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| 1 | Differentiation of rat iPS cells and ES cells into granulosa cell-like cells in vitro显示文摘早熟的卵巢的失败(POF ) 是卵巢的滤泡的早熟的弄空在 40 岁前描绘的一个卵巢的缺点,代表女不孕的一个主要原因。干细胞为 POF 提供一个潜在的处理的可能性。在这研究,老鼠胚胎的干细胞(转换字符) 和导致的 pluripotent 干细胞(iPSCs ) 与 granulosa 房间(GC ) 是 co 有教养的区分到象 GC 一样房间。放射性免疫测定分析的 estradiol (E2 ) 的水平证明 co 有教养的老鼠 iPSCs 和转换字符的文化上层清液的 E2 集中以一种时间依赖者方式增加了,与有一个相反的趋势的 GC 组相比。刺激滤泡的荷尔蒙受体(FSHR ) 的表示被 immunostaining 证实。这些结果显示了那老鼠 iPSCs,转换字符有效地通过间接 cell-to-cell 接触被导致到象 GC 一样房间。实时聚合酶链反应被执行在 POF 分析标记基因的表示水平,包括 BMP15, FMR1, FSHR, INHA, AMH, NOBOX, FOXO3, EIF2B, FIGLA,和 GDF9。BMP15, FSHR, INHA, AMH, NOBOX,和 GDF9 基因在 iPSCs 和与与不是 co 有教养的房间比较的 GC co 有教养的转换字符是显著地起来调整的。因此,这里,我们表明了一个可得到的方法为 POF 的可能的房间治疗在 vitro 区分老鼠 iPSCs 和转换字符进象 GC 一样房间。 | Juan Zhang Hui Li Zhao Wu XiaoJun Tan Fengying Liu Xianghong Huang Xiaoling Fang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，4： | 7 |
| 2 | Total ionizing radiation effects of 2-T SONOS for 130 nm/4 Mb NOR flash memory technology显示文摘In this paper,we have studied the total ionizing dose(TID)radiation response up to 2 Mrad(Si)of silicon-oxide-nitride-oxide-silicon(SONOS)memory cells and memory circuits,fabricated in a 130 nm complimentary metal-oxide-semiconductor(CMOS)SONOS technology.We explored the threshold voltage(VT)degradation mechanism and found that the VT shifts of SONOS cells depend on the charge state;simply programming the cell to a higher VT cannot compensate for the radiation induced VT loss.The off-state current(Ioff)increase in the SONOS cell is also studied in this paper.Both VT and Ioffdegradation would affect the memory system.Read data failures are mainly caused by VT shifts under irradiation,and program and erase failures are mainly caused by increased Ioff,which overloads the charge pumping circuit.By varying the reference current,our 4 Mb NOR flash chip has the potential to survive a radiation dose of 1 Mrad(Si)in read mode. | QIAO FengYing PAN LiYang YU Xiao MA HaoZhi WU Dong XU Jun | 2014 | Science China(Information Sciences)2014，57，6： | 3 |
| 3 | Adaptive segmentation based on multi-classification model for dermoscopy images显示文摘 | Fengying XIE Yefen WU Yang LI Zhiguo JIANG Rusong MENG | 2015 | Frontiers of Computer Science2015，9，5： | 2 |
| 4 | Efficacy of ICIs on patients with oncogene-driven non-small cell lung cancer:a retrospective study显示文摘Aim:The objective of our study was to assess the efficacy of immune checkpoint inhibitors(ICIs)on patients with non-small-cell lung cancer(NSCLC)harboring oncogenic alterations.Methods:We retrospectively enrolled patients with advanced non-squamous NSCLC who were treated with anti-PD-1-based monotherapy or combined immunotherapy.Major characteristics including PD-L1 expression,treatment,and survival were analyzed.Results:In total,309 non-squamous NSCLC patients with a median age of 61 years(range 20-88 years)including 70.9%male were retrospectively enrolled.The molecular alterations involved epidermal growth factor receptor(EGFR)(n=81),V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog(KRAS)(n=31),anaplastic lymphoma kinase(ALK)(n=1),human epidermal growth factor receptor 2(HER2)(n=12),V-raf murine sarcoma viral oncogene homolog(BRAF)(n=2),rearranged during transfection(n=4),and c-ros oncogene 1(ROS1)(n=3).In the EGFR subset,the ORR was 30.9%(n=81)and PFS was significantly shorter than WT group(median PFS:5.7 months vs.7.1 months;P=0.0061).In subgroup analyses,ICI combined therapy was significantly correlated with a longer PFS compared with ICI monotherapy(median PFS:7.7 months vs.4.7 months;P=0.0112).In KRAS patients,ORR was 51.6%(n=31).No significant difference was found in subgroup analyses.The ORR and