|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Controlling factors on the submarine canyon system: A case study of the Central Canyon System in the Qiongdongnan Basin, northern South China Sea显示文摘Based on an integrated analysis of high-resolution 2D/3D seismic data and drilling results, this study analyzes the tectonicsedimentary evolution of the Qiongdongnan Basin(QDNB) since the late Miocene, and discusses the controlling factors on the formation and development of the Central Canyon System(CCS). The sediment failures caused by the relative sea level falling might have discharged deposits from the slope to the canyon. The two suits of the infillings, i.e., turbidites and mass transport complex(MTC), were derived from the northwestern source and northern source, respectively. The sediment supplies, which differ significantly among different areas, might have led to the variations observed in the internal architectures. Tectonic transformation around 11.6 Ma had provided the tectonic setting for the CCS and formed an axial sub-basin in the central part of the Changchang Depression, which could be called the rudiment of the CCS. The tectonic activity of the Red River Fault(RRF) at about 5.7 Ma might have strengthened the hydrodynamics of the deposits at the junction of the Yinggehai Basin(YGHB) and the QDNB to trigger a high-energy turbidity current. The MTC from the northern continental slope system might have been constrained by the Southern Uplift, functioning as a barrier for the infillings of the CCS. Thanks to a sufficient sediment supply during the Holocene period and the paleo-seafloor morphology, the relief of modern central canyon with the starving landform in the eastern Changchang Depression might have been accentuated by deposition of sediments and vertical growth along the canyon flanks, where collapse deposits were widely developed. Corresponding to the segmentation of the CCS, the forming mechanisms of the canyon between the three segments would be different. The turbidite channel in the head area had likely been triggered by the abundant sediment supply from the northwestern source together with the fault activity at about 5.7 Ma of the RRF. The formation and evolution of the canyon in the western segment were caused by combined effects of the turbidite channel from the northwestern source, the MTC from the northern continental slope, and the paleo-seafloor geomorphology. In the eastern segment, the canyon was constrained by the tectonic transformation occurring at approximately 11.6 Ma and the insufficient sediment supply from the wide-gentle slope. | SU Ming ZHANG Cheng XIE XiNong WANG ZhenFeng JIANG Tao HE YunLong ZHANG CuiMei | 2014 | Science China Earth Sciences2014，57，10： | 21 |
| 2 | Gravity Flow on Slope and Abyssal Systems in the Qiongdongnan Basin,Northern South China Sea显示文摘新地震数据的学习在架并且在 Qiongdongnan 盆(QDNB ) 的深渊的设定上以内部建筑学和分发允许沉积严肃流动的鉴定。六种严肃流动类型被认出:(1 ) 有基础、一致的 truncational 的 turbidite 隧道压垂沿着架边和斜坡的关系,包括旁边地转移、使河床升高得垂直地的隧道建筑群;(2 ) 有塑造汤勺的形态学的滑坡在架裂缝上滑动步并且从变丑产生了糟糕巩固并且高水位线内容沉积;(3 ) 商业萧条在架斜坡上被限制,由一个异常斜坡坡度或由差错活动被触发;(4 ) turbidite 表建筑群(TSC ) 被归功于到盆地板扇子和斜坡扇子起源,偶尔由混浊水流喂深海洋的存款;(5 ) 沉积飘动在更低的斜坡盆地板发生,并且盖住约 400 km2 的一个区域,在越过海床流动的水流下面被产生;并且(6 ) 在深水区域的中央峡谷表示严肃流动的一种例外的类型碎片流动, turbidite 隧道,和 TSC 的一个协会创作了。它介绍平面 multisegment 和垂直多相的特征。在峡谷与好 petrophysical 性质联系的 Turbidite 能在 QDNB 被当作一个潜在的探索目标。 | SU Ming XIE Xinong LI Junliang JIANG Tao ZHANG Cheng HE Yunlong TIAN Shanshan ZHANG Cuimei | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 19 |
