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| 1 | Streptococcus mutans activates the AIM2, NLRP3 and NLRC4 inflammasomes in human THP-1 macrophages显示文摘Streptococcus mutans(S. mutans), a major aetiologic agent of dental caries, is involved in systemic diseases, such as bacterial endocarditis, if it enters the bloodstream through temporary bacteraemia. Interleukin(IL)-1β, a proinflammatory cytokine, is related to the host defences against pathogens, and its synthesis, maturation, and secretion are tightly regulated by the activation of the inflammasome, an inflammatory signalling complex. This study examined the signalling mechanism of IL-1β secretion and the inflammasome pathway induced by S. mutans to explain the molecular mechanism through which systemic infection by oral streptococci can occur. After infection of THP-1 cells with S. mutans, the expression of inflammasome components was detected using various methods. S. mutans induced IL-1β secretion via caspase-1 activation, and S. mutans-induced IL-1β secretion required absent in melanoma(AIM2), NLR family pyrin domain-containing 3(NLRP3) and NLR family CARD domain-containing 4(NLRC4)inflammasome activation. In particular, the S. mutans-induced NLRP3 inflammasome was mediated by adenosine triphosphate(ATP) release, potassium depletion and lysosomal damage. Our study provides novel insight into the innate immune response against S. mutans infection. | Yuri Song Hee Sam Na Eunjoo Park Mi Hee Park Hyun Ah Lee Jin Chung | 2018 | International Journal of Oral Science2018，10，3： | 6 |
| 2 | Nano-Structured Carbide-Derived Carbon Films and Their Tribology显示文摘Carbide-derived carbon (CDC) is a form of carbon produced by reacting metal carbides, such as SiC or TiC, with halogens at temperatures high enough to produce fast kinetics, but too low to permit the re- arrangement of the carbon atoms into an equilibrium graphitic structure. The structure of CDC is derivative of the original carbide structure and contains nanoscale porosity and both sp2 and sp3 bonded carbon in a variety of nanoscale structures. CDC can be produced as a thin film on hard carbides to improve their tri- bological performance. CDC coatings are distinguished by their low friction coefficients and high wear resis- tance in many important industrial environments and by their resistance to spallation and delamination. The tribology of CDC coatings on SiC surfaces is described in detail. | Michael McNallan Daniel Ersoy Ranyi Zhu Allen Lee Christopher White Sascha Welz Yury Gogotsi Ali Erdemir Andriy Kovalchenko | 2005 | Tsinghua Science and Technology2005，10，6： | 6 |
| 3 | Fucoidan protects hepatocytes from apoptosis and inhibits invasion of hepatocellular carcinoma by up-regulating p42/44 MAPK-dependent NDRG-1/CAP43显示文摘Fucoidan is a traditional Chinese medicine suggested to possess anti-tumor effects.In this study the anti-metastatic effects of fucoidan were investigated in vitro in human hepatocellular carcinoma(HCC) cells(Huh-7 and SNU-761) under normoxic and hypoxic conditions and in vivo using a distant liver metastasis model involving injection of MH134 cells into spleen via the portal vein.Its ability to protect hepatocytes against bile acid(BA)-induced apoptosis was investigated in primary hepatocytes.Fucoidan was found to suppress the invasion of HCC cells through up-regulation of p42/44 MAPKdependent NDRG-1/CAP43 