PFS were 16.7%(n=12)and 28.6%(n=7),7.8 months and 9.0 months for HER2 and EGFR Exon20 insertion patients,respectively.Three ROS1 patients were enrolled with a PFS of 16.0,34.2,and 45.0 months individually,and one ALK patient with PFS of 4.4 months was identified.No response was found in two BRAF patients.Conclusion:ICI-based combination therapy can bring benefit to patients with EGFR-mutant NSCLC.ICI-based combination therapy could be considered for patients with ROS1 rearrangement,HER2 mutation and EGFR Exon20 insertion NSCLC. | Xiaojin Guo He Du Jiayu Li Menghang Yang Anweng Xiong Haiping Zhang Fengying Wu | 2022 | Cancer Drug Resistance2022，5，1： | 2 |
| 5 | PC4 serves as a negative regulator of skin wound healing in mice显示文摘Background:Human positive cofactor 4(PC4)was initially characterized as a multifunctional transcriptional cofactor,but its role in skin wound healing is still unclear.The purpose of this study was to explore the role of PC4 in skin wound healing through PC4 knock-in mouse model.Methods:A PC4 knock-in mouse model(PC4^(+/+))with a dorsal full-thickness wound was used to investigate the biological functions of PC4 in skin wound healing.Quantitative PCR,Western blot analysis and immunohistochemistry were performed to evaluate the expression of PC4;Sirius red staining and immunofluorescence were performed to explore the change of collagen deposition and angiogenesis.Proliferation and apoptosis were detected using Ki67 staining and TUNEL assay.Primary dermal fibroblasts were isolated from mouse skin to perform cell scratch experiments,cck-8 assay and colony formation assay.Results:The PC4^(+/+)mice were fertile and did not display overt abnormalities but showed an obvious delay in cutaneous healing of dorsal skin.Histological staining showed insufficient re-epithelialization,decreased angiogenesis and collagen deposition,increased apoptosis and decreased cell proliferation in PC4^(+/+)skin.Our data also showed decreased migration rate and proliferation ability in cultured primary fibroblasts from PC4^(+/+)mice in vitro.Conclusions:This study suggests that PC4 might serve as a negative regulator of skin wound healing in mice. | Fengying Liao Long Chen Peng Luo Zhongyong Jiang Zelin Chen Ziwen Wang Chi Zhang Yu Wang JintaoHe Qing Wang Yawei Wang Lang Liu Yu Huang Huilan Wang Qingzhi Jiang Min Luo YiboGan Yunsheng Liu Yang Wang Jie Wu Wentao Xie Zhuo Cheng Yali Dai Jialun Li Zujuan Liu Fan Yang Chunmeng Shi | 2020 | Burns & Trauma2020，8，1： | 1 |
| 6 | Preliminary Research on Behaviors of Recycled Concrete-filled Steel Stub Columns 显示文摘 | Wu Fengying Yang Youfu | 2005 | Journal of Fuzhou University : Natural Science2005，，： | 1 |
| 7 | A delta-class glutathione transferase from the Chinese mitten crab Eriocheir sinensis : cDNA cloning, characterization and mRNA expression显示文摘 | Daxian Zhao Liqiao Chen Chuanjie Qin Hao Zhang Ping Wu Fengying Zhang | 2010 | Fish and Shellfish Immunology2010，，4： | 1 |
| 8 | Preliminary research on behaviors of recycled concrete-filled steel stub columns显示文摘 | Wu Fengying Yang Youfu | 2005 | Journal of Fuzhou U- niversity Natural Science2005，，： | 1 |
| 9 | Berberine attenuates cAMP-induced lipolysis via reducing the inhibition of phosphodiesterase in 3T3-L1 adipocytes显示文摘 | Libin Zhou Xiao Wang Ying Yang Ling Wu Fengying Li Rong Zhang Guoyue Yuan Ning Wang Mingdao Chen Guang Ning | 2010 | BBA - Molecular Basis of Disease2010，，4： | 1 |
| 10 | Effect of Agar on the Microstructure and Performance of Potato Starch Film 显示文摘 | WU Ying GENG Fengying CHANG P R | 2009 | Carbohydrate Polymers2009，76，2： | 1 |
