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| 1 | Application of deep learning in ecological resource research:Theories, methods, and challenges显示文摘Ecological resources are an important material foundation for the survival,development,and self-realization of human beings.In-depth and comprehensive research and understanding of ecological resources are beneficial for the sustainable development of human society.Advances in observation technology have improved the ability to acquire long-term,cross-scale,massive,heterogeneous,and multi-source data.Ecological resource research is entering a new era driven by big data.Traditional statistical learning and machine learning algorithms have problems with saturation in dealing with big data.Deep learning is a method for automatically extracting complex high-dimensional nonlinear features,which is increasingly used for scientific and industrial data processing because of its ability to avoid saturation with big data.To promote the application of deep learning in the field of ecological resource research,here,we first introduce the relationship between deep learning theory and research on ecological resources,common tools,and datasets.Second,applications of deep learning in classification and recognition,detection and localization,semantic segmentation,instance segmentation,and graph neural network in typical spatial discrete data are presented through three cases:species classification,crop breeding,and vegetation mapping.Finally,challenges and opportunities for the application of deep learning in ecological resource research in the era of big data are summarized by considering the characteristics of ecological resource data and the development status of deep learning.It is anticipated that the cooperation and training of cross-disciplinary talents may promote the standardization and sharing of ecological resource data,improve the universality and interpretability of algorithms,and enrich applications with the development of hardware. | Qinghua GUO Shichao JIN Min LI Qiuli YANG Kexin XU Yuanzhen JU Jing ZHANG Jing XUAN Jin LIU Yanjun SU Qiang XU Yu LIU | 2020 | Science China Earth Sciences2020，63，10： | 7 |
| 2 | In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells显示文摘Circulating tumor cells(CTCs)is an established biomarker of cancer metastasis.The circulation dynamics of CTCs are important for understanding the mechanisms underlying tumor cell dissemination.Although studies have revealed that the circadian rhythm may disrupt the growth of tumors,it is generally unclear whether the circadian rhythm controls the release of CTCs.In clinical examinations,the current in vitro methods for detecting CTCs in blood samples are based on a fundamental assumption that CTC counts in the peripheral blood do not change significantly over time,which is being challenged by recent studies.Since it is not practical to draw blood from patients repeatedly,a feasible strategy to investigate the circadian rhythm of CTCs is to monitor them by in vivo detection methods.Fluoresce nee in vivo flow cytometry(IVFC)is a powerful optical technique that is able to detect fluoresce nt circulating cells directly in living animals in a noninvasive manner over a long period of time.In this study,we applied fluorescence IVFC to monitor CTCs noninvasively in an orthotopic mouse model of human prostate cancer.We observed that CTCs exhibited stochastic bursts over cancer progression.The probability of the bursting activity was higher at early stages than at late stages.We longitudinally monitored CTCs over a 24-h period,and our results revealed striking daily oscillations in CTC counts that peaked at the onset of the night(active phase for rodents),suggesting that the release of CTCs might be regulated by the circadian rhythm. | Xi Zhu Yuanzhen Suo Yuting Fu Fuli Zhang Nan Ding Kai Pang Chengying Xie Xiaofu Weng Meilu Tian Hao He Xunbin Wei | 2021 | Light(Science & Applications)2021，10，6： | 6 |