and partly,under normoxic conditions,through up-regulation of p42/44MAPK-dependent VMP-1 expression.It also significantly decreased liver metastasis in vivo.As regards its hepatoprotective effect,fucoidan decreased BA-induced hepatocyte apoptosis as shown by the attenuation of caspase-8,and-7 cleavages and suppression of the mobilization of caspase-8 and Fas associated death domain(FADD) into the death-inducing signaling complex.In summary,fucoidandisplays inhibitory effects on proliferation of HCC cells and protective effects on hepatocytes.The results suggest fucoidan is a potent suppressor of tumor invasion with hepatoprotective effects. | Yuri Cho Jung-Hwan Yoon Jeong-ju Yoo Minjong Lee Dong Hyeon Lee Eun Ju Cho Jeong-Hoon Lee Su Jong Yu Yoon Jun Kim Chung Yong Kim | 2015 | Acta Pharmaceutica Sinica B2015，5，6： | 3 |
| 4 | Highly efficient gene silencing and bioimaging based on fluorescent carbon dots in vitro and in vivo显示文摘小介入 RNA (siRNA ) 是一个吸引人的治疗学的候选人让顺序特定的基因 silencing 用小分子药对待不治之症。然而,它的有效细胞内部的交货仍然是挑战。这里,我们发展了一高度 biocompatible 荧光灯碳点(CD ) ,并且表明导致在 vitro 并且在 vivo 击倒的有效基因的一个功能的 siRNA 交货系统。我们发现 CD nanoparticles (NP ) 提高 siRNA 的细胞的举起,经由在肿瘤房间的 endocytosis,与低 cytotoxicity 和意外有免疫力的回答。在实时房间的荧光成像的实时学习证明 CD NP 有利地在细胞质本地化并且成功地在 12 h 以内释放 siRNA。而且,我们显著地表明那 CD 调停 NP 的 siRNA 交货沉默绿色荧光蛋白质(GFP ) 表示并且在肿瘤特定的治疗的一个乳癌房间异种皮移植鼠标模型禁止肿瘤生长。我们开发了启用同时的 bioimaging 和基因表示的有效 downregulation 的多功能的 siRNA 交货车辆,那为基因治疗显示出优秀潜力。 | Seongchan Kim Yuri Choi Ginam Park Cheolhee Won Young-Joon Park Younghoon Lee Byeong-Su Kim DaI-Hee Min | 2017 | Nano Research2017，10，2： | 3 |
| 5 | Efficacy of Adefovir-Based Combination Therapy for Patients with Lamivudine- and Entecavir-Resistant Chronic Hepatitis B Virus Infection显示文摘 | Yun Bin Lee Jeong-Hoon Lee Won-mook Choi Young Youn Cho Jeong-ju Yoo Minjong Lee Dong Hyeon Lee Yuri Cho Su Jong Yu Yoon Jun Kim Jung-Hwan Yoon Chung Yong Kim Hyo-Suk Lee | 2013 | Antimicrobial Agents and Chemotherapy2013，，12： | 1 |
| 6 | Fermented Red Ginseng Extract Inhibits Cancer Cell Proliferation and Viability显示文摘 | Jisun O h Seong Bin Jeon Yuri Lee | 2015 | J Med Food2015，18，4： | 1 |
| 7 | Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines显示文摘 | Jeongwu Lee Svetlana Kotliarova Yuri Kotliarov Aiguo Li Qin Su Nicholas M. Donin Sandra Pastorino Benjamin W. Purow Neil Christopher Wei Zhang John K. Park Howard A. Fine | 2006 | Cancer Cell2006，，5： | 1 |
| 8 | High sensitivity C-reactive Protein Level is an Independent Predictor of Poor Prognosis in Cirrhotic Patients With Spontaneous Bacterial Peritonitis显示文摘 | Yuri Cho So Youn Park Jeong-Hoon Lee | 2014 | Journal of Clinical Gastroenterology2014，，： | 1 |
| 9 | Medical Utilization and Cost in Patients with Overlap Syndrome of Chronic Obstructive Pulmonary Disease and Asthma显示文摘 | Chin Kook Rhee Hyoung Kyu Yoon Kwang Ha Yoo Young Sam Kim Sei Won Lee Yong Bum Park Jin Hwa Lee Yuri Kim Kyungjoo Kim Jinhee Kim Yeon Mok Oh Sang Do Lee | 2014 | COPD: Journal of Chronic Obstructive Pulmonary Disease2014，，2： | 1 |
| 10 | Global online marketplace:a cross-cultural comparison of website quality显示文摘 | Soyoung Kim Yuri Lee | | 0，，6： | 1 |
| 11 | Efficacy of antiviral prophylaxis in HB sAg‐negative, anti‐ HB c positive patients undergoing hematopoietic stem cell transplantation显示文摘 | Jeong‐Ju Yoo Eun Ju Cho Young Youn Cho Minjong Lee Dong Hyeon Lee Yuri Cho Jeong‐Hoon Lee Su Jong Yu Sung‐Soo Yoon Jung‐Hwan Yoon Yoon Jun Kim | 2015 | Liver Int2015，，12： | 1 |