| 11 | Electrofluorochromic imaging analysis of dopamine release from living PC12 cells with bipolar nanoelectrodes array显示文摘The coupling of bipolar electrode(BPE)arrays and electrofluorochromic(EFC)imaging has exhibited great abilities in bioanalysis.However,the imaging resolution and analytical performance are hampered by the large size of the electrode and the rapid diffusion of EFC molecules on the electrode surface.Here,to address the challenges,bipolar nanoelectrodes(BPn E)array and in situ immobilization strategy of EFC molecules were proposed.Anodized aluminum oxide(AAO)template-assisted Au nanoelectrodes array with high density was fabricated as BPn E array for high spatial imaging resolution.By electrically polymerizing EFC molecules on the surface of single Au nanoelectrode,the rapid diffusion of EFC molecules on the electrode surface was not only avoided,but also realizing electrofluorescent imaging on an individual nanoelectrode.Using dopamine(DA)released from living PC12 cells as a model,the proposed strategy exhibited an ultra-high sensitivity for DA analysis with a detection limit of 0.45 nmol/L and the DA release amount from a single cell was calculated to be 0.13 pmol/L.Moreover,the dynamic change of DA release under the drug stimulation from living PC12 cells could also be monitored. | Zhaoyan Tian Xiang Qin Fengying Shao Xiuxiu Li Zhi Wang Songqin Liu Yafeng Wu | 2023 | Chinese Chemical Letters2023，34，1： | 1 |
| 12 | Front and Back contact engineering for high-efficient and low-cost hydrothermal derived Sb_(2)(S, Se)_(3) solar cells by using FTO/SnO_(2) and carbon显示文摘Antimony chalcogenide Sb_(2)(S, Se)_(3) is attracting a lot of attention as photovoltaic absorber owing to its rewarding photoelectric properties, low toxicity, and earth abundance. However, its device efficiency is still limited by the absorber material quality and device interface recombination. In this work, a fluorinedoped tin oxide(FTO) substrate with ultra-thin SnO_(2) layer and a low-cost stabilized carbon paste are introduced as a front and back contact layer respectively in Sb_(2)(S, Se)_(3) based planar solar cells. Over 5.2% efficiency is demonstrated in the structure of FTO/SnO_(2)/Cd S/Sb_(2)(S, Se)_3/Carbon/Ag, where the Sb_(2)(S, Se)_(3) is prepared by hydrothermal technique. The complementary device physics characterizations reveal that the interfacial recombination between TCO and Cd S is significantly suppressed by the introduction of ultra-thin SnO_(2) layer, which is profited from the leakage protection and bandgap offset engineering by its high resistivity and suitable conduction band minimum. Meanwhile, the successful adoption of the lowcost stabilized carbon as a back contact here shows an enormous potential to replace the conventional organic hole transport materials and noble metal. We hope this work can provide positive guidance to optimize Sb_(2)(S, Se)_(3) based planar solar cells in the future. | Liquan Yao Limei Lin Hui Liu Fengying Wu Jianmin Li Shuiyuan Chen Zhigao Huang Guilin Chen | 2020 | Journal of Materials Science & Technology2020，58，23： | 1 |
| 13 | Multiplexed imaging of tumor immune microenvironmental markers in locally advanced or metastatic non-small-cell lung cancer characterizes the features of response to PD-1 blockade plus chemotherapy显示文摘Background:Although programmed cell death 1(PD-1)blockade plus chemotherapy can significantly prolong the progression-free survival(PFS)and overall survival(OS)in first-line settings in patients with driver-negative advanced non-small-cell lung cancer(NSCLC),the predictive biomarkers remain undetermined.Here,we investigated the predictive value of tumor immune microenvironmental marker expression to characterize the response features to PD-1 blockade plus chemotherapy.Methods:Tumor