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| 1 | Spatial patterns and driving forces of land use change in China during the early 21st century显示文摘Land use and land cover change as the core of coupled human-environment systems has become a potential field of land change science (LCS) in the study of global environmental change. Based on remotely sensed data of land use change with a spatial resolution of 1 km × 1 km on national scale among every 5 years, this paper designed a new dynamic regionalization according to the comprehensive characteristics of land use change including regional differentiation, physical, economic, and macro-policy factors as well. Spatial pattern of land use change and its driving forces were investigated in China in the early 21st century. To sum up, land use change pattern of this period was characterized by rapid changes in the whole country. Over the agricultural zones, e.g., Huang-Huai-Hai Plain, the southeast coastal areas and Sichuan Basin, a great proportion of fine arable land were engrossed owing to considerable expansion of the built-up and residential areas, resulting in decrease of paddy land area in southern China. The development of oasis agriculture in Northwest China and the reclamation in Northeast China led to a slight increase in arable land area in northern China. Due to the 'Grain for Green' policy, forest area was significantly increased in the middle and western developing regions, where the vegetation coverage was substantially enlarged, likewise. This paper argued the main driving forces as the implementation of the strategy on land use and regional development, such as policies of 'Western Development', 'Revitalization of Northeast', coupled with rapidly economic development during this period. | LIU Jiyuan ZHANG Zengxiang XU Xinliang KUANG Wenhui ZHOU Wancun ZHANG Shuwen LI Rendong YAN Changzhen YU Dongsheng WU Shixin JIANG Nan | 2010 | Journal of Geographical Sciences2010，20，4： | 154 |
| 2 | Spatiotemporal characteristics, patterns, and causes of land-use changes in China since the late 1980s显示文摘Land-use/land-cover 变化(LUCC ) 有连接到人和自然相互作用。瓷器 Land-Use/cover 数据集(CLUD ) 从 1980 年代末在 5 年的间隔定期被更新到 2010,与基于 Landsat TMETM+ 图象的标准过程。陆地使用动态区域化方法被建议分析主要陆地使用变换。在国家规模的陆地使用变化的空间与时间的特征,差别,和原因然后被检验。主要调查结果如下被总结。越过中国的陆地使用变化(LUC ) 在最后 20 年(19902010 ) 里在空间、时间的特征显示了一个重要变化。农田变化的区域在南方减少了并且在北方,而是仍然是的全部的区域增加了几乎未改变。回收农田从东北被转移到西北。布满建筑物陆地很快膨胀了,主要在东方被散布,并且逐渐地展开到中央、西方的中国。树林首先减少了,然后增加但是荒芜的区域是反面。草地继续减少。在中国的 LUC 的不同空间模式被发现在之间迟了第 20 世纪并且早第 21 世纪。原版 13 个 LUC 地区在一些地区被边界的变化由 15 个单位代替。包括的这些变化(1 ) 的主要空间特征加速的扩大布满建筑物在 Huang-Huai-Hai 区域,东南的沿海的区域,长江的中流区域,和四川盆登陆;(2 ) 从东北中国和东方内部蒙古在北方转移了陆地开垦到绿洲在西北中国的农业区域;(3 ) 从在到稻的东北中国的喂雨的农田的连续转变回答;并且(4 ) 为在内部蒙古,黄土高原,和西南的多山的区域的南部的农业牧剧的交错群落的格林工程的谷物的有效性。在最后二十年,尽管在北方的气候变化在农田影响了变化,政策规定和经济驱动力仍然是越过中国的 LUC 的主要原因。在第 21 世纪的第一十年期间,在陆地使用模式驾驶了变化的人为的因素从单程的陆地开发转移了强调到开发和保存。动态区域化方法被用来在单位的 zoning 边界,地区的内部特征,和生长和减少的空间模式分析变化。结果揭示了变化过程的模式,也就是 LUC 的过程和在在不同阶段的特征的地区性的差别。地区的生长和减少在这动态 LUC zoning,在统一边界的变化,和在前者和后者十年之间的变化紧张的特征期间被检验。在为在不同类型和陆地使用的不同区域的变化的陆地使用和原因的模式和过程之间的其他的转变的模式被探索。 | LIU Jiyuan KUANG Wenhui ZHANG Zengxiang XU Xinliang QIN Yuanwei NING Jia ZHOU Wancun ZHANG Shuwen LI Rendong YAN Changzhe WU Shixin SHI Xuezheng JIANG Nan YU Dongsheng PAN Xianzhang CHI Wenfeng | 2014 | Journal of Geographical Sciences2014，24，2： | 245 |
| 3 | Selection and development of representative simple sequence repeat primers and multiplex SSR sets for high throughput automated genotyping in maize显示文摘In the current study, 1900 maize simple sequence repeat (SSR) primers published in MaizeGDB were screened utilizing reference literature, 15 representative Chinese maize inbred lines and 15 Chinese maize hybrids from national regional testing. In total, 500 highly polymorphic primers were identified and used to construct a genetic map. 100 evenly distributed primers, 10 primers per chromosome, were further selected as a set of universal SSR core primers, recommended as preferred primers for general studies. These core primers were then redesigned and used to construct a high throughput multiplex PCR system based on a five-color fluorescence capillary detection system. We report here that two sets of ten-plex PCR combinations have been constructed, each consisting of 10 primers, with one primer per chromosome. | WANG FengGe ZHAO JiuRan DAI JingRui YI HongMei KUANG Meng SUN YanMei YU XinYan GUO JingLun WANG Lu | 2007 | Chinese Science Bulletin2007，52，2： | 35 |