| 3 | Effects of biochar-based fertilizers on nutrient leaching in a tobacco-planting soil显示文摘Biochar is a soil amendment for increasing soil quality and decreasing nutrient leaching. However, there is little information on the impact of biochar-based fertilizer(BF) on soil nutrient leaching in agricultural soils. We conducted a soil column leaching experiment to study the effects of BF on the leaching of total nitrogen(TN), total phosphorus, and total potassium(TK) in tobacco soils. The distribution characteristics of NH_4^+-N, available P, and available K in soil profiles were analyzed after the application of BF. Biochar was prepared by pyrolysis of fluecured tobacco stems. It was applied at four levels, 0%, 3%,9%, and 15%(w/w), respectively, to the compound fertilizer. Compared with the control, the leaching loss of soil TN decreased by 8.36%, 6.72%, and 6.45%, and the loss of soil TK decreased by 9.18%, 9.31% and 11.82% in the 3%,9%, and 15% BF treatments, respectively. However, BF had no significant effect on the P leaching due to the low movement of P in the soil profile. In addition, the BF addition increased the immobilization of NH_4^+-N, available P, and available K in the soil profile. These results indicate that addition of BF to a tobacco-planting soil reduced nutrient leaching, and suggest that BF could be an effective method of applying biochar to agriculture fields. | Yunlong Li Jianzhong Cheng Xinqing Lee Yi Chen Weichang Gao Wenjie Pan Yuan Tang | 2019 | Acta Geochimica2019，38，1： | 13 |
| 4 | Seasonal bioconcentration of heavy metals in Onchidium struma(Gastropoda:Pulmonata)from Chongming Island,the Yangtze Estuary,China显示文摘The seasonal concentration changes of selected heavy metal Cd,Cr,Cu,Fe,Mn,Pb,and Zn in five tissues of marine gastropod Onchidium struma were studied in the Chongming Island,the Yangtze Estuary in April 2007,July 2006,September 2006,and November 2006,respectively.The results demonstrated that the bioconcentration factor of Cu(biomass/water) in all selected tissues was about 104 magnitudes,Fe and Cd were 103,Zn was 102,and Mn,Pb,and Cr were 101.Hepatopancreas was proven to be the dominant storage tissue of Cr,Cu,Mn,and Zn,whereas Fe and Pb were mainly stored in muscle and digenetic gland,and Cd was stored in vitelline gland and albumen gland.Additionally,it was found that Cu,Fe,Mn,and Zn were concentrated significantly by O.struma(whole-body) in summer or autumn,and Cd,Cr,and Pb increased slightly in spring and winter.Furthermore,the bioconcentration of Cr was nearly 2-fold higher and Zn was 1.6-fold higher in the water compared with the Water Quality Standard for Fisheries.With view of excessive amount of Pb,Cd,and Cu according to seafood standard,the consumption of O.struma might have the risk of health hazard. | LI Xiaobo JIA Linzhi ZHAO Yunlong WANG Qun CHENG Yongxu | 2009 | Journal of Environmental Sciences2009，21，2： | 7 |
| 5 | Effect of sulfate-reducing bacteria on corrosion of X80 pipeline steel under disbonded coating in a red soil solution显示文摘Effect of sulfate-reducing bacteria on the corrosion behaviors of API-X80 pipeline steel has been studied in crevices under simulated disbonded coatings in red soil solution.The results show that there are amounts of SRB in the crevice under the simulated disbonded coating in the red soil solution during the whole period of experiment.The electrochemical impedance spectroscopy shows that SRB can enhance the corrosion of the steel in the crevice under the simulated disbonded coating,and the thermodynamic analyses indicate that SRB can accelerate the corrosion of steel using not only sulfate but also ferric hydroxide as electron acceptors. | Boxin Wei Jin Xu Qi Fua Qingyu Qin Yunlong Bai Cheng Sun Chuan Wang Zhenyao Wang Wei Ke | 2021 | Journal of Materials Science & Technology2021，，28： | 4 |
