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| 1 | Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor显示文摘According to the World Health Organization(WHO)newly updated situation report on March 18th,2020,the coronavirus disease 2019(COVID-19)pandemic has confirmed 191,127 cases and claimed 7807 deaths worldwide.1 The etiological agent of COVID-19 has been identified as a novel coronavirus,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),belonging to Sarbecovirus subgenus(genus Betacoronavirus,family Coronaviridae)and showing 79.6 and 96.2%sequence identity in nucleotide to SARS-CoV and a bat coronavirus(BatCoV RaTG13),respectively.2–4 Like SARS-CoV infection,a substantial fraction of COVID-19 patients exhibits severe respiratory symptoms and has to be hospitalized in intensive care unit.5–8 Although the mortality rate of COVID-19 is significantly lower than that of SARS-CoV infection,SARS-CoV-2 shows much higher human-to-human transmission rate,rapidly leading to a global pandemic declared by WHO on March 11th,2020. | Xiangyu Chen Ren Li Zhiwei Pan Chunfang Qian Yang Yang Renrong You Jing Zhao Pinghuang Liu Leiqiong Gao Zhirong Li Qizhao Huang Lifan Xu Jianfang Tang Qin Tian Wei Yao Li Hu Xiaofeng Yan Xinyuan Zhou Yuzhang Wu Kai Deng Zheng Zhang Zhaohui Qian Yaokai Chen Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，6： | 17 |
| 2 | Intelligent control of mode-locked femtosecond pulses by time-stretch-assisted real-time spectral analysis显示文摘Mode-locked fiber lasers based on nonlinear polarization evolution can generate femtosecond pulses with different pulse widths and rich spectral distributions for versatile applications through polarization tuning.However,a precise and repeatable location of a specific pulsation regime is extremely challenging.Here,by using fast spectral analysis based on a time-stretched dispersion Fourier transform as the spectral discrimination criterion,along with an intelligent polarization search algorithm,for the first time,we achieved real-time control of the spectral width and shape of mode-locked femtosecond pulses;the spectral width can be tuned from 10 to 40 nm with a resolution of ~1.47 nm,and the spectral shape can be programmed to be hyperbolic secant or triangular.Furthermore,we reveal the complex,repeatable transition dynamics of the spectrum broadening of femtosecond pulses,including five middle phases,which provides deep insight into ultrashort pulse formation that cannot be observed with traditional mode-locked lasers. | Guoqing Pu Lilin Yi Li Zhang Chao Luo Zhaohui Li Weisheng Hu | 2020 | Light(Science & Applications)2020，9，1： | 16 |
| 3 | Small interfering RNA targeted to secretory clusterin blocks tumor growth, motility, and invasion in breast cancer显示文摘Clusterin/apolipoprotein J (Clu ) 是在几个生理的过程被含有的无所不在地表示的分泌 heterodimeric glycoprotein。这被报导了分泌 clusterin (sClu ) 的提高的水平蛋白质在乳癌病人与差的幸存被联系并且能在啮齿类动物模型导致转移。在这研究,我们在 vitro 并且在 vivo 在细胞活动性,侵略,和生长上与小介入 RNA (siRNAs ) 调查了 sClu 抑制的效果。MDA-MB-231 房间是有 pSuper-siRNA/sClu 的 transfected。房间幸存和增长被 3-(4,5-dimethyl-thiazol-2yl ) 检验 -5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium 和 clonogenic 幸存试金。结果证明 sClu silencing 显著地禁止了 MDA-MB-231 房间的增长。侵略和迁居能力戏剧性地也被减少,它被 matrigel 试金检测。染色的 TUNEL 和 caspase-3 活动试金证明 sClu silencing 能也增加房间的 apoptosis 率,导致房间生长的抑制。我们也在一个 orthotopic 乳癌模型在肿瘤生长和变形前进上决定了 sClu silencing 的效果。结果比肿瘤源于父母 MDA-MB-231 或 MDA-MB-231/pSuper 的证明主要肿瘤从 MDA-MB-231/pSuper sClu siRNA 房间导出的 orthotopic 变得显著地慢爬 siRNA 房间,并且少些转移到肺。这些数据建议能分泌的 clusterin 在肿瘤生长和变形前进起一个重要作用。敲门下面 sClu 基因表示可以为乳癌治疗提供一个珍贵方法。 | Zhaohe Niu Xinhui Li Bin Hu Rong Li Ligang Wang Lilin Wu Xingang Wang | 2012 | Acta Biochimica et Biophysica Sinica2012，44，12： | 6 |
