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| 1 | Ephedrine hydrochloride inhibits PGN-induced inflammatory responses by promoting IL-10 production and decreasing proinflammatory cytokine secretion via the PI3K/Akt/GSK3β pathway显示文摘 | Yuejuan Zheng Yang Yang Yuhu Li Limin Xu Yi Wang Ziyi Guo Haiyan Song Muyi Yang Beier Luo Aoxiang Zheng Ping Li Yan Zhang Guang Ji Yizhi Yu | 2013 | Cellular & Molecular Immunology2013，10，4： | 4 |
| 2 | Future Research Trend for Improving Large Reflector Antenna Service Performance显示文摘A large reflector antenna is one of the key components of a deep space telemetry track and command(TT&C)network,which is of great importance for human space activities,such as satellite communication,spaceflight,and deep space exploration[1].The main feature of this antenna type is its large aperture and often it requires strict surface accuracy to ensure high gain and high pointing performance[2,3].There are two kinds of reflector antennas:non-fully movable antenna and fully steerable antenna.The Fivehundred-meter Aperture Spherical Radio Telescope in China is one representative non-fully movable antenna with a super large aperture and low operation frequency.The fully steerable reflector antennas worldwide can be further divided into four categories according to their aperture diameters and highest operation frequencies,as shown in Fig.1.Most of the antennas in Fig.1 can be found in Ref.[4]and the details are not presented here.Category 1 includes the traditional reflectors with large apertures and low operation frequencies. | Peiyuan Lian Congsi Wang Song Xue Yan Wang Yuefei Yan Qian Xu Baoyan Duan Na Wang Yuhu Duan Yang Wu | 2021 | Engineering2021，7，8： | 2 |
| 3 | Retrorsine Cooperates with Gut Microbiota to Promote Hepatic Sinusoidal Obstruction Syndrome by Disrupting the Gut Barrier显示文摘Background and Aims:Hepatic sinusoidal obstruction syndrome(HSOS)is a life-threatening syndrome,and a cause is exposure to pyrrolizidine alkaloid(PA)-containing products.It is well-established that retrorsine(RTS),a rep-resentative Pas,insults hepatic sinusoidal endothelial cells and ensues congestion of hepatic sinusoids.However,little known about the impact of Pas on gut microbiota and intesti-nal barrier and inflammation in HSOS.Methods:Mice were gavaged with or without nonabsorbable antibiotics(ABX),followed by a single dose of RTS.The gut microbiota was examined by 16S rDNA sequencing.Results:ABX pretreat-ment significantly reversed RTS-induced liver damage.RTS altered gut microbiota composition,increasing Gram-nega-tive bacteria and resulting in a sharp elevation of circulating lipopolysaccharides(LPS)in HSOS mice.Gut decontamina-tion with ABX alleviated RTS-induced intestine inflamma-tion,protected against disruption of the intestinal epithelial barrier and gut vascular barrier(GVB),and suppressed he-patic LPS-NF-κB pathway activation in RTS-induced HSOS.Importantly,the LPS level was positively correlated with MELD score in patients with HSOS.Elevated LPS in patients with HSOS confirmed that Gram-negative bacteria were in-volved in the pathogenesis of HSOS.Conclusions:RTS,a PA,cooperated with gut dysbiosis to cause intestinal inflam-mation and gut barrier compromise that increased transport of gut-derived LPS into the liver through the portal vein,which contributed to the pathology of HSOS.Modulating the gut microbiota,protecting the intestinal barrier,and sup-pressing intestinal inflammation with prebiotics or antibiot-ics might be a useful pharmacologic intervention in HSOS. | Li Xiao Lilin Hu Huikuan Chu Liuying Chen Jingjing Yan Weijun Wang Xiaoqian Yang Qingjing Zhu Fan Du Yuhu Song Peng Chen Xiaohua Hou Ling Yang | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 2 |
| 4 | Clinical study about the treatment of ECMO in CPR显示文摘 | Yu Kun Long Cun Song Yuhu | 2006 | Chinese Journal of critical care medicine2006，26，： | 1 |