| 12 | Reactive oxygen species-induced activation of Yes-associated protein-1 through the c-Myc pathway is a therapeutic target in hepatocellular carcinoma显示文摘BACKGROUND The Hippo signaling pathway regulates organ size by regulating cell proliferation and apoptosis with terminal effectors including Yes-associated protein-1(YAP-1).Dysregulation in Hippo pathway has been proposed as one of the therapeutic targets in hepatocarcinogenesis.The levels of reactive oxygen species(ROS)increase during the progression from early to advanced hepatocellular carcinoma(HCC).AIM To study the activation of YAP-1 by ROS-induced damage in HCC and the involved signaling pathway.METHODS The expression of YAP-1 in HCC cells(Huh-7,HepG2,and SNU-761)was quantified using real-time polymerase chain reaction and immunoblotting.Human HCC cells were treated with H2O2,which is a major component of ROS in living organisms,and with either YAP-1 small interfering RNA(siRNA)or control siRNA.To investigate the role of YAP-1 in HCC cells under oxidative stress,MTS assays were performed.Immunoblotting was performed to evaluate the signaling pathway responsible for the activation of YAP-1.Eighty-eight surgically resected frozen HCC tissue samples and 88 nontumor liver tissue samples were used for gene expression analyses.RESULTS H2O2 treatment increased the mRNA and protein expression of YAP-1 in HCC cells(Huh-7,HepG2,and SNU-761).Suppression of YAP-1 using siRNA transfection resulted in a significant decrease in tumor proliferation during H2O2 treatment both in vitro and in vivo(both P<0.05).The oncogenic action of YAP-1 occurred via the activation of the c-Myc pathway,leading to the upregulation of components of the unfolded protein response(UPR),including 78-kDa glucoseregulated protein and activating transcription factor-6(ATF-6).The YAP-1 mRNA levels in human HCC tissues were upregulated by 2.6-fold compared with those in nontumor tissues(P<0.05)and were positively correlated with the ATF-6 Levels(Pearson’s coefficient=0.299;P<0.05).CONCLUSION This study shows a novel connection between YAP-1 and the UPR through the c-Myc pathway during oxidative stress in HCC.The ROS-induced activation of YAP-1 via the c-Myc pathway,which leads to the activation of the UPR pathway,might be a therapeutic target in HCC. | Yuri Cho Min Ji Park Koeun Kim Sun Woong Kim Wonjin Kim Sooyeon Oh Joo Ho Lee | 2020 | World Journal of Gastroenterology2020，26，42： | 1 |
| 13 | Estimating the Extent of Potential Competition in the Korean Mobile Telecommunications Market:Switching Costs and Number Portability显示文摘 | Jongsu Lee Yeonbae Kim Jeong-Dong Lee Yuri Park | 2006 | International Journal of Industrial Organization2006，24，： | 1 |
| 14 | Serum Insulin-like Growth Factor-I Level Is an Independent Predictor of Recurrence and Survival in Early Hepatocellular Carcinoma: A Prospective Cohort Study显示文摘 | Eun Ju Cho Jeong-Hoon Lee Jeong-Ju Yoo Won-Mook Choi Min Jong Lee Yuri Cho Dong Hyeon Lee Yun Bin Lee Jung Hee Kwon Su Jong Yu Jeong Min Lee Kyung-Suk Suh Kion Kim Yoon Jun Kim Jung-Hwan Yoon Chung Yong Kim Hyo-Suk Lee | 2013 | Clinical Cancer Research2013，，15： | 1 |
| 15 | Tourists' attitudes towards textiles and apparel-related cultural products:A cross-cultural marketing study显示文摘 | Yuri Lee Soyoung Kim Yoo-Kyoung Seock | | 0，，： | 1 |