| 6 | Low-strain TiP_(2)O_(7) withthree-dimensionalionchannelsas long-life and high-rate anode material for Mg-ion batteries显示文摘Rechargeable magnesium batteries are identified as a promising next-generation energy storage system,but their development is hindered by the anode−electrolyte−cathode incompatibilities and passivation of magnesium metal anode.To avoid or alleviate these problems,the exploitation of alternative anode materials is a promising choice.Herein,we present titanium pyrophosphate(TiP_(2)O_(7))as anode materials for magnesium-ion batteries(MIBs)and investigate the effect of the crystal phase on its magnesium storage performance.Compared with the me-tastable layered TiP_(2)O_(7),the thermodynamically stable cubic TiP_(2)O_(7) displays a better rate capability of 72 mAh g^(−1) at 5000 mA g^(−1).Moreover,cubic TiP_(2)O_(7) exhibits excellent cycling stability with the capacity of 60 mAh g^(−1) after 5000 cycles at 1000 mA g^(−1),which are better than pre-viously reported Ti-based anode materials for MIBs.In situ X-ray diffraction technology confirms the single-phase magnesiumion inter-calation/deintercalation reaction mechanism of cubic TiP_(2)O_(7) with a low volume change of 3.2%.In addition,the density functional theory calcu-lation results demonstrate that three-dimensional magnesiumion diffu-sion can be allowed in cubic TiP_(2)O_(7) with a low migration energy barrier of 0.62 eV.Our work demonstrates the promise of TiP_(2)O_(7) as high-rate and long-life anode materials for MIBs and may pave the way for further development of MIBs. | Fangyu Xiong Yalong Jiang Li Cheng Ruohan Yu Shuangshuang Tan Chen Tang Chunli Zuo Qinyou An Yunlong Zhao Jean-Jacques Gaumet Liqiang Mai | 2022 | Interdisciplinary Materials2022，1，1： | 3 |
| 7 | A recombinant receptor-binding domain in trimeric form generates protective immunity against SARSCoV-2 infection in nonhuman primates显示文摘A safe and effective vaccine is critical to combat the COVID-19 pandemic.Here,we developed a trimeric SARS-CoV-2 receptor-binding domain(RBD)subunit vaccine candidate that simulates the natural structure of the spike(S)trimer glycoprotein.Immunization with the RBD trimer-induced robust humoral and cellular immune responses,and a high level of neutralizing antibodies was maintained for at least 4.5 months.Moreover,the antibodies that were produced in response to the vaccine effectively cross-neutralized the SARS-CoV-2501Y.V2 variant(B.1.351).Of note,when the vaccine-induced antibodies dropped to a sufficiently low level,only one boost quickly activated the anamnestic immune response,conferring full protection against a SARSCoV-2 challenge in rhesus macaques without typical histopathological changes in the lung tissues.These results demonstrated that the SARS-CoV-2 RBD trimer vaccine candidate is highly immunogenic and safe,providing long-lasting,broad,and significant immunity protection in nonhuman primates,thereby offering an optimal vaccination strategy against COVID-19. | Limin Yang Deyu Tian Jian-bao Han Wenhui Fan Yuan Zhang Yunlong Li Wenqiang Sun Yanqiu Wei Xiaodong Tian Dan-dan Yu Xiao-li Feng Gong Cheng Yuhai Bi Yong-tang Zheng Wenjun Liu | 2021 | The Innovation2021，2，3： | 3 |
| 8 | A novel stochastic reaction-diffusion model of Ca^2+ blink in cardiac myocytes显示文摘In cardiac myocytes,the sarcoplasmic reticulum(SR)is the main storage organelle of free Ca^(2+).The concentration of free Ca^(2+)in the SR is 0.5–1.0 mmol/L and is 2–3 orders of magnitude greater than that in the cytosol.The SR is composed of interconnected cisternae(junctional SR,i.e.,JSR)and tubules(free SR network,i.e.,FSR)that extend throughout the cytosol[1].Ca^(2+)is released from the JSR into the cytosol via Ca^(2+)release units(CRUs, | Jinghui Li Wenjun Xie Xi Chen Yunlong Huo Heping Cheng Wenchang Tan | 2017 | Science Bulletin2017，62，1： | 2 |
