|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The second natural gas hydrate production test in the South China Sea显示文摘Clayey silt reservoirs bearing natural gas hydrates(NGH)are considered to be the hydrate-bearing reservoirs that boast the highest reserves but tend to be the most difficult to exploit.They are proved to be exploitable by the first NGH production test conducted in the South China Sea in 2017.Based on the understanding of the first production test,the China Geological Survey determined the optimal target NGH reservoirs for production test and conducted a detailed assessment,numerical and experimental simulation,and onshore testing of the reservoirs.After that,it conducted the second offshore NGH production test in 1225 m deep Shenhu Area,South China Sea(also referred to as the second production test)from October 2019 to April 2020.During the second production test,a series of technical challenges of drilling horizontal wells in shallow soft strata in deep sea were met,including wellhead stability,directional drilling of a horizontal well,reservoir stimulation and sand control,and accurate depressurization.As a result,30 days of continuous gas production was achieved,with a cumulative gas production of 86.14×104 m3.Thus,the average daily gas production is 2.87×10^4 m^3,which is 5.57 times as much as that obtained in the first production test.Therefore,both the cumulative gas production and the daily gas production were highly improved compared to the first production test.As indicated by the monitoring results of the second production test,there was no anomaly in methane content in the seafloor,seawater,and atmosphere throughout the whole production test.This successful production test further indicates that safe and effective NGH exploitation is feasible in clayey silt NGH reservoirs.The industrialization of hydrates consists of five stages in general,namely theoretical research and simulation experiments,exploratory production test,experimental production test,productive production test,and commercial production.The second production test serves as an important step from the exploratory production test to experimental production test. | Jian-liang Ye Xu-wen Qin Wen-wei Xie Hai-long Lu Bao-jin Ma Hai-jun Qiu Jin-qiang Liang Jing-an Lu Zeng-gui Kuang Cheng Lu Qian-yong Liang Shi-peng Wei Yan-jiang Yu Chunsheng Liu Bin Li Kai-xiang Shen Hao-xian Shi Qiu-ping Lu Jing Li Bei-bei Kou Gang Song Bo Li He-en Zhang Hong-feng Lu Chao Ma Yi-fei Dong Hang Bian | 2020 | China Geology2020，3，2： | 22 |
| 2 | Antisense MMP-9 RNA inhibits malignant glioma cell growth in vitro and in vivo显示文摘The matrix-degrading metalloproteinases (MMPs), particularly MMP-9, play important roles in the pathogenesis and development of malignant gliomas. In the present study, the oncogenic role of MMP-9 in malignant glioma cells was investigated via antisense RNA blockade in vitro and in vivo. TJ905 malignant glioma cells were transfected with pcDNA3.0 vector expressing antisense MMP-9 RNA (pcDNA-AS-MMP9), which significantly decreased MMP-9 expression, and cell proliferation was assessed. For in vivo studies, U251 cells, a human malignant glioma cell line, were implanted subcutaneously into 4-to 6-week-old BALB/c nude mice. The mice bearing well-established U251 gliomas were treated with intratumoral pcDNA-AS-MMP9-Lipofectamine complex (AS-MMP-9-treated group), subcutaneous injection of endostatin (endostatin-treated group), or both (combined therapy group). Mice treated with pcDNA (empty vector)-Lipofectamine served as the control group. Four or eight weeks later, the volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity were assayed. We demonstrate that pcDNA-AS-MMP9 significantly decreased MMP-9 expression and inhibited glioma cell proliferation. Volume and weight of tumor, MMP-9 expression, microvessel density and proliferative activity in the antisense-MMP-9-treated and therapeutic alliance groups were significantly lower than those in the control group. The results suggest that MMP-9 not only promotes malignant glioma cell invasiveness, but also affects tumor cell proliferation. Blocking the expression of MMP-9 with antisense RNA substantially suppresses the malignant phenotype of glioma cells, and thus can be used as an effective therapeutic strategy for malignant gliomas. | Cuiyun Sun Qian Wang Hongxu Zhou Shizhu Yu Alain R. Simard Chunsheng Kang Yanyan Li Yanling Kong Tongling An Yanjun Wen Fudong Shi Junwei Hao | 2013 | Neuroscience Bulletin2013，29，1： | 14 |