| 4 | The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection显示文摘Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)cells.The histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1,TH2 and regulatory T(Treg)cells.However,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain unknown.Using a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1 cells.Ablation of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH maintenance.Mechanistically,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell commitment.Therefore,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection. | Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin Wang Zhiwei Pan Jianbao Gao Qin Tian Lifan Xu Zhirong Li Yaxing Hao Qizhao Huang Pengcheng Wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu Liu Li Hu Jianfang Tang Ran He Li Wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng Sun Bo Zhu Jun Huang Lilin Ye | 2020 | Cellular & Molecular Immunology2020，17，3： | 4 |
| 5 | Automatic mode-locking fiber lasers: progress and perspectives显示文摘Polarization control in nonlinear polarization rotation based mode-locked fiber lasers is a longterm challenge.Suffering from the polarization drifts induced by environmental disturbances,nonlinear polarization rotation based mode-locked fiber lasers is difficult in continuously operating under the desired pulsation regime thereby substantially hindering their utilizations.The appearance of automatic modelocking techniques brings the light in addressing this challenge.Combining with various algorithms and electrical polarization control,automatic mode-locking techniques resolve the dilemma of nonlinear polarization rotation based mode-locked fiber lasers.We review the research progress of automatic mode-locking techniques in detail.Furthermore,we comment on the perspectives and potential applications of automatic mode-locking techniques. | Guoqing PU Li ZHANG Weisheng HU Lilin YI | 2020 | Science China(Information Sciences)2020，63，6： | 4 |
| 6 | Fabrication and application of a graphene polarizer with strong saturable absorption显示文摘By transferring 100 nm gold-coated CVD monolayer graphene onto the well-polished surface of D-shaped fiber, we achieve a graphene in-line polarizer with a high polarization extinction ratio of ~27 d B and low insertion loss of 5 d B at 1550 nm, meanwhile achieving a strong saturable absorption effect of 14%. The manufacture of this graphene in-line polarizer also simplifies the graphene transfer process. To explore the potential applications of the new device, we also demonstrate noise-like pulse generation and supercontinuum spectrum generation. By launching the designed graphene device into a fiber ring laser cavity, 51 nm bandwidth noise-like pulse is obtained. Then, launching the high-power noise-like pulse into high nonlinear fiber, a 1000 nm wide supercontinuum spectrum is obtained, which is favorable for sensing and nonlinearities scientific fields. | Weixiong Li Lilin Yi Ran Zheng Zhenghua Ni Weisheng Hu | 2016 | Photonics Research2016，4，2： | 2 |
| 7 | The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity显示文摘The adaptive immunity that protects patients from coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is not well characterized.In particular,the asymptomatic patients have been found to induce weak and transient SARS-CoV-2 antibody responses,but the underlying mechanisms remain unknown;meanwhile,the protective immunity that guide the recovery of these asymptomatic patients is elusive.Here,we characterized SARS-CoV-2-specific B-cell and T-cell responses in 10 asymptomatic patients and 64 patients with other disease severity(mild,n=10,moderate,n=32,severe,n=12)and found that asymptomatic or mild symptomatic patients failed to mount virus-specific germinal center(GC)B cell responses that result in robust and prolonged humoral immunity,assessed by GC response indicators including follicular helper T(TFH)cell and memory B cell responses as well as serum CXCL13 