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| 1 | Integrated Energy Production Unit: An Innovative Concept and Design for Energy Transition Toward Low-carbon Development显示文摘To achieve the goals of emission peak and carbon neutrality,significant effort is invested to accelerate the energy transition,with a focus on the development and utilization of renewable energy,as well as the upgrading of conventional units.Within this context,this paper proposes an innovative concept,known as the integrated energy production unit(IEPU),providing a variety of energy products and flexible adjustment functions for power systems with high penetration of non-hydro renewable energy.In the IEPU framework,a photovoltaic(PV)power plant is installed to produce electricity;CO_(2) capture technology is applied to the existing coal-fired power plant with biomass co-combustion.The generated CO_(2) is used to synthesize methane or methanol with hydrogen through electrolysis.First,the operational principle and advantages of this concept are illustrated.Then,a simplified model is built to provide an optimal configuration scheme of equipment capacity.Finally,the potential contribution of IEPU to the operational flexibility of the power system is also analyzed. | Xiaoxin Zhou Qiang Zhao Yuqiong Zhang Li Sun | 2021 | CSEE Journal of Power and Energy Systems2021，7，6： | 7 |
| 2 | Genetic basis of high aroma and stress toleranee in the oolong tea cultivar genome显示文摘Tea plants(Camellia sinensis)are commercially cultivated in>60 countries,and their fresh leaves are processed into tea,which is the most widely consumed beverage in the world.Although several chromosome-level tea plant genomes have been published,they collapsed the two haplotypes and ignored a large number of allelic variations that may underlie important biological functions in this species.Here,we present a phased chromosome-scale assembly for an elite oolong tea cultivar,'Huangdan',that is well known for its high levels of aroma.Based on the two sets of haplotype genome data,we identi fi ed numerous genetic variations and a substantial proportion of allelic imbalance related to important traits,including aroma-and stress-related alleles.Comparative genomics revealed extensive structural variations as well as expansion of some gene families,such as terpene synthases(TPSs),that likely contribute to the high-aroma characteristics of the backbone parent,underlying the molecular basis for the biosynthesis of aroma-related chemicals in oolong tea.Our results uncovered the genetic basis of special features of this oolong tea cultivar,providing fundamental genomic resources to study evolution and domestication for the economically important tea crop. | Pengjie Wang Jiaxin Yu Shan Jin Shuai Chen Chuan Yue Wenling Wang Shuilian Gao Hongli Cao Yucheng Zheng Mengya Gu Xuejin Chen Yun Sun Yuqiong Guo Jiangfan Yang Xingtan Zhang Naixing Ye | 2021 | Horticulture Research2021，8，1： | 4 |
| 3 | RNA Methylome Reveals the m^(6)A-mediated Regulation of Flavor Metabolites in Tea Leaves under Solar-withering显示文摘The epitranscriptomic mark N6-methyladenosine(m^(6)A),which is the predominant internal modification in RNA,is important for plant responses to diverse stresses.Multiple environmental stresses caused by the tea-withering process can greatly influence the accumulation of specialized metabolites and the formation of tea flavor.However,the effects of the m^(6)A-mediated regulatory mechanism on flavor-related metabolic pathways in tea leaves remain relatively uncharacterized.We performed an integrated RNA methylome and transcriptome analysis to explore the m^(6)Amediated regulatory mechanism and its effects on flavonoid and terpenoid metabolism in tea(Camellia sinensis)leaves under solar-withering conditions.Dynamic changes in global m^(6)A level in tea leaves were mainly controlled by two m^(6)A erasers(CsALKBH4A and CsALKBH4B)during solar-withering treatments.Differentially methylated peak-associated genes following solarwithering treatments with different shading rates were assigned to terpenoid biosynthesis and spliceosome pathways.Further analyses indicated that CsALKBH4-driven RNA demethylation can directly affect the accumulation of volatile terpenoids by mediating the stability and abundance of terpenoid biosynthesis-related transcripts and also indirectly influence the flavonoid,catechin,and theaflavin contents by triggering alternative splicing-mediated regulation.Our findings revealed a novel layer of epitranscriptomic gene regulation in tea flavor-related metabolic pathways and established a link between the m^(6)A-mediated regulatory mechanism and the formation of tea flavor under solar-withering conditions. | Chen Zhu Shuting Zhang Chengzhe Zhou Caiyun Tian Biying Shi Kai Xu Linjie Huang Yun Sun Yuling Lin Zhongxiong Lai Yuqiong Guo | 2023 | Genomics, Proteomics & Bioinformatics2023，21，4： | 2 |
