|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A new drug carrier:Magnetite nanoparticles coated with amphiphilic block copolymer显示文摘This paper reports on the synthesis and characterization of 4 nm magnetite nanoparticles coated with amphiphilic block copolymers of poly(ethyl methacrylate)-b-poly(2-hydroxyethyl methacrylate) (PEMA- b-PHEMA) by surface-initiated atom transfer radical polymerization (ATRP), which can act as new potential carriers for hydrophobic targeted drug delivery. Vibrating sample magnetometer analysis indi-cated that the magnetite nanoparticles were superparamagnetic at room temperature. Thermogravim-etric analysis (TGA) was applied to studying the property of surface of magnetite nanoparticles, and the surface density of macromolecules was calculated. The grafting density of oleic acid, BrMPA and PEMA was 5.8, 3.9, 0.16 chain/nm2 respectively, which indicates that the initiation efficiency decreases due to the influence of large space of oleic acid molecules. In vitro progesterone and (-)-isoproterenol hy-drochloride release in phosphate buffered saline (PBS) at pH 7.0 and 37℃ was conducted in order to demonstrate the function of drug loading and release. The results showed that the amount of drug carried into the core-shell Fe3O4@PEMA-b-PHEMA depends on the length of hydrophobic segment of block copolymer. The release of progesterone (37% after 22 h in our previous work) was compared with the release of (-)-isoproterenol hydrochloride (80% after 50 min), demonstrating that the strong hy-drophobic interaction between hydrophobic segment and drug can effectively control the release of hydrophobic drugs. | CHANG Yu BAI YunPeng TENG Bao LiZhaoLong | 2009 | Chinese Science Bulletin2009，54，7： | 6 |
| 2 | Cell sheet formation enhances the therapeutic effects of human umbilical cord mesenchymal stem cells on myocardial infarction as a bioactive material显示文摘Stem cell-based therapy has been used to treat ischaemic heart diseases for two decades.However,optimal cell types and transplantation methods remain unclear.This study evaluated the therapeutic effects of human umbilical cord mesenchymal stem cell(hUCMSC)sheet on myocardial infarction(MI).Methods:hUCMSCs expressing luciferase were generated by lentiviral transduction for in vivo bio-luminescent imaging tracking of cells.We applied a temperature-responsive cell culture surface-based method to form the hUCMSC sheet.Cell retention was evaluated using an in vivo bio-luminescent imaging tracking system.Unbiased transcriptional profiling of infarcted hearts and further immunohistochemical assessment of monocyte and macrophage subtypes were used to determine the mechanisms underlying the therapeutic effects of the hUCMSC sheet.Echocardiography and pathological analyses of heart sections were performed to evaluate cardiac function,angiogenesis and left ventricular remodelling.Results:When transplanted to the infarcted mouse hearts,hUCMSC sheet significantly improved the retention and survival compared with cell suspension.At the early stage of MI,hUCMSC sheet modulated inflammation by decreasing Mcp1-positive monocytes and CD68-positive macrophages and increasing Cx3cr1-positive non-classical macrophages,preserving the cardiomyocytes from acute injury.Moreover,the extracellular matrix produced by hUCMSC sheet then served as bioactive scaffold for the host cells to graft and generate new epicardial tissue,providing mechanical support and routes for revascularsation.These effects of hUCMSC sheet treatment significantly improved the cardiac function at days 7 and 28 post-MI.Conclusions:hUCMSC sheet formation dramatically improved the biological functions of hUCMSCs,mitigating adverse post-MI remodelling by modulating the inflammatory response and providing bioactive scaffold upon transplantation into the heart.Translational perspective:Due to its excellent availability as well