tissue samples at baseline were prospectively collected from 144 locally advanced or metastatic NSCLC patients without driver gene alterations who received camrelizumab plus chemotherapy or chemotherapy alone.Tumor immune microenvironmental markers,including PD-1 ligand(PDL1),CD8,CD68,CD4 and forkhead box P3,were assessed using multiplex immunofluorescence(mIF)assays.Kaplan-Meier curveswere used to determine treatment outcome differences according to their expression status.Mutational profiles were compared between tumors with distinct expression levels of these markers and their combinations.Results:Responders had significantly higher CD8/PD-L1(P=0.015)or CD68/PD-L1 co-expression levels(P=0.021)than non-responders in the camrelizumab plus chemotherapy group,while no difference was observed in the chemotherapy group.Patients with high CD8/PD-L1 or CD68/PD-L1 co-expression level was associated with significantly longer PFS(P=0.002,P=0.024;respectively)and OS(P=0.006,P=0.026;respectively)than those with low co-expression in camrelizumab plus chemotherapy group.When comparing survival in the camrelizumab plus chemotherapy with chemotherapy by CD8/PD-L1 co-expression stratification,significantly better PFS(P=0.003)and OS(P=0.032)were observed in high co-expression subgroups.The predictive value of CD8/PD-L1 and CD68/PD-L1 co-expression remained statistically significant for PFS and OS when adjusting clinicopathological features.Although the prevalence of TP53 or KRAS mutations was similar between patients with and without CD8/PD-L1 or CD68/PD-L1 co-expression,the positive groups had a significantly higher proportion of TP53/KRAS co-mutations than the negative groups(both 13.0%vs.0.0%,P=0.023).Notably,enriched PI3K(P=0.012)and cell cycle pathway(P=0.021)were found in the CD8/PD-L1 co-expression group.Conclusion:Tumor immune microenvironmental marker expression,especially CD8/PD-L1 or CD68/PD-L1 co-expression,was associated with the efficacy of PD-1 blockade plus chemotherapy as first-line treatment in patients with advanced NSCLC. | Fengying Wu Tao Jiang Gongyan Chen Yunchao Huang Jianying Zhou Lizhu Lin Jifeng Feng Zhehai Wang Yongqian Shu Jianhua Shi Yi Hu Qiming Wang Ying Cheng Jianhua Chen Xiaoyan Lin Yongsheng Wang Jianan Huang Jiuwei Cui Lejie Cao Yunpeng Liu Yiping Zhang Yueyin Pan Jun Zhao LiPing Wang Jianhua Chang Qun Chen Xiubao Ren Wei Zhang Yun Fan Zhiyong He Jian Fang Kangsheng Gu Xiaorong Dong Tao Zhang Wei Shi Jianjun Zou Xuejuan Bai Shengxiang Ren Caicun Zhou | 2022 | Cancer Communications2022，42，12： | 1 |
| 14 | Preliminary Research on Behaviors of Recycled Concrete - filled Steel Stub Columns 显示文摘 | Wu Fengying YangYoufu | 2005 | Journal of Fuzhou University : Natural Science2005，，： | 1 |
| 15 | Effect of agar on microsmcture and performance of potato starch film显示文摘 | WU Ying GENG Fengying CHANG P R | 2007 | Food Chemistry2007，105，3： | 1 |
| 16 | Highly sensitive electrochemical determination of rutin based on the synergistic effect of 3D porous carbon and cobalt tungstate nanosheets显示文摘Rutin,a flavonoid found in fruits and vegetables,is a potential anticancer compound with strong anticancer activity.Therefore,electrochemical sensor was developed for the detection of rutin.In this study,CoWO_(4) nanosheets were synthesized via a hydrothermal method,and porous carbon(PC)was prepared via high-temperature pyrolysis.Successful preparation of the materials was confirmed,and characterization was performed by transmission electron microscopy,scanning electron microscopy,and X-ray photoelectron spectroscopy.A mixture of PC and CoWO_(4) nanosheets was used as an electrode modifier to fabricate the electrochemical sensor for the electrochemical