| 16 | Pyruvate kinase isoenzyme M2 is a therapeutic target of gemcitabine-resistant pancreatic cancer cells显示文摘 | Dong Joon Kim Young Soo Park Min Gu Kang Yeon-Mi You Yuri Jung Han Koo Jung-Ae Kim Mi-Ju Kim Seung-Mo Hong Kyong Bun Lee Ja-June Jang Kyung Chan Park Young Il Yeom | 2015 | Experimental Cell Research2015，，1： | 1 |
| 17 | Tourists' Attitudes Towards Textiles and Apparel-related Cultural Prod- ucts: A Cross-cultural Marketing Study显示文摘 | Yuri Lee Soyoung Kim Yoo-Kyoung Seock Yunjin Cho | 2009 | Tourism Management2009，30，5： | 1 |
| 18 | Retinoic acid and CTCF play key roles in inducing the collinear expression of the Hoxa cluster显示文摘 | Ji Hoon Oh Clara Yuri Kim Ji-Yeon Lee Myoung Hee Kim | 2018 | Acta Biochimica et Biophysica Sinica2018，50，6： | 0 |
| 19 | Preparation of a Hybrid Organic-inorganic Monolith for Extraction and Purification of Quercetin and Myricetin from Chamaecyparis obtusa显示文摘 | ZHU Tao LEE Yuri ROW Kyungho | 2014 | Chemical Research in Chinese Universities2014，30，2： | 0 |
| 20 | Amphotericin B release rate is the link between drug status in the liposomal bilayer and toxicity显示文摘Amphotericin B(AmB)is an amphiphilic drug commonly formulated in liposomes and administered intravenously to treat systemic fungal infections.Recent studies on the liposomal drug product have shed light on the AmB aggregation status in the bilayer,which heat treatment(curing)modifies.Although toxicity was found related to aggregation status-loose aggregates significantly more toxic than tight aggregates-the precise mechanism linking aggregation and toxicitywas notwell understood.This study directlymeasured drug release rate fromvarious AmB liposomal preparations made with modified curing protocols to evaluate correlations among drug aggregation state,drug release,and in vitro toxicity.UV–Vis spectroscopy of these products detected unique curing-induced changes in the UV spectral features:a∼25nm blue-shift of the main absorption peak(λ_(max))in aqueous buffer and a decrease in the OD_(346)/OD_(322) ratio upon thermal curing,reflecting tighter aggregation.In vitro release testing(IVRT)data showed,by applying and fitting first-order release kinetic models for one or two pools,that curing impacts two significant changes:a 3–5-fold drop in the overall drug release rate and a ten-fold decrease in the ratio between the loosely aggregated and the tightly aggregated,more thermodynamically stable drug pool.The kinetic data thus corroborated the trend independently deduced from the UV–Vis spectral data.The in vitro toxicity assay indicated a decreased toxicity with curing,as shown by the significantly increased concentration,causing half-maximal potassium release(TC50).The data suggest that the release of AmB requires dissociation of the tight complexes within the bilayer and that the reduced toxicity relates to this slower rate of dissociation.This study demonstrates the relationship between AmB aggregation status within the lipid bilayer and drug release(directly measured rate constants),providing a mechanistic link between aggregation status and in vitro toxicity in the liposomal formulations. | Yuri Svirkin Jaeweon Lee Richard Marx Seongkyu Yoon Nelson Landrau Md Abul Kaisar Bin Qin Jin H.Park Khondoker Alam Darby Kozak Yan Wang Xiaoming Xu Jiwen Zheng Benjamin Rivnay | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，4： | 0 |
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