| 3 | ^(40)Ar/^(39)Ar ages of seamount trachytes from the South China Sea and implications for the evolution of the northwestern sub-basin显示文摘A chronological study of seamount rocks in the South China Sea basin provides a great opportunity to understand the expansion and evolution history of the sea basin.In this paper,we analyzed the40Ar/39Ar age of trachytic samples collected from the Shuangfeng seamounts in the northwestern sub-basin of the South China Sea.The two samples yielded plateau ages of 23.80 0.18 and 23.29 0.22 Ma,respectively,which indicate magmatic activity in late Oligocene which helpful constraints the expansion time of the northwest sub-basin.Previous studies suggested that the northwestern sub-basin and southwestern sub-basin have experienced a relatively consistent expansion in the NWeSE direction followed by a late expansion of the eastern sub-basin.We concluded that the expansion of the northwestern sub-basin began prior to ca.24 Ma,which also implicated magmatic events of a late or stop expansion of the northwestern sub-basin combined with our results of40Ar/39Ar age data and previous geophysical data. | Xiaohu Li Jiabiao Li Xing Yu Chunsheng Wang Fred Jourdan | 2015 | Geoscience Frontiers2015，6，4： | 9 |
| 4 | Analysis of 2D Flow and Heat Transfer Modeling in Fracture of Porous Media显示文摘Heat and mass transfer between porous media and fluid is a complex coupling process, which is widely used in various fields of engineering applications, especially for natural and artificial fractures in oil and gas extraction. In this study, a new method is proposed to deal with the flow and heat transfer problem of steady flow in a fracture. The fluid flow in a fracture was described using the same method as Mohais, who considered a fracture as a channel with porous wall, and the perturbation method was used to solve the mathematical model. Unlike previous studies, the shear jump boundary condition proposed by Ochoa-Tapia and Whitaker was used at the interface between the fluid and porous media. The main methods were perturbation analysis and the application of shear jump boundary conditions. The influence of permeability, channel width, shear jump degree and effective dynamic viscosity on the flow and heat transfer in the channel was studied by analysing the analytical solution. The distribution of axial velocity in the channel with the change of the typical parameters and the sensitivity of the heat transfer was obtained. | GUO Chunsheng NIAN Xianbo LIU Yong QI Chao SONG Jinsheng YU Wenhe | 2017 | Journal of Thermal Science2017，26，4： | 9 |
| 5 | FAK-targeting PROTAC as a chemical tool for the investigation of non-enzymatic FAK function in mice显示文摘Dear Editor,Animal models,most commonly mice,that lack a protein of interest play an important role in phenotypic and functional studies of a target gene,allowing researchers to answer various biological questions(Chaible et al,2010).At pre-sent,a variety of tools act at the DNA or RNA level to enable researchers to model gene function(and thus protein)deficiency,including nucleic acid based RNA interference(EI-bashir et al.,2001),antisense oligonucleotides(Schoch and Miller,2017),and genome editing-based CRISPR-Cas9(Doudna and Charpentier,2014)strategies.However,challenges remain. | Hongying Gao Chunwei Zheng Jian Du Yue Wu Yonghui Sun Chunsheng Han Kehkooi Kee Yu Rao | 2020 | Protein & Cell2020，11，7： | 5 |
| 6 | Recent Progress of Aerosol Light-scattering Enhancement Factor Studies in China显示文摘Assessment of the radiative forcing of aerosols in models still lacks sufficient input data for aerosol hygroscopicity. The light scattering enhancement factor [ f(RH, λ)] is a crucial parameter for describing aerosol hygroscopic growth properties.In this paper, we provide a survey of f(RH, λ) studies in China for the past seven years, including instrument developments of humidified nephelometers, ambient f(RH, λ) measurements in China, f(RH, λ) parameterization schemes, and f(RH, λ)applications in aerosol measurements. Comparisons of different f(RH, λ) parameterizations are carried out to check their performance in China using field measurement datasets. We also summary the parameterization schemes for predicting f(RH, λ)with aerosol chemical compositions. The recently developed methods to observe other aerosol properties using f(RH, λ)measurements, such as calculating the aerosol hygroscopicity parameter, cloud condensation nuclei number concentration,aerosol liquid water content, and aerosol asymmetry factor, are introduced. Suggestions for further research on f(RH, λ) in China are given. | Chunsheng ZHAO Yingli YU Ye KUANG Jiangchuan TAO Gang ZHAO | 2019 | Advances in Atmospheric Sciences2019，36，9： | 5 |