| 9 | Establishment of two-dimensional gel electrophoresis for soybean protein isolate and its application显示文摘To optimize the conditions for the establishment of two-dimensional gel electrophoresis(2-DE)of soybean protein isolate(SPI),we investigated Ampholine mixture,anodic and cathodic electrolytes,loading amount of sample,acrylamide concentration,p H gradient and gel staining method in twodimensional gel electrophoresis to optimize the protein imaging conditions in two-dimensional gel.The results of mixed-level design experiments showed that Ampholine,loading amount and gel staining method had significant effect(P<0.05)on 2-DE of SPI.The optimal conditions were Ampholine mixture(pH 3–10+pH 5–7 or pH 4–6+pH 5–7),loading amount of 2 mg sample and silver staining.Although the acrylamide concentration of the gel,the p H gradient,the anodic and cathodic electrolyte solutions had significant statistical effects on the protein separation degree,the complexity of the protein composition and the visibility of the gel images were more inclined to the 12%gel,the 3–10 pH gradient and the H3PO4/NaOH electrolyte.According to the established conditions,the hydrolyzed products of SPI emulsion were determined by 2-DE,and the dynamic changes of protein in the process of enzymatic hydrolysis were described. | Xinkai Lu Yaoming Cui Junjun Guan Xue Liu Hao Zhu Xuyang Ji Jianzhang Zheng Yunlong Cheng Xiaofei Fu | 2020 | Grain & Oil Science and Technology2020，3，3： | 2 |
| 10 | CFD–DEM simulation of particle deposition characteristics of pleated air filter media based on porous media model显示文摘In this study, the three-dimensional physical model of pleated air filtration media was simplified to porous media model, and the calculation parameters of porous media were obtained based on experimental data. The model of V-shaped pleated air filter media is constructed, the height of the media pleat is 50 mm and the pleat thickness is 4 mm, the pleat angle is 3.7°. The Hertz-Mindlin contact model was modified by Johnson Kendall Roberts (JKR) adhesion contact model. The deposition process of particles in media was simulated based on computational fluid dynamics (CFD) theory and discrete element method (DEM). Results show that the CFD–DEM coupling method can be effectively applied to the macro research of pleated air filter media. The particles will form dust layer and dendrite structure on the fiber surface, and the dust layer will affect the subsequent air flow organization, and the dendrite structure will eventually form a “particle wall”. The formation of the “particle wall” will prevent the particles from moving further in the fluid domain, which makes area of pleated angle become the “low efficiency” part about the particle deposition. Compared with area of pleated angle, the particles are concentrated in the opening area and the middle area of the pleated to agglomerate and deposit. | Kaiwen Cheng Jingjing Zhu Fuping Qian Bowen Cao Jinli Lu Yunlong Han | 2023 | Particuology2023，，1： | 1 |
| 11 | Investigation on Crystallization and Influence of Nd3+ Doping of Transparent Oxyfiuoride Glass-ceramics显示文摘 | Yu Yunlong Chen Daqin Cheng Yao | 2006 | Journal of the European Ceramic Society2006，26，： | 1 |
| 12 | Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer’s disease显示文摘Compromised autophagy and defective lysosomal clearance significantly contribute to impaired neuronal proteostasis,which represents a hallmark of Alzheimer’s disease(AD)and other age-related neurodegenerative disorders.Growing evidence has implicated that modulating autophagic flux,instead of inducing autophagosome formation alone,would be more reliable to rescue neuronal proteostasis.Concurrently,selectively enhancing drug concentrations in the leision areas,instead of the whole brain,will maximize therapeutic efficacy while reduing non-selective autophagy induction.Herein,we design a ROS-responsive targeted micelle system(TT-NM/Rapa)to enhance the delivery efficiency of rapamycin to neurons in AD lesions guided by the fusion peptide TPL,and facilitate its