions, and should be both taken into account in the sensitivity study. The sensitivity of secondary aerosol formation to NOx was further investigated under 'winter-like' and NH3-rich conditions. No obvious difference for the sensitivity of secondary aerosol formation except nitrate to NOx was observed. | Biwu Chu Tengyu Liu Xiao Zhang Yongchun Liu Qingxin Ma Jinzhu Ma Hong He Xinming Wang Junhua Li Jiming Hao | 2015 | Science China Chemistry2015，58，9： | 3 |
| 9 | Effect of aluminium dust on secondary organic aerosol formation in m-xylene/NO_x photo-oxidation显示文摘As an important anthropogenic volatile organic compound(VOC), m-xylene has attracted numerous attentions due to its potential in secondary organic aerosol(SOA) formation. In this study, effects of aluminium dust seeds(boehmite and alumina) on SOA yield and aerosol size in m-xylene/NOx photo-oxidation were investigated in a 2 m3 smog chamber at 30°C and 50% relative humidity. Compared to the seed-free system, the presence of aluminium seeds resulted in an increase in the SOA yield, and also enhanced the O3 concentration in the chamber. The photolysis of O3 is a major source of OH radical, which is the most important oxidant of m-xylene. The increase in O3 concentration could result in the generation of more OH radicals, and finally contribute to the SOA formation. Seed particles influence the SOA size mainly by acting as condensation nuclei. Semi-volatile organic compounds(SVOCs) were condensed onto these nuclei, resulting in the increase in SOA size. However, when aluminium seeds with high concentrations were introduced into the system, SVOCs that had been condensed onto each particle were dispersed by these seeds, leading to the reduction in aerosol size. | LIU Chang MA QingXin CHU BiWu LIU YongChun HE Hong ZHANG XiaoYe LI JunHua HAO JiMing | 2015 | Science China Earth Sciences2015，58，2： | 2 |
| 10 | Air plasma-sprayed high-entropy (Y_(0.2)Yb_(0.2)Lu_(0.2)Eu_(0.2)Er_(0.2))_(3)Al_(5)O_(12) coating with high thermal protection performance显示文摘High-entropy rare-earth aluminate(Y_(0.2)Yb_(0.2)Lu_(0.2)Eu_(0.2)Er_(0.2))_(3)Al_(5)O_(12)(HE-RE_(3)Al_(5)O_(12))has been considered as a promising thermal protection coating(TPC)material based on its low thermal conductivity and close thermal expansion coefficient to that of Al2O3.However,such a coating has not been experimentally prepared,and its thermal protection performance has not been evaluated.To prove the feasibility of utilizing HE-RE_(3)Al_(5)O_(12) as a TPC,HE-RE_(3)Al_(5)O_(12) coating was deposited on a nickelbased superalloy for the first time using the atmospheric plasma spraying technique.The stability,surface,and cross-sectional morphologies,as well as the fracture surface of the HE-RE_(3)Al_(5)O_(12) coating were investigated,and the thermal shock resistance was evaluated using the oxyacetylene flame test.The results show that the HE-RE_(3)Al_(5)O_(12) coating can remain intact after 50 cycles at 1200℃ for 200 s,while the edge peeling phenomenon occurs after 10 cycles at 1400℃ for 200 s.This study clearly demonstrates that HE-RE_(3)Al_(5)O_(12) coating is effective for protecting the nickel-based superalloy,and the atmospheric plasma spraying is a suitable method for preparing this kind of coatings. | Kailun WANG Jinpeng ZHU Hailong WANG Kaijun YANG Yameng ZHU Yubin QING Zhuang MA Lihong GAO Yanbo LIU Sihao WEI Yongchun SHU Yanchun ZHOU Jilin HE | 2022 | Journal of Advanced Ceramics2022，11，10： | 2 |
| 11 | Syner- gistic reaction between SO2 and NOz on mineral oxides: A potential formation pathway of sulfate aerosol 显示文摘 | Lin Chang Ma Qingxin Liu Yongchun | 2012 | Physical Chemistry Chemical Physics2012，14，5： | 1 |
| 12 | A motion planning based adaptive control method for an underactuated crane system 显示文摘 | FANG Yongchun MA Bojun WANG Pengcheng | | IEEE Transactions on0，，： | 1 |
| 13 | Influence of combustion conditions on hydrophilic properties and microstructure of flame soot 显示文摘 | Han Chong Liu Yongchun Liu Chang Ma Jinzhu He Hong | 2012 | The Journal of Physical Chemistry2012，116，： | 1 |
| 14 | Application of smog chambers in atmospheric process studies显示文摘Smog chamber experimental systems,which have been widely used in laboratory simulation for studying atmospheric processes,are comprehensively reviewed in this paper.The components,development history,main research topics and main achievements of smog chambers are introduced.Typical smog chambers in the world,including their volumes,wall materials,light sources and features,are summarized and compared.Key factors of smog chambers and their influences on the simulation of the atmospheric environment are discussed,including wall loss,wall emission and background pollutants.The features of next-generation smog chambers and their application prospect in future studies of the atmospheric environment are also outlined in this paper. | Biwu Chu Tianzeng Chen Yongchun Liu Qingxin Ma Yujing Mu Yonghong Wang Jinzhu Ma Peng Zhang Jun Liu Chunshan Liu Huaqiao Gui Renzhi Hu Bo Hu Xinming Wang Yuesi Wang Jianguo Liu Pinhua Xie Jianmin Chen Qian Liu Jingkun Jiang Junhua Li Kebin He Wenqing Liu Guibin Jiang Jiming Hao Hong He | 2022 | National Science Review2022，9，2： | 1 |
