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| 1 | Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer显示文摘MicroRNAs (miRNAs ) 玩在在各种各样的癌症的发展和前进的关键角色。不正常的 miR-9 表示仍然保持模糊,并且卵巢的癌症的变形前进上的一致都没被到达。在这研究,从生物信息学分析的结果证明 E-cadherin mRNA 的 3-UTR 被 miR-9 直接调整。酶记者试金结果证实 miR-9 能直接指向这 3-UTR。在卵巢的癌症织物的 miR-9 和 E-cadherin 表示被 qRT-PCR 确定。移植和侵略被在 SKOV3 和 A2780 愈合弯屈和 Transwell 系统试金检测。qRT-PCR 和西方的污点被执行检测上皮 ? 间充质的联系转变的 mRNA 和蛋白质。Immunofluorescence 技术被用来分析表示和 E-cadherin, N-cadherin,和 vimentin 的 subcellular 本地化。结果证明 miR-9 经常与配对的主要的相比是在变形浆液的卵巢的癌症织物的 upregulated。miR-9 的 Upregulation 能 downregulate E-cadherin 的表示但是 upregulate 间充质的标记(N-cadherin 和 vimentin ) 的表示。miR-9 的 Overexpression 能在卵巢的癌症支持房间移植和侵略,并且这些进程能有效地经由 miR-9 禁止者被禁止。因此,我们的学习证明 miR-9 可以经由指向 E-cadherin 和一条新奇潜在的治疗学的途径控制卵巢的癌症的转移支持卵巢的癌症转移。 | Bo Zhou Hongbin Xu Meng Xia Chaoyang Sun Na Li Ensong Guo Lili Guo Wanying Shan Hao Lu Yifan Wu Yuan Li Degui Yang Danhui Weng Li Meng Junbo Hu Ding Ma Gang Chen Kezhen Li | 2017 | Frontiers of Medicine2017，11，2： | 10 |
| 2 | Atomic process of oxidative etching in monolayer molybdenum disulfide显示文摘The microscopic process of oxidative etching of two-dimensional molybdenum disulfide(2D MoS_2) at an atomic scale is investigated using a correlative transmission electron microscope(TEM)-etching study.MoS_2 flakes on graphene TEM grids are precisely tracked and characterized by TEM before and after the oxidative etching. This allows us to determine the structural change with an atomic resolution on the edges of the domains, of well-oriented triangular pits and along the grain boundaries. We observe that the etching mostly starts from the open edges, grain boundaries and pre-existing atomic defects.A zigzag Mo edge is assigned as the dominant termination of the triangular pits, and profound terraces and grooves are observed on the etched edges. Based on the statistical TEM analysis, we reveal possible routes for the kinetics of the oxidative etching in 2D MoS_2, which should also be applicable for other 2D transition metal dichalcogenide materials like MoSe_2 and WS_2. | Danhui Lv Hulian Wang Dancheng Zhu Jie Lin Guoli Yin Fang Lin Ze Zhang ChuanhongJin | 2017 | Science Bulletin2017，62，12： | 7 |
| 3 | Sand-fixing characteristics of Carex brunnescens and its application with straw checkerboard technique in restoration of degraded alpine meadows显示文摘Carex brunnescens(Pers.), a typical clonal species, is considered to be the only herb found to date that can develop on sand dunes in Maqu alpine region of northwestern China. However, the characteristics that C. brunnescens resists to harsh alpine environment have not been documented. In this study, we conducted a field investigation to determine the morphological, reproductive, and sand-fixing characteristics of C. brunnescens. Concomitantly, we transplanted the belowground rhizomes of C. brunnescens to sand dunes and compared the abilities to restore degraded alpine meadows among sand dunes that had no further treatment(SD+N), sand dunes that had straw checkerboard technique but no transplanted rhizomes of C. brunnescens(SD+SCT), and sand dunes that had both SCT and transplanted rhizomes of C. brunnescens(SD+SCT+P). We found that belowground vertical rhizomes and horizontal rhizomes(including branching rhizomes and main rhizomes) of C. brunnescens were highly developed and that population reproduction was dominated by horizontal rhizomes. C. brunnescens exhibited a significant sand-fixation effect under following conditions: population density was 145–156 ramets/m^2, vegetation cover was 31.2%–39.3%, total length of belowground rhizomes was 11,223 cm/m^2, total length of belowground first-order roots was 9161–10,524 cm/m^2, fresh weight of aboveground part was 198.5–212.6 g/m^2, and fresh weight of belowground part was 578.8–612.4 g/m^2. It should be particularly noted that SD+SCT+P treatment(sand dunes that had both straw checkerboard technique and transplanted rhizomes of C. brunnescens) was the best and SD+N(sand dunes that had no further treatment) was the worst in terms of following biotic indicators: total number of reproductive