| 5 | Recommendations for the diagnosis and treatment of paroxysmal kinesigemc dyskinesia: an expert consensus in China显示文摘Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes.Paroxysmal kinesigenic dyskinesia(PKD)is the most common type of paroxysmal dyskinesia and can be divided into primary and secondary types based on the etiology.Clinically,PKD is characterized by recurrent and transient attacks of involuntary movements precipitated by a sudden voluntary action.The major cause of primary PKD is genetic abnormalities,and the inheritance pattern of PKD is mainly autosomal-dominant with incomplete penetrance.The proline-rich transmembrane protein 2(PRRT2)was the first identified causative gene of PKD,accounting for the majority of PKD cases worldwide.An increasing number of studies has revealed the clinical and genetic characteristics,as well as the underlying mechanisms of PKD.By seeking the views of domestic experts,we propose an expert consensus regarding the diagnosis and treatment of PKD to help establish standardized clinical evaluation and therapies for PKD.In this consensus,we review the clinical manifestations,etiology,clinical diagnostic criteria and therapeutic recommendations for PKD,and results of genetic analyses in PKD patients performed in domestic hospitals. | Li Cao Xiaojun Huang Ning Wang Zhiying Wu Cheng Zhang Weihong Gu Shuyan Cong Jianhua Ma Ling Wei Yanchun Deng Qi Fang Qi Niu Jin Wang Zhaoxia Wang You Yin Jinyong Tian Shufen Tian Hongyan Bi Hong Jiang Xiaorong Liu Yang Lu Meizhen Sun Jianjun Wu Erhe Xu Tao Chen Tao Chen Xu Chen Wei Li Shujian Li Qinghua Li Xiaonan Song Ying Tang Ping Yang Yun Yang Min Zhang Xiong Zhang Yuhu Zhang Ruxu Zhang Yi Ouyang Jintai Yu Quanzhong Hu Qing Ke Yuanrong Yao Zhe Zhao Xiuhe Zhao Guohua Zhao Furu Liang Nan Cheng Jianhong Han Rong Peng Shengdi Chen Beisha Tang | 2021 | Translational Neurodegeneration2021，10，1： | 1 |
| 6 | Predictive Model of Ursodeoxycholic Acid Treatment Response in Primary Biliary Cholangitis显示文摘Background and Aims:Although ursodeoxycholic acid(UDCA)treatment in primary biliary cholangitis is effective in many patients,there are still many people who respond poorly to it.Identifying and intervening these patients early is important.Therefore,exploring the risk factors and proposing a predictor index to predict the UDCA treatment nonresponse earlier among primary biliary cholangitis patients were the aims of this research.Methods:A total of 135 primary biliary cholangitis patients treated with UDCA(13–15 mg/kg/d)were enrolled in this retrospective study.The response to treatment was evaluated based on Paris I criteria.The univariate and logistic multivariate regression analyses were adopted to determine the independent risk factors and propose a predictor index.Receiver operating characteristic curve was used to evaluate the predictive ability of the predictor index.Results:Total bilirubin,albumin,globulin,immunoglobin M,and aspartate aminotransferase-to-platelet ratio index were the five independent risk factors associating with early biochemical nonresponse to UDCA treatment.Based on these factors,we established a predictor index with the predictive value being 0.886(sensitivity:82.80%,specificity:84.40%).Conclusions:We developed a predictor index that had an accurate prediction of the early biochemical nonresponse to UDCA treatment,which is expected to provide valuable information for the high-risk group before treatment begins. | Yanyun Shu Yuhu Song Tao Bai Xiaoli Pan Haitao Shang Ling Yang Jin Ye Fan Du | 2021 | Journal of Clinical and Translational Hepatology2021，9，2： | 1 |
| 7 | β‐2 Spectrin is involved in hepatocyte proliferation through the interaction of TGF β/Smad and PI 3K/ AKT signalling显示文摘 | Zhijun Wang Yuhu Song Wei Tu Xingxing He Jusheng Lin Fang Liu | 2012 | Liver Int2012，，7： | 1 |
| 8 | 2 - 8 Oblate Band Structures in Odd-odd 186Au显示文摘 | Li Shicheng Zhang Yuhu Zhou Xiaohong Ding Bing Guo Song Li Guangshun Zhou Houbing M. Oshima Y. Toh M. Koizumi A. Osa A. Kimura Y. Hatsukawa M. Sugawara H. Kusakari | 2010 | IMP & HIRFL Annual Report2010，，1： | 0 |