| 15 | Adsorption and desorption of Cd in reclaimed soil under the influence of humic acid:characteristics and mechanisms显示文摘Exogenous humus can change the content and migration activity of cadmium(Cd)in soil.Humic acid(HA)is an important soluble humus component in soil.In order to explore the relationship between cadmium pollution mechanism and ecological environment of humic acid in reclaimed soil,the characteristics of humic acid adsorbing cadmium in alkaline conditions were studied.This study employed reclaimed soil from the Huainan mining area,China.The adsorption and desorption characteristics as well as influence mechanisms on the heavy metal cadmium(Cd)were explored under the influence of HA.The results show that:(1)When Cd concentration was low(0.2–10 mg/L),HA had little effect on Cd adsorption and desorption in reclaimed soil.When the Cd concentration was high(15–80 mg/L),HA had a great influence on the adsorption and desorption of Cd in reclaimed soil.The addition of HA can inhibit the adsorption of Cd by reclaimed soil and effectively improve the desorption capacity of Cd by reclaimed soil.(2)The kinetic curves of Cd adsorption and desorption of reclaimed soil with added HA show that both processes(adsorption and desorption)include two stages:rapid reaction and slow reaction.The adsorption of Cd by reclaimed soil under the influence of HA was 18.18%lower than that of normal reclaimed soil,and the increase of Cd desorption was 50.29%.(3)The factors affecting the adsorption and desorption of Cd in the soil were analyzed with gray theory,and their importance can be ordered as follows:Cd concentration>HA concentration>pH>temperature.Considering the influence of HA,a multi-factor coupling function model of adsorption and desorption of Cd in soil is established.This model provides theoretical guidance for the scientific prediction and evaluation of Cd environmental pollution risks in soil and will be useful for developing a new solution for engineering remediation of high concentration Cd contaminated soil. | Yonghong Zheng Zhiguo Zhang Yongchun Chen Shikai An Lei Zhang Fangling Chen Chengnan Ma Weiqing CAi | 2022 | International Journal of Coal Science & Technology2022，9，1： | 1 |
| 16 | A kinetic model for thermally induced hydrogen and carbon isotope fractionation of individual n -alkanes in crude oil显示文摘 | Yongchun Tang Yongsong Huang Geoffrey S. Ellis Yi Wang Paul G. Kralert Bruno Gillaizeau Qisheng Ma Rong Hwang | 2005 | Geochimica et Cosmochimica Acta2005，，： | 1 |
| 17 | Atomic-resolution investigation of structural transformation caused by oxygen vacancy in La_(0.9)Sr_(0.1)TiO_(3+δ)titanate layer perovskite ceramics显示文摘Perovskite functional ceramics have been widely applied for thermal protection owing to their unique physical properties.However,formation of oxygen vacancies under external stimuli usually limits their performance in practical applications.Therefore,the mechanism of the effect of oxygen vacancy on the layer structure of perovskite La_(0.9)Sr_(0.1)TiO_(3+δ)was investigated by experiments and first-principles simulations.The experimental results showed that the lattice distortion occurred in oxygen-deficient environment to give a longer c-axis,along with a significant adjustment in the modes of A/B–O bond vibration,resulting in lower reflectivity.Advanced transmission electron microscopy studies revealed that oxygen vacancies induced localized atomic rearrangements via[TiO_(6)]layer movements to adapt to the lattice distortion.This eventually restructured a part of the layer interfaces by expanding the overlapping projection of atoms in the c-axial direction.The specific transformation process was described as a compendious process,while geometric phase analysis effectively clarified how oxygen vacancies can inhibit reflectivity on the layer structure.Thus,this study provides effective approaches for researching the effects of oxygen vacancy on the physical properties of orthorhombic layer perovskite structures,which may facilitate the development of perovskite-based functional devices. | Yang Zhao Yameng Zhu Jinpeng Zhu Hailong Wang Zhuang Ma Lihong Gao Yanbo Liu Kaijun Yang Yongchun Shu Jilin He | 2022 | Journal of Materials Science & Technology2022，，9： | 0 |