as superior local cellular retention and survival,allogenic transplantation of hUCMSC sheets can more effectively acquire the biological functions of hUCMSCs,such as modulating inflammation and enhancing angiogenesis.Moreover,the hUCMSC sheet method allows the transfer of an intact extracellular matrix without introducing exogenous or synthetic biomaterial,further improving its clinical applicability. | Rui Guo Feng Wan Masatoshi Morimatsu Qing Xu Tian Feng Hang Yang Yichen Gong Shuhong Ma Yun Chang Siyao Zhang Youxu Jiang Heqing Wang Dehua Chang Hongjia Zhang Yunpeng Ling Feng Lan | 2021 | Bioactive Materials2021，6，9： | 6 |
| 3 | Relation of Isotope Geochemical Steep Zones with Geophysical Fields and Tectonics in the Junction Area of the Cathaysian,Yangtze and Indochina Plates显示文摘Through lead isotope geochemical mapping in the Yunnan-Guizhou area geochemical steep zones (GSZ) have been established, which clearly reveal the junction relationship of the Cathaysian, Yangtze and Indo-China plates. GSZ are closey related to gravity Mono gradient zones and lithospheric thickness. The GSZ between the Yangtze and Cathaysian plates is consistent with the Shizong-Mile tectonic belt, where island arc basalts are well developed. The Yangtze-Indo-China GSZ is parallel to the Jingdong-Mojiang volcanic belt in rift-island arc environments. The evidence of geology, geophysics and geochemistry all indicates that Cathaysia was subducted towards the Yangtze plate and that the Yangtze plate was underthrust beneath the Indo-China, which took place from the Early Carboniferous to the Early Triassic. | ZHU Bingquan Dong Yunpeng CHANG Xiangyang ZHANG Zhengwei | 2000 | Acta Geologica Sinica(English Edition)2000，74，2： | 5 |
| 4 | 北半球高山和极地虎耳草属物种丰富度的地理格局:温度和生境异质性的作用显示文摘现代气候、生境异质性和长期气候变化对森林生态系统中分布的木本植物的物种丰富度格局的影响在以往研究中受到广泛关注,但对高寒-极地生态系统中的草本植物物种丰富度格局及其影响因素的研究仍较少。本研究旨在检验以往研究中基于物种丰富度和环境因子关系提出的假说是否能够解释高寒-极地地区典型草本植物-虎耳草属(Saxifraga)的物种丰富度格局。本研究利用全球437种虎耳草属物种分布数据,探讨了全部物种、广域和狭域物种丰富度格局的影响因素。采用广义线性模型和空间自回归模型,评估了现代气候、生境异质性和历史气候对虎耳草属物种丰富度格局的影响。采用偏回归分析了不同变量对物种丰富度的独立解释率和共同解释率,并检验了4种广泛使用的物种丰富度与环境关系模型对物种丰富度格局的解释能力。研究结果表明,温度与虎耳草属所有物种和广域物种的物种丰富度格局呈显著负相关关系,是影响物种丰富度格局最重要的环境因子,这可能反映了虎耳草属对其祖先温带生态位的保守性。生境异质性和末次冰期以来的气候变化是虎耳草属狭域物种丰富度空间变异的最佳预测因子。总体而言,包含5个预测变量的组合模型可以解释大约40%–50%的虎耳草属物种丰富度的空间变异。此外,进化和生物地理过程在虎耳草属物种丰富度格局形成方面可能发挥了重要作用,这有待进一步研究。 | Lian Liu Xiaoting Xu Lei Zhang Yaoqi Li Nawal Shrestha Danilo M.Neves Qinggang Wang Hong Chang Xiangyan Su Yunpeng Liu Jianyong Wu Dimitar Dimitrov Zhiheng Wang Jianquan Liu | 2022 | Journal of Plant Ecology2022，15，2： | 1 |
| 5 | Improving Language Translation Using the Hidden Markov Model显示文摘Translation software has become an important tool for communication between different languages.People’s requirements for translation are higher and higher,mainly reflected in people’s desire for barrier free cultural exchange.With a large corpus,the performance of statistical machine translation based on words and phrases is limited due to the small size of modeling units.Previous statistical methods rely primarily on the size of corpus and number of its statistical results to avoid ambiguity in translation,ignoring context.To support the ongoing improvement of translation methods built upon deep learning,we propose a translation algorithm based on the Hidden Markov Model to improve the use of context in the process of translation.During translation,our Hidden Markov Model prediction chain selects a number of phrases with the highest result probability to form a sentence.The collection of all of the generated sentences forms a topic sequence.Using probabilities and article sequences determined from the training set,our method again applies the Hidden Markov Model to form the final translation to improve the context relevance in the process of translation.This algorithm improves the accuracy of translation,avoids the combination of invalid words,and enhances the readability and meaning of the resulting translation. | Yunpeng Chang Xiaoliang Wang Meihua Xue Yuzhen Liu Frank Jiang | 2021 | Computers, Materials & Continua2021，，6： | 1 |