| 9 | Experimental Study of High-Spin Band Structures of ^(183)Au显示文摘High-spin states in 183Au have been studied experimentally by using the 159Tb(29Si, 5n)183Au reaction at a beam energy of 140 MeV. The 29Si beam of 8 pnA was provided by the accelerator complex of the Tandem-XTU and ALPI at the Laroratori Nazionali di Legnero, Italy, and focussed onto a natural metallic 159Tb foil of | Song Litao Zhou Xiaohong Zhang Yuhu Guo Yingxiang Lei Xiangguo Zheng Yong Liu Minliang G. de Angelis N. Marginean A. Gadea D. R. Napoli M. Axiotis C. Rusu T. Martinez | 2004 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2004，，1： | 0 |
| 10 | First Observation of Signature Inversion in πh_(9/2) ■ vi_(13/2) Oblate Band in ^(190)Tl显示文摘The high-spin states of 190Tl, populated via the 160Gd(35Cl, 5n)190Tl fusion-evaporation reaction at 167 and 175 MeV beam energies, have been investigated by in-beam γ-ray spectroscopy. Based on the experiment measured results, together with references to the previous in-beam work and the studies of the 194Bi αdecay, the level scheme of 190Tl has been established as shown in Fig.1. Spins for the levels above the 300 keV 10-state were proposed from the measured DCO and γ-ray anisotropy results. It is the first time that spin | Xie Chengying Zhou Xiaohong Zhang Yuhu Guo Yingxiang Lei Xiangguo Song Litao Wang Hualei Liu Minliang Zheng Yong Guo Wentao Yu Haiping Luo Peng Wen Shuxian Zhu Lihua Wu Xiaoguang | 2004 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2004，，1： | 0 |
| 11 | 2-2 Complete and Incomplete Fusion of 9Be + 169Tm, 187Re at Near-barrier Energies显示文摘Fusion cross sections with weakly bound nuclei have been a subject of great interest in the last few years[1;2]. Inthis field, the basic question is whether complete fusion (CF) is enhanced or suppressed due to diffused density andhigh probability of breakup. The answer to this question depends on the energy regime (above or below Coulombbarrier) and on different target mass regions. Therefore, one important approach to investigate this subject is tostudy the systematic behavior of the CF suppression as a function of the target mass or charge.For fusion induced by 9Be, there are some reported works on the CF on different targets, ranging from 89Y to209Bi[2], but the suppression factor of the CF at near barrier energies does not follow a systematic behavior. Forlighter targets, like 27Al and 64Zn [3;4] and for 238U[5], only total fusion (TF) cross sections were measured. Inorder to contribute to the investigation of the fusion of 9Be, we performed experiments to measure complete andincomplete fusion (ICF) of 9Be on the 187Re and 169Tm targets at energies close to the Coulomb barrier. | Fang Yongde Zhang Ningtao Li Guangshun Liu Minliang Wang Jianguo Guo Song Qiang Yunhua Zhou Xiaohong Zhang Yuhu Lei Xiangguo Zheng Yong Gao Bingshui He Xiaofeng Wang Kailong Ding Bing | 2014 | IMP & HIRFL Annual Report2014，，1： | 0 |
| 12 | Signature Inversion in πh_(9/2)vi_(13/2) Oblate Bands in Doubly Odd Thallium Nuclei显示文摘The high-spin states of neutron-deficient doubly odd nucleus 190Tl have been investigated via the 160Gd (35Cl,5n)19Tl reaction at 167 and 175 MeV beam energies by using techniques of in-beamγ-ray spectroscopy. Measurements of X-γandγ-γ-t coincidences were performed with 12 BGO(AC)HPGe detectors. The detailed results of the present work have been reported.With the configuration and spin-parity as- | Xie Chengying, Zhou Xiaohong, Zhang Yuhu, Guo Yingxiang, Lei Xiangguo, Song Litao Wang Hualei, Zheng Ypng, Liu Minliang and Guo Wentao | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 13 | Signature Inversion in High-j Two-quasiparticle Bands in Odd-Odd ^(174)Re显示文摘High spin states in 174Re have been re-investigated via the 152Sm(27Al,5n)174 Re reaction at a bombarding energy of 14-0 MeV. The 