intracellular release via ROS-mediated disassembly of micelles,thereby maximizing autophagic flux modulating efficacy of rapamycin in neurons.Consequently,it promotes the efficient clearance of intracellular neurotoxic proteins,β-amyloid and hyperphosphorylated tau proteins,and ameliorates memory defects and neuronal damage in 3×Tg-AD transgenic mice.Our studies demonstrate a promising strategy to restore autophagic flux and improve neuronal proteostasis by rationally-engineered nano-systems for delaying the progression of AD. | Shuting Xu Peng Yang Kang Qian Yixian Li Qian Guo Pengzhen Wang Ran Meng Jing Wu Jinxu Cao Yunlong Cheng Minjun Xu Qizhi Zhang | 2022 | Bioactive Materials2022，7，5： | 1 |
| 13 | 显示文摘 | Yu Yunlong Chen Daqin Cheng Yao | 2006 | J Eur Ceram Soc2006，26，： | 1 |
| 14 | Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors显示文摘Background:Tumors possess incessant growth features,and expansion of their masses demands sufficient oxygen supply by red blood cells(RBCs).In adult mammals,the bone marrow(BM)is the main organ regulating hematopoiesis with dedicated manners.Other than BM,extramedullary hematopoiesis is discovered in various pathophysiological settings.However,whether tumors can contribute to hematopoiesis is completely unknown.Accumulating evidence shows that,in the tumor microenvironment(TME),perivascular localized cells retain progenitor cell properties and can differentiate into other cells.Here,we sought to better understand whether and how perivascular localized pericytes in tumors manipulate hematopoiesis.Methods:To test if vascular cells can differentiate into RBCs,genome-wide expression profiling was performed using mouse-derived pericytes.Genetic tracing of perivascular localized cells employing NG2-CreERT2:R26R-tdTomato mouse strain was used to validate the findings in vivo.Fluorescence-activated cell sorting(FACS),single-cell sequencing,and colony formation assays were applied for biological studies.The production of erythroid differentiationspecific cytokine,erythropoietin(EPO),in TME was checked using quantitative polymerase chain reaction(qPCR),enzyme-linked immunosorbent assay(ELISA,magnetic-activated cell sorting and immunohistochemistry.To investigate BM function in tumor erythropoiesis,BM transplantation mouse models were employed.Results:Genome-wide expression profiling showed that in response to plateletderived growth factor subunit B(PDGF-B),neural/glial antigen 2(NG2)+perivascular localized cells exhibited hematopoietic stem and progenitor-like features and underwent differentiation towards the erythroid lineage.PDGF-B simultaneously targeted cancer-associated fibroblasts to produce high levels of EPO,a crucial hormone that necessitates erythropoiesis.FACS analysis using genetic tracing of NG2+cells in tumors defined the perivascular localized cell-derived subpopulation of hematopoietic cells.Single-cell sequencing and colony formation assays validated the fact that,upon PDGF-B stimulation,NG2+cells isolated from tumors acted as erythroblast progenitor cells,which were distinctive from the canonical BM hematopoietic stem cells.Conclusions:Our data provide a new concept of hematopoiesis within tumor tissues and novel mechanistic insights into perivascular localized cell-derived erythroid cells within TME.Targeting tumor hematopoiesis is a novel therapeutic concept for treating various cancers that may have profound impacts on cancer therapy. | Kayoko Hosaka Chenchen Wang Shiyue Zhang Xue Lv Takahiro Seki Yin Zhang Xu Jing Jieyu Wu Qiqiao Du Xingkang He Yulong Fan Xuan Li Makoto Kondo Masahito Yoshihara Hong Qian Lihong Shi Ping Zhu Yuanfu Xu Yunlong Yang Tao Cheng Yihai Cao | 2023 | Cancer Communications2023，43，6： | 1 |