levels.Alternatively,these patients mounted potent virus-specific TH1 and CD8+T cell responses.In sharp contrast,patients of moderate or severe disease induced vigorous virus-specific GC B cell responses and associated TFH responses;however,the virus-specific TH1 and CD8+T cells were minimally induced in these patients.These results,therefore,uncovered the protective immunity in asymptomatic patients and also revealed the strikingly dichotomous and incomplete humoral and cellular immune responses in COVID-19 patients with different disease severity,providing important insights into rational design of effective COVID-19 vaccines. | Leiqiong Gao Jing Zhou Sen Yang Lisha Wang Xiangyu Chen Yang Yang Ren Li Zhiwei Pan Jing Zhao Zhirong Li Qizhao Huang Jianfang Tang Li Hu Pinghuang Liu Guozhong Zhang Yaokai Chen Lilin Ye | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 8 | Retrorsine Cooperates with Gut Microbiota to Promote Hepatic Sinusoidal Obstruction Syndrome by Disrupting the Gut Barrier显示文摘Background and Aims:Hepatic sinusoidal obstruction syndrome(HSOS)is a life-threatening syndrome,and a cause is exposure to pyrrolizidine alkaloid(PA)-containing products.It is well-established that retrorsine(RTS),a rep-resentative Pas,insults hepatic sinusoidal endothelial cells and ensues congestion of hepatic sinusoids.However,little known about the impact of Pas on gut microbiota and intesti-nal barrier and inflammation in HSOS.Methods:Mice were gavaged with or without nonabsorbable antibiotics(ABX),followed by a single dose of RTS.The gut microbiota was examined by 16S rDNA sequencing.Results:ABX pretreat-ment significantly reversed RTS-induced liver damage.RTS altered gut microbiota composition,increasing Gram-nega-tive bacteria and resulting in a sharp elevation of circulating lipopolysaccharides(LPS)in HSOS mice.Gut decontamina-tion with ABX alleviated RTS-induced intestine inflamma-tion,protected against disruption of the intestinal epithelial barrier and gut vascular barrier(GVB),and suppressed he-patic LPS-NF-κB pathway activation in RTS-induced HSOS.Importantly,the LPS level was positively correlated with MELD score in patients with HSOS.Elevated LPS in patients with HSOS confirmed that Gram-negative bacteria were in-volved in the pathogenesis of HSOS.Conclusions:RTS,a PA,cooperated with gut dysbiosis to cause intestinal inflam-mation and gut barrier compromise that increased transport of gut-derived LPS into the liver through the portal vein,which contributed to the pathology of HSOS.Modulating the gut microbiota,protecting the intestinal barrier,and sup-pressing intestinal inflammation with prebiotics or antibiot-ics might be a useful pharmacologic intervention in HSOS. | Li Xiao Lilin Hu Huikuan Chu Liuying Chen Jingjing Yan Weijun Wang Xiaoqian Yang Qingjing Zhu Fan Du Yuhu Song Peng Chen Xiaohua Hou Ling Yang | 2022 | Journal of Clinical and Translational Hepatology2022，10，6： | 2 |
| 9 | Classification performance of model coal mill classifiers with swirling and non-swirling inlets显示文摘The classification performance of model coal mill classifiers with different bottom incoming flow inlets was experimentally and numerically studied.The flow field adjacent to two neighboring impeller blades was measured using the particle image velocimetry technique.The results showed that the flow field adjacent to two neighboring blades with the swirling inlet was significantly different from that with the non-swirling inlet.With the swirling inlet,there was a vortex located between two neighboring blades,while with the nonswirling inlet,the vortex was attached to the blade tip.The vorticity of the vortex with the non-swirling inlet was much lower than that with the swirling inlet.The classifier with the non-swirling inlet demonstrated a larger cut size than that with the swirling inlet when