| 3 | Geohazard Recognition and Inventory Mapping Using Airborne LiDAR Data in Complex Mountainous Areas显示文摘Geohazard recognition and inventory mapping are absolutely the keys to the establishment of reliable susceptibility and hazard maps. However, it has been challenging to implement geohazards recognition and inventory mapping in mountainous areas with complex topography and vegetation cover. Progress in the light detection and ranging(Li DAR) technology provides a new possibility for geohazard recognition in such areas. Specifically, this study aims to evaluate the performances of the Li DAR technology in recognizing geohazard in the mountainous areas of Southwest China through visually analyzing airborne Li DAR DEM derivatives. Quasi-3 D relief image maps are generated based on the sky-view factor(SVF), which makes it feasible to interpret precisely the features of geohazard. A total of 146 geohazards are remotely mapped in the entire 135 km^(2) study area in Danba County, Southwest China, and classified as landslide, rock fall, debris flow based on morphologic characteristics interpreted from SVF visualization maps. Field validation indicate the success rate of Li DAR-derived DEM in recognition and mapping geohazard with higher precision and accuracy. These mapped geohazards lie along both sides of the river, and their spatial distributions are related highly to human engineering activities, such as road excavation and slope cutting. The minimum geohazard that can be recognized in the 0.5 m resolution DEM is about 900 m^(2). Meanwhile, the SVF visualization method is demonstrated to be a great alternative to the classical hillshaded DEM method when it comes to the determination of geomorphological properties of geohazard. Results of this study highlight the importance of Li DAR data for creating complete and accurate geohazard inventories, which can then be used for the production of reliable susceptibility and hazard maps and thus contribute to a better understanding of the movement processes and reducing related losses. | Chen Guo Qiang Xu Xiujun Dong Weile Li Kuanyao Zhao Huiyan Lu Yuanzhen Ju | 2021 | Journal of Earth Science2021，32，5： | 6 |
| 4 | One compound approach combining factor-analytic model with AMMI and GGE biplot to improve multi-environment trials analysis显示文摘To improve multi-environmental trial(MET)analysis,a compound method—which combines factor analytic(FA)model with additive main effect and multiplicative interaction(AMMI)and genotype main effect plus genotype-by-environment interaction(GGE)biplot—was conducted in this study.The diameter at breast height of 36 open-pollinated(OP)families of Pinus taeda at six sites in South China was used as a raw dataset.The best linear unbiased prediction(BLUP)data of all individual trees in each site was obtained by fitting the spatial effects with the FA method from raw data.The raw data and BLUP data were analyzed and compared by using the AMMI and GGE biplot.BLUP results showed that the six sites were heterogeneous and spatial variation could be effectively fitted by spatial analysis with the FA method.AMMI analysis identified that two datasets had highly significant effects on the site,family,and their interactions,while BLUP data had a smaller residual error,but higher variation explaining ability and more credible stability than raw data.GGE biplot results revealed that raw data and BLUP data had different results in mega-environment delineation,test-environment evaluation,and genotype evaluation.In addition,BLUP data results were more reasonable due to the stronger analytical ability of the first two principal components.Our study suggests that the compound method combing the FA method with the AMMI and GGE biplot could improve the analysis result of MET data in Pinus teada as it was more reliable than direct AMMI and GGE biplot analysis on raw data. | Weihua Zhang Jianlin Hu Yuanmu Yang Yuanzhen Lin | 2020 | Journal of Forestry Research2020，31，1： | 4 |
| 5 | Microglia modulation with 1070-nm light attenuates Aβ burden and cognitive impairment in Alzheimer’s disease mouse model显示文摘Photobiomodulation,by utilizing low-power light in the visible and near-infrared spectra to trigger biological responses in cells and tissues,has been considered as a possible therapeutic strategy for Alzheimer’s disease(AD),while its specific mechanisms have remained elusive.Here,we demonstrate that cognitive and memory impairment in an AD mouse model can be ameliorated by 1070-nm light via reducing cerebralβ-amyloid(Aβ)burden,the hallmark of AD.The glial cells,including microglia and astrocytes,play important roles in Aβclearance.Our results show that 1070-nm light pulsed at 10 Hz triggers microglia rather than astrocyte responses in AD mice.The 1070-nm lightinduced microglia responses with alteration in morphology and increased colocalization with Aβare sufficient to reduce Aβload in AD mice.Moreover,1070-nm light pulsed at 10 Hz can reduce perivascular microglia and promote angiogenesis to further enhance Aβclearance.Our study confirms the important roles of microglia and cerebral vessels in the use of 1070-nm light for the treatment of AD mice and provides a framework for developing a novel therapeutic approach for AD. | Lechan Tao Qi Liu Fuli Zhang Yuting Fu Xi Zhu Xiaofu Weng Hongbin Han Yong Huang Yuanzhen Suo Liang Chen Xiaoling Gao Xunbin Wei | 2021 | Light(Science & Applications)2021，10，10： | 4 |
