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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | 21世纪的卒中新定义:美国心脏协会/美国卒中协会对医疗专业人员的声明显示文摘尽管脑血管病的影响广泛且对其病理生理学的理解已取得一些进展,但“卒中”一词在临床实践、临床研究和公共卫生评价中的定义并不统一。经典的卒中定义主要是临床定义,不能反映科学技术的进步。因此,美国心脏协会卒中委员会/美国卒中协会召集了一个写作组,旨在对21世纪的卒中新定义制定一份专家共识文件。中枢神经系统(centralnervoussystem,CNS)梗死被定义为缺血导致的脑、脊髓或视网膜细胞死亡,并且具有永久性损伤的神经病理学、神经影像学和(或)临床证据。CNS梗死具有一系列临床表现:缺血性卒中特指伴有明显症状的CNS梗死,而无症状梗死则顾名思义不引起明显症状。广义的卒中还包括脑出血和蛛网膜下腔出血。卒中的新定义结合了临床和组织学标准,因此能被融入临床实践、研究和公共卫生评价。 | Ralph L. Sacco Scott E. Kasner Joseph P. Broderick Louis R. Caplan J.J. (Buddy) Connors Antonio Culebras Mitchell S.V. Elkind Mary G. George Allen D. Hamdan Randall T. Higashida Brian L. Hoh L. Scott Janis Carlos S. Kase Dawn O. Kleindorfer Jin-Moo Lee Michael E. Moseley Eric D. Peterson Tanya N. Turan Amy L. Valderrama Harry V. Vinters 王胜男(译) 吴齐恒(译) 邓镇(译) 周晓(译) 袁超(译) 潘速跃(译) | 2014 | 国际脑血管病杂志2014，22，1： | 7 |
| 3 | Nano-Structured Carbide-Derived Carbon Films and Their Tribology显示文摘Carbide-derived carbon (CDC) is a form of carbon produced by reacting metal carbides, such as SiC or TiC, with halogens at temperatures high enough to produce fast kinetics, but too low to permit the re- arrangement of the carbon atoms into an equilibrium graphitic structure. The structure of CDC is derivative of the original carbide structure and contains nanoscale porosity and both sp2 and sp3 bonded carbon in a variety of nanoscale structures. CDC can be produced as a thin film on hard carbides to improve their tri- bological performance. CDC coatings are distinguished by their low friction coefficients and high wear resis- tance in many important industrial environments and by their resistance to spallation and delamination. The tribology of CDC coatings on SiC surfaces is described in detail. | Michael McNallan Daniel Ersoy Ranyi Zhu Allen Lee Christopher White Sascha Welz Yury Gogotsi Ali Erdemir Andriy Kovalchenko | 2005 | Tsinghua Science and Technology2005，10，6： | 6 |
| 4 | Evaluation of a point of care ultrasound curriculum for Indonesian physicians taught by fi rst-year medical students显示文摘BACKGROUND: The purpose of this study was to assess the short-term efficacy of a 4-week ultrasound curriculum taught by American first-year medical students to general practitioners working in public health care clinics, or puskesmas, in Bandung, Indonesia.METHODS: We performed a prospective, observational study of Indonesian health care practitioners from public clinics in Bandung, Indonesia. These practitioners were enrolled in a 4-week ultrasound training course taught by first-year American medical students. A total of six sessions were held comprising of 38 ultrasound milestones. A pre-course and post-course written exam and practical exam was taken by each participant.RESULTS: We enrolled 41 clinicians in the course. The average pre-course exam score was 35.2% with a 2.4% pass rate, whereas the average post-course exam score was 82.0% with a 92.7% pass rate. The average practical score at the completion of the course was 83.2%(SD=0.145) with 82.9% of the class passing(score above 75.0%).CONCLUSION: Our data suggests that first-year medical students can effectively teach ultrasound to physicians in Indonesia using a 4-week intensive ultrasound training course. Future studies are needed to determine the amount of training required for proficiency and to evaluate the physicians' perceptions of the student-instructors' depth of knowledge and skill in point of care ultrasound. | Jonathan B.Lee Christina Tse Thomas Keown Michael Louthan Christopher Gabriel Alexander Anshus Bima Hasjim Katrina Lee Esther Kim Luke Yu Allen Yu Shadi Lahham Steven Bunch Maili Alvarado Abdulatif Gari John C.Fox | 2017 | World Journal of Emergency Medicine2017，8，4： | 4 |
| 5 | Wild dogma: An examination of recent "evidence" for dingo regulation of invasive mesopredator release in Australia显示文摘 | Benjamin L. ALLEN Richard M. ENGEMAN Lee R. ALLEN | 2011 | Current Zoology2011，57，5： | 3 |
| 6 | An Updated Definition of Stroke for the 21st Century: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association显示文摘 | Ralph L. Sacco Scott E. Kasner Joseph P. Broderick Louis R. Caplan J.J. (Buddy) Connors Antonio Culebras Mitchell S.V. Elkind Mary G. George Allen D. Hamdan Randall T. Higashida Brian L. Hoh L. Scott Janis Carlos S. Kase Dawn O. Kleindorfer Jin-Moo Lee Mi | 2013 | Stroke2013，，7： | 3 |