| 4 | Z-ligustilide attenuates lipopolysaccharide-induced proinflammatory response via inhibiting NF-KB pathway in primary rat microglia显示文摘 | Jing WANG Jun-rong DU Yu WANG Xi KUANG Cheng-yuan WANG | 2010 | Acta Pharmacologica Sinica2010，31，7： | 22 |
| 5 | Acupuncture inhibits Notch1 and Hes1 protein expression in the basal ganglia of rats with cerebral hemorrhage显示文摘Notch pathway activation maintains neural stem cells in a proliferating state and increases nerve repair capacity. To date, studies have rarely focused on changes or damage to signal transduction pathways during cerebral hemorrhage. Here, we examined the effect of acupuncture in a rat model of cerebral hemorrhage. We examined four groups: in the control group, rats received no treatment. In the model group, cerebral hemorrhage models were established by infusing non-heparinized blood into the brain. In the acupuncture group, modeled rats had Baihui(DU20) and Qubin(GB7) acupoints treated once a day for 30 minutes. In the DAPT group, modeled rats had 0.15 μg/m L DAPT solution(10 m L) infused into the brain. Immunohistochemistry and western blot results showed that acupuncture effectively inhibits Notch1 and Hes1 protein expression in rat basal ganglia. These inhibitory effects were identical to DAPT, a Notch signaling pathway inhibitor. Our results suggest that acupuncture has a neuroprotective effect on cerebral hemorrhage by inhibiting Notch-Hes signaling pathway transduction in rat basal ganglia after cerebral hemorrhage. | Wei Zou Qiu-xin Chen Xiao-wei Sun Qing-bin Chi Hong-yu Kuang Xue-ping Yu Xiao-hong Dai | 2015 | Neural Regeneration Research2015，10，3： | 23 |
| 6 | The second natural gas hydrate production test in the South China Sea显示文摘Clayey silt reservoirs bearing natural gas hydrates(NGH)are considered to be the hydrate-bearing reservoirs that boast the highest reserves but tend to be the most difficult to exploit.They are proved to be exploitable by the first NGH production test conducted in the South China Sea in 2017.Based on the understanding of the first production test,the China Geological Survey determined the optimal target NGH reservoirs for production test and conducted a detailed assessment,numerical and experimental simulation,and onshore testing of the reservoirs.After that,it conducted the second offshore NGH production test in 1225 m deep Shenhu Area,South China Sea(also referred to as the second production test)from October 2019 to April 2020.During the second production test,a series of technical challenges of drilling horizontal wells in shallow soft strata in deep sea were met,including wellhead stability,directional drilling of a horizontal well,reservoir stimulation and sand control,and accurate depressurization.As a result,30 days of continuous gas production was achieved,with a cumulative gas production of 86.14×104 m3.Thus,the average daily gas production is 2.87×10^4 m^3,which is 5.57 times as much as that obtained in the first production test.Therefore,both the cumulative gas production and the daily gas production were highly improved compared to the first production test.As indicated by the monitoring results of the second production test,there was no anomaly in methane content in the seafloor,seawater,and atmosphere throughout the whole production test.This successful production test further indicates that safe and effective NGH exploitation is feasible in clayey silt NGH reservoirs.The