ramets, total number of belowground rhizomes, and fresh weight of aboveground and belowground parts of C. brunnescens, contents of soil organic carbon, available nitrogen, microbial biomass carbon, and microbial biomass nitrogen. It implies that applying SCT in sand dunes and transplanting belowground rhizomes to sand dunes with SCT could improve both soil fertility and growth of C. brunnescens. These results suggest that the SCT-promoted high reproductive abilities of belowground rhizomes of C. brunnescens can successfully facilitate the establishment of ramets and can thus be an effective strategy to restore degraded vegetation in Maqu alpine region of northwestern China. | KANG Jianjun ZHAO Ming TAN Yanrong ZHU li BING Danhui ZHANG Yangdong TONG Shengli | 2017 | Journal of Arid Land2017，9，5： | 4 |
| 4 | Cellulose Functionalization via ATRP Grafting of Glycidyl Methacrylate for Cr(VI) Adsorption显示文摘纤维素在经由原子转移激进分子聚合(ATRP ) 的离子的液体是有 glycidyl methacrylate (GMA ) 的第一 grafted 然后介绍环氧基树脂组与 ethanediamine (EDA ) 被反应获得氨基的吸附物。grafting 共聚物和获得的吸附物被 FTIR, 1H NMR, TEM 和 SEM 描绘。结果证明 grafted 共聚物与控制得好的分子的重量和多分散性有 grafted 聚合物链,聚合是一个控制系统。纤维素吸附物在表面上有众多的 micropores 并且为 Cr (VI ) 吸附显示出高效。吸附行为是依赖的 pH,吸着平衡在吸附物上在 2 h 以内被完成。 | Chunxiang Lin Sha Qiao Danhui Liu Minghua Liu | 2013 | Chinese Journal of Chemistry2013，31，12： | 3 |
| 5 | Application research on the chaos synchro-nization self-maintenance characteristic to secret communication显示文摘Chua's circuit, which is improved to integrate conveniently, is presented. A drive-response chaotic synchronization system is constructed, which possesses a certain stability, resisting-disturbance, and so on. By means of research, it can be concluded that the chaotic synchronization system is provided with the character- istic of chaos synchronization self-maintenance. Utilizing the characteristic, the critical problem of how to simultaneously transmit the controlling signal of chaotic synchronization and the secret signal at a channel can be solved, and that a prac- tical experiment validates the method; as a result, the research in the paper pro- vides the foundation of putting chaos into practice application to secret commu- nication. | WU DanHui ZHAO ChenFei ZHANGYuJie | 2007 | Science in China(Series F)2007，50，4： | 2 |
| 6 | Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomized clinical trial显示文摘We aimed to evaluate the effectiveness and safety of single-course initial regimens in patients with low-risk gestational trophoblastic neoplasia(GTN).In this trial (NCT01823315),276 patients were analyzed.Patients were allocated to three initiated regimens:single-course methotrexate(MTX),single-course MTX+dactinomycin(ACTD),and multi-course MTX(control arm).The primary endpoint was the complete remission(CR)rate by initial drug(s).The primary CR rate was 64.4%with multi-course MTX in the control arm.For the single-course MTX arm,the CR rate was 35.8%by one course;it increased to 59.3%after subsequent multi-course MTX,with non-inferiority to the control(difference-5.1%,95%confidence interval(CI)-19.4%to 9.2%,P=0.014).After further treatment with multi-course ACTD,the CR rate(93.3%)was similar to that of the control(95.2%,P=0.577).For the single-course MTX+ACTD arm,the CR rate was 46.7%by one course,which increased to 89.1%after subsequent multi-course,with non-inferiority(difference 24.7%,95%CI 12.8%-36.6%,P<0.001)to the control.It was similar to the CR rate by MTX and further ACTD in the control arm(89.1%vs.95.2%,P=0.135).Four patients experienced recurrence,with no death,during the 2-year follow-up.We demonstrated that chemotherapy initiation with single-course MTX may be an alternative regimen for patients with low-risk GTN. | Lili Chen Ling Xi Jie Jiang Rutie Yin Pengpeng Qu Xiuqin Li Xiaoyun Wan Yaxia Chen Dongxiao Hu Yuyan Mao Zimin Pan Xiaodong Cheng Xinyu Wang Qingli Li Danhui Weng Xi Zhang Hong Zhang Quanhong Ping Xiaomei Liu Xing Xie Beihua Kong Ding Ma Weiguo Lu | 2022 | Frontiers of Medicine2022，16，2： | 2 |