| 6 | Enhancement of potassium resistance of Ce-Ti oxide catalyst for NH_(3)-SCR reaction by modification with holmium显示文摘Alkali metal K in exhaust gas has a deactivation effect on NH_(3)-SCR catalysts.In this work,it is discovered that the addition of Ho on CeTi catalyst can remarkably strengthen its K tolerance.The conclusions of Brunauer-Emmett-Teller(BET),X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),NH_(3) temperature programmed desorption(NH_(3)-TPD)and H_(2)temperature programmed reduction(H_(2)-TPR)analyses demonstrate that the enhancement of K resistance mainly originates from its stronger surface acidity and redox capability,the higher concentration of Ce^(3+)species and surface chemisorbed oxygen.In situ DRIFT analysis reveals that the introduction of Ho on CeTi can remarkably improve the adsorption of NH_(3) and NO_(x) species on catalyst surface,accompanied by the intensified reactivity of ad-NH_(3) species,which should also administer to improve the K resistance. | Chaopeng Duan Ruitang Guo Yuanzhen Liu Guilin Wu Yufang Miao Jingwen Gu Weiguo Pan | 2022 | Journal of Rare Earths2022，40，1： | 3 |
| 7 | A multicenter retrospective cohort study of ketogenic diet therapy in 481 children with infantile spasms显示文摘Background:Ketogenic diet(KD)therapy is one of the main treatments for drug-resistant epilepsy.However,the KD therapy has been applied in only a small number of infantile spasm cases.In this large multicenter study,we investigated the efficacy of KD therapy in the treatment of infantile spasms.Methods:In this retrospective,multicenter cohort study,clinical data from main epilepsy centers were analyzed.Patients were classified into different groups according to age,type of drug and whether glucocorticoid was used before initiation of KD.Results:From October 2014 to March 2020,481 patients(308 males and 173 females)with infantile spasms were treated with the KD therapy.The age of the patients ranged from 2 months to 20 years,with a mean age of 1 year and 10 months.The number of anti-seizure medications(ASMs)used before KD initiation ranged 0-6,with a median of 3.In different time from initiation(1,3,6,and 12 months),the rates of seizure freedom after KD were 6.9,11.6;16.0 and 16.8%,respectively(x^(2)=27.1772,P<0.0001).There was a significant difference in the rate of seizure freedom between 3 months and 1 month(x^(2)=6.5498,P=0.0105)groups,and 6 months and 3 months(x^(2)=3.8478,P=0.0498)groups,but not between 12 months and 6 months(x^(2)=0.1212,P=0.7278)groups.The rates of effectiveness were 44.7;62.8,49.1 and 32.0%(x^(2)=93.2674,P<0.0001),respectively.The retention rates were 94.0,82.5,55.7 and 33.1%(x^(2)=483.7551,P<0.0001),correspondingly.The rate of effectiveness and the retention rate of KD were significantly different among the 1,3,6 and 12 months.KD treatment was the first choice in 25 patients(5.2%),55 patients(11.4%)started KD after the failure of the first ASM,158 patients(32.8%)started KD after the failure of the second ASM,157 patients(32.6%)started KD after the failure of the third drug,and 86 patients(17.9%)started KD after the failure of the fourth and more.The KD effect was not related to the number of ASMs used before KD startup(P>0.05).Two hundred and eighteen patients(45.3%)failed to respond to corticotropin or glucocorticoid before initiation.There was no significant difference in the effectiveness rate at different time points between the group of KD therapy after glucocorticoid failure and the group after non-hormone failure (x^(2)=0.8613,P=0.8348).The rate of adverse events of KD in 1,3,6,and 12 months after KD initiation were 22.3,21.7,16.8 and 6.9%,respectively.The adverse events mainly occurred during the first 3 months of KD,and the main adverse events were gastrointestinal disturbance and constipation.Conclusions:The efficacy of the KD treatment for infantile spasms was not affected by age,medication,and glucocorticoid use before initiation.KD is one of the effective treatments for infantile spasms. | Yuanzhen Ye Dan Sun Hua Li Jianmin Zhong Rong Luo Baomin Li Dengna Zhu Dan Li Shaoping Huang Yuwu Jiang Nong Xiao Yucai Chen Yuqin Zhang Mei Yu Xiaoyun Shen Li Gao Guo Zheng Congmin Zhao Baoqiang Yuan Jianxiang Liao Jiong Qin CAAE KD group | 2022 | Acta Epileptologica2022，5，1： | 2 |