27Al beam was provided by the JAERI tandem accelerator and impinged on an enriched 152Sm metallic foil of 2 mg/cm2 thickness. From detailed analysis ofγ-ray excitation functions, | Gou Song Zhang Yuhu Zhou Xiaohong Ma Long M. Oshima Y. Toh M. Koizumi A. Osa A. Kimura Y. Hatsukawa M. Sugawara H. Kusakari | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 14 | Study of Collective Rotational Bands in ^(179)Pt显示文摘In-beamγ-ray spectroscopic experiment for the deformed odd-A nucleus 179Pt has been performed via the 149Sm(35Cl, p4n) reaction at beam energy of 180 MeV. The 35Cl beam was provided by the tandem accelerator at the Japan Atomic Energy Research Institute (JAERI). The target was an isotopic 149Sm foil of 1. 5 mg /cm2 thickness with a 5 me/cm2 Pb backing. Based on the measured results, three rotational | Xu Yanbing Zhou Xiaohong Zhang Yuhu Song Litao Guo Yingxiang Sun Zhiyu M. Oshima T. Toh A. Osa M. Koizumi J. Katakura Y. Hatsukawa M. Matsuda M. Sugawara | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 15 | Identification of a Low-spin Isomer in ^(176)Ir显示文摘Theβ+/EC decay of doubly odd 176Ir has been studied via the 146Nd(35Cl,5nγ) heavy ion fusion evaporation reaction at the Sector-Focusing Cyclotron (SFC) accelerator in the Institute of Modern Physics (IMP), Lanzhou. A 210 MeV 35C1 beam from the cyclotron entered a helium-filed target chamber, | Wang Hualei, Zhang Yuhu, Zhou Xiaohong, Guo Yingxiang, Lei Xiangguo, Xu Shuwei Xie Yuanxiang,Liu Minliang, Zheng Yong, Xing Yebing, Xie Chengying, Song Litao Lou Peng, Yu Haiping, Guo Wentao,Ding Huajie and Niu Yanning | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 16 | Fenofibrate in a patient with primary biliary cholangitis with an inadequate response to bezafibrate显示文摘To the Editor,A 48-year-old male patient presented to our hospital with abnormal liver function.The results of his liver function tests were as follows:alanine transaminase,118 U/L(normal range,5-35 U/L);aspartate transaminase,86 U/L(8-40 U/L);alkaline phosphatase(ALP),246 U/L(40-150 U/L);andγglutamyl transferase(γ-GT),792 U/L(17-53 U/L).His immunoglobulin(Ig)G and IgM levels were 13.0 g/L(7.51-15.60 g/L)and 2.44 g/L(0.460-3.040 g/L),respectively,and his autoimmune antibody tests were positive for antinuclear antibodies and M2 subtype antimitochondrial antibodies. | Yangyang Zhou Haonan Gao Yuhu Song | 2023 | Portal Hypertension & Cirrhosis2023，2，4： | 0 |
| 17 | Partical-core Coupling in ^(139)Ce显示文摘The high-spin states in 139Ce have been populated via the 130Te(12C, 3n) 139Ce reaction by using techniques of in-beamγ-ray spectroscopy. The 12C beam at 50 MeV energy was provided by the HI-13 tandem accelerator at the China Institute of Atomic Energy, Beijing. The 130Te target is an enriched metallic foil of about 1. 4 mg/cm2 thickness with a 9 mg/cm2 197Au backing to stop the recoiling nuclei. 14 BGO(AC) | Hua Wei, Zhou Xiaohong, Zhang Yuhu, Guo Yingxiang, Lei Xiangguo Xie Chengying,Song Litao and Wang Hualei | 2005 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2005，，1： | 0 |
| 18 | Construction and expression of hepatitis B virus vector encoding TC-tagged core protein显示文摘Virus tagged with greenfluorescent protein(GFP)contributes to the visualization and study of the virus in living cells.However,the hepatitis B virus(HBV)particle,which is a compact virion with limited internal space,cannot be incorporated with GFP tag as a large fragment.It was recently reported that protein genetically inserted with a smaller size tetracysteine(TC)tag could be specially labeled by a biarsenicalfluorescent dye in living cells.In this study,we constructed a recombinant HBV vector encoding TC-tagged core protein for biarsenical labeling of HBV virion.TC tag was genetically inserted near the immunodominant c/e1 site of HBV core protein by mutagenesis.Western blot and enzyme-linked immu-nosorbent assay(ELISA)analysis showed that the TC-tagged core protein,hepatitis B