industrialization of hydrates consists of five stages in general,namely theoretical research and simulation experiments,exploratory production test,experimental production test,productive production test,and commercial production.The second production test serves as an important step from the exploratory production test to experimental production test. | Jian-liang Ye Xu-wen Qin Wen-wei Xie Hai-long Lu Bao-jin Ma Hai-jun Qiu Jin-qiang Liang Jing-an Lu Zeng-gui Kuang Cheng Lu Qian-yong Liang Shi-peng Wei Yan-jiang Yu Chunsheng Liu Bin Li Kai-xiang Shen Hao-xian Shi Qiu-ping Lu Jing Li Bei-bei Kou Gang Song Bo Li He-en Zhang Hong-feng Lu Chao Ma Yi-fei Dong Hang Bian | 2020 | China Geology2020，3，2： | 22 |
| 7 | Decreased osteogenesis of adult mesenchymal stem cel s by reactive oxygen species under cyclic stretch: a possible mechanism of age related osteoporosis显示文摘Age related defect of the osteogenic differentiation of mesenchymal stem cells(MSCs) plays a key role in osteoporosis. Mechanical loading is one of the most important physical stimuli for osteoblast differentiation.Here, we compared the osteogenic potential of MSCs from young and adult rats under three rounds of 2 h of cyclic stretch of 2.5% elongation at 1 Hz on 3 consecutive days. Cyclic stretch induced a significant osteogenic differentiation of MSCs from young rats, while a compromised osteogenesis in MSCs from the adult rats.Accordingly, there were much more reactive oxygen species(ROS) production in adult MSCs under cyclic stretch compared to young MSCs. Moreover, ROS scavenger N-acetylcysteine rescued the osteogenic differentiation of adult MSCs under cyclic stretch. Gene expression analysis revealed that superoxide dismutase 1(SOD1) was significantly downregulated in those MSCs from adult rats. In summary, our data suggest that reduced SOD1 may result in excessive ROS production in adult MSCs under cyclic stretch, and thus manipulation of the MSCs from the adult donors with antioxidant would improve their osteogenic ability. | Jiali Tan Xin Xu Zhongchun Tong Jiong lin Qiujun Yu Yao Lin Wei Kuang | 2015 | Bone Research2015，3，1： | 15 |
| 8 | Changes in aortic endothelium ultrastructure in male rats following castration, replacement with testosterone and administration of 50α-reductase inhibitor显示文摘瞄准:调查在低雄激素水平和脉管的内皮细胞层的超微结构之间的关系。方法:48 只男 Sprague-Dawley 老鼠随机被划分成四个组:组 A,有假冒的阉割的正常老鼠;组 B,阉割的老鼠;组 C,给睾丸激素(T) undecanoate 的阉割的老鼠;并且组织 D,与 5 α - reductase 禁止者对待的未经触动的老鼠。在 10 星期处理或阉割以后,在不同的组的老鼠被打死,浆液 T,免费 T (英尺) 和 dihydrotestosterone (DHT ) 被测量。大动脉的 endothelia 在电子缩微本下面被扫描,脉管的内皮细胞层结构分数(VESS ) 被计算。结果:在组 B 的老鼠的浆液 T 和英尺集中是比另外的三个组的那些显著地低的(P <
0.01 ) ;组 D 老鼠的 DHT 集中显著地被减少(P <
0.01 ) 什么时候与那些相比组 A 和 C。在组 B 和 D 老鼠的老鼠(与低雄激素层次) 他们的 endothelial 表面的有的明显的损坏,它出现了成波形,不平,粘合剂并且破裂,并且有 VESS 的高破坏。结论:这些结果建议 T 和 DHT 的低集中在雄的老鼠与大动脉的 endothelia 的极端结构的损坏被联系。 | Ying-Li Lu Lin Kuang Hui Zhu Hui Wu Xue-Fang Wang Yu-Ping Pang Ning-Jian Wang Dan-Lu Yu | 2007 | Asian Journal of Andrology2007，9，6： | 13 |
| 9 | An enriched environment increases the expression of fibronectin type Ⅲ domain-containing protein 5 and brain-derived neurotrophic factor in the cerebral cortex of the ischemic mouse brain显示文摘Many studies have shown that fibronectin type III domain-containing protein 5(FDNC5) and brain-derived neurotrophic factor(BDNF) play vital roles in plasticity after brain injury. An enriched environment refers to an environment that provides animals with multi-sensory stimulation and movement opportunities. An enriched environment has been shown to promote the regeneration of nerve cells, synapses, and blood vessels in the animal brain after cerebral ischemia;however, the exact mechanisms have not been clarified. This study aimed to determine whether an enriched environment could improve neurobehavioral functions after the experimental inducement of cerebral ischemia and whether neurobehavioral outcomes were associated with the expression of FDNC5 and