determination of rutin.The 3D CoWO_(4) nanosheets exhibited high electrocatalytic activity and good stability.PC has a high surface-to-volume ratio and superior conductivity.Moreover,the hydrophobicity of PC allows large amounts of rutin to be adsorbed,thereby increasing the concentration of rutin at the electrode surface.Owing to the synergistic effect of the 3D CoWO_(4) nanosheets and PC,the developed electrochemical sensor was employed to quantitively determine rutin with high stability and sensitivity.The sensor showed a good linear range(5-5000 ng/mL)with a detection limit of 0.45 ng/mL.The developed sensor was successfully applied to the determination of rutin in crushed tablets and human serum samples. | Guangjun Feng Yang Yang Jiantao Zeng Jun Zhu Jingjian Liu Lun Wu Zhiming Yang Guanyi Yang Quanxi Mei Qinhua Chen Fengying Ran | 2022 | Journal of Pharmaceutical Analysis2022，12，3： | 1 |
| 17 | The status quo of clinical nursing path in obstetric application and prospects of 显示文摘 | Wu Fengying | 2014 | Journal of PLA nursing journal2014，12，23： | 1 |
| 18 | Preliminary research on behaviors of recycled concrete-filled steel stub columns 显示文摘 | WU FENGYING YANG YOUFU | 2005 | Journal of Fuzhou University ( Natural Science)2005，33，1： | 1 |
| 19 | Current climate overrides past climate change in explaining multi-site beta diversity of Lauraceae species in China显示文摘Background:We aimed to characterise the geographical distribution of Sørensen-based multi-site dissimilarity(β_(sor))and its underlying true turnover(β_(sim))and nestedness(βsne)components for Chinese Lauraceae and to analyse their relationships to current climate and past climate change.Methods:We used ensembles of small models(ESMs)to map the current distributions of 353 Lauraceae species in China and calculated β_(sor) and its β_(sim) and β_(sne) components.We tested the relationship between β_(sor),β_(sne) and β_(sim) with current climate and past climate change related predictors using a series of simultaneous autoregressive(SAR_(err))models.Results:Spatial distribution of β_(sor)of Lauraceae is positively correlated with latitude,showing an inverse rela-tionship to the latitudinalα-diversity(species richness)gradient.High β_(sor) occurs at the boundaries of the warm temperate and subtropical zones and at the Qinghai-Tibet Plateau due to high β_(sne).The optimized SAR_(err) model explainsβ_(sor) andβ_(sne) well,but notβ_(sim).Current mean annual temperature determinesβ_(sor) and β_(sne) of Lauraceae more than anomalies and velocities of temperature or precipitation since the Last Glacial Maximum.Conclusions:Current low temperatures and high climatic heterogeneity are the main factors explaining the high multi-siteβ-diversity of Lauraceae.In contrast to analyses of the β-diversity of entire species assemblages,studies of single plant families can provide complementary insights into the drivers of β-diversity of evolutionarily more narrowly defined entities. | Ziyan Liao Youhua Chen Kaiwen Pan Mohammed A.Dakhil Kexin Lin Xianglin Tian Fengying Zhang Xiaogang Wu Bikram Pandey Bin Wang Niklaus E.Zimmermann Lin Zhang Michael P.Nobis | 2022 | Forest Ecosystems2022，9，2： | 1 |
| 20 | Amide as Terminal Groups: Synthesis and Properties as New Tolane-Type Liquid Crystals显示文摘与终端组被准备了的酰胺组一起的一系列新奇 tolane 类型液体晶体。终端酰胺组被修改,并且液体水晶阶段上的这些结构的参数的影响被极化调查光显微镜(POM ) 和微分扫描热量测定(DSC ) 。三这些新混合物展出 nematic 阶段,好热稳定性。一般来说,有结束组织的酰胺的这些液体晶体有高融化的点和阶段转变温度,它源于氢契约。基于理论计算,有强壮的电子捐赠的这些新分子是的酰胺结束组比 tolane 有更狭窄的 HOMO-LUMO 精力差距和更高的偶极子时刻。 | Hong Zhang Fengying Hong Dezhao Zhu Zhengce Xia Hongxiang Wu Hui Wang Zhuo Zeng | 2015 | Chinese Journal of Chemistry2015，33，7： | 0 |
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