| 7 | Co-delivery of doxorubicin and paclitaxel with linear-dendritic block copolymer for enhanced anti-cancer efficacy显示文摘A series of well-defined amphiphilic linear-dendritic block copolymers(telodendrimers, MPEG-b-PAMAM-cholesterol) with 1,2,4 or 8 cholesteryl groups(named as P1, P2, P4, P8, respectively) were synthesized. Their chemical structures were characterized with 1H NMR and mass spectrum(MALDI-TOF MS). The telodendrimers could self-assemble into micelles in aqueous solution, and encapsulate chemotherapeutic drug doxorubicin(DOX) and paclitaxel(PTX) for combination therapy. All the telodendrimers could encapsulate DOX with similar capability. However, their drug-loading capability of PTX is increased with the increasing number of cholesteryl groups. P8 exhibited much higher PTX loading efficiency than its counterparts. Thus, P8 was selected for further application of drug delivery in the paper. The drug-loading micellar nanoparticles(NPs) of P8 were spherical in shape and their diameters were less than 150 nm which were determined by dynamic light scattering measurements(DLS) and transmission electron microscope(TEM). In vitro drug release experiment demonstrated that P8 exhibited a controlled release manner for both DOX and PTX, and the two drugs were released simultaneously. In vitro cytotoxicity experiment further demonstrated that the co-delivery of DOX and PTX in P8 exhibited better anti-cancer efficiency than the delivery systems encapsulated with single drug(DOX or PTX). This indicates a synergistic effect. The co-delivery system showed potential in future anti-cancer treatment. | ZHANG Yu XIAO ChunSheng LI MingQiang DING JianXun YANG ChenGuang ZHUANG XiuLi CHEN XueSi | 2014 | Science China Chemistry2014，57，4： | 4 |
| 8 | Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy - an illustration with, firsthand examples显示文摘纳米技术在药交货广泛地被使用了改进各种各样的疾病的治疗学的结果。巨大的努力在与他们的生物命运和函数的关系集中于 nanoparticles 的物理化学的性质的新奇 nanoparticles 和描述的开发。然而在这些基于纳米技术的药交货系统的设计和评估,交付的药的药理学并且(patho-) 主人的生理学收到了更少的注意。在这评论,我们讨论集成于使纳米技术能的药交货系统和治疗的设计的重要药理学机制,生理的特征,和病理学的因素。第一手的例子被举由利用 1 为癌症治疗说明如此的综合设计策略的原则和优点)到克服的multidrug抵抗的癌症的药药和 drug-nanomaterial 联合的细胞内部的 synergistic 相互作用, 2 )循环系统到的血流动方向为肺转移最大化药交货到肿瘤 neovasculature 和房间 overexpressing integrin 受体, 3 )装饰 nanocarriers 和 t 的内长的脂蛋白关于在糖尿病管理的申请,一个使纳米技术能的靠近环的胰岛素交货系统被设计在生理地相关的时间规模和葡萄糖层次提供动态胰岛素版本。和另外的研究结果,这些例子建议药理学的相互影响的那利用,(patho-) 生理学和纳米技术是一条灵巧的途径与高效率和翻译潜力开发创新的药交货系统和治疗。 | Rui Xue ZHANG Jason LI Tian ZHANG Mohammad A AMINI Chunsheng HE Brian LU Taksim AHMED HoYin LIP Andrew M RAUTH Xiao Yu WU | 2018 | Acta Pharmacologica Sinica2018，39，5： | 3 |
| 9 | Overexpression of programmed cell death-1 (PD-1) affects circulatory Th1 and Th2 cells in patients with cardiac arrest in the early period after the return of spontaneous circulation显示文摘To the Editor:Cardiac arrest(CA)is the leading cause of morbidity and mortality among hospitalized patients globally and has low rates of overall survival.After the return of spontaneous circulation(ROSC),patients with CA and systemic ischemia/reperfusion injury can manifest as sepsis-like syndromes and immune disorders that increase the risk of infections.CD4^(+)T lymphocytes play an important role in organ ischemia-reperfusion injury.T-helper(Th)types 1 and 2 cells are classical subsets of CD4^(+)T cells.Extensive research on their functions in infectious and immune-related inflammatory diseases indicates that both subsets participate in host defense and direct immune responses.Data from CA/cardiopulmonary resuscitation porcine models and patients have revealed imbalances in Th1/Th2 cell ratio.[1]Therefore,Th1 and Th2 cells are important for understanding post-ROSC immune dysfunction in patients with CA. | Yanan Yu Miaorong Xie Jiabao Li Chenchen Hang Fei Shao Chunsheng Li | 2022 | Chinese Medical Journal2022，，1： | 2 |
| 10 | Dual-targeted hybrid nanoparticles of synergistic drugs for treating lung metastases of triple negative breast cancer in mice显示文摘 | Tian ZHANG Preethy PRASAD Ping CAI Chunsheng HE Dan SHAN Andrew Michael RAUTH Xiao Yu WU | 2017 | Acta Pharmacologica Sinica2017，38，6： | 2 |