BDNF. This study established ischemic mouse models using permanent middle cerebral artery occlusion(pMCAO) on the left side. On postoperative day 1, the mice were randomly assigned to either enriched environment or standard housing condition groups. Mice in the standard housing condition group were housed and fed under standard conditions. Mice in the enriched environment group were housed in a large cage, containing various toys, and fed with a standard diet. Sham-operated mice received the same procedure, but without artery occlusion, and were housed and fed under standard conditions. On postoperative days 7 and 14, a beam-walking test was used to assess coordination, balance, and spatial learning. On postoperative days 16–20, a Morris water maze test was used to assess spatial learning and memory. On postoperative day 15, the expression levels of FDNC5 and BDNF proteins in the ipsilateral cerebral cortex were analyzed by western blot assay. The results showed that compared with the standard housing condition group, the motor balance and coordination functions(based on beam-walking test scores 7 and 14 days after operation), spatial learning abilities(based on the spatial learning scores from the Morris water maze test 16–19 days after operation), and memory abilities(based on the memory scores of the Morris water maze test 20 days after operation) of the enriched environment group improved significantly. In addition, the expression levels of FDNC5 and BDNF proteins in the ipsilateral cerebral cortex increased in the enriched environment group compared with those in the standard housing condition group. Furthermore, the Pearson correlation coefficient showed that neurobehavioral functions were positively associated with the expression levels of FDNC5 and BDNF(r = 0.587 and r = 0.840, respectively). These findings suggest that an enriched environment upregulates FDNC5 protein expression in the ipsilateral cerebral cortex after cerebral ischemia, which then activates BDNF protein expression, improving neurological function. BDNF protein expression was positively correlated with improved neurological function. The experimental protocols were approved by the Institutional Animal Care and Use Committee of Fudan University, China(approval Nos. 20160858 A232, 20160860 A234) on February 24, 2016. | Ke-Wei Yu Chuan-Jie Wang Yi Wu Yu-Yang Wang Nian-Hong Wang Shen-Yi Kuang Gang Liu Hong-Yu Xie Cong-Yu Jiang Jun-Fa Wu | 2020 | Neural Regeneration Research2020，15，9： | 12 |
| 10 | Effect of continuous annealing parameters on the mechanical properties and microstructures of a cold rolled dual phase steel显示文摘A cold rolled dual phase (DP) steel with the C-Si-Mn alloy system was trial-produced in the laboratory,utilizing a Glee-ble-3800 thermal simulator. The effects of continuous annealing parameters on the mechanical properties and microstructures of the DP steel were investigated by mechanical testing and microstructure observation. The results show that soaking between 760 and 820°C for more than 80 s,rapid cooling at the rate of more than 30°C/s from the quenching temperature between 620 and 680°C,and overaging lower than 300°C are beneficial for the mechanical properties of DP steels. An appropriate proportion of the two phases is one of the key factors for the favorable properties of DP steels. If the volume fraction of martensite and,thereby,free dislocations are deficient,the tensile strength and n value of DP steels will decrease,whereas,the yield strength will increase. But if the volume fraction of martensite is excessive to make it become a dominant phase,the yield and tensile strength will increase,whereas,the elongation will decrease obviously. When rapid cooling rate is not fast enough,pearlite or cementite will appear,which will degrade the mechanical properties. Even though martensite is sufficient,if it is decomposed in high temperature tempering,the properties will be unsatisfied. | Shuang Kuang Yong-lin Kang Hao Yu Ren-dong Liu | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，2： | 11 |
