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| 1 | Assessment of the validity of the clinical pathway for colon endoscopic submucosal dissection显示文摘AIM: To determine the effective hospitalization period as the clinical pathway to prepare patients for endoscopic submucosal dissection (ESD). METHODS: This is a retrospective observational study which included 189 patients consecutively treated by ESD at the National Cancer Center Hospital from May 2007 to March 2009. Patients were divided into 2 groups; patients in group A were discharged in 5 d and patients in group B included those who stayed longer than 5 d. The following data were collected for both groups: mean hospitalization period, tumor site, median tumor size, post-ESD rectal bleeding requiring urgent endoscopy, perforation during or after ESD, abdominal pain, fever above 38 ℃, and blood test results positive for inflammatory markers before and after ESD. Each parameter was compared after data collection. RESULTS: A total of 83% (156/189) of all patients could be discharged from the hospital on day 3 postESD. Complications were observed in 12.1% (23/189) of patients. Perforation occurred in 3.7% (7/189) of patients. All the perforations occurred during the ESD procedure and they were managed with endoscopic clipping. The incidence of post-operative bleeding was 2.6% (5/189); all the cases involved rectal bleeding. We divided the subjects into 2 groups: tumor diameter ≥ 4 cm and < 4 cm; there was no significant difference between the 2 groups (P = 0.93, χ 2 test with Yates correction). The incidence of abdominal pain was 3.7% (7/189). All the cases occurred on the day of the procedure or the next day. The median white blood cell count was 6800 ± 2280 (cells/μL; ± SD) for group A, and 7700 ± 2775 (cells/μL; ± SD) for group B, showing a statistically significant difference (P = 0.023, t-test). The mean C-reactive protein values the day after ESD were 0.4 ± 1.3 mg/dL and 0.5 ± 1.3 mg/dL for groups A and B, respectively, with no significant difference between the 2 groups (P = 0.54, t -test). CONCLUSION: One-day admission is sufficient in the absence of complications during ESD or early postoperative bleeding. | Takaya Aoki Takeshi Nakajima Yutaka Saito Takahisa Matsuda Taku Sakamoto Takao Itoi Yassir Khiyar Fuminori Moriyasu | 2012 | World Journal of Gastroenterology2012，18，28： | 22 |
| 2 | Prognostic Impact of Anatomic Resection for Hepatocellular Carcinoma显示文摘 | Kiyoshi Hasegawa Norihiro Kokudo Hiroshi Imamura Yutaka Matsuyama Taku Aoki Masami Minagawa Keiji Sano Yasuhiko Sugawara Tadatoshi Takayama Masatoshi Makuuchi | 2005 | Annals of Surgery2005，，2： | 6 |
| 3 | AFP, AFP-L3, DCP, and GP73 as markers for monitoring treatment response and recurrence and as surrogate markers of clinicopathological variables of HCC显示文摘 | Kentaroh Yamamoto Hiroshi Imamura Yutaka Matsuyama Yukio Kume Hitoshi Ikeda Gary L. Norman Zakera Shums Taku Aoki Kiyoshi Hasegawa Yoshifumi Beck Yasuhiko Sugawara Norihiro Kokudo | 2010 | Journal of Gastroenterology2010，，12： | 6 |