| 6 | A novel image encryption algorithm based on logistic maps 显示文摘 | Chen Dangming Chang Yunpeng | 2011 | Advances in Information Science and Service Seiences2011，3，7： | 1 |
| 7 | Low-temperature mineralization domain associated with the parallel positions between geochemical steep zones and geophysical gradient zones显示文摘THE parallel strike of geochemical steep zones and geophysical gradient zones represent geochemicalboundaries with tectonic hiding and almost no magmatism, but there existed great variation of lithosphereor crustal thickness. Tectonically, these areas were located in the foreland basins of craton margin. Thesegeochemical boundaries were usually associated with the low-temperature mineralization and petroleumgeneration. The Nd, Sr and Pb isotopic evidence indicated that there still existed strong crustal-mantle interaction through fluid activation along deep-seated faults at the craton margin. Fig. 1 is the 207Pb/204 Pb-208Pb/204 Pb diagram, which shows the evident crust-mantle mixing for crude oil, chloroform bitumen-A, | ZHU Bingquan, DONG Yunpeng, CHANG Xiangyang and ZHANG Zhengwei Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China | 1999 | Chinese Science Bulletin1999，44，S2： | 1 |
| 8 | Multiplexed imaging of tumor immune microenvironmental markers in locally advanced or metastatic non-small-cell lung cancer characterizes the features of response to PD-1 blockade plus chemotherapy显示文摘Background:Although programmed cell death 1(PD-1)blockade plus chemotherapy can significantly prolong the progression-free survival(PFS)and overall survival(OS)in first-line settings in patients with driver-negative advanced non-small-cell lung cancer(NSCLC),the predictive biomarkers remain undetermined.Here,we investigated the predictive value of tumor immune microenvironmental marker expression to characterize the response features to PD-1 blockade plus chemotherapy.Methods:Tumor tissue samples at baseline were prospectively collected from 144 locally advanced or metastatic NSCLC patients without driver gene alterations who received camrelizumab plus chemotherapy or chemotherapy alone.Tumor immune microenvironmental markers,including PD-1 ligand(PDL1),CD8,CD68,CD4 and forkhead box P3,were assessed using multiplex immunofluorescence(mIF)assays.Kaplan-Meier curveswere used to determine treatment outcome differences according to their expression status.Mutational profiles were compared between tumors with distinct expression levels of these markers and their combinations.Results:Responders had significantly higher CD8/PD-L1(P=0.015)or CD68/PD-L1 co-expression levels(P=0.021)than non-responders in the camrelizumab plus chemotherapy group,while no difference was observed in the chemotherapy group.Patients with high CD8/PD-L1 or CD68/PD-L1 co-expression level was associated with significantly longer PFS(P=0.002,P=0.024;respectively)and OS(P=0.006,P=0.026;respectively)than those with low co-expression in camrelizumab plus chemotherapy group.When comparing survival in the camrelizumab plus chemotherapy with chemotherapy by CD8/PD-L1 co-expression stratification,significantly better PFS(P=0.003)and OS(P=0.032)were observed in high co-expression subgroups.The predictive value of CD8/PD-L1 and CD68/PD-L1 co-expression remained statistically significant for PFS and OS when adjusting clinicopathological features.Although the prevalence of TP53 or KRAS mutations was similar between patients with and without CD8/PD-L1 or CD68/PD-L1 co-expression,the positive groups had a significantly higher proportion of TP53/KRAS co-mutations than the negative groups(both 13.0%vs.0.0%,P=0.023).Notably,enriched PI3K(P=0.012)and cell cycle pathway(P=0.021)were found in the CD8/PD-L1 co-expression