| 11 | Compressive sensing SAR range compression with chirp scaling principle显示文摘Compressive sensing(CS) techniques offer a framework for the detection and allocation of sparse signal with a reduced number of measurements.This paper proposes a novel SAR range compression,namely compressive sensing with chirp scaling(CS-CS),achieving the same range resolution as conventional SAR approach,while using fewer range samplings.In order to realize accurate range cell migration correction(RCMC),chirp scaling principle is used to construct reference matrix for compressive sensing recovery.Additionally,error diagrams are designed for measurement of the performance of CS-CS,and some experiments of using real data are performed to deal with the errors caused by three conditions:SNR,sparsity and sampling. | XIAO Peng YU Ze LI ChunSheng | 2012 | Science China(Information Sciences)2012，55，10： | 2 |
| 12 | Silencing of IKKε using siRNA inhibits proliferation and invasion ofglioma cells in vitro and in vivo显示文摘 | Huibing Li Lingchao Chen Anling Zhang Guangxiu Wang Lei Han Kai Yu Peiyu Pu Chunsheng Kang Qiang Huang | 2012 | International Journal of Oncology2012，，1： | 1 |
| 13 | Robust recognition of checkerboard pattern for camera calibration 显示文摘 | Yu Chunsheng Peng Qingjin | 2006 | Optical Engineering2006，45，9： | 1 |
| 14 | MicroRNA-221 and -222 Regulate Radiation Sensitivity by Targeting the PTEN Pathway显示文摘 | Chunzhi Zhang Chunsheng Kang Ping Wang Yongzhen Cao Zhonghong Lv Shizhu Yu Guangxiu Wang Anling Zhang Zhifan Jia Lei Han Chunying Yang Hiromichi Ishiyama Bin S. Teh Bo Xu Peiyu Pu | 2011 | International Journal of Radiation Oncology Biology Physics2011，，1： | 1 |
| 15 | Precision Medicine:What Challenges Are We Facing?显示文摘Following the publication of the US National Research Council(NRC)report‘‘Toward Precision Medicine:Building a Knowledge Network for Biomedical Research and a New Taxonomy of Diseases'in 2011[1],several nations have announced that their national research programs would definitely head toward this direction.Now,precision medicine(PM)became a banner for many large-scale | Yu Xue Eric-Wubbo Lameijer Kai Ye Kunlin Zhang Suhua Chang Xiaoyue Wang Jianmin Wu Ge Gao Fangqing Zhao Jian Li Chunsheng Han Shuhua Xu Jingfa Xiao Xuerui Yang Xiaomin Ying Xuegong Zhang Wei-Hua Chen Yun Liu Zhang Zhang Kun Huang Jun Yu | 2016 | Genomics, Proteomics & Bioinformatics2016，14，5： | 1 |
| 16 | Exposure to DE-71 alters thyroid hormone levels and gene transcription in the hypothalamic–pituitary–thyroid axis of zebrafish larvae显示文摘 | Liqin Yu Jun Deng Xiongjie Shi Chunsheng Liu Ke Yu Bingsheng Zhou | 2009 | Aquatic Toxicology2009，，3： | 1 |
| 17 | Effects of early hemodynamics,oxygen metabolism,and lactate dynamics on prognosis of post-cardiac arrest syndrome显示文摘With an annual incidence of 0.5 to 1.5/1000,cardiac arrest(CA)has emerged as a major global public health concern.[1]Although the American Heart Association(AHA)-International Liaison Committee on Resuscitation updates the cardiopulmonary resuscitation(CPR)guidelines every 5 years,the survival rate and percentage of patients with good neurologic outcomes post-CA after hospital discharge have been relatively low.Therefore,the AHA 2010 CPR guidelines mention the treatment of post-cardiac arrest syndrome(PCAS)in the intensive care unit(ICU)as the fifth link in the CA survival chain.PCAS is a pathophysiological process that includes(1)brain injury,(2)myocardial dysfunction leading to hemodynamic instability,and(3)systemic ischemia/reperfusion response leading to lactate accumulation.[2]These key factors affect the survival and neurological prognosis of CA patients in the early stages.We assessed the effects of early hemodynamics,oxygen metabolism,and lactate dynamics during PCAS on a 28-day survival rate and neurological outcomes. | Mingqing Zhang Qian Zhang Yanan Yu Le An Zhijiang Qi Chunsheng Li | 2022 | Chinese Medical Journal2022，，3： | 1 |
| 18 | Aircraft measurements of O 3 , NO x , CO, VOCs, and SO 2 in the Yangtze River Delta region显示文摘 | Fuhai Geng Qiang Zhang Xuexi Tie Mengyu Huang Xincheng Ma Zhaoze Deng Qiong Yu Jiannong Quan Chunsheng Zhao | 2008 | Atmospheric Environment2008，，3： | 1 |
| 19 | ' Personal innovativeness, social influences and adoption of wireless Internet services via mobile technology 显示文摘 | LU J YAO J E Yu Chunsheng | 2005 | Journal of Strategic Information Systems2005，14，3： | 1 |
| 20 | Co-delivery of as-miR-21 and 5-FU by poly(amidoamine) dendrimer attenuates human glioma cell growth in vitro显示文摘 | Ren Yu Kang ChunSheng Yuan Xubo | 2010 | J Biomater Sci2010，3，21： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员