| 7 | Changes of plant species diversity and biomass with reclaimed marshes restoration显示文摘Wetland restoration had been implemented for more than two decades in Sanjiang Plain,Northeast China.To assess the restoration effi ciency of wetland vegetation,we investigated plants composition of community,plant species diversity and aboveground biomass of restored sites in a chronosequence of restoration(1,2,3,6,8,11,15 and 25 years)in the Sanjiang Nature Reserve.As comparison,we also investigated the same factors in a cropland and a natural marsh adjacent to the restored sites.The results showed that wetland plant species can invade quickly after croplands were abandoned when there were suitable hydrology conditions.On the early stage of the restoration,weeds were main plant species in the restored sites.Wetland species appeared at the same time but diff ered from the dominant species from the adjacent natural marshes.Common native wetland species could dominance the community after 3-year restoration.Species richness and diversity increased on the early stage,and then decreased to the similar level of the natural marsh with the extension of restoration.Plant biomass could restore easier than the species composition and diversity.Our results indicated that plant species composition and diversity of abandoned reclaimed wetlands can restore gradually by natural succession in Sanjiang Plain.However,25-year restoration site had similarity index of only 56%with the natural marsh,which revealed that two decades are not enough for complete restoration of vegetation. | Xin Jin Xiaoxin Sun Haixing Li Danhui Zhao Dong Li Lei Wang Xiuling Man | 2021 | Journal of Forestry Research2021，32，1： | 2 |
| 8 | Ocular chemical bum patient's clinical first aid and nursing care显示文摘 | PAN Hong Gong Danhui Chi Cheng | | 0，，15： | 1 |
| 9 | Green synthesis of graphene oxide sheets decorated by silver nanoprisms and their anti-bacterial properties显示文摘 | Zhang Danhui Liu Xiaoheng Wang Xin | 2011 | J Inorg Biochem2011，105，9： | 1 |
| 10 | Effect of tumor suppressor gene PTEN on the resistance to cisplatin in human ovarian cancer cell lines and related mechanisms显示文摘 | HuiJuan Wu Yang Cao Danhui Weng Hui Xing Xiaohong Song Jianfeng Zhou Gang Xu Yunping Lu Shixuan Wang Ding Ma | 2008 | Cancer Letters2008，，2： | 1 |
| 11 | Association of visceral and total body fat with hypertension and prehypertension in a middle-aged Chinese population显示文摘 | Zengwu Wang Xianbin Zeng Zuo Chen Xin Wang Linfeng Zhang Manlu Zhu Danhui Yi | 2015 | Journal of Hypertension2015，，： | 1 |
| 12 | Biological indicators of sub-optimal health status显示文摘OBJECTIVE:To investigate biological indicators of sub-optimal health status and provide means of objective assessment of sub-optimal health status.METHODS:We set the unified standards for diagnosing a SHS.We tested various laboratory indicators in 407 cases that we selected randomly from2807 subjects and collected 15 mL of fasting venous blood from each case.We measured serum immunoglobulin A(IgA)and immunoglobulin G(IgG)concentrations,serum beta endorphins(β-EP),cortisol(C),testosterone(T),plasma adrenocorticotropic hormone(ACTH)and serum T lymphocyte subsets CD3+and CD4+.RESULTS:Mean serum testosterone concentrations and their ratio to cortisol(C)concentrations weresignificantly higher in the healthy group than in those with sub-optimal health status(P<0.01).Mean serum CD3+concentrations were significantly higher in those with sub-optimal health status than in the healthy group(P<0.05).CONCLUSION:Decreased serum testosterone/cortisol ratio may be an objective indication of sub-optimal health status.Changes in neuroendocrine and immunological indicators may explain some of the symptoms,including malaise and poor work performance,attributable to persistent or relapsing fatigue in subjects with sub-optimal health status. | Limin Wang Xin Zhao Jiaxu Chen Xiaoling Guo Xin Liang Danhui Yi Huating Cui Yueyun Liu | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 1 |
| 13 | Overexpression,purification,and structural analysis of the hydrophobic E5 protein from human papillomavirus type 16显示文摘 | Wildeman AG Sharom FJ | 2003 | Protein Expr Purif2003，30，1： | 1 |