group.Conclusion:Tumor immune microenvironmental marker expression,especially CD8/PD-L1 or CD68/PD-L1 co-expression,was associated with the efficacy of PD-1 blockade plus chemotherapy as first-line treatment in patients with advanced NSCLC. | Fengying Wu Tao Jiang Gongyan Chen Yunchao Huang Jianying Zhou Lizhu Lin Jifeng Feng Zhehai Wang Yongqian Shu Jianhua Shi Yi Hu Qiming Wang Ying Cheng Jianhua Chen Xiaoyan Lin Yongsheng Wang Jianan Huang Jiuwei Cui Lejie Cao Yunpeng Liu Yiping Zhang Yueyin Pan Jun Zhao LiPing Wang Jianhua Chang Qun Chen Xiubao Ren Wei Zhang Yun Fan Zhiyong He Jian Fang Kangsheng Gu Xiaorong Dong Tao Zhang Wei Shi Jianjun Zou Xuejuan Bai Shengxiang Ren Caicun Zhou | 2022 | Cancer Communications2022，42，12： | 1 |
| 9 | Improvement of Camera Calibration Accuracy Based on Periodic Arrangement Characteristics of Calibration Target Pattern显示文摘Conventional camera calibration that employs calibration targets is a commonly used method to acquire a camera's intrinsic and/or extrinsic parameters. The calibration targets are usually designed as periodic arrays of simple high-contrast patterns that provide highly accurate world coordinate system points and the corresponding image pixel coordinate system points. The existing pixel coordinate extraction algorithms can reach a sub-pixel level; however, they treat each single pattern in one image as an independent individual, which makes it difficult to further improve extraction accuracy. In this paper, a novel method is proposed by utilizing the periodic arrangement characteristics of the calibration target pattern as a global constraint to improve the calibration accuracy. Based on a camera's pinhole model, the intersection point of two fitted curves is used as an optimized pixel point to replace the initial one. Following the pixel coordinate optimization procedures, experiments were performed using real data from a 3D laser line scanner and a dynamic precision calibration target. Our results show that the relative errors of camera homography matrix elements obtained by the proposed optimization method were reduced compared with the commonly used method. The average coordinate measurement accuracy can be improved by nearly 0.05 mm. It is shown that the proposed optimization method can enhance the camera calibration accuracy,especially when the extracted pixels are of poorer precision. | Qingguo Tian Yunpeng Li Jinjiang Wang Tianyu Chang | 2017 | Transactions of Tianjin University2017，23，6： | 0 |
| 10 | A wake-up call: signaling in regulating ornamental geophytes dormancy显示文摘Ornamental geophytes are a group of important flowers worldwide.As perennial plants,geophytes go through several rounds of life cycle under seasonal climates.The dormant trait of underground modified organs in geophytes is critical for the process of storage,planting as well as breeding.Although the dormant physiology in geophytes is complex and largely unknown,several advancements have been achieved in this field.Here,we review the knowledge on the role of environmental factors,endogenous hormones,carbohydrates,and epigenetics in the regulation of geophytes dormancy release(GDR).We also discuss dormancy release(DR)methods and their roles in geophytes,including small molecular chemicals and wounding treatments. | Yajie Zhao Chang Liu Juanjuan Sui Jiahui Liang Jintao Ge Jingru Li Wenqiang Pan Mingfang Yi Yunpeng Du Jian Wu | 2022 | Ornamental Plant Research2022，2，1： | 0 |
| 11 | The Application of Experimental Research Centers and Research Oriented Model to Specialty Materials Experimental Teaching显示文摘 | Xuming Zhang Dengyu Gai Zhongyi Niu Yunpeng Chang Minghui Ding Legan Hou | 2016 | International Journal of Technology Management2016，，7： | 0 |