surface antigen(HBsAg)and hepatitis B e antigen(HBeAg)could be expressed in cells transfected with the recombinant HBV vector,which is similar to the cells transfected with wild-type HBV vector.Reverse transcription-polymerase chain reaction(RT-PCR)and Southern blot analysis showed that HBV virion formation was affected by the genetic insertion of TC tag into core protein in some degree,but cells transfected with the HBV vector could still produce HBV virions incorporated with TC-tagged core proteins.Taken together,the recombinant HBV vector can serve as a useful tool to produce HBV virions incorporated with TC-tagged core proteins to befluorescently labeled by biarsencial dye for visualizing and studying HBV in living cells. | Yuanyuan LIN Xiaoming CHENG Yuhu SONG Li ZHOU Peiyuan LI Ying CHANG Leiming XU Jinjian YAO Jusheng LIN | 2009 | Frontiers of Medicine2009，3，4： | 0 |
| 19 | Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines显示文摘To investigate the regulation of tumor sup-pressor XAF1 gene expression in digestive system cancers,we studied XAF1 gene promoter transcription activity and mRNA level in digestive system cancer cell lines(human hepatoma cell line HepG2,human colon cancer cell line LoVo,and human gastric cancer cell line AGS)and nontumor cell lines(human embryonic liver cell line L02(L02 cells)and human embryonic kidney 293 cells[HEK293 cells])as controls.1395-bp-promoter fragment of XAF1 gene was amplified by polymerase chain reaction(PCR)and cloned into pGL3-basic vector and pEGFP-1 vector to assay its promoter transcription activity.The plasmids were transfected into a variety of cell lines by lipofectamine 2000.The promoter transcription activity was determined by dual-luciferase report assay,and enhanced greenfluorescent protein(EGFP)-positive cells were detected byfluorescence microscope.The expression of XAF1 mRNA in HEK293 and L02 were significantly higher than that in any of the three digestive system cancer cell lines.The dual-luciferase reporter assay showed that the promoter transcription activity in digestive system tumor cell lines transfected with pGL3-XAF1p promoter was apparently lower than that of both HEK293 and L02 cells.Expression of greenfluorescent protein(GFP)under the control of XAF1 promoter in the three digestive system cancer cell lines was lower than that of both HEK293 and L02 cells.The activities of pGL3-XAF1p in the three digestive system cancer cell lines after treatment with heat stress were significantly lower than those in the unstressed cells.The results suggested that remarkably down-regulated XAF1 mRNA expression in digestive system cancer cell lines may be due to loss of transcription activity of XAF1 promoter. | Qiong CHEN Qing YU Yuhu SONG Peiyuan Li Ying CHANG Zhijun WANG Lifeng LIU Wei WU Jusheng LIN | 2009 | Frontiers of Medicine2009，3，2： | 0 |
| 20 | 2-3 Lifetime Measurement of the First 7/2^+State in 143Eu Based on Gas-flled Spectroscopy显示文摘The application of Lanthanum Bromide(LaBr3)detectors provides a unique opportunity to measure lifetime of excited states in picosecond-nanosecond region.Reducing the background is of critical importance to get precise results.For some excited states feeding from isomers with lifetime longer than 1μs,it can be achieved by the Spectrometer for Heavy Atom and Nuclear Structure(SHANS)[1].143Eu nuclei were populated via the 123Sb(24Mg,4n)fusion-evaporation reaction.Most of the evaporation residues at ground state or long-lived isomers were transferred to detection terminal after a flight of about 1.4μs in SHANS.In the case of 143Eu,three transitions have been observed(Fig.1). | Guo Song Wang Kailong Liu Minliang Zheng Yong Zhou Xiaohong Wang Jianguo Qiang Yunhua Zhang Yuhu Gan Zaiguo Zhang Zhiyuan Ma Long Yang Huabin Yu Lin Ding Bing Jiang Jian Fang Yongde Li Guangshun Zheng Kuankuan | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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