| 14 | Green synthesis of graphene oxide sheets decorated by silver nanoprisms and their anti-bacterial properties 显示文摘 | Zhang Danhui Liu Xiaoheng Wang Xin | 2011 | Inorg Biochem2011，105，9： | 1 |
| 15 | Physiology and patha physiology of mitochondrial DNA显示文摘 | Hongzhi Li Danhui Liu Jianxin Lu | 2012 | Adv Exp Med Bi- ol2012，942，： | 1 |
| 16 | Correlation of TWIST2 up-regulation and epithelial–mesenchymal transition during tumorigenesis and progression of cervical carcinoma显示文摘 | Yan Li Wei Wang Wenwen Wang Runfeng Yang Tian Wang Tiefen Su Danhui Weng Tao Tao Wei Li Ding Ma Shixuan Wang | 2011 | Gynecologic Oncology2011，，1： | 1 |
| 17 | Neuroprotective effects of salvianolic acid B on secondary spinal cord damage显示文摘Salvianolic acid B(Sal B),an effective ingredient of Danshen(salvia miltiorrhiza root),has been shown to exhibit anti-oxidative and anti-inflammatory effects.The present study investigated whether Sal B has a neuroprotective effect on secondary spinal cord injury when administrated alone.In addition,the effects of Sal B on attenuating expression of tumor necrosis factor-α(TNF-α) following acute spinal cord injury were analyzed,as well as the effects of combined treatment of Sal B and etanercept.Immunohistochemical staining demonstrated that Sal B significantly reduced matrix metalloproteinase-1 and c-Fos expression at 24 hours after spinal cord injury,and decreased tissue edema was detected using the dry-wet weight method at 3 days after injury.In addition,Sal B significantly promoted recovery of motor function in rats.These effects were most significant at a dose of 20 mg/kg Sal B.At 24 hours after spinal cord injury,reverse transcription-polymerase chain reaction and western blot assay results showed that Sal B,etanercept,or the combination significantly suppressed increased TNF-α mRNA and protein expression,although the combination resulted in more significant outcomes.These results suggested that Sal B exerted neuroprotective effects against secondary spinal cord injury by reducing expression of matrix metalloproteinase-1,c-Fos,and TNF-α.Moreover,Sal B combined with etanercept resulted in more significant anti-inflammatory effects. | Ye, Zhizhong Deng, Yubin Wu, Hongfu Gan, Danhui | 2011 | Neural Regeneration Research2011，6，3： | 1 |
| 18 | Magnetic field sensor based on asymmetric optical fiber taper and magnetic fluid显示文摘 | Ming Deng Danhui Liu Decai Li | 2014 | Physical2014，，： | 1 |
| 19 | Numerical investigation and optimal design of fiber Bragg grating based wind pressure sensor显示文摘 | Xiangjie WANG Danhui DAN Rong XIAO Xingfei YAN | 2017 | Frontiers of Structural and Civil Engineering2017，11，3： | 1 |
| 20 | Dynamic properties analysis of a stay cable-damper system in consideration of design and construction factors显示文摘A numerical solution based on the Steffensen stable point iterative method is proposed to resolve the transcendental frequency equation of a stay cable-damper system. The frequency equation, which considers clamped supports and fl exural rigidity of the cable, is intended to investigate the infl uence of the parameters of the cable damper system on its dynamic characteristics. Two factors involved in the design and construction phases, the damping coeffi cient induced by external dampers and the cable tension, are the focus of this study. Their impact on modal frequencies and damping ratios in these two phases of cable-damper systems are investigated by resolving the equation with the proposed solution. It is shown that the damping coeffi cient and cable tension exert more noticeable effects on the modal damping ratios than on the modal frequencies of stay cable-damper systems, and the two factors can serve as design variables in the design phase and as adjustment factors in the construction phase. On the basis of the results, a roadmap for system-level optimal design of stay cable-damper systems that can achieve global optimal vibration suppression for the entire bridge is proposed and discussed. | Dan Danhui Chen Yanyang Xiao Rong | 2014 | Earthquake Engineering and Engineering Vibration2014，13，2： | 1 |
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