| 11 | Astragaloside Ⅳ protects RGC-5 cells against oxidative stress显示文摘Astragaloside Ⅳ is the main active compound of Astragalus membranaceus. Astragaloside Ⅳ has strong anti-oxidative activities and protective effects against progression of peripheral neuropathy. In this study, we determined whether astragaloside Ⅳ protects retinal ganglion cells(RGC) from oxidative stress injury using the rat RGC-5 cell line. Hydrogen peroxide(H_2O_2) was used to induce oxidative stress injury, with the protective effect of astragaloside Ⅳ examined. Cell Counting Kit-8 and 4′,6-diamidino-2-phenylindole staining showed that astragaloside Ⅳ increased cell survival rate and decreased apoptotic cell number. Flow cytometry showed that astragaloside Ⅳ decreased H_2O_2-induced reactive oxygen species levels. While laser confocal microscopy showed that astragaloside Ⅳ inhibited the H_2O_2-induced decrease of mitochondrial membrane potential. Western blot assay showed that astragaloside Ⅳ reduced cytochrome c release induced by H_2O_2, inhibited Bax and caspase-3 expression, and increased Bcl-2 expression. Altogether, these results indicate that astragaloside Ⅳ has potential protective effects against H_2O_2-induced oxidative stress in retinal ganglion cells. | Ming Hao Yu Liu Ping Chen Hong Jiang Hong-Yu Kuang | 2018 | Neural Regeneration Research2018，13，6： | 10 |
| 12 | Cucurbitacin I inhibits STAT3, but enhances STAT1 signaling in human cancer cells in vitro through disrupting actin filaments显示文摘STAT1 和 STAT3 是 STAT (抄写的信号变换器和使活跃之物) 的二个重要成员在调整癌症房间生长反对角色的蛋白质家庭和玩。压制 STAT3 或提高 STAT1 发信号被认为是吸引人的 anticancer 策略。Cucurbitacin (CuI ) 我从 cucurbitacin 家庭孤立被报导是 STAT3 发信号和肌动朊细胞骨架的 disruptor 的一个禁止者。在这研究,我们在调整在 vitro 在人的癌症房间发信号的 STAT 调查了 CuI 的功能和机制。CuI (0.1-10 mmol/L ) dose-dependently 禁止了 STAT3 的 phosphorylation,并且通过破坏肌动朊细丝可能在肺腺癌 A549 房间提高了 STAT1 的 phosphorylation。我们进一步证明肌动朊细丝身体上在 A549 房间与 JAK2 和 STAT3 联系了并且通过二调整了他们的 phosphorylation 表明建筑群, IL-6 受体建筑群和焦点的粘附建筑群。肌动朊细丝也在 A549 房间与 STAT1 交往了并且调整了它的 dephosphorylation。一起拿,这研究在 STAT 发信号的规定并且在人的癌症细胞生长的可能的抑制揭示 CuI 的分子的机制。更重要地,这研究揭开在调整 STAT 发信号的肌动朊和联系肌动朊的发信号建筑群的一个新奇角色。 | Hui GUO Shan KUANG Qiao-ling SONG Man LIU Xiao-xiao SUN Qiang YU | 2018 | Acta Pharmacologica Sinica2018，39，3： | 8 |
| 13 | Transfer of the IL-37b gene elicits anti-tumor responses in mice bearing 4T1 breast cancer显示文摘目的: IL-37b 除了它的反煽动性的性质显示出反癌症活动。在这研究,我们在老鼠并且到在胸癌生长上调查了 IL-37b 的效果在效果决定 T 房间激活的参与。 | Wei-qiang WANG Dan ZHAO Yu-shan ZHOU Xiao-yu HU Zhi-na SUN Gang YU Wan-tong WU Song CHEN Jiu-long KUANG Guo-gang XU Zhong-chao HAN Bang-mao WANG Jing-xian YANG Xiao-ming FEN | 2015 | Acta Pharmacologica Sinica2015，36，4： | 7 |
| 14 | Stress-strain partitioning analysis of constituent phases in dual phase steel based on the modified law of mixture显示文摘A more accurate estimation of stress-strain relationships for martensite and ferrite was developed, and the modified law of mixture was used to investigate the stress-strain partitioning of constituent phases in dual phase (DP) steels with two different martensite volume fractions. The results show that there exist great differences in the stress-strain contribution of martensite and ferrite to DP steel. The stress-strain partitioning coefficient is not constant in the whole strain range, but decreases with increasing the true strain of DP steel. The softening effect caused by the dilution of carbon concentration in martensite with the increase of martensite volume fraction has great influence on the strain contribution of martensite. The strain ratio of ferrite to martensite almost linearly increases with increasing the true strain of DP steel when the martensite volume fraction is 22%, because martensite always keeps elastic. But the strain ratio of ferrite to martensite varies indistinctively with the further increase in true strain of DP steel above 0.034 when the martensite volume fraction is 50%, because plastic deformation happens in martensite. The stress ratio of martensite to ferrite decreases monotonously with increasing the true strain of DP steel whether the martensite volume fraction is 22% or 50%. | Shuang Kuang Yong-lin Kang Hao Yu Ren-dong Liu | 2009 | International Journal of Minerals,Metallurgy and Materials2009，16，4： | 7 |