the impeller was stationary(~0 r·min-1).As the impeller rotational speed increased,the cut size of the cases with non-swirling and swirling inlets both decreased,and the one with the non-swirling inlet decreased more dramatically.The values of the cut size of the two classifiers were close to each other at a high impeller rotational speed(≥120 r·min-1).The overall separation efficiency of the classifier with the non-swirling inlet was lower than that with the swirling inlet,and monotonically increased as the impeller rotational speed increased.With the swirling inlet,the overall separation efficiency first increased with the impeller rotational speed and then decreased when the rotational speed was above 120 r·min-1,and the variation trend of the separation efficiency was more moderate.As the initial particle concentration increased,the cut sizes of both swirling and non-swirling inlet cases decreased first and then barely changed.At a low initial particle concentration(b 0.04 kg·m-3),the classifier with the swirling inlet had a larger cut size than that with the non-swirling inlet. | Lele Feng Hai Zhang Lilin Hu Yang Zhang Yuxin Wu Yuzhao Wang Hairui Yang | 2020 | Chinese Journal of Chemical Engineering2020，28，3： | 1 |
| 10 | Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19显示文摘COVID-19 patients exhibit differential disease severity after SARS-CoV-2 infection.It is currently unknown as to the correlation between the magnitude of neutralizing antibody(NAb)responses and the disease severity in COVID-19 patients.In a cohort of 59 recovered patients with disease severity including severe,moderate,mild,and asymptomatic,we observed the positive correlation between serum neutralizing capacity and disease severity,in particular,the highest NAb capacity in sera from the patients with severe disease,while a lack of ability of asymptomatic patients to mount competent NAbs.Furthermore,the compositions of NAb subtypes were also different between recovered patients with severe symptoms and with mild-tomoderate symptoms.These results reveal the tremendous heterogeneity of SARS-CoV-2-specific NAb responses and their correlations to disease severity,highlighting the needs of future vaccination in COVID-19 patients recovered from asymptomatic or mild illness. | Xiangyu Chen Zhiwei Pan Shuai Yue Fei Yu Junsong Zhang Yang Yang Ren Li Bingfeng Liu Xiaofan Yang Leiqiong Gao Zhirong Li Yao Lin Qizhao Huang Lifan Xu Jianfang Tang Li Hu Jing Zhao Pinghuang Liu Guozhong Zhang Yaokai Chen Kai Deng Lilin Ye | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 11 | Key technologies in chaotic optical communications显示文摘在这篇论文,混乱光通讯的关键技术和研究进步被考察。我们首先基于不同非线性的部件讨论混乱产生方法。然后,我们集中于混乱光通讯的边疆,包括怎么改进关于传播能力和在实验室和领域的混乱光通讯的距离的安全,和发展。最后,我们讨论混乱光通讯的限制和潜力并且得出一个结论。 | Junxiang KE Lilin YI Tongtong HOU Weisheng HU | 2016 | Frontiers of Optoelectronics2016，9，3： | 1 |
| 12 | Clinicopathological analysis of 17 cases of papillary Padge disease显示文摘 | LI Tao HU Qjchan YANG Lilin | 2012 | Med & Pharm J Chin PLA2012，24，5： | 1 |
| 13 | Scheduling problem for hot-rolling seamless steel tube production显示文摘Taking the seamless tube plant of Baoshan Iron & Steel Complex in China as the background,we analyze the characters of hot rolling seamless steel tube:multi varieties,low volume,complicated production process,flexible production routes.Then integrated scheduling problem for hot rolling seamless steel tube production is studied,which covers two key points;order-grouping problem and solution method for flowshop/jobshop scheduling problem.On the basis of these two problems,integrated scheduling decision system is developed.The design idea,function flow sheet,data processing method,and functional module of visualized human-computer interactive scheduling system implemented in seamless steel tube plant of Shanghai Baoshan Iron & Steel Complex are described into detail.Compared with manual system,the performance of system shows the applicability and superiority in several criteria. | HUO Jiazhen~(1)),LILin~(1,2)) and LI Hu~(1)) 1) School of Economics and Management TongJi University,Shanghai 20009,China 2) School of Business,East China University of Science and Technology,Shanghai 200237,China | 2010 | Baosteel Technical Research2010，4，S1： | 1 |