| 15 | Investigation on Crystallization and Influence of Nda+ Doping of Transparent Oxyfi- uoride Glass-eeramics显示文摘 | Yu Yunlong Chen Daqin Cheng Yao | 2006 | Journal of the Europ Ceram Soc2006，26，： | 1 |
| 16 | Characterization and transcriptional analyses of cDNAs encoding three trypsin- and chymotrypsin-like proteinases in CrylAb-susceptible and CrylAb-resistant strains of sugarcane borer, Diatraea saccharalis显示文摘Diatraea saccharalis 是一个主要玉米 borer 害虫。Midgut 丝氨酸朊酶为昆虫生长和开发是必要的。midgut 朊酶的改变为在某种类的 Bt 抵抗开发负责。克隆 midgut 胰岛素和糜蛋白酶 cDNAs 并且如果,测试在 D 的 Cry1Ab 抵抗。saccharalis 在三胰岛素的 midgut 朊酶,全部的 midgut tryptic 和 chymotryptic 活动, cDNA 序列,和基因表情与变化被联系,三糜蛋白酶基因比较地被检验在之间 Cry1Ab 易受影响(Cry1Ab-SS ) 并且 Cry1Ab 抵抗(Cry1Ab-RR ) 紧张。编码三胰岛素的全身的 cDNAs -- 并且三像糜蛋白酶的朊酶从 Cry1Ab-SS 和 Cry1Ab-RR 幼虫被定序。包括信号肽,为有所有功能的主题的 midgut 丝氨酸朊酶的活跃形式的这些 cDNAs 代码为催化三个一组,为二硫化物桥配置的三半胱氨酸,和保存底层特性决心残余保存了 His-Asp-Ser。一般来说, cDNA 和通常认为的蛋白质序列在 Cry1Ab-SS 和 Cry1Ab-RR 紧张之间是高度类似的,除了一些核苷酸和预言的氨基酸替换,其功能需要进一步被澄清。全部的胰岛素和糜蛋白酶活动在 Cry1Ab-SS 和 Cry1Ab-RR 紧张之间也是类似的。胰岛素和糜蛋白酶基因的 Transcriptional 层次有 Cry1Ab-SS 和 Cry1Ab-RR 紧张之间的数字差别,但是差别不是统计上重要的。数据建议在 D 的 Cry1Ab 抵抗的开发。saccharalis 显著地没与这些胰岛素和糜蛋白酶被联系。结果澄清了六 midgut 朊酶的角色并且为在 Bt 抵抗开发和另外的重要生物化学的过程继续另外的 midgut 朊酶的潜在的参与的检查提供了一个基础。 | Yunlong Yang Yu Cheng Zhu James Ottea Claudia Husseneder B. Rogers Leonard Craig Abel Randall Luttrell Fangneng Huang | 2013 | Insect Science2013，20，4： | 1 |
| 17 | Sedimentary evolution of the Central Canyon System in the Qiongdongnan Basin, northern South China Sea显示文摘This study elucidates sedimentary evolution history of the Central Canyon System(CCS),a large axial submarine canyon in the Qiongdongnan Basin(QDNB),northern South China Sea.Thegeomorphological characteristics and infill architectures of the CCS are summarized based on theanalysis of two-and three-dimensional seismic data.Based on a comparative analysis of the CCS indifferent segments and evolutionary stages and in consideration of the tectono-sedimentary conditionsof the QDNB four stages of the sedimentary evolution of the CCS can be divided,i.e.initialdevelopment stage in the Late Miocene(11.6-5.7Ma),erosion-infilling stage in the Early Pliocene(5.7-3.7 Ma),tranquil infilling stage in the Late Pliocene(3.7-1.81 Ma),and rejuvenation stage sincethe Pleistocene(1.81 Ma to present).In the 1ate Middle Miocene(~11.6 Ma),the rudiment of CCswas developed by a regional tectonic transformation in the eastern part of the basin.In the EarlyPliocene,the CCS was further developed from west to east and restrained in the central depressionbelt of the basin due to abundant sediment supplies from the northwestern and northem provenances,the blocking effect of the southern uplift belt,and the restrictive geomorphological features of theeastern part of the basin.In the Late Pliocene,changes in the sedimentary environment resulted in thedevelopment of the CCS in the eastern part of the basin only.Since the Pleistocene,the joint action ofclimatic factors and geomorphological features of the eastern part of the basin led to the rejuvenationof the CCS. | Ming Su Xinong Xie Zhenfen Wang Tao Jiang Cheng Zhang Yunlong He | 2016 | Petroleum Research2016，1，1： | 1 |
| 18 | Chiral AuCu heterostructures with site-specific geometric control and tailored plasmonic chirality显示文摘Rational design and construction of chiral-achiral hybrid structures are of great importance to realize the multifunctional complex chiral structures toward emerging technological applications. However, significant challenges remain due to the lack of fine control over the heterostructure. Here, we have developed a general bottom-up synthetic strategy for the site-selective growth of Cu nanodomains on intrinsically chiral Au nanocrystals. Chiral AuCu heterostructures with three distinct architectures were achieved by controlling the overgrowth of Cu nanodomains in a site-specific manner. The geometry-dependent plasmonic chirality of the heterostructures