| 8 | Reply to Comment on “In vivo flow cytometry reveals a circadian rhythm of circulating tumor cells”显示文摘Dear Editor,We thank Niedre et al.for their correspondence regarding our recent paper1.They proposed a point that the temporal distribution of circulating tumor cells(CTCs)monitored by diffuse in vivo flow cytometry in a multiple myeloma mouse model in their previous work2 might be different from our results.Niedre et al.claimed that CTC detection statistics deviated from Poisson but did not found circadian variations in CTC numbers in a multiple myeloma mouse model.They also cite another literature by Juratli.et al.3,in which the authors reported that CTC numbers did not always correlate with tumor size during cancer progression.However,by establishing an orthotopic mouse model of prostate cancer and utilizing the technology in vivo flow cytometry(IVFC),we found CTCs exhibited bursting activity and daily oscillation in an orthotopic model of prostate cancer. | Xi Zhu Yuanzhen Suo Yuting Fu Fuli Zhang Nan Ding Kai Pang Chengying Xie Xiaofu Weng Meilu Tian Hao He Xunbin Wei | 2021 | Light(Science & Applications)2021，10，10： | 2 |
| 9 | On the Connectivity of One-dimensional Vehicular Ad Hoc Networks显示文摘In this paper we analyze connectivity of one-dimensional Vehicular Ad Hoc Networks where vehicle gap distribution can be approximated by an exponential distribution. The probabilities of Vehicular Ad Hoc Network connectivity for difference cases are derived. Furthermore we proof that the nodes in a sub-interval [z1,z1 +Δz] of interval [0, z], z>0 where all the nodes are independently uniform distributed is a Poisson process and the relationship of Vehicle Ad hoc Networks and one-dimensional Ad Hoc networks where nodes independently uniform distributed in [z1,z1 +Δz] is explained. The analysis is validated by computing the probability of network connectivity and comparing it with the Mont Carlo simulation results. | Liao Jianxin Li Yuanzhen Li Tonghong Zhu Xiaomin Zhang Lei | 2010 | China Communications2010，7，2： | 2 |
| 10 | The angular characteristics of Moon-based Earth observations显示文摘The Moon,Earth’s only natural satellite,is a potential new platform for Earth observation.Moreover,with the wide applicability of the angular information from remote sensing data,it has been attracting increasingly more attention.Accordingly,this study focuses on the angular characteristics of Moon-based Earth observations.Using ephemeris DE430 and Earth orientation parameters,the position and attitude of the Sun,Earth,and Moon were obtained and their coordinates normalized to a single framework using coordinate transformations between the related reference systems.Then,an angular geometric model of Moon-based Earth observations was constructed,and the corresponding angular algorithms were presented.The results revealed the angular range and distribution characteristics of Moon-based Earth observations.For every point on the surface of the Earth,the view and solar zenith angles all vary widely,which decreases with increasing latitude.The view and solar zenith angles all vary widely with the largest range of values in the equatorial and polar regions and a smaller range of values in mid-latitudes.Furthermore,the range of solar angles of Moon-based Earth observations is the same as that of alltime solar angles,indicating the potential for monitoring and understanding large-scale geoscientific phenomena using Moon-based Earth observations. | Huadong Guo Yuanzhen Ren Guang Liu Hanlin Ye | 2020 | International Journal of Digital Earth2020，13，3： | 1 |
| 11 | Induetion of a program gene expression during osteoblast differentiation with strontium ranelate显示文摘 | ZHU Lingling ZAIDI S PENG Yuanzhen | 2007 | Biochem Biophys Res Commun2007，355，2： | 1 |
| 12 | Mix design for re-cycled aggregate thermal insulation concrete with mineral admi-xtures显示文摘 | WANG Wenjing ZHAO Lin LIU Yuanzhen | 2014 | Magazine of Concrete Research2014，66，10： | 1 |
| 13 | Simuhaneous Determination of Quercetin and Luteolin in Dried Flowers by Multivariate HPLC-ECD Calibration显示文摘 | Zhou Yuanzhen Liu Xiaoxing Zheng Xiaohui | 2007 | Chromatographia2007，66，78： | 1 |