| 14 | Key technologies and system proposals of TWDM-PON显示文摘In this paper, key technologies, system proposals and future directions of next generation passive optical networks stage 2 (NG-PON2) are reviewed. We first discuss the potential solutions for NG-PON2 standardiza- tion. Then we focus on time and wavelength division multiplexed PON (TWDM-PON), which is the primary solution selected by Full Service Access Network (FSAN). The key technologies in TWDM-PON configuration are analyzed, including how to improve the bandwidth capacity and power budget of the system, and choose upstream tunable transceiver, etc. Several system proposals are illustrated as candidates for NG-PON2 configuration. | Zhengxuan LI Lilin YI Weisheng HU | 2013 | Frontiers of Optoelectronics2013，6，1： | 1 |
| 15 | The epidemic status and genetic diversity of 14 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) isolates from China in 2009显示文摘 | Zhi Zhou Jianqiang Ni Zhen Cao Xue Han Yingju Xia Zhanchao Zi Kun Ning Qi Liu Lin Cai Peng Qiu Xiaoyu Deng Dongmei Hu Qian Zhang Yunfeng Fan Jiajun Wu Lilin Wang Miaojie Zhang Xiuling Yu Xinyan Zhai Kegong Tian | 2011 | Veterinary Microbiology2011，，3： | 1 |
| 16 | Whole genome variants across 57 pig breeds enable comprehensive identification of genetic signatures that underlie breed features显示文摘Background:A large number of pig breeds are distributed around the world,their features and characteristics vary among breeds,and they are valuable resources.Understanding the underlying genetic mechanisms that explain across-breed variation can help breeders develop improved pig breeds.Results:In this study,we performed GWAS using a standard mixed linear model with three types of genome variants(SNP,InDel,and CNV)that were identified from public,whole-genome,sequencing data sets.We used 469 pigs of 57 breeds,and we identified and analyzed approximately 19 million SNPs,1.8 million InDels,and 18,016 CNVs.We defined six biological phenotypes by the characteristics of breed features to identify the associated genome variants and candidate genes,which included coat color,ear shape,gradient zone,body weight,body length,and body height.A total of 37 candidate genes was identified,which included 27 that were reported previously(e.g.,PLAG1 for body weight),but the other 10 were newly detected candidate genes(e.g.,ADAMTS9 for coat color).Conclusion:Our study indicated that using GWAS across a modest number of breeds with high density genome variants provided efficient mapping of complex traits. | Jingya Xu Yuhua Fu Yan Hu Lilin Yin Zhenshuang Tang Dong Yin Mengjin Zhu Mei Yu Xinyun Li Yang Zhou Shuhong Zhao Xiaolei Liu | 2021 | Journal of Animal Science and Biotechnology2021，12，2： | 1 |
| 17 | An experimental study on ignition of single coal particles at low oxygen concentrations显示文摘An experimental study on the ignition of single coal particles at low oxygen concentrations (XO_(2)<21%) was conducted using a tube furnace. The surface temperature (Ts) and the center temperature (Tc) of the coal particles were obtained from the images taken by an infrared camera and thermocouples respectively. The ignition processes were recorded by a high-speed camera at different XO_(2) values and furnace temperatures Tw. Compared with literature experimental data obtained at a high XO_(2) value, the ignition delay time τi decreases more rapidly as XO_(2) increases at the low XO_(2) region. The responses of Ts and Tc to the variation of XO_(2) are different: Ts decreases while Tc remains nearly constant with increasing XO_(2) at a low XO_(2) value. In addition, τi is less sensitive to Tw while the ignition temperature Ti is more sensitive to Tw at a low XO_(2) value than in air. Observations of the position of flame front evolution illustrate that the ignition of a coal particle may change from a homogeneous mode to a heterogeneous or combined ignition mode as XO_(2) decreases. At a low XO_(2) value, buoyancy plays a more significant role in sweeping away the released volatiles during the ignition process. | Wantao YANG Yang ZHANG Lilin HU Junfu LYU Hai ZHANG | 2021 | Frontiers in Energy2021，15，1： | 1 |
| 18 | A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD显示文摘The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has caused a global pandemic of novel coronavirus disease(COVID-19).The neutralizing monoclonal antibodies(mAbs)targeting the receptor-binding domain(RBD)of SARS-CoV-2 are among the most promising strategies to prevent and treat COVID-19.However,SARS-CoV-2 variants of concern(VOCs)profoundly reduced the efficacies of most of mAbs and vaccines approved for clinical use.Herein,we demonstrated mAb 35B5 efficiently neutralizes both wild-type(WT)SARS-CoV-2 and VOCs. | Xiaofei Wang Ao Hu Xiangyu Chen Yixin Zhang Fei Yu Shuai Yue Arong Li Junsong Zhang Zhiwei Pan Yang Yang Yao Lin Leiqiong Gao Jing Zhou Jing Zhao Fang Li Yaling Shi Feng Huang Xiaofan Yang Yi Peng Luoyang Tu Huan Zhang Huanying Zheng Jun He Hui Zhang Lifan Xu Qizhao Huang Yongqun Zhu Kai Deng Lilin Ye | 2022 | Signal Transduction and Targeted Therapy2022，7，5： | 1 |
| 19 | Tunable gain - clamped double-pass Erbium - doped fiber amplifier显示文摘 | Lilin Yi Li Zhan Weisheng Hu | 2006 | OPTICS EXPRESS2006，14，2： | 1 |
| 20 | The lncRNA Snhgl-Vpsl3D vesicle trafficking system promotes memory CD8 T cell establishment via regulating the dual effects of IL-7 signaling显示文摘The efficient induction and long-term persistence of pathogen-specific memory CD8 T cells are pivotal to rapidly curb the reinfection.Recent studies indicated that long-noncoding RNAs expression is highly cell-and stage-specific during T cell development and differentiation,suggesting their potential roles in T cell programs.However,the key lncRNAs playing crucial roles in memory CD8 T cell establishment remain to be clarified.Through CD8 T cell subsets profiling of lncRNAs,this study found a key lncRNA-Snhgl with the conserved naivehl-effectorlo-memoryh,expression pattern in CD8 T cells of both mice and human,that can promote memory formation while impeding effector CD8 in acute viral infection.Further,Snhgl was found interacting with the conserved vesicle trafficking protein Vps13D to promote IL-7Ra membrane location specifically.With the deep mechanism probing,the results show Snhgl-Vps13D regulated IL-7 signaling with its dual effects in memory CD8 generation,which not just because of the sustaining role of STAT5-BCL-2 axis for memory survival,but more through the STAT3-TCF1-Blimp1 axis for transcriptional launch program of memory differentiation.Moreover,we performed further study with finding a similar high-low-high expression pattern of human SNHG1A/PS13D/IL7R/TCF7 in CD8 T cell subsets from PBMC samples of the convalescent COVID-19 patients.The central role of Snhgl-Vps13D-IL-7R-TCF1 axis in memory CD8 establishment makes it a potential target for improving the vaccination effects to control the ongoing pandemic. | Yanyan Zhang Baohua Li Qiang Bai Pengcheng Wang Gang Wei Zhirong Li Li Hu Qin Tian Jing Zhou Qizhao Huang Zhiming Wang Shuai Yue Jialin Wu Liuqing Yang Xinyuan Zhou Lubin Jiang Ting Ni Lilin Ye Yuzhang Wu | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 0 |
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