| 12 | A controlled random gene perturbation method identifies ARPC1B gene as a key regulator of cancer metastasis显示文摘The discovery of clinically useful targets to treat specific pathological conditions can provide novel therapeutic approaches.To unbiasedly identify key genes related to tumor metastasis,we developed a random gene perturbation method using a piggyBac transposon system under the control of a doxycycline regulated promoter.Using this random gene perturbation method and utilizing a mouse model of metastatic pancreatic cancer,we identified genes dysregulated in metastasized cells from a random mutagenesis library after multiple rounds of in vivo selection.Analysis of these metastasized clones revealed the downregulation of ARPC1B gene.Our further mechanistic studies revealed that ARPC1B gene and its closely related gene ARPC1A worked in a regulatory loop to control tumor metastasis.These findings validate that piggyBac transposon mediated random gene perturbation is a powerful tool to investigate the functional relevance of novel genes and the ARPC1A/B axis is a potential key regulator of tumor metastasis. | De Chang Hongzhen Du Xiaowei Chen Xiaocui Bian Wenjia Tian Jing Shen Yiju Wei Yunpeng Jiang Charles Dela Cruz Lixin Xie Lokesh Sharma Kailong Li | 2023 | Genes & Diseases2023，10，3： | 0 |
| 13 | Preferable background filtering for next-generation sequencing analysis in non-small cell lung cancer:pericarcinomatous tissues or peripheral blood lymphocytes?显示文摘Dear editor,Lung cancer is the leading cause of cancer-related death worldwide,with the predominant pathological type being non-small cell lung cancer(NSCLC)[1,2].Next-gener-ation sequencing(NGS)analysis is increasingly used to help clinicians select appropriate target therapies,such as epidermal growth factor receptor-tyrosine kinase inhibitors(EGFR-TKIs)for EGFR-mutant patients[3].Both pericarcinomatous tissues and peripheral blood lymphocytes are widely used as normal control for NGS analysis.However,whether pericarcinomatous tissue is suitable for background filtering in mutation analysis remains controversial.According to the whole-genome sequencing data from The Cancer Genome Atlas(TCGA)database,there were some genomic variations in peri-carcinomatous tissue from NSCLC patients,but no driver gene mutation was detected[4,5].Therefore,deep sequencing of pericarcinomatous and tumor tissues is necessary to confirm whether pericarcinomatous tissue harbors low-frequency mutations. | Yaxiong Zhang Lianpeng Chang Wenfeng Fang Yunpeng Yang Lanjun Zhang Shaodong Hong Huaqiang Zhou Yanfang Guan Xin Yi Li Zhang | 2019 | Cancer Communications2019，39，1： | 0 |
| 14 | Proterozoic copper metaliogenic framework and geochemistry steep zone in central Yunnan Province显示文摘THE wildly horizontal and vertical chemical heterogeneties, which result from the inchoate core-mantledifferentiation of the globe and the spatio-temporal difference of various regions in the globe, bring on themantle and crust from different landmass and oceans with markedly elemental and isotopic signatures.Wherefore these signatures could be used to differentiate the attribute from various landmass or oceans andrecover the scent of kinematics and chemical geodynamics process. It is a quantificational method compared with the division by geotectonics facies and paleontologic fauna. Based on the geochemistry mapping of elements and multi-isotopic systematics of rocks derived frommantle and crust and combined with the studies on geophysical tomographic image, four type geochemicalprovinces can be distinguished. They are: (i) the Pacific (such as N-Pacific, N-Atlantic, the | CHANG Xiangyang, ZHU Bingquan and DONG Yunpeng Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China | 1999 | Chinese Science Bulletin1999，44，S2： | 0 |