was demonstrated experimentally by circular dichroism spectroscopy and theoretically through finite-difference time-domain simulations. The site-specific geometric control of chiral AuCu heterostructures was also extended to employ anisotropic chiral Au nanoplates and nanorods as the building blocks. By virtue of the galvanic replacement reactions between metal ions and Cu atoms, chiral heterostructures with increasing architectural complexity and compositional diversity can be further achieved. The current work not only opens up a promising strategy to synthesize complex chiral hybrid nanostructures but also provides an important knowledge framework that guides the rational design of multifunctional chiral hybrid nanostructures toward chiroptical applications. | Guizeng Yang Lichao Sun Yunlong Tao Qingqing Cheng Xuehao Sun Chuang Liu Qingfeng Zhang | 2023 | Science China Chemistry2023，66，11： | 0 |
| 19 | Targeting tumor endothelial hyperglycolysis enhances immunotherapy through remodeling tumor microenvironment显示文摘Vascular abnormality is a hallmark of most solid tumors and facilitates immune evasion.Targeting the abnormal metabolism of tumor endothelial cells(TECs)may provide an opportunity to improve the outcome of immunotherapy.Here,in comparison to vascular endothelial cells from adjacent peritumoral tissues in patients with colorectal cancer(CRC),TECs presented enhanced glycolysis with higher glyceraldehyde-3-phosphate dehydrogenase(GAPDH)expression.Then an unbiased screening identified that osimertinib could modify the GAPDH and thus inhibit its activity in TECs.Low-dose osimertinib treatment caused tumor regression with vascular normalization and increased infiltration of immune effector cells in tumor,which was due to the reduced secretion of lactate from TECs by osimertinib through the inhibition of GAPDH.Moreover,osimertinib and anti-PD-1 blockade synergistically retarded tumor growth.This study provides a potential strategy to enhance immunotherapy by targeting the abnormal metabolism of TECs. | Yunlong Shan Qi Ni Qixiang Zhang Mengying Zhang Bin Wei Lingge Cheng Chongjin Zhong Xinyu Wang Qingqing Wang Jiali Liu Jingwei Zhang Jingjing Wu Guangji Wang Fang Zhou | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 20 | Microstructure and microhardness of aluminium alloy with underwater and in-air wire-feed laser deposition显示文摘This study carried out the underwater and in-air wire-feed laser deposition of an aluminium alloy with a thin-walled tubular structure. For both the underwater and in-air deposition layers, both were well-formed and incomplete fusion, cracks, or other defects did not exist.Compared with the single-track deposition layer in air, the oxidation degree of the underwater single-track deposition layer was slightly higher.In both the underwater and in-air deposition layers, columnar dendrites nucleated close to the fusion line and grew along the direction of the maximum cooling rate in the fusion region(FR), while equiaxed grains formed in the deposited region(DR). As the environment changed from air to water, the width of DR and height of FR decreased, but the deposition angle and height of DR increased. The grain size and ratio of the high-angle boundaries also decreased due to the large cooling rate and low peak temperature in the water environment.Besides, the existence of a water environment benefitted the reduction of magnesium element burning loss in the DR. The microhardness values of the underwater deposition layer were much larger than those of the in-air layer, owing to the fine grains and high magnesium content. | Ning Guo Qi Cheng Yunlong Fu Yang Gao Hao Chen Shuai Zhang Xin Zhang Jinlong He | 2023 | International Journal of Minerals,Metallurgy and Materials2023，30，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员