| 15 | Preparation and characterization of chitosan porous microcarriers for hepatocyte culture显示文摘BACKGROUND: The bioartificial liver (BAL) is considered a possible alternative method for treating liver failure. The core of the BAL system is culturing liver cells in vitro with high density and activity. Microcarrier culture is a mode of high-density culture. We set out to prepare a novel porous microcarrier to improve the activity of liver cells in vitro. METHODS: Chitosan was used to prepare a novel porous spherical microcarrier with interconnected structure. The chitosan porous microcarriers (CPMs) were modified with gelatin to improve their biocompatibility. CPMs were co-cultured with liver cells, HL-7702 (L-02), to evaluate their effect on cell culture. RESULTS: The average size of the CPMs was about 400 μm in diameter and their apertures were less than 30 μm. The pores of the microcarrier were interconnected. After fixation by sodium tripolyphosphate, the structure of the first freeze-dried CPMs was stable. To further improve the biocompatibility, the surface of CPMs was modified with gelatin through chemical crosslinking (GM-CPMs). Comparing the proliferation curves of L-02 cells cultured on simple CPMs, GM-CPMs and tissue culture polystyrene (TCPS, a mode of planar cell culture), the proliferation rates were similar in the first 5 days and the cells proliferated until day 8 in culture with microcarriers. The OD value of liver cells cultured on GM-CPMs was 1.97-fold higher than that on TCPS culture at day 8. Levels of urea and albumin in supernatants of cells cultured on GM-CPMs increased steadily for 8 days, and were clearly higher than those of cells cultured on TCPS (P<0.05).CONCLUSIONS: The novel CPMs were promising microcarriers for hepatocyte culture and the GM-CPM seemed better. Porous microcarrier culture was beneficial for hepatocyte function and activity. | Xu-Bo Wu, Cheng-Hong Peng, Fang Huang, Jie Kuang, Song-Lin Yu, Ya-Dong Dong and Bao-San Han Center of Organ Transplantation, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China Department of General Surgery, Central Hospital, Minhang District, Shanghai 201100, China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 6 |
| 16 | Proteomic Analysis of the Response of Liangyoupeijiu(Super High-Yield Hybrid Rice) Seedlings to Cold Stress显示文摘Liangyoupeijiu 是超级产量很高的杂交稻。尽管有它关于产量和谷物质量的优点,它对寒冷敏感,它阻止它广泛地被栽培。我们使 Liangyoupeijiu 幼苗遭到了到 4 ° C 寒冷处理,然后提取了叶蛋白质。在 2-D 胶化电气泳动分离和帮助矩阵的激光 desorption/ionizationtime-of-flight 质谱法分析以后,一系列差别显示了蛋白质被识别。联系新陈代谢的蛋白质在 down 之中被发现的一些调整了蛋白质,如此的 ascarbamoyl 磷酸盐合成酶, transketolase 1, dihydrolipoamide 脱氢酶和 glyceraldehyde3 磷酸盐脱氢酶。起来调整蛋白质包括了两压力抵抗蛋白质如此的 asnucleoside diphosphate kinase 我和为米饭生长是否定的蛋白质例如 FtsH-likeprotein,质体熔化或 translocation 因素(Pftf ) 和肌动朊。我们的结果显示那感冒可以通过减少的新陈代谢的活动和损坏细胞结构禁止 Liangyoupeijiu 生长。 | Ping-Fang Yang Xiao-Juan Li Yu Liang Yu-Xiang Jing Shi-Hua Shen Ting-Yun Kuang | 2006 | Journal of Integrative Plant Biology2006，48，8： | 6 |