| 18 | Study on the mechanism of cholic acid derivatives in traditional Chinese medicine based on the regulation of gene expression显示文摘Objective:To investigate the pharmacological action and mechanism of cholic acid derivatives in traditional Chinese medicine(TCM)based on the regulation of gene expression.Methods:Genome-wide gene expression profiles of Michigan Cancer Foundation-7(MCF-7)cells treated with or without 4 cholic acid derivatives were detected by gene chip technology.Similarities in upregulated and downregulated genes were analyzed using the Connectivity Map(CMap)database.The affinity between cholic acid derivatives and the potential target was confirmed by molecular docking.The cholic acid derivative-regulated pathway enrichment analysis was performed by the STRING database,and the potential pathway was confirmed by in vitro experiments on MD Anderson-Metastatic Breast-231(MDA-MB-231)cells.Results:Compared with the reference genome in the CMap database,the gene expression profiles of cholic acid derivatives were similar to those of antipsychotic,anticancer,anti-inflammatory,and antiinfective drugs.Among them,4 derivatives were associated with antianxiety drugs,and molecular docking results showed that these compounds may act by binding to the ligand-binding site of gammaaminobutyric acid(GABA)receptors.Moreover,the cytoskeletal pathway is one of the pathways enriched in the derivatives.Of them,ursodeoxycholic acid showed significant inhibitory activity on the cytoskeleton formation of MDA-MB-231 cells.Conclusion:The gene expression detection method,combined with CMap and pathway enrichment analysis,could be used to study the mechanism of the active ingredients of TCM.In addition,our research showed that cholic acid derivatives have a potential affinity for membrane receptors,where they can exert anxiolytic activity by modulating opioid receptor,GABA receptor,and dopamine receptor.Moreover,ursodeoxycholic and chenodeoxycholic acid inhibit cytoskeleton formation,probably by acting on membrane proteins to activate the corresponding cytoskeletal pathways. | Yongchun Huang Jie Zhang Pengxiang Zhao Yufeng Ma Qiangqiang Jia Shoude Zhang | 2023 | Journal of Traditional Chinese Medical Sciences2023，10，1： | 0 |
| 19 | Case report of Cushing's syndrome with an acute psychotic presentation显示文摘一位36岁的中国女性因出现狂躁、被害妄想和自杀意念3天被送至某综合医院急诊。六个月来患者易醒、过度警觉并出现躯体症状。入心身病房后,体检发现该患者满月脸、突眼,且双腿有紫纹,因此考虑急性精神症状继发于库欣综合征。血浆皮质醇、促肾上腺皮质激素(adrenocorticotropic hormone ACTH)水平升高,腹部计算机断层扫描(computed tomography,CT)发现左肾上腺肿块,证实了该诊断。使用小剂量喹硫平(75-125 mg/d)和阿普唑仑(0.4 mg/qn)来控制精神病性症状并改善其睡眠。将一个良性的非ACTH依赖性肾上腺肿瘤手术切除后,患者的皮质醇和ACTH水平恢复正常,其精神症状也在一个月内逐渐减少,此时该患者出院。患者出院后一直门诊随诊,维持喹硫平治疗(因为担心停药对睡眠和情绪稳定的影响),总时间持续1年左右,剂量从50mg渐减至25mg至减停。这时她的精神症状已经完全消失。该病例中,病人具有库欣综合征的特殊症状,因此相对容易诊断;但在库欣综合征中急性精神病性症状可能会危及生命,也可能不出现库欣综合征的典型躯体症状(如果皮质醇增多症不严重),所以临床精神科医师在鉴别难以解释的急性精神病时,应该始终考虑将库欣综合征纳入可能的鉴别诊断。 | Yuejing WU Jiong CHEN Yongchun MA Zhenxin CHEN | 2016 | 上海精神医学2016，28，3： | 0 |
| 20 | The missing base molecules in atmospheric acid–base nucleation显示文摘Transformation of low-volatility gaseous precursors to new particles affects aerosol number concentration,cloud formation and hence the climate.The clustering of acid and base molecules is a major mechanism driving fast nucleation and initial growth of new particles in the atmosphere.However,the acid–base cluster composition,measured using state-of-the-art mass spectrometers,cannot explain the measured high formation rate of new particles.Here we present strong evidence for the existence of base molecules such as amines in the smallest atmospheric sulfuric acid clusters prior to their detection by mass spectrometers.We demonstrate that forming(H_(2)SO_(4))1(amine)1 is the rate-limiting step in atmospheric H_(2)SO_(4)-amine nucleation and the uptake of(H_(2)SO_(4))1(amine)1 is a major pathway for the initial growth of H_(2)SO_(4)clusters.The proposed mechanism is very consistent with measured new particle formation in urban Beijing,in which dimethylamine is the key base for H_(2)SO_(4)nucleation while other bases such as ammonia may contribute to the growth of larger clusters.Our findings further underline the fact that strong amines,even at low concentrations and when undetected in the smallest clusters,can be crucial to particle formation in the planetary boundary layer. | Runlong Cai Rujing Yin Chao Yan Dongsen Yang Chenjuan Deng Lubna Dada Juha Kangasluoma Jenni Kontkanen Roope Halonen Yan Ma Xiuhui Zhang Pauli Paasonen Tuukka Petaja Veli-Matti Kerminen Yongchun Liu Federico Bianchi Jun Zheng Lin Wang Jiming Hao James N.Smith Neil M.Donahue Markku Kulmala Douglas R.Worsnop Jingkun Jiang | 2022 | National Science Review2022，9，10： | 0 |
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