| 4 | A Meta-Analysis of Randomized Controlled Trials that Compared Laparoscopy-Assisted and Open Distal Gastrectomy for Early Gastric Cancer显示文摘 | Hiroshi Ohtani Yutaka Tamamori Kozo Noguchi Takashi Azuma Shunsuke Fujimoto Hiroko Oba Tetsuya Aoki Mieko Minami Kosei Hirakawa | 2010 | Journal of Gastrointestinal Surgery2010，，6： | 3 |
| 5 | Hepatitis B virus X induces cell proliferation in the hepatocarcinogenesis via up‐regulation of cytoplasmic p21 expression显示文摘 | Masahiko Yano Shogo Ohkoshi Yo‐hei Aoki Hiromichi Takahashi Sou Kurita Kazuhide Yamazaki Kenta Suzuki Satoshi Yamagiwa Ayumi Sanpei Shun Fujimaki Toshifumi Wakai Shin‐ei Kudo Yasunobu Matsuda Yutaka Aoyagi | 2013 | Liver Int2013，，8： | 1 |
| 6 | AFP, AFP-L3, DCP, and GP73 as markers for monitoring treatment response and recurrence and as surrogate markers of clinicopathological variables of HCC显示文摘 | Kentaroh Yamamoto Hiroshi Imamura Yutaka Matsuyama Yukio Kume Hitoshi Ikeda Gary L. Norman Zakera Shums Taku Aoki Kiyoshi Hasegawa Yoshifumi Beck Yasuhiko Sugawara Norihiro Kokudo | 2010 | Journal of Gastroenterology2010，，12： | 1 |
| 7 | AFP, AFP-L3, DCP, and GP73 as markers for monitoring treatment response and recurrence and as surrogate markers of clinicopathological variables of HCC显示文摘 | Kentaroh Yamamoto Hiroshi Imamura Yutaka Matsuyama Yukio Kume Hitoshi Ikeda Gary L. Norman Zakera Shums Taku Aoki Kiyoshi Hasegawa Yoshifumi Beck Yasuhiko Sugawara Norihiro Kokudo | 2010 | Journal of Gastroenterology2010，，12： | 1 |
| 8 | Effects of ecabet sodium on experimentally induced reflux esophagitis显示文摘 | Nobuo Omura Hideyuki Kashiwagi Ganz Chen Fumiaki Yano Yutaka Suzuki Teruaki Aoki | 2000 | Journal of Gastroenterology2000，，7： | 1 |
| 9 | New closure technique for large mucosal defects after endoscopic submucosal dissection of colorectal tumors (with video)显示文摘 | Yosuke Otake Yutaka Saito Taku Sakamoto Takaya Aoki Takeshi Nakajima Naoya Toyoshima Takahisa Matsuda Hiroyuki Ono | 2012 | Gastrointestinal Endoscopy2012，，3： | 1 |
| 10 | N-phenylation of N-arylaminophthalimides with Triphenylbismuth and Cupric Acetate:A Convenient Synthesis of 1-Ary1-1-Phenylhydrazines显示文摘 | Yutaka Aoki Yuko Saito Take shi Sakamoto etc | 2000 | Synthetic communications2000，30，1： | 1 |
| 11 | Clinical pharmacology and efficacy of levofloxacin in elderly patients显示文摘 | 1.Nobuki Aoki Toshimaru Usuda Yutaka Koda, | 1992 | Jap J Antibiot1992，45，5： | 1 |
| 12 | Serum Autotaxin is not a Useful Biomarker for Ovarian Cancer显示文摘 | Kazuhiro Nakamura Koji Igarashi Ryunosuke Ohkawa Hiromitsu Yokota Akiko Masuda Shunsuke Nakagawa Tetsu Yano Hitoshi Ikeda Junken Aoki Yutaka Yatomi | 2012 | Lipids2012，，9： | 1 |
| 13 | Meta-analysis of Laparoscopy-Assisted and Open Distal Gastrectomy for Gastric Cancer显示文摘 | Hiroshi Ohtani Yutaka Tamamori Kozou Noguchi Takashi Azuma Shunsuke Fujimoto Hiroko Oba Tetsuya Aoki Mieko Minami Kosei Hirakawa | 2011 | Journal of Surgical Research2011，，2： | 1 |
| 14 | A Meta-Analysis of Randomized Controlled Trials that Compared Laparoscopy-Assisted and Open Distal Gastrectomy for Early Gastric Cancer显示文摘 | Hiroshi Ohtani Yutaka Tamamori Kozo Noguchi Takashi Azuma Shunsuke Fujimoto Hiroko Oba Tetsuya Aoki Mieko Minami Kosei Hirakawa | 2010 | Journal of Gastrointestinal Surgery2010，，6： | 1 |