| 17 | Anti-inflammatory effects of characterized orange peel extracts enriched with bioactive polymethoxyflavones显示文摘In view of the potential of polymethoxyflavones(PMFs)and hydroxylated PMFs(OH-PMFs)as bioactives against inflammation,we prepared six different orange peel extracts(OPEs).The major compounds of these extracts were characterized and quantified by high performance liquid chromatography(HPLC).Effects on inflammation were analyzed by nutrigenomics using a human cell-based TPA-induced monocyte–macrophage differentiation model employing U-937 cells and inflammatory surrogate genes.Dose response and kinetics analysis of OPEs with different chemical profiles revealed less cytotoxic effects of PMFs as compared to OH-PMFs as demonstrated by the MTT-method.Noteworthy,a comparison of two PMF members such as 3,5,6,7,3,4-hexamethoxyflavone(HexaMF)and 3,5,6,7,8,3,4-heptamethoxyflavone(HeptaMF)exhibited less cytotoxic effects of HeptaMF as compared to HexaMF.A specific OPE enriched with HeptaMF,PMFs and OH-PMFs at low concentrations(10g/mL)significantly down-regulated the expression of a panel of genes involved in inflammatory response,including COX-2,TNF-α,ICAM-1,NFκB,IL-1β,IL-6,and IL-8 with an inflammatory index of−0.55.The strong anti-inflammatory effects were then validated in a mouse carrageenan-induced paw edema model.Oral intake of OPE reduced paw edema significantly in a dose-dependent manner.Importantly,a dosage of 250 mg/kg gave an anti-inflammatory effect comparable to ibuprofen.A preliminary clinical study showed that OPE was well tolerated showing no adverse side effects.In summary,enrichment of phyto extracts such as OPEs with specific polymethoxyflavones as anti-inflammatory bioactives is a promising strategy to find naturally derived extracts that are effective against diseases associated with inflammation.©2014 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Alexander Gosslau Kuang Yu Chen Chi-Tang Ho Shiming Li | 2014 | Food Science and Human Wellness2014，3，1： | 5 |
| 18 | Comparison of nonhuman primates identified the suitable model for COVID-19显示文摘Identification of a suitable nonhuman primate(NHP)model of COVID-19 remains challenging.Here,we characterized severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in three NHP species:Old World monkeys Macaca mulatta(M.mulatta)and Macaca fascicularis(M.fascicularis)and New World monkey Callithrix jacchus(C.jacchus).Infected M.mulatta and M.fascicularis showed abnormal chest radiographs,an increased body temperature and a decreased body weight.Viral genomes were detected in swab and blood samples from all animals.Viral load was detected in the pulmonary tissues of M.mulatta and M.fascicularis but not C.jacchus.Furthermore,among the three animal species,M.mulatta showed the strongest response to SARS-CoV-2,including increased inflammatory cytokine expression and pathological changes in the pulmonary tissues.Collectively,these data revealed the different susceptibilities of Old World and New World monkeys to SARS-CoV-2 and identified M.mulatta as the most suitable for modeling COVID-19. | Shuaiyao Lu Yuan Zhao Wenhai Yu Yun Yang Jiahong Gao Junbin Wang Dexuan Kuang Mengli Yang Jing Yang Chunxia Ma Jingwen Xu Xingli Qian Haiyan Li Siwen Zhao Jingmei Li Haixuan Wang Haiting Long Jingxian Zhou Fangyu Luo Kaiyun Ding Daoju Wu Yong Zhang Yinliang Dong Yuqin Liu Yinqiu Zheng Xiaochen Lin Li Jiao Huanying Zheng Qing Dai Qiangming Sun Yunzhang Hu Changwen Ke Hongqi Liu Xiaozhong Peng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 19 | Recent Progress of Aerosol Light-scattering Enhancement Factor Studies in China显示文摘Assessment of the radiative forcing of aerosols in models still lacks sufficient input data for aerosol hygroscopicity. The light scattering enhancement factor [ f(RH, λ)] is a crucial parameter for describing aerosol hygroscopic growth properties.In this paper, we provide a survey of f(RH, λ) studies in China for the past seven years, including instrument developments of humidified nephelometers, ambient f(RH, λ) measurements in China, f(RH, λ) parameterization schemes, and f(RH, λ)applications in aerosol measurements. Comparisons of different f(RH, λ) parameterizations are carried out to check their performance in China using field measurement datasets. We also summary the parameterization schemes for predicting f(RH, λ)with aerosol chemical compositions. The recently developed methods to observe other aerosol properties using f(RH, λ)measurements, such as calculating the aerosol hygroscopicity parameter, cloud condensation nuclei number concentration,aerosol liquid water content, and aerosol asymmetry factor, are introduced. Suggestions for further research on f(RH, λ) in China are given. | Chunsheng ZHAO Yingli YU Ye KUANG Jiangchuan TAO Gang ZHAO | 2019 | Advances in Atmospheric Sciences2019，36，9： | 5 |