| 15 | Tectonic implications of the isotopic geochemical steep zone in eastern Yunnan, China显示文摘THE studies on geology, geochemistry and geophysics of mantle and crust show that there exist distinctvertical and lateral heterogenetics of the composition and structures of lithosphere. Especially, continentallithosphere possesses a complex rheological structure, which is one of the important factors controlling thedeformation and evolution of continent. Recently, the comprehensive studies in China and other countries suggest that the geochemical mapping and provincial division is a reliable method to reveal the heterogenetics, and Pb isotopic compositionhaving strong tectonic and regional characteristics. Therefore, Pb isotopic mapping is a key to revealingthe structure, formation and evolution of the lithosphere. Based on Pb isotopic mapping in South Chinacontinent, it has been revealed that there exists a Pb isotopic geochemical steep zone between Yangtzeblock and Cathaysia | DONG Yunpeng, ZHU Bingquan and CHANG Xiangyang Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, China | 1999 | Chinese Science Bulletin1999，44，S2： | 0 |
| 16 | Local symmetry distortion induced anomalous thermal conduction in thermoelectric layered oxyselenides显示文摘Polyhedral distortion,associated closely with the atomic arrangement and interatomic interactions,drives many unique behaviors in solids,such as phase transition and negative thermal expansion.In thermoelectric heteroanionic oxides,the anionic polyhedra are widely present,but their effect on thermal transport is rarely investigated.Here,we report an anomalous thermal conduction induced by local symmetry distortion in layered oxyselenides via solving the Boltzmann transport equation based on first-principles calculations.We found interestingly that lighter BiCuSeO exhibits lower thermal conductivity than heavier BiAgSeO.Due to the different distorted degrees of CuSe4 and AgSe4 tetrahedrons,Cu prefers the in-plane vibration,while Ag has more tendency of out-of-plane vibration.Thus,the heat-carrying phonons dominated by the rattling-like vibration of Cu are significantly suppressed,resulting in lower thermal conductivity of BiCuSeO.This study highlights the importance of polyhedral distortion in regulating thermal conduction in layered heteroanionic materials. | Bin Wei Jiale Li Yueyang Yang Wang Li Zhifang Zhou Yunpeng Zheng Wenyu Zhang Yifan Chai Zheng Chang Ce-Wen Nan Yuan-Hua Lin | 2023 | npj Computational Materials2023，，1： | 0 |
| 17 | Cytokine levels and pathological characteristics of a patient with severe coronavirus disease 2019:a case report显示文摘To the Editor:The clinical spectrum of coronavirus disease 2019(COVID-19)appears to be wide,ranging from asymptomatic to severe progressive pneumonia with respiratory failure,multiorgan failure,and even death.Here,we investigated the clinical and pathological characteristics of a patient who died from severe COVID-19.Our findings will facilitate a deeper understanding of the pathogenesis and progression of COVID-19 and improve clinical strategies to combat the disease.On January 23,2020,a 57-year-old man without relevant history presented with fatigue and fever after attending a family party 2 days prior.Among the members of the family party,one relative had traveled from Wuhan.Over 9 days,the fever and cough developed,and the patient visited the emergency department.A throat swab was positive for severe acute respiratory syndrome coronavirus 2(SARS-COV-2)on real-time reverse-transcription polymerase chain reaction.He was admitted to the local hospital and received supportive therapies,anti-viral agents,atomized inhalation of interferon-γ,and oxygen therapy.Cough,fever,and dyspnea further developed on February 8.He received non-invasive mechanical ventilation therapy.On February 18,he was transferred to a superior hospital with shortness of breath. | Kai Kang Yang Gao Mingyan Zhao Dongsheng Fei Ming Ye Yan Gao Wei Yang Changsong Wang Haitao Liu Guangping Chang Xianxin Kang Yunpeng Luo Xue Du Jiping Qi Lin Tian Min Zhou Chunfang Hao Kaijiang Yu | 2022 | Chinese Medical Journal2022，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员