| 15 | Polymorphisms in the human high sulfur hair keratin-asso- ciated proteinl ,KAP1 ,gene family显示文摘 | Yutaka Shimomura Noriaki Aoki Jurgen Schweizer | 2002 | The Journal of Bi- ological Chemistry2002，277，45： | 1 |
| 16 | Distinct expression of polycomb group proteins EZH2 and BMI1 in hepatocellular carcinoma显示文摘 | Yutaka Yonemitsu Fumio Imazeki Tetsuhiro Chiba Kenichi Fukai Yuichiro Nagai Satoru Miyagi Makoto Arai Ryutaro Aoki Masaru Miyazaki Yukio Nakatani Atsushi Iwama Osamu Yokosuka | 2009 | Human Pathology2009，，9： | 1 |
| 17 | Preparation and characterization of phospholipid-conjugated indocyanine green as a near-infrared probe显示文摘 | Akiko Suganami Taro Toyota Shigetoshi Okazaki Kengo Saito Katsuhiko Miyamoto Yasunori Akutsu Hiroshi Kawahira Akira Aoki Yutaka Muraki Tomoyuki Madono Hideki Hayashi Hisahiro Matsubara Takashige Omatsu Hiroshi Shirasawa Yutaka Tamura | 2012 | Bioorganic & Medicinal Chemistry Letters2012，，24： | 1 |
| 18 | Prognostic Impact of Anatomic Resection for Hepatocellular Carcinoma显示文摘 | Kiyoshi Hasegawa Norihiro Kokudo Hiroshi Imamura Yutaka Matsuyama Taku Aoki Masami Minagawa Keiji Sano Yasuhiko Sugawara Tadatoshi Takayama Masatoshi Makuuchi | 2005 | Annals of Surgery2005，，2： | 1 |
| 19 | Necessity of Lysophosphatidic Acid Receptor 1 for Development of Arthritis显示文摘 | Yoshishige Miyabe Chie Miyabe Yoshiko Iwai Aiko Takayasu Shin Fukuda Waka Yokoyama Jun Nagai Masahiro Jona Yasunori Tokuhara Ryunosuke Ohkawa Harald M. Albers Huib Ovaa Junken Aoki Jerold Chun Yutaka Yatomi Hiroshi Ueda Masayuki Miyasaka Nobuyuki Miyasaka | 2013 | Arthritis & Rheumatism2013，，8： | 1 |
| 20 | Synchronous coexistence of liver metastases from cecal leiomyosarcoma and rectal adenocarcinoma: A case report显示文摘Multiple liver tumors represent a challenging condition for abdominal surgeons both in the selection of technique and the rarity of diagnosis. There are no case reports on co-existence of liver metastases from both intestinal leiomyosarcoma and adenocarcinoma. The patient described in this report successfully underwent resection of both primary lesions and liver metastases in combination with chemotherapy. As for the leiomyosarcoma, the primary cecal lesion was revealed more than three years after the patient's first visit. Peritoneal, lymph-node, and lung recurrences were observed afterward, and thus surgeries on those regions were performed. Pathologically, the peritoneal and lung recurrences comprised leiomyosarcoma and the lymphnode recurrence was diagnosed as adenocarcinoma. Despite newly discovered multiple lung recurrences and regional lymph-node metastases, the patient lived a normal life for 73 mo after the initial operation based on multidisciplinary therapy. He ultimately died of liver failure due to invasive lymph-node recurrence from the rectal adenocarcinoma, in addition to multiple lung recurrences from the leiomyosarcoma. Hepatic recurrence did not occur in this patient's case, which appears to be one reason for his long-term survival. | Hideki Aoki Takashi Arata Masashi Utsumi Yutaka Mushiake Tomoyoshi Kunitomo Isao Yasuhara Fumitaka Taniguchi Koh Katsuda Kohji Tanakaya Hitoshi Takeuchi Rie Yamasaki | 2017 | World Journal of Gastroenterology2017，23，9： | 0 |
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