| 7 | Comparison of ultrasound-measured properties of the common carotid artery to tobacco smoke exposure in a cohort of Indonesian patients显示文摘BACKGROUND: The purpose of this study was to use point-of-care ultrasound(POCUS) to investigate the relationship between tobacco smoke exposure and the characteristics of the common carotid artery(CCA). The effect of both primary and secondary smoking on CCA properties was evaluated.METHODS: We performed a prospective cross-sectional study across 20 primary care clinics in Bandung, West Java, Indonesia in July 2016. Point of care ultrasound was performed on a convenience sample of Indonesian patients presenting to clinic. The CCA wall stiffness and carotid intima-media thickness(CIMT) were measured during diastole and systole. These measurements were correlated with smoke exposure and cardiovascular disease.RESULTS: We enrolled 663 patients in the study, with 426 patients enrolled in the smoking category and 237 patients enrolled in the second-hand smoke category. There was an overall positive correlation with the measured lifestyle factors and the ultrasound-measured variables in the group of individuals who smoked. For all variables, age seemed to contribute the most out of all of the lifestyle factors for the positive changes in CIMT and CCA wall stiffness.CONCLUSION: Our data yielded correlations between CCA properties and cardiovascular risk, as well as between CIMT and arterial stiffness. We were also able to demonstrate an increase in thickness of the CIMT in patients who have been exposed by tobacco through the use of ultrasound. Further large scale studies comparing patients with multiple cardiac risk factors need to be performed to confi rm the utility of ultrasound fi ndings of cardiovascular disease and stroke. | Allen R.Yu Bima Hasjim Luke E.Yu Christopher Gabriel Alexander Anshus Jonathan B.Lee Michael J. Louthan Esther C.Kim Katrina Lee Christina Tse Thomas Keown Shadi Lahham Maili Alvarado Steven Bunch Abdulatif Gari J.Christian Fox | 2017 | World Journal of Emergency Medicine2017，8，3： | 2 |
| 8 | A comparison of liquid hot water and steam pretreatments of sugar cane bagasse for bioconversion to ethanol显示文摘 | Mark Laser Deborah Schulman Stephen G Allen Joseph Lichwa Michael J Antal Lee R Lynd | 2001 | Bioresource Technology2001，，1： | 2 |
| 9 | Polymorphism in the TNFα and TNF-receptor genes in patients with coronary artery disease显示文摘 | Allen RA Lee EM Roberts DH | 2001 | Eur J Clin Invest2001，31，： | 2 |
| 10 | Control of carbon and ammonium ratio for simultaneous nitrification and denitrification in a sequencing batch bioreactor显示文摘 | Ying-Chih Chiu Li-Ling Lee Cheng-Nan Chang Allen C. Chao | 2006 | International Biodeterioration & Biodegradation2006，，1： | 2 |
| 11 | Human autoantibodies to carcinoembryonic antigen (CEA) induced by a vaccinia-CEA vaccine 显示文摘 | Conry RM Allen KO Lee H | 2000 | ClinCancer Res2000，6，1： | 2 |
| 12 | Expression and mapping of the mouse S7/Pmsc2 gene, homolog of an essential mitotic gene in yeast显示文摘 | Jeremy Allen Laurence Colleaux Duncan Davidson Elisabeth Graham Muriel Lee Robert Hill Cathy Abbott Colin Gordon | 1997 | Mammalian Genome1997，，5： | 1 |
| 13 | Development and Validation of a Standardized Method for Contouring the Brachial Plexus: Preliminary Dosimetric Analysis Among Patients Treated With IMRT for Head-and-Neck Cancer显示文摘 | William H. Hall Michael Guiou Nancy Y. Lee Arthur Dublin Samir Narayan Srinivasan Vijayakumar James A. Purdy Allen M. Chen | 2008 | International Journal of Radiation Oncology Biology Physics2008，，5： | 1 |
| 14 | High magnetoreistance permalloy films deposited on a thin NiFeCr or NiCr underlayer显示文摘 | Lee W.Y Toney M.F Tameerug P Allen E and Mauri D | | 0，，： | 1 |
| 15 | Organizational citizenship behavior and workplace deviance : the role of affect and cognitions显示文摘 | LEE K ALLEN N J | 2002 | Journal of Applied Psychology2002，87，1： | 1 |
| 16 | Prevalence of venous reflux in the general population on duplex scanning : The Edinburgh vein study 显示文摘 | Evans C Allen P Lee A | 1998 | J Vasc Surg1998，28，5： | 1 |
| 17 | Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC 显示文摘 | Kucukdereli H Allen N J Lee AT | 2011 | Proc Natl Acad Sci USA2011，108，32： | 1 |
| 18 | Performance of Delayed-Enhancement Magnetic Resonance Imaging With Gadoversetamide Contrast for the Detection and Assessment of Myocardial Infarction: An International, Multicenter, Double-Blinded, Randomized Trial显示文摘 | Raymond J. Kim Timothy S.E. Albert James H. Wible Michael D. Elliott John C. Allen Jennifer C. Lee Michele Parker Alicia Napoli Robert M. Judd | 2008 | Circulation2008，，5： | 1 |
| 19 | Comprehensive study of bladder neck contracture after transurethral resection of prostate显示文摘 | Ying-Huei Lee Allen W Chiu | | 0，，03： | 1 |
| 20 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
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