| 14 | Mechanical prop- erties and Stress- strain relationship in axial compression for thermal insulation concrete using construction waste显示文摘 | Wenjing Wang Lin Zhao Yuanzhen Iu | 2014 | Construc- tion and Building Materials2014，71，11： | 1 |
| 15 | Seismie behavior ofrecycled aggregate thermal insulation concrete (Ratic) shear walls显示文摘 | Gang Ma Yu Zbang Yuanzhen Liu et a/ | 2015 | Mbgazine of Concrete Research2015，67，3： | 1 |
| 16 | Severe Flooding in Yangtze-Huaihe rivers-A response to El Nino events显示文摘 | Bao Chenglan | 1993 | Journal of Agricultural Meteorology1993，48，5： | 1 |
| 17 | Houttuynia cordata polysaccharides alleviate ulcerative colitis by restoring intestinal homeostasis显示文摘Houttuynia cordata is traditionally used as phytoantibiotics for treating lung disease in China.Houttuynia cordata polysaccharides(HCPs)have been reported to alleviate influenza virus-induced intestinal and lung immune injury by regulating the gutlung axis.The present study aims to investigate the effects and mechanisms of HCPs on ulcerative colitis(UC).Male C57BL/6 mice were induced by dextran sodium sulfate(DSS)to establish the UC animal model.Our results showed that HCPs significantly reduced the weight loss and the shortening of colon length in colitis mice,and relieved the pathological damage of colon mucosa and inhibited the expression of pro-inflammatory cytokines such as TNF-α,IL-1β,IL-6,etc.It was suggested that HCPs could significantly improve DSS-induced colitis in mice.HCPs directly protected intestinal epithelial cells,ameliorated epithelial barrier dysfunction and cell apoptosis,which was also proved in H2O2 stimulated cell apoptosis model.HCPs inhibited inflammation in the colon,which was related to suppressing the infiltration of macrophages,inhibiting the expression of pro-inflammatory cytokines and proteins(TLR4,NF-κB),and restoring the dysfunction of Th17 and Treg cells.HCPs also restored the alteration of intestinal flora induced by DSS,increased the abundance of Firmicutes and Bacteroides,and reduced the abundance of Proteobacteria.This study confirmed the protective effect of Houttuynia cordata polysaccharide extracted from traditional Chinese medicine on ulcerative colitis,of which the mechanism was closely related to the maintenance of intestinal homeostasis(intestinal barrier,immune cells,and intestinal bacteria). | CEN Lifeng YI Tong HAO Yuanzhen SHI Chenchen SHI Xunlong LU Yan CHEN Daofeng ZHU Haiyan | 2022 | Chinese Journal of Natural Medicines2022，20，12： | 1 |
| 18 | Induction of a program gene expression during osteoblast differentiation with strontium ranelate 显示文摘 | Ling-Ling Z Samir Z Yuanzhen P | 2007 | Biochemical and Biophysical Research Communications2007，，355： | 1 |
| 19 | Consensus of heterogeneous first‐ and second‐order multi‐agent systems with directed communication topologies显示文摘 | Yuanzhen Feng Shengyuan Xu Frank L. Lewis Baoyong Zhang | 2015 | Robust Nonlinear Control2015，，： | 1 |
| 20 | Hierarchical and lamellar porous carbon as interconnected sulfur host and polysulfide-proof interlayer for Li–S batteries显示文摘A robust three-dimensional(3D)interconnected sulfur host and a polysulfide-proof interlayer are key components in high-performance Li–S batteries.Herein,cellulose-based 3D hierarchical porous carbon(HPC)and two-dimensional(2D)lamellar porous carbon(LPC)are employed as the sulfur host and polysulfide-proof inter-layer,respectively,for a Li–S battery.The 3D HPC displays a cross-linked macroporous structure,which allows high sulfur loading and restriction capability and provides unobstructed electrolyte diffusion channels.With a stackable carbon sheet of 2D LPC that has a large plane view size and is ultrathin and porous,the LPC-coated separator effectively inhibits polysulfides.An optimized combination of the HPC and LPC yields an electrode structure that effectively protects the lithium anode against corrosion by polysulfides,giving the cell a high ca-pacity of 1339.4 mAh g^(-1) and high stability,with a capacity decay rate of 0.021% per cycle at 0.2C.This work provides a new understanding of biomaterials and offers a novel strategy to improve the performance of Li–S batteries for practical applications. | Peifan Wang Xin Dai Peng Xu Sijiang Hu Xuyang Xiong Kunyang Zou Shengwu Guo Junjie Sun Chaofeng Zhang Yongning Liu Tengfei Zhou Yuanzhen Chen | 2023 | eScience2023，3，1： | 1 |
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