| 4 | Luteolin enhances TNF-related apoptosis-inducing ligand’s anticancer activity in a lung cancer xenograft mouse model显示文摘 | Jiaqi Yan Qiong Wang Xuelian Zheng Hong Sun Yuqiong Zhou Daoxia Li Yong Lin Xia Wang | 2011 | Biochemical and Biophysical Research Communications2011，，2： | 1 |
| 5 | Biomimetic nanochannel membrane for cascade response of borate and cis-hydroxyl compounds:An IMP logic gate device显示文摘Biomimetic nanodevice is an important branch to expand the potential applications of artificial nanochannels. Here, we constructed nanochannels for cascade response of borate and cis-hydroxyl compounds by modifying the nanochannels of track-etched polycarbonate (TEPC) membranes with polyvinyl alcohol (PVA). Firstly, borate bound to PVA and increased the negative charge density on the surface of the nanochannels, which obstructed the transport of 1,5-naphthalene disulfonate (NDS2-). Subsequently, the addition of cis-hydroxyl compounds induced leaving of borate due to the stronger binding affinities between borate and cis-hydroxyl compounds, which reduced the negative charge density on nanochannels and then enhanced the transport of NDS2-. The cascade response of the nanochannels also accord with the properties of IMP (implication) logic gate. In addition, such nanochannels showed good reproducibility and reversibility. Therefore, this cascade response model based on nanochannels has the potential to be used as switches in area of actuators and biosensors, and is also expected to be used to understand the interaction of substances in nanoscale and simulate the physiological functions of boron. | Meitao Deng Meng Yang Yaqing Xu Yuqiong Sun Qing Wang Jianbo Liu Jin Huang Xiaohai Yang Kemin Wang | 2019 | Chinese Chemical Letters2019，30，7： | 1 |
| 6 | Complexation of DNA with poly-( L -lysine) and its copolymers in dimethylformamide显示文摘 | Jihan Zhou Fuyou Ke Yuqiong Xia Jianbo Sun Ning Xu Zi-Chen Li Dehai Liang | 2013 | Polymer2013，，10： | 1 |
| 7 | Effects of chain length and hydrophobicity/charge ratio of AMP on its antimicrobial activity显示文摘Using two series of de novo designed antimicrobial peptides,we studied the effects of peptide length and hydrophobicity/charge(H/C) ratio on the antimicrobial activities.For these peptides,a correlation was established between their antimicrobial efficacy and the leakage,aggregation,and fusion activities on artificial membrane.The results showed that peptides with an H/C ratio of 1.3,and a length of about half of the membrane thickness caused most potent membrane leakage,and negligible membrane aggregation and fusion.In addition,such peptide also exhibited the highest antimicrobial activity.Analysis of the hydrophobic and electrostatic interactions showed that the strength,the order and the position of these interactions determined the activities of the peptides on the artificial membrane and thus the antimicrobial efficacy.Further analyses on the tilt angle of the peptides on the membrane surface indicated that the peptides distorted the membrane in a dynamic mode,instead of being fixed in the membrane at a constant angle. | Qiuhong Yu Zhengxi Zhang Jianbo Sun Yuqiong Xia Quan Du Dehai Liang | 2017 | Science China Chemistry2017，60，3： | 0 |
| 8 | Two antibodies show broad,synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD显示文摘Continual evolution of the severe acute respiratory syndrome coronavirus(SARS-CoV-2)virus has allowed for its gradual evasion of neutralizing antibodies(nAbs)produced in response to natural infection or vaccination.The rapid nature of these changes has incited a need for the development of superior broad nAbs(bnAbs)and/or the rational design of an antibody cocktail that can protect against the mutated virus strain.Here,we report two angiotensin-converting enzyme 2 competing nAbs—8H12 and 3E2—with synergistic neutralization but evaded by some Omicron subvariants.Cryo-electron microscopy reveals the two nAbs synergistic neutralizing virus through a rigorous pairing permitted by rearrangement of the 472-489 loop in the receptor-binding domain to avoid steric clashing.Bispecific antibodies based on these two nAbs tremendously extend the neutralizing breadth and restore neutralization against recent variants including currently dominant XBB.1.5.Together,these findings expand our understanding of the potential strategies for the neutralization of SARS-CoV-2 variants toward the design of broad-acting antibody therapeutics and vaccines. | Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zheng Zhang Hai Yu Jun Zhang Wenxin Luo Shaowei Li Qingbing Zheng Ying Gu Ningshao Xia | 2024 | Protein & Cell2024，15，2： | 0 |
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