| 20 | Stromatolite characteristics of Mesoproterozoic Shennongjia Group in the northern margin of Yangtze Block, China显示文摘Mesoproterozoic Shennongjia Group in Shennongjia Area can be divided into three subgroups in ascender order. Of which the lower subgroup includes Yingwodong, Dayanping, Macaoyuan, Luanshigou, Dawokeng and Kuangshishan formations;the middle subgroup is formed by Yemahe, Wenshuihe and Shicaohe formations;the upper subgroup consists of Songziyuan and Wagangxi formations. Stromatolites developed very well in the carbonate rocks of each subgroup in Shennongjia Group. Based on descriptions of stromatolites macrotypes and their characteristics, this paper studied the formation environments, discussed the relationship among types, sizes, abundance of stromatolites and sedimentary environment, and established the formation and development pattern of stromatolites. As a result, this research also reveals the paleoenvironment and paleoclimate during the period of the Shennongjia Group deposited, which is beneficial to the study of paleoenvironment, paleogeography and paleoclimate, stratigraphic succession and regional correlation of the northern edge of Yangtze block. Stromatolites of Shennongjia Group are mainly conical, columnar, domal, wavy, stratiform and stromatolite reefs. The columnar and conical stromatolites are well developed. Conical stromatolites are mainly monomers, with a variety of pyramidal types, ranging in diameter from a few millimeters to several meters and formed in the high energy subtidal zone and tidal lagoon environment. Most of the columnar stromatolites are medium to small sizes implied a wide and gentle slope environment at that time. Stratiform (including wavy) stromatolites are larger scales and extends far away and distributed most widely in almost every horizon in the carbonate rocks. Stratiform stromatolites can be formed in low energy environments such as subtidal and intertidal zones and supratidal belts. Wavy stromatolites often developed in the hydrodynamic energy condition from weak energy intertidal zone gradually strengthened to the below of the high energy supratidal. Although stromatolite reefs can be a single or multiform combination, they developed mainly consisted of laminar or small walled columnar and large domal stromatolites. Shicaohe Formation also partially developed large domical stromatolites, the depositional environment is from the upper intertidal to supratidal zone. Stromatolite in Shennongjia Group usually appears as a combination of “Stratiform (wavy)-dome-columnar-coniform ” or “stratiform-dome-coniform-columnar-dome-stratiform ” vertieally, which represents the seawater depth from shallower to deeper or from shallow to deep and then to shallow again. These phenomenons generally reflected a stable sea level and companied with a high frequency oscillation. Comprehensive researches on the stratigraphy, sedimentary facies, sedimentary environment and the stromatolite types and their characteristics in the Shennongjia Group indicated that the Shennongjia Area is located on a gentle slope of carbonate platform in the passive continental edge, generally, i.e., one of warm and humid climate shallow water zone or/and a cold-drought climate, and had been experienced with eustatic cycles during the Shennongjia Group deposited. | Hong-wei Kuang Zheng-xiu Fan Yong-qing Liu Nan Peng Zhi-cai Zhu Zhen-rui Yang Zhi-xian Wang Hui-liang Yu Quan Zhong